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P48986 (NDF6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Neurogenic differentiation factor 6
Short name=NeuroD6
Alternative name(s):
Helix-loop-helix protein mATH-2
Short name=mATH2
Protein NEX-1
Protein atonal homolog 2
Gene names
Name:Neurod6
Synonyms:Ath2, Atoh2, Nex1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene.

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein.

Subcellular location

Nucleus Probable.

Tissue specificity

Specific to the nervous system of both embryos and adults. Highest levels in the cortical plate of the cerebrum.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Neurogenic differentiation factor 6
PRO_0000127394

Regions

Domain94 – 14653bHLH
Motif80 – 867Nuclear localization signal Potential
Compositional bias54 – 6310Poly-Glu

Sequences

Sequence LengthMass (Da)Tools
P48986 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 35C18ACD8EE1EFBA

FASTA33738,644
        10         20         30         40         50         60 
MLTLPFDESV VMPESQMCRK FARQCEDQKQ IKKPESFPKQ VVLRGKSIKR APGEETEKEE 

        70         80         90        100        110        120 
EEEDREEEDE NGLSRRRGLR KKKTTKLRLE RVKFRRQEAN ARERNRMHGL NDALDNLRKV 

       130        140        150        160        170        180 
VPCYSKTQKL SKIETLRLAK NYIWALSEIL RIGKRPDLLT FVQNLCKGLS QPTTNLVAGC 

       190        200        210        220        230        240 
LQLNARSFLM GQGGEAAHHT RSPYSTFYPP YHSPELATPP GHGTLDNSKS MKPYNYCSAY 

       250        260        270        280        290        300 
ESFYESTSPE CASPQFEGPL SPPPINYNGI FSLKQEETLD YGKNYNYGMH YCAVPPRGPL 

       310        320        330 
GQGAMFRLPT DSHFPYDLHL RSQSLTMQDE LNAVFHN

« Hide

References

[1]"MATH-2, a mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal, is specifically expressed in the nervous system."
Shimizu C., Akazawa C., Nakanishi S., Kageyama R.
Eur. J. Biochem. 229:239-248(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/J.
[2]"NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons."
Bartholomae A., Nave K.-A.
Mech. Dev. 48:217-228(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D44480 Genomic DNA. Translation: BAA07923.1.
U29086 mRNA. Translation: AAC14576.1.
IPIIPI00115630.
PIRI48682.
I57038.
RefSeqNP_033847.1. NM_009717.2.
UniGeneMm.5106.

3D structure databases

ProteinModelPortalP48986.
SMRP48986. Positions 95-151.
ModBaseSearch...

PTM databases

PhosphoSiteP48986.

Proteomic databases

PRIDEP48986.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000044767; ENSMUSP00000047016; ENSMUSG00000037984.
GeneID11922.
KEGGmmu:11922.

Organism-specific databases

CTD63974.
MGIMGI:106593. Neurod6.

Phylogenomic databases

eggNOGNOG242996.
HOGENOMHOG000049256.
HOVERGENHBG000250.
InParanoidP48986.
KOK09080.
OMALPTESHF.
OrthoDBEOG408N8N.

Gene expression databases

ArrayExpressP48986.
BgeeP48986.
CleanExMM_NEUROD6.
GenevestigatorP48986.
GermOnlineENSMUSG00000037984. Mus musculus.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
IPR022575. Neurogenic_DUF.
IPR016637. TF_bHLH_NeuroD.
[Graphical view]
PfamPF00010. HLH. 1 hit.
PF12533. Neuro_bHLH. 1 hit.
[Graphical view]
PIRSFPIRSF015618. bHLH_NeuroD. 1 hit.
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. HLH_basic. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio279993.
SOURCESearch...

Entry information

Entry nameNDF6_MOUSE
AccessionPrimary (citable) accession number: P48986
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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