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Protein

Neurogenic differentiation factor 6

Gene

Neurod6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene.

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • dentate gyrus development Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenic differentiation factor 6
Short name:
NeuroD6
Alternative name(s):
Helix-loop-helix protein mATH-2
Short name:
mATH2
Protein NEX-1
Protein atonal homolog 2
Gene namesi
Name:Neurod6
Synonyms:Ath2, Atoh2, Nex1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:106593. Neurod6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Neurogenic differentiation factor 6PRO_0000127394Add
BLAST

Proteomic databases

PaxDbiP48986.
PRIDEiP48986.

PTM databases

PhosphoSiteiP48986.

Expressioni

Tissue specificityi

Specific to the nervous system of both embryos and adults. Highest levels in the cortical plate of the cerebrum.

Gene expression databases

BgeeiENSMUSG00000037984.
CleanExiMM_NEUROD6.
ExpressionAtlasiP48986. baseline and differential.
GenevisibleiP48986. MM.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047016.

Structurei

3D structure databases

ProteinModelPortaliP48986.
SMRiP48986. Positions 95-151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 14653bHLHPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi80 – 867Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi54 – 6310Poly-Glu

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQ4G. Eukaryota.
ENOG41118Y2. LUCA.
HOGENOMiHOG000049256.
HOVERGENiHBG000250.
InParanoidiP48986.
KOiK09080.
OMAiVERVKFR.
OrthoDBiEOG091G15AI.
PhylomeDBiP48986.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR032650. Neurod6.
IPR022575. Neurogenic_DUF.
IPR016637. TF_bHLH_NeuroD.
[Graphical view]
PANTHERiPTHR19290:SF9. PTHR19290:SF9. 2 hits.
PfamiPF00010. HLH. 1 hit.
PF12533. Neuro_bHLH. 1 hit.
[Graphical view]
PIRSFiPIRSF015618. bHLH_NeuroD. 1 hit.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48986-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTLPFDESV VMPESQMCRK FARQCEDQKQ IKKPESFPKQ VVLRGKSIKR
60 70 80 90 100
APGEETEKEE EEEDREEEDE NGLSRRRGLR KKKTTKLRLE RVKFRRQEAN
110 120 130 140 150
ARERNRMHGL NDALDNLRKV VPCYSKTQKL SKIETLRLAK NYIWALSEIL
160 170 180 190 200
RIGKRPDLLT FVQNLCKGLS QPTTNLVAGC LQLNARSFLM GQGGEAAHHT
210 220 230 240 250
RSPYSTFYPP YHSPELATPP GHGTLDNSKS MKPYNYCSAY ESFYESTSPE
260 270 280 290 300
CASPQFEGPL SPPPINYNGI FSLKQEETLD YGKNYNYGMH YCAVPPRGPL
310 320 330
GQGAMFRLPT DSHFPYDLHL RSQSLTMQDE LNAVFHN
Length:337
Mass (Da):38,644
Last modified:February 1, 1996 - v1
Checksum:i35C18ACD8EE1EFBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D44480 Genomic DNA. Translation: BAA07923.1.
U29086 mRNA. Translation: AAC14576.1.
CCDSiCCDS20168.1.
PIRiI48682.
I57038.
RefSeqiNP_033847.1. NM_009717.2.
UniGeneiMm.5106.

Genome annotation databases

EnsembliENSMUST00000044767; ENSMUSP00000047016; ENSMUSG00000037984.
GeneIDi11922.
KEGGimmu:11922.
UCSCiuc009cav.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D44480 Genomic DNA. Translation: BAA07923.1.
U29086 mRNA. Translation: AAC14576.1.
CCDSiCCDS20168.1.
PIRiI48682.
I57038.
RefSeqiNP_033847.1. NM_009717.2.
UniGeneiMm.5106.

3D structure databases

ProteinModelPortaliP48986.
SMRiP48986. Positions 95-151.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047016.

PTM databases

PhosphoSiteiP48986.

Proteomic databases

PaxDbiP48986.
PRIDEiP48986.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044767; ENSMUSP00000047016; ENSMUSG00000037984.
GeneIDi11922.
KEGGimmu:11922.
UCSCiuc009cav.2. mouse.

Organism-specific databases

CTDi63974.
MGIiMGI:106593. Neurod6.

Phylogenomic databases

eggNOGiENOG410IQ4G. Eukaryota.
ENOG41118Y2. LUCA.
HOGENOMiHOG000049256.
HOVERGENiHBG000250.
InParanoidiP48986.
KOiK09080.
OMAiVERVKFR.
OrthoDBiEOG091G15AI.
PhylomeDBiP48986.
TreeFamiTF315153.

Miscellaneous databases

PROiP48986.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037984.
CleanExiMM_NEUROD6.
ExpressionAtlasiP48986. baseline and differential.
GenevisibleiP48986. MM.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR032650. Neurod6.
IPR022575. Neurogenic_DUF.
IPR016637. TF_bHLH_NeuroD.
[Graphical view]
PANTHERiPTHR19290:SF9. PTHR19290:SF9. 2 hits.
PfamiPF00010. HLH. 1 hit.
PF12533. Neuro_bHLH. 1 hit.
[Graphical view]
PIRSFiPIRSF015618. bHLH_NeuroD. 1 hit.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDF6_MOUSE
AccessioniPrimary (citable) accession number: P48986
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.