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Reviewed, UniProtKB/Swiss-Prot P48985 (ATOH1_MOUSE)

Last modified June 16, 2009. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Protein atonal homolog 1
Alternative name(s):
    Helix-loop-helix protein mATH-1
      Short name=MATH1
Gene names
Name: Atoh1
Synonyms: Ath1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein.

Subcellular location

Nucleus Probable.

Tissue specificity

Developing nervous system, and in adult epithelial cells of the gastrointestinal tract.

Developmental stage

First detected in the cranial ganglions and the dorsal part of the central nervous system on embryonic day 9.5 (E9.5). From E10.5 onward, prominent expression of MATH-1 continues in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by E18 and is undetectable in the adult nervous system.

Sequence similarities

Contains 1 basic helix-loop-helix (bHLH) domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Protein atonal homolog 1
PRO_0000127140

Regions

Domain169 – 20941Helix-loop-helix motif
DNA binding157 – 16812Basic motif
Compositional bias221 – 2244Poly-Pro

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Sequences

Sequence LengthMass (Da)Tools
P48985-1 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 596E03DF23C3BF96

FASTA35137,854
        10         20         30         40         50         60 
MSRLLHAEEW AEVKELGDHH RHPQPHHVPP LTPQPPATLQ ARDLPVYPAE LSLLDSTDPR 

        70         80         90        100        110        120 
AWLTPTLQGL CTARAAQYLL HSPELGASEA AAPRDEADSQ GELVRRSGCG GLSKSPGPVK 

       130        140        150        160        170        180 
VREQLCKLKG GVVVDELGCS RQRAPSSKQV NGVQKQRRLA ANARERRRMH GLNHAFDQLR 

       190        200        210        220        230        240 
NVIPSFNNDK KLSKYETLQM AQIYINALSE LLQTPNVGEQ PPPPTASCKN DHHHLRTASS 

       250        260        270        280        290        300 
YEGGAGASAV AGAQPAPGGG PRPTPPGPCR TRFSGPASSG GYSVQLDALH FPAFEDRALT 

       310        320        330        340        350 
AMMAQKDLSP SLPGGILQPV QEDNSKTSPR SHRSDGEFSP HSHYSDSDEA S

« Hide

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References

« Hide 'large scale' references
[1]"A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system."
Akazawa C., Ishibashi M., Shimizu C., Nakanishi S., Kageyama R.
J. Biol. Chem. 270:8730-8738(1995) [PubMed: 7721778] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
+Additional computationally mapped references.

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Cross-references

Sequence databases

D43694 Genomic DNA. Translation: BAA07791.1.
BC010820 mRNA. Translation: AAH10820.1.
BC051256 mRNA. Translation: AAH51256.1.
IPIIPI00115629.
PIRA56387.
RefSeqNP_031526.1.
UniGeneMm.57229

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteP48985.

Genome annotation databases

EnsemblENSMUSG00000073043. Mus musculus. [Contig view]
GeneID11921.
KEGGmmu:11921.

Organism-specific databases

MGIMGI:104654. Atoh1.

Phylogenomic databases

HOGENOMP48985.
HOVERGENP48985.
OMAP48985. PSSKQVN.

Gene expression databases

ArrayExpressP48985.
BgeeP48985.
CleanExMM_ATOH1.
GermOnlineENSMUSG00000073043. Mus musculus.

Family and domain databases

InterProIPR001092. HLH_basic.
IPR011598. HLH_DNA_bd.
[Graphical view]
Gene3DG3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
PROSITEPS50888. HLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio279989.
SOURCESearch...

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Entry information

Entry nameATOH1_MOUSE
AccessionPrimary (citable) accession number: P48985
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 16, 2009
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents