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P48985

- ATOH1_MOUSE

UniProt

P48985 - ATOH1_MOUSE

Protein

Protein atonal homolog 1

Gene

Atoh1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.1 Publication

    GO - Molecular functioni

    1. chromatin DNA binding Source: MGI
    2. DNA binding Source: MGI
    3. protein binding Source: MGI
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    6. sequence-specific DNA binding Source: MGI

    GO - Biological processi

    1. auditory receptor cell differentiation Source: MGI
    2. auditory receptor cell fate determination Source: MGI
    3. auditory receptor cell fate specification Source: MGI
    4. axon guidance Source: MGI
    5. brain development Source: MGI
    6. cell differentiation Source: MGI
    7. cerebral cortex development Source: MGI
    8. inner ear development Source: MGI
    9. inner ear morphogenesis Source: MGI
    10. negative regulation of apoptotic process Source: MGI
    11. neuron differentiation Source: MGI
    12. neuron migration Source: MGI
    13. positive regulation of auditory receptor cell differentiation Source: MGI
    14. positive regulation of inner ear receptor cell differentiation Source: UniProtKB
    15. positive regulation of neuron differentiation Source: UniProtKB
    16. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    17. regulation of neuron differentiation Source: MGI

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein atonal homolog 1
    Alternative name(s):
    Helix-loop-helix protein mATH-1
    Short name:
    mATH1
    Gene namesi
    Name:Atoh1
    Synonyms:Ath1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:104654. Atoh1.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Protein atonal homolog 1PRO_0000127140Add
    BLAST

    Proteomic databases

    PRIDEiP48985.

    PTM databases

    PhosphoSiteiP48985.

    Expressioni

    Tissue specificityi

    Developing nervous system, and in adult epithelial cells of the gastrointestinal tract.

    Developmental stagei

    First detected in the cranial ganglions and the dorsal part of the central nervous system on embryonic day 9.5 (E9.5). From E10.5 onward, prominent expression of MATH-1 continues in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by E18 and is undetectable in the adult nervous system.

    Gene expression databases

    BgeeiP48985.
    CleanExiMM_ATOH1.
    GenevestigatoriP48985.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein.

    Protein-protein interaction databases

    BioGridi198237. 1 interaction.
    DIPiDIP-46434N.
    STRINGi10090.ENSMUSP00000098903.

    Structurei

    3D structure databases

    ProteinModelPortaliP48985.
    SMRiP48985. Positions 157-213.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini156 – 20853bHLHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi221 – 2244Poly-Pro

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG267878.
    GeneTreeiENSGT00740000115474.
    HOGENOMiHOG000261611.
    HOVERGENiHBG050609.
    InParanoidiP48985.
    KOiK09083.
    OMAiHSHYSDS.
    OrthoDBiEOG7PGDSD.
    PhylomeDBiP48985.
    TreeFamiTF315153.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48985-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRLLHAEEW AEVKELGDHH RHPQPHHVPP LTPQPPATLQ ARDLPVYPAE    50
    LSLLDSTDPR AWLTPTLQGL CTARAAQYLL HSPELGASEA AAPRDEADSQ 100
    GELVRRSGCG GLSKSPGPVK VREQLCKLKG GVVVDELGCS RQRAPSSKQV 150
    NGVQKQRRLA ANARERRRMH GLNHAFDQLR NVIPSFNNDK KLSKYETLQM 200
    AQIYINALSE LLQTPNVGEQ PPPPTASCKN DHHHLRTASS YEGGAGASAV 250
    AGAQPAPGGG PRPTPPGPCR TRFSGPASSG GYSVQLDALH FPAFEDRALT 300
    AMMAQKDLSP SLPGGILQPV QEDNSKTSPR SHRSDGEFSP HSHYSDSDEA 350
    S 351
    Length:351
    Mass (Da):37,854
    Last modified:February 1, 1996 - v1
    Checksum:i596E03DF23C3BF96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D43694 Genomic DNA. Translation: BAA07791.1.
    BC010820 mRNA. Translation: AAH10820.1.
    BC051256 mRNA. Translation: AAH51256.1.
    CCDSiCCDS20203.1.
    PIRiA56387.
    RefSeqiNP_031526.1. NM_007500.4.
    UniGeneiMm.57229.

    Genome annotation databases

    EnsembliENSMUST00000101351; ENSMUSP00000098903; ENSMUSG00000073043.
    GeneIDi11921.
    KEGGimmu:11921.
    UCSCiuc009ceb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D43694 Genomic DNA. Translation: BAA07791.1 .
    BC010820 mRNA. Translation: AAH10820.1 .
    BC051256 mRNA. Translation: AAH51256.1 .
    CCDSi CCDS20203.1.
    PIRi A56387.
    RefSeqi NP_031526.1. NM_007500.4.
    UniGenei Mm.57229.

    3D structure databases

    ProteinModelPortali P48985.
    SMRi P48985. Positions 157-213.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198237. 1 interaction.
    DIPi DIP-46434N.
    STRINGi 10090.ENSMUSP00000098903.

    PTM databases

    PhosphoSitei P48985.

    Proteomic databases

    PRIDEi P48985.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000101351 ; ENSMUSP00000098903 ; ENSMUSG00000073043 .
    GeneIDi 11921.
    KEGGi mmu:11921.
    UCSCi uc009ceb.2. mouse.

    Organism-specific databases

    CTDi 474.
    MGIi MGI:104654. Atoh1.

    Phylogenomic databases

    eggNOGi NOG267878.
    GeneTreei ENSGT00740000115474.
    HOGENOMi HOG000261611.
    HOVERGENi HBG050609.
    InParanoidi P48985.
    KOi K09083.
    OMAi HSHYSDS.
    OrthoDBi EOG7PGDSD.
    PhylomeDBi P48985.
    TreeFami TF315153.

    Miscellaneous databases

    NextBioi 279989.
    PROi P48985.
    SOURCEi Search...

    Gene expression databases

    Bgeei P48985.
    CleanExi MM_ATOH1.
    Genevestigatori P48985.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system."
      Akazawa C., Ishibashi M., Shimizu C., Nakanishi S., Kageyama R.
      J. Biol. Chem. 270:8730-8738(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    3. "Generation of neurons by transient expression of neural bHLH proteins in mammalian cells."
      Farah M.H., Olson J.M., Sucic H.B., Hume R.I., Tapscott S.J., Turner D.L.
      Development 127:693-702(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiATOH1_MOUSE
    AccessioniPrimary (citable) accession number: P48985
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3