P48985 (ATOH1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein atonal homolog 1

Alternative name(s):
Helix-loop-helix protein mATH-1
Short name=mATH1

Gene names

Name:	Atoh1
Synonyms:	Ath1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription. Ref.3
Subunit structure	Efficient DNA binding requires dimerization with another bHLH protein.
Subcellular location	Nucleus Ref.3.
Tissue specificity	Developing nervous system, and in adult epithelial cells of the gastrointestinal tract.
Developmental stage	First detected in the cranial ganglions and the dorsal part of the central nervous system on embryonic day 9.5 (E9.5). From E10.5 onward, prominent expression of MATH-1 continues in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by E18 and is undetectable in the adult nervous system.
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from mutant phenotype. Source: MGI auditory receptor cell fate determination Inferred from direct assay. Source: MGI auditory receptor cell fate specification Inferred from mutant phenotype. Source: MGI axon guidance Inferred from mutant phenotype. Source: MGI cerebral cortex development Inferred from mutant phenotype. Source: MGI inner ear morphogenesis Inferred from mutant phenotype. Source: MGI neuron migration Inferred from mutant phenotype. Source: MGI positive regulation of auditory receptor cell differentiation Inferred from direct assay. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay Ref.3. Source: UniProtKB
Molecular function	chromatin DNA binding Inferred from direct assay. Source: MGI protein binding Inferred from physical interaction. Source: MGI sequence-specific DNA binding Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Protein atonal homolog 1		PRO_0000127140
Regions
	Domain	169 – 209	41	Helix-loop-helix motif
	DNA binding	157 – 168	12	Basic motif
	Compositional bias	221 – 224	4	Poly-Pro

Sequences

	Sequence		Length	Mass (Da)
	P48985 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 596E03DF23C3BF96	FASTA	351	37,854
	10 20 30 40 50 60 MSRLLHAEEW AEVKELGDHH RHPQPHHVPP LTPQPPATLQ ARDLPVYPAE LSLLDSTDPR 70 80 90 100 110 120 AWLTPTLQGL CTARAAQYLL HSPELGASEA AAPRDEADSQ GELVRRSGCG GLSKSPGPVK 130 140 150 160 170 180 VREQLCKLKG GVVVDELGCS RQRAPSSKQV NGVQKQRRLA ANARERRRMH GLNHAFDQLR 190 200 210 220 230 240 NVIPSFNNDK KLSKYETLQM AQIYINALSE LLQTPNVGEQ PPPPTASCKN DHHHLRTASS 250 260 270 280 290 300 YEGGAGASAV AGAQPAPGGG PRPTPPGPCR TRFSGPASSG GYSVQLDALH FPAFEDRALT 310 320 330 340 350 AMMAQKDLSP SLPGGILQPV QEDNSKTSPR SHRSDGEFSP HSHYSDSDEA S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system." Akazawa C., Ishibashi M., Shimizu C., Nakanishi S., Kageyama R. J. Biol. Chem. 270:8730-8738(1995) [PubMed: 7721778] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
[3]	"Generation of neurons by transient expression of neural bHLH proteins in mammalian cells." Farah M.H., Olson J.M., Sucic H.B., Hume R.I., Tapscott S.J., Turner D.L. Development 127:693-702(2000) [PubMed: 10648228] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D43694 Genomic DNA. Translation: BAA07791.1. BC010820 mRNA. Translation: AAH10820.1. BC051256 mRNA. Translation: AAH51256.1.
IPI	IPI00115629.
PIR	A56387.
RefSeq	NP_031526.1. NM_007500.4.
UniGene	Mm.57229.
3D structure databases
ProteinModelPortal	P48985.
SMR	P48985. Positions 157-213.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-46434N.
STRING	P48985.
Proteomic databases
PRIDE	P48985.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000101351; ENSMUSP00000098903; ENSMUSG00000073043.
GeneID	11921.
KEGG	mmu:11921.
UCSC	uc009ceb.2. mouse.
Organism-specific databases
CTD	474.
MGI	MGI:104654. Atoh1.
Phylogenomic databases
eggNOG	roNOG11746.
GeneTree	ENSGT00550000074162.
HOGENOM	HBG713501.
HOVERGEN	HBG050609.
InParanoid	P48985.
OMA	HSHYSDS.
OrthoDB	EOG4PNXJ0.
PhylomeDB	P48985.
Gene expression databases
ArrayExpress	P48985.
Bgee	P48985.
CleanEx	MM_ATOH1.
Genevestigator	P48985.
GermOnline	ENSMUSG00000073043. Mus musculus.
Family and domain databases
InterPro	IPR011598. HLH_DNA-bd. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
KO	K09083.
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. HLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	279989.
SOURCE	Search...

Entry information

Entry name

ATOH1_MOUSE

Accession

Primary (citable) accession number: P48985

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 16, 2011
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program