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P48982

- BGAL_XANMN

UniProt

P48982 - BGAL_XANMN

Protein

Beta-galactosidase

Gene

bga

Organism
Xanthomonas manihotis
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Preferentially hydrolyzes beta(1->3) galactosyl linkages over beta(1->4) linkages.

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

    pH dependencei

    Optimum pH is 4.5.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei184 – 1841Proton donorSequence Analysis
    Active sitei260 – 2601NucleophileSequence Analysis

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH35. Glycoside Hydrolase Family 35.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-galactosidase (EC:3.2.1.23)
    Short name:
    Lactase
    Gene namesi
    Name:bga
    OrganismiXanthomonas manihotis
    Taxonomic identifieri43353 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Chaini22 – 598577Beta-galactosidasePRO_0000012198Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP48982.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 35 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR026283. B-gal_1-like.
    IPR008979. Galactose-bd-like.
    IPR019801. Glyco_hydro_35_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR23421. PTHR23421. 1 hit.
    PfamiPF01301. Glyco_hydro_35. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006336. B-gal. 1 hit.
    PRINTSiPR00742. GLHYDRLASE35.
    SUPFAMiSSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.
    PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48982-1 [UniParc]FASTAAdd to Basket

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    MLRTTLAPLV LALALALPAA AATPESWPTF GTQGTQFVRD GKPYQLLSGA    50
    IHFQRIPRAY WKDRLQKARA LGLNTVETYV FWNLVEPQQG QFDFSGNNDV 100
    AAFVKEAAAQ GLNVILRPGP YACAEWEAGG YPAWLFGKGN IRVRSRDPRF 150
    LAASQAYLDA LAKQVQPLLN HNGGPIIAVQ VENEYGSYAD DHAYMADNRA 200
    MYVKAGFDKA LLFTSDGADM LANGTLPDTL AVVNFAPGEA KSAFDKLIKF 250
    RPDQPRMVGE YWAGWFDHWG KPHAATDARQ QAEEFEWILR QGHSANLYMF 300
    IGGTSFGFMN GANFQNNPSD HYAPQTTSYD YDAILDEAGH PTPKFALMRD 350
    AIARVTGVQP PALPAPITTT TLPATPLRES ASLWDNLPTP IAIDTPQPME 400
    QFGQDYGYIL YRTTITGPRK GPLYLGDVRD VARVYVDQRP VGSVERRLQQ 450
    VSLEVEIPAG QHTLDVLVEN SGRINYGTRM ADGRAGLVDP VLLDSQQLTG 500
    WQAFPLPMRT PDSIRGWTGK AVQGPAFHRG TLRIGTPTDT YLDMRAFGKG 550
    FAWANGVNLG RHWNIGPQTA LYLRPSSARV TTRWWSSTWT MLHPSVRG 598
    Length:598
    Mass (Da):66,086
    Last modified:February 1, 1996 - v1
    Checksum:iDB4C3F05E01435BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L35444 Genomic DNA. Translation: AAC41485.1.
    PIRiA57249.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L35444 Genomic DNA. Translation: AAC41485.1 .
    PIRi A57249.

    3D structure databases

    ProteinModelPortali P48982.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH35. Glycoside Hydrolase Family 35.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR026283. B-gal_1-like.
    IPR008979. Galactose-bd-like.
    IPR019801. Glyco_hydro_35_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR23421. PTHR23421. 1 hit.
    Pfami PF01301. Glyco_hydro_35. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006336. B-gal. 1 hit.
    PRINTSi PR00742. GLHYDRLASE35.
    SUPFAMi SSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.
    PROSITEi PS01182. GLYCOSYL_HYDROL_F35. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel beta-galactosidase gene isolated from the bacterium Xanthomonas manihotis exhibits strong homology to several eukaryotic beta-galactosidases."
      Taron C.H., Benner J.S., Hornstra L.J., Guthrie E.P.
      Glycobiology 5:603-610(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 22-38, BIOPHYSICOCHEMICAL PROPERTIES.
      Strain: 7AS1.

    Entry informationi

    Entry nameiBGAL_XANMN
    AccessioniPrimary (citable) accession number: P48982
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3