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P48985 (ATOH1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein atonal homolog 1
Alternative name(s):
Helix-loop-helix protein mATH-1
Short name=mATH1
Gene names
Name:Atoh1
Synonyms:Ath1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription. Ref.3

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein.

Subcellular location

Nucleus Ref.3.

Tissue specificity

Developing nervous system, and in adult epithelial cells of the gastrointestinal tract.

Developmental stage

First detected in the cranial ganglions and the dorsal part of the central nervous system on embryonic day 9.5 (E9.5). From E10.5 onward, prominent expression of MATH-1 continues in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by E18 and is undetectable in the adult nervous system.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionActivator
Developmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processauditory receptor cell differentiation

Inferred from direct assay PubMed 15543141. Source: MGI

auditory receptor cell fate determination

Inferred from direct assay PubMed 16407553. Source: MGI

auditory receptor cell fate specification

Inferred from mutant phenotype PubMed 10364557. Source: MGI

axon guidance

Inferred from mutant phenotype PubMed 16145671. Source: MGI

brain development

Inferred from mutant phenotype PubMed 12223565. Source: MGI

cell differentiation

Inferred from mutant phenotype PubMed 15543141. Source: MGI

cerebral cortex development

Inferred from mutant phenotype PubMed 16325379. Source: MGI

inner ear development

Inferred from mutant phenotype PubMed 21146598. Source: MGI

inner ear morphogenesis

Inferred from mutant phenotype PubMed 15543141PubMed 16145671. Source: MGI

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 11973280. Source: MGI

neuron differentiation

Inferred from mutant phenotype PubMed 14999071. Source: MGI

neuron migration

Inferred from mutant phenotype PubMed 16202707. Source: MGI

positive regulation of auditory receptor cell differentiation

Inferred from direct assay PubMed 11023859PubMed 19154718. Source: MGI

positive regulation of inner ear receptor cell differentiation

Inferred from mutant phenotype PubMed 12208538. Source: UniProtKB

positive regulation of neuron differentiation

Inferred from direct assay Ref.3. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 16679559. Source: MGI

regulation of neuron differentiation

Inferred from direct assay PubMed 14757642. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay Ref.3. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from direct assay PubMed 14757642. Source: MGI

chromatin DNA binding

Inferred from direct assay PubMed 15788459. Source: MGI

protein binding

Inferred from physical interaction PubMed 14757642. Source: MGI

sequence-specific DNA binding

Inferred from direct assay PubMed 16679559. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Protein atonal homolog 1
PRO_0000127140

Regions

Domain156 – 20853bHLH
Compositional bias221 – 2244Poly-Pro

Sequences

Sequence LengthMass (Da)Tools
P48985 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 596E03DF23C3BF96

FASTA35137,854
        10         20         30         40         50         60 
MSRLLHAEEW AEVKELGDHH RHPQPHHVPP LTPQPPATLQ ARDLPVYPAE LSLLDSTDPR 

        70         80         90        100        110        120 
AWLTPTLQGL CTARAAQYLL HSPELGASEA AAPRDEADSQ GELVRRSGCG GLSKSPGPVK 

       130        140        150        160        170        180 
VREQLCKLKG GVVVDELGCS RQRAPSSKQV NGVQKQRRLA ANARERRRMH GLNHAFDQLR 

       190        200        210        220        230        240 
NVIPSFNNDK KLSKYETLQM AQIYINALSE LLQTPNVGEQ PPPPTASCKN DHHHLRTASS 

       250        260        270        280        290        300 
YEGGAGASAV AGAQPAPGGG PRPTPPGPCR TRFSGPASSG GYSVQLDALH FPAFEDRALT 

       310        320        330        340        350 
AMMAQKDLSP SLPGGILQPV QEDNSKTSPR SHRSDGEFSP HSHYSDSDEA S 

« Hide

References

« Hide 'large scale' references
[1]"A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system."
Akazawa C., Ishibashi M., Shimizu C., Nakanishi S., Kageyama R.
J. Biol. Chem. 270:8730-8738(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
[3]"Generation of neurons by transient expression of neural bHLH proteins in mammalian cells."
Farah M.H., Olson J.M., Sucic H.B., Hume R.I., Tapscott S.J., Turner D.L.
Development 127:693-702(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D43694 Genomic DNA. Translation: BAA07791.1.
BC010820 mRNA. Translation: AAH10820.1.
BC051256 mRNA. Translation: AAH51256.1.
CCDSCCDS20203.1.
PIRA56387.
RefSeqNP_031526.1. NM_007500.4.
UniGeneMm.57229.

3D structure databases

ProteinModelPortalP48985.
SMRP48985. Positions 157-213.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198237. 1 interaction.
DIPDIP-46434N.
STRING10090.ENSMUSP00000098903.

PTM databases

PhosphoSiteP48985.

Proteomic databases

PRIDEP48985.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000101351; ENSMUSP00000098903; ENSMUSG00000073043.
GeneID11921.
KEGGmmu:11921.
UCSCuc009ceb.2. mouse.

Organism-specific databases

CTD474.
MGIMGI:104654. Atoh1.

Phylogenomic databases

eggNOGNOG267878.
GeneTreeENSGT00740000115474.
HOGENOMHOG000261611.
HOVERGENHBG050609.
InParanoidP48985.
KOK09083.
OMAHSHYSDS.
OrthoDBEOG7PGDSD.
PhylomeDBP48985.
TreeFamTF315153.

Gene expression databases

BgeeP48985.
CleanExMM_ATOH1.
GenevestigatorP48985.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio279989.
PROP48985.
SOURCESearch...

Entry information

Entry nameATOH1_MOUSE
AccessionPrimary (citable) accession number: P48985
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot