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Protein

Protein atonal homolog 1

Gene

Atoh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.1 Publication

GO - Molecular functioni

  • chromatin DNA binding Source: MGI
  • DNA binding Source: MGI
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI

GO - Biological processi

  • auditory receptor cell differentiation Source: MGI
  • auditory receptor cell fate determination Source: MGI
  • auditory receptor cell fate specification Source: MGI
  • axon guidance Source: MGI
  • brain development Source: MGI
  • cell differentiation Source: MGI
  • cerebral cortex development Source: MGI
  • inner ear development Source: MGI
  • inner ear morphogenesis Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • neuron differentiation Source: MGI
  • neuron migration Source: MGI
  • positive regulation of auditory receptor cell differentiation Source: MGI
  • positive regulation of inner ear receptor cell differentiation Source: UniProtKB
  • positive regulation of neuron differentiation Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of neuron differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein atonal homolog 1
Alternative name(s):
Helix-loop-helix protein mATH-1
Short name:
mATH1
Gene namesi
Name:Atoh1
Synonyms:Ath1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:104654. Atoh1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Protein atonal homolog 1PRO_0000127140Add
BLAST

Proteomic databases

PRIDEiP48985.

PTM databases

PhosphoSiteiP48985.

Expressioni

Tissue specificityi

Developing nervous system, and in adult epithelial cells of the gastrointestinal tract.

Developmental stagei

First detected in the cranial ganglions and the dorsal part of the central nervous system on embryonic day 9.5 (E9.5). From E10.5 onward, prominent expression of MATH-1 continues in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by E18 and is undetectable in the adult nervous system.

Gene expression databases

BgeeiP48985.
CleanExiMM_ATOH1.
GenevestigatoriP48985.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Protein-protein interaction databases

BioGridi198237. 1 interaction.
DIPiDIP-46434N.
STRINGi10090.ENSMUSP00000098903.

Structurei

3D structure databases

ProteinModelPortaliP48985.
SMRiP48985. Positions 157-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini156 – 20853bHLHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi221 – 2244Poly-Pro

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG267878.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000261611.
HOVERGENiHBG050609.
InParanoidiP48985.
KOiK09083.
OMAiLHAEEWA.
OrthoDBiEOG7PGDSD.
PhylomeDBiP48985.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48985-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLLHAEEW AEVKELGDHH RHPQPHHVPP LTPQPPATLQ ARDLPVYPAE
60 70 80 90 100
LSLLDSTDPR AWLTPTLQGL CTARAAQYLL HSPELGASEA AAPRDEADSQ
110 120 130 140 150
GELVRRSGCG GLSKSPGPVK VREQLCKLKG GVVVDELGCS RQRAPSSKQV
160 170 180 190 200
NGVQKQRRLA ANARERRRMH GLNHAFDQLR NVIPSFNNDK KLSKYETLQM
210 220 230 240 250
AQIYINALSE LLQTPNVGEQ PPPPTASCKN DHHHLRTASS YEGGAGASAV
260 270 280 290 300
AGAQPAPGGG PRPTPPGPCR TRFSGPASSG GYSVQLDALH FPAFEDRALT
310 320 330 340 350
AMMAQKDLSP SLPGGILQPV QEDNSKTSPR SHRSDGEFSP HSHYSDSDEA

S
Length:351
Mass (Da):37,854
Last modified:February 1, 1996 - v1
Checksum:i596E03DF23C3BF96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43694 Genomic DNA. Translation: BAA07791.1.
BC010820 mRNA. Translation: AAH10820.1.
BC051256 mRNA. Translation: AAH51256.1.
CCDSiCCDS20203.1.
PIRiA56387.
RefSeqiNP_031526.1. NM_007500.4.
UniGeneiMm.57229.

Genome annotation databases

EnsembliENSMUST00000101351; ENSMUSP00000098903; ENSMUSG00000073043.
GeneIDi11921.
KEGGimmu:11921.
UCSCiuc009ceb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43694 Genomic DNA. Translation: BAA07791.1.
BC010820 mRNA. Translation: AAH10820.1.
BC051256 mRNA. Translation: AAH51256.1.
CCDSiCCDS20203.1.
PIRiA56387.
RefSeqiNP_031526.1. NM_007500.4.
UniGeneiMm.57229.

3D structure databases

ProteinModelPortaliP48985.
SMRiP48985. Positions 157-213.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198237. 1 interaction.
DIPiDIP-46434N.
STRINGi10090.ENSMUSP00000098903.

PTM databases

PhosphoSiteiP48985.

Proteomic databases

PRIDEiP48985.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101351; ENSMUSP00000098903; ENSMUSG00000073043.
GeneIDi11921.
KEGGimmu:11921.
UCSCiuc009ceb.2. mouse.

Organism-specific databases

CTDi474.
MGIiMGI:104654. Atoh1.

Phylogenomic databases

eggNOGiNOG267878.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000261611.
HOVERGENiHBG050609.
InParanoidiP48985.
KOiK09083.
OMAiLHAEEWA.
OrthoDBiEOG7PGDSD.
PhylomeDBiP48985.
TreeFamiTF315153.

Miscellaneous databases

NextBioi279989.
PROiP48985.
SOURCEiSearch...

Gene expression databases

BgeeiP48985.
CleanExiMM_ATOH1.
GenevestigatoriP48985.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system."
    Akazawa C., Ishibashi M., Shimizu C., Nakanishi S., Kageyama R.
    J. Biol. Chem. 270:8730-8738(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "Generation of neurons by transient expression of neural bHLH proteins in mammalian cells."
    Farah M.H., Olson J.M., Sucic H.B., Hume R.I., Tapscott S.J., Turner D.L.
    Development 127:693-702(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiATOH1_MOUSE
AccessioniPrimary (citable) accession number: P48985
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.