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Protein

Protein atonal homolog 1

Gene

Atoh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.1 Publication

GO - Molecular functioni

  • chromatin DNA binding Source: MGI
  • DNA binding Source: MGI
  • protein dimerization activity Source: InterPro
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • auditory receptor cell fate determination Source: MGI
  • auditory receptor cell fate specification Source: MGI
  • axon guidance Source: MGI
  • brain development Source: MGI
  • cell differentiation Source: MGI
  • cerebral cortex development Source: MGI
  • inner ear auditory receptor cell differentiation Source: MGI
  • inner ear development Source: MGI
  • inner ear morphogenesis Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • neuron differentiation Source: MGI
  • neuron migration Source: MGI
  • Notch signaling pathway Source: MGI
  • positive regulation of inner ear auditory receptor cell differentiation Source: MGI
  • positive regulation of inner ear receptor cell differentiation Source: UniProtKB
  • positive regulation of neuron differentiation Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • regulation of neuron differentiation Source: MGI

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein atonal homolog 1
Alternative name(s):
Helix-loop-helix protein mATH-1
Short name:
mATH1
Gene namesi
Name:Atoh1
Synonyms:Ath1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:104654 Atoh1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001271401 – 351Protein atonal homolog 1Add BLAST351

Proteomic databases

PaxDbiP48985
PRIDEiP48985

PTM databases

iPTMnetiP48985
PhosphoSitePlusiP48985

Expressioni

Tissue specificityi

Developing nervous system, and in adult epithelial cells of the gastrointestinal tract.

Developmental stagei

First detected in the cranial ganglions and the dorsal part of the central nervous system on embryonic day 9.5 (E9.5). From E10.5 onward, prominent expression of MATH-1 continues in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by E18 and is undetectable in the adult nervous system.

Gene expression databases

BgeeiENSMUSG00000073043
CleanExiMM_ATOH1
GenevisibleiP48985 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Binary interactionsi

WithEntry#Exp.IntActNotes
Tcf4Q91YV02EBI-15659000,EBI-15658970

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198237, 1 interactor
DIPiDIP-46434N
IntActiP48985, 2 interactors
STRINGi10090.ENSMUSP00000098903

Structurei

3D structure databases

ProteinModelPortaliP48985
SMRiP48985
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini156 – 208bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi221 – 224Poly-Pro4

Phylogenomic databases

eggNOGiKOG4395 Eukaryota
ENOG411269K LUCA
GeneTreeiENSGT00680000099860
HOGENOMiHOG000261611
HOVERGENiHBG050609
InParanoidiP48985
KOiK09083
OMAiKQVNGVQ
OrthoDBiEOG091G0R1N
PhylomeDBiP48985
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR032661 ATOH1
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR19290:SF82 PTHR19290:SF82, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P48985-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLLHAEEW AEVKELGDHH RHPQPHHVPP LTPQPPATLQ ARDLPVYPAE
60 70 80 90 100
LSLLDSTDPR AWLTPTLQGL CTARAAQYLL HSPELGASEA AAPRDEADSQ
110 120 130 140 150
GELVRRSGCG GLSKSPGPVK VREQLCKLKG GVVVDELGCS RQRAPSSKQV
160 170 180 190 200
NGVQKQRRLA ANARERRRMH GLNHAFDQLR NVIPSFNNDK KLSKYETLQM
210 220 230 240 250
AQIYINALSE LLQTPNVGEQ PPPPTASCKN DHHHLRTASS YEGGAGASAV
260 270 280 290 300
AGAQPAPGGG PRPTPPGPCR TRFSGPASSG GYSVQLDALH FPAFEDRALT
310 320 330 340 350
AMMAQKDLSP SLPGGILQPV QEDNSKTSPR SHRSDGEFSP HSHYSDSDEA

S
Length:351
Mass (Da):37,854
Last modified:February 1, 1996 - v1
Checksum:i596E03DF23C3BF96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43694 Genomic DNA Translation: BAA07791.1
BC010820 mRNA Translation: AAH10820.1
BC051256 mRNA Translation: AAH51256.1
CCDSiCCDS20203.1
PIRiA56387
RefSeqiNP_031526.1, NM_007500.4
UniGeneiMm.57229

Genome annotation databases

EnsembliENSMUST00000101351; ENSMUSP00000098903; ENSMUSG00000073043
GeneIDi11921
KEGGimmu:11921
UCSCiuc009ceb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiATOH1_MOUSE
AccessioniPrimary (citable) accession number: P48985
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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