P48985 (ATOH1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein atonal homolog 1

Alternative name(s):
Helix-loop-helix protein mATH-1
Short name=mATH1

Gene names

Name:	Atoh1
Synonyms:	Ath1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription. Ref.3
Subunit structure	Efficient DNA binding requires dimerization with another bHLH protein.
Subcellular location	Nucleus Ref.3.
Tissue specificity	Developing nervous system, and in adult epithelial cells of the gastrointestinal tract.
Developmental stage	First detected in the cranial ganglions and the dorsal part of the central nervous system on embryonic day 9.5 (E9.5). From E10.5 onward, prominent expression of MATH-1 continues in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by E18 and is undetectable in the adult nervous system.
Sequence similarities	Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from mutant phenotype PubMed 11973280. Source: MGI auditory receptor cell fate determination Inferred from direct assay PubMed 16407553. Source: MGI auditory receptor cell fate specification Inferred from mutant phenotype PubMed 10364557. Source: MGI axon guidance Inferred from mutant phenotype PubMed 16145671. Source: MGI cerebral cortex development Inferred from mutant phenotype PubMed 16325379. Source: MGI inner ear morphogenesis Inferred from mutant phenotype PubMed 15543141PubMed 16145671. Source: MGI neuron migration Inferred from mutant phenotype PubMed 16202707. Source: MGI positive regulation of auditory receptor cell differentiation Inferred from direct assay PubMed 11023859PubMed 19154718. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 16679559. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay Ref.3. Source: UniProtKB
Molecular_function	chromatin DNA binding Inferred from direct assay PubMed 15788459. Source: MGI sequence-specific DNA binding Inferred from direct assay PubMed 16679559. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Protein atonal homolog 1		PRO_0000127140
Regions
	Domain	156 – 208	53	bHLH
	Compositional bias	221 – 224	4	Poly-Pro

Sequences

	Sequence		Length	Mass (Da)
	P48985 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 596E03DF23C3BF96	FASTA	351	37,854
	10 20 30 40 50 60 MSRLLHAEEW AEVKELGDHH RHPQPHHVPP LTPQPPATLQ ARDLPVYPAE LSLLDSTDPR 70 80 90 100 110 120 AWLTPTLQGL CTARAAQYLL HSPELGASEA AAPRDEADSQ GELVRRSGCG GLSKSPGPVK 130 140 150 160 170 180 VREQLCKLKG GVVVDELGCS RQRAPSSKQV NGVQKQRRLA ANARERRRMH GLNHAFDQLR 190 200 210 220 230 240 NVIPSFNNDK KLSKYETLQM AQIYINALSE LLQTPNVGEQ PPPPTASCKN DHHHLRTASS 250 260 270 280 290 300 YEGGAGASAV AGAQPAPGGG PRPTPPGPCR TRFSGPASSG GYSVQLDALH FPAFEDRALT 310 320 330 340 350 AMMAQKDLSP SLPGGILQPV QEDNSKTSPR SHRSDGEFSP HSHYSDSDEA S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system." Akazawa C., Ishibashi M., Shimizu C., Nakanishi S., Kageyama R. J. Biol. Chem. 270:8730-8738(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
[3]	"Generation of neurons by transient expression of neural bHLH proteins in mammalian cells." Farah M.H., Olson J.M., Sucic H.B., Hume R.I., Tapscott S.J., Turner D.L. Development 127:693-702(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D43694 Genomic DNA. Translation: BAA07791.1. BC010820 mRNA. Translation: AAH10820.1. BC051256 mRNA. Translation: AAH51256.1.
IPI	IPI00115629.
PIR	A56387.
RefSeq	NP_031526.1. NM_007500.4.
UniGene	Mm.57229.
3D structure databases
ProteinModelPortal	P48985.
SMR	P48985. Positions 157-213.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-46434N.
STRING	10090.ENSMUSP00000098903.
PTM databases
PhosphoSite	P48985.
Proteomic databases
PRIDE	P48985.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000101351; ENSMUSP00000098903; ENSMUSG00000073043.
GeneID	11921.
KEGG	mmu:11921.
UCSC	uc009ceb.2. mouse.
Organism-specific databases
CTD	474.
MGI	MGI:104654. Atoh1.
Phylogenomic databases
eggNOG	NOG267878.
GeneTree	ENSGT00680000099574.
HOGENOM	HOG000261611.
HOVERGEN	HBG050609.
InParanoid	P48985.
KO	K09083.
OMA	HSHYSDS.
OrthoDB	EOG4PNXJ0.
Gene expression databases
Bgee	P48985.
CleanEx	MM_ATOH1.
Genevestigator	P48985.
GermOnline	ENSMUSG00000073043. Mus musculus.
Family and domain databases
Gene3D	4.10.280.10. 1 hit.
InterPro	IPR011598. bHLH_dom. [Graphical view]
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. BHLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	279989.
SOURCE	Search...

Entry information

Entry name

ATOH1_MOUSE

Accession

Primary (citable) accession number: P48985

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program