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Protein

Beta-galactosidase

Gene
N/A
Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cell wall degradation. Degrades polysaccharides containing beta-(1-->4)-linked galactans, acting as an exo-(1-->4)-beta-D-galactanase.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

pH dependencei

Optimum pH is 4.5.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei180 – 1801Proton donorSequence Analysis
Active sitei249 – 2491NucleophileSequence Analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Alternative name(s):
Acid beta-galactosidase
Short name:
Lactase
Exo-(1-->4)-beta-D-galactanase
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
ProteomesiUP000004994 Componenti: Chromosome 12

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Add
BLAST
Chaini23 – 835813Beta-galactosidasePRO_0000012195Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4081.Solyc12g044880.1.1.

Structurei

3D structure databases

ProteinModelPortaliP48980.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini749 – 83587SUEL-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated
Contains 1 SUEL-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiP48980.
OMAiINITRDV.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
IPR000922. Lectin_gal-bd_dom.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF02140. Gal_Lectin. 1 hit.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 3 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48980-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFWMAMLLM LLLCLWVSCG IASVSYDHKA IIVNGQRKIL ISGSIHYPRS
60 70 80 90 100
TPEMWPDLIQ KAKEGGVDVI QTYVFWNGHE PEEGKYYFEE RYDLVKFIKV
110 120 130 140 150
VQEAGLYVHL RIGPYACAEW NFGGFPVWLK YVPGISFRTN NEPFKAAMQK
160 170 180 190 200
FTTKIVDMMK AEKLYETQGG PIILSQIENE YGPMEWELGE PGKVYSEWAA
210 220 230 240 250
KMAVDLGTGV PWIMCKQDDV PDPIINTCNG FYCDYFTPNK ANKPKMWTEA
260 270 280 290 300
WTAWFTEFGG PVPYRPAEDM AFAVARFIQT GGSFINYYMY HGGTNFGRTS
310 320 330 340 350
GGPFIATSYD YDAPLDEFGS LRQPKWGHLK DLHRAIKLCE PALVSVDPTV
360 370 380 390 400
TSLGNYQEAR VFKSESGACA AFLANYNQHS FAKVAFGNMH YNLPPWSISI
410 420 430 440 450
LPDCKNTVYN TARVGAQSAQ MKMTPVSRGF SWESFNEDAA SHEDDTFTVV
460 470 480 490 500
GLLEQINITR DVSDYLWYMT DIEIDPTEGF LNSGNWPWLT VFSAGHALHV
510 520 530 540 550
FVNGQLAGTV YGSLENPKLT FSNGINLRAG VNKISLLSIA VGLPNVGPHF
560 570 580 590 600
ETWNAGVLGP VSLNGLNEGT RDLTWQKWFY KVGLKGEALS LHSLSGSPSV
610 620 630 640 650
EWVEGSLVAQ KQPLSWYKTT FNAPDGNEPL ALDMNTMGKG QVWINGQSLG
660 670 680 690 700
RHWPAYKSSG SCSVCNYTGW FDEKKCLTNC GEGSQRWYHV PRSWLYPTGN
710 720 730 740 750
LLVVFEEWGG DPYGITLVKR EIGSVCADIY EWQPQLLNWQ RLVSGKFDRP
760 770 780 790 800
LRPKAHLKCA PGQKISSIKF ASFGTPEGVC GNFQQGSCHA PRSYDAFKKN
810 820 830
CVGKESCSVQ VTPENFGGDP CRNVLKKLSV EAICS
Length:835
Mass (Da):93,336
Last modified:February 1, 1996 - v1
Checksum:i94C9685F95C4A646
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83854 mRNA. Translation: CAA58734.1.
PIRiT06590.
RefSeqiNP_001234465.1. NM_001247536.1.
UniGeneiLes.3979.

Genome annotation databases

EnsemblPlantsiSolyc12g044880.1.1; Solyc12g044880.1.1; Solyc12g044880.1.
GeneIDi544167.
KEGGisly:544167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83854 mRNA. Translation: CAA58734.1.
PIRiT06590.
RefSeqiNP_001234465.1. NM_001247536.1.
UniGeneiLes.3979.

3D structure databases

ProteinModelPortaliP48980.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4081.Solyc12g044880.1.1.

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiSolyc12g044880.1.1; Solyc12g044880.1.1; Solyc12g044880.1.
GeneIDi544167.
KEGGisly:544167.

Phylogenomic databases

InParanoidiP48980.
OMAiINITRDV.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
IPR000922. Lectin_gal-bd_dom.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF02140. Gal_Lectin. 1 hit.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 3 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
PS50228. SUEL_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Tomato exo-(1-->4)-beta-D-galactanase. Isolation, changes during ripening in normal and mutant tomato fruit, and characterization of a related cDNA clone."
    Carey A.T., Holt K., Picard S., Wilde R., Tucker G.A., Bird C.R., Schuch W., Seymour G.B.
    Plant Physiol. 108:1099-1107(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: cv. Ailsa Craig.
    Tissue: Pericarp.

Entry informationi

Entry nameiBGAL_SOLLC
AccessioniPrimary (citable) accession number: P48980
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 24, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.