ID   V1BR_RAT                Reviewed;         425 AA.
AC   P48974;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   24-JAN-2024, entry version 139.
DE   RecName: Full=Vasopressin V1b receptor;
DE            Short=V1bR;
DE   AltName: Full=AVPR V1b;
DE   AltName: Full=AVPR V3;
DE   AltName: Full=Antidiuretic hormone receptor 1b;
DE   AltName: Full=Vasopressin V3 receptor;
GN   Name=Avpr1b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Pituitary;
RX   PubMed=7626108; DOI=10.1006/bbrc.1995.2033;
RA   Saito M., Sugimoto T., Tahara A., Kawashima H.;
RT   "Molecular cloning and characterization of rat V1b vasopressin receptor:
RT   evidence for its expression in extra-pituitary tissues.";
RL   Biochem. Biophys. Res. Commun. 212:751-757(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Pituitary;
RX   PubMed=7624319; DOI=10.1073/pnas.92.15.6783;
RA   Lolait S.J., O'Carroll A.-M., Mahan L.C., Felder C.C., Button D.C.,
RA   Young W.S. III, Mezey E., Brownstein M.J.;
RT   "Extrapituitary expression of the rat V1b vasopressin receptor gene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:6783-6787(1995).
CC   -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC       receptor is mediated by G proteins which activate a phosphatidyl-
CC       inositol-calcium second messenger system.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00521}.
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DR   EMBL; D45400; BAA08242.1; -; mRNA.
DR   EMBL; U27322; AAC52235.1; -; mRNA.
DR   PIR; JC4179; JC4179.
DR   AlphaFoldDB; P48974; -.
DR   SMR; P48974; -.
DR   STRING; 10116.ENSRNOP00000064689; -.
DR   BindingDB; P48974; -.
DR   ChEMBL; CHEMBL2659; -.
DR   DrugCentral; P48974; -.
DR   GuidetoPHARMACOLOGY; 367; -.
DR   CarbonylDB; P48974; -.
DR   GlyCosmos; P48974; 1 site, No reported glycans.
DR   GlyGen; P48974; 1 site.
DR   PhosphoSitePlus; P48974; -.
DR   PaxDb; 10116-ENSRNOP00000064689; -.
DR   Ensembl; ENSRNOT00055035146; ENSRNOP00055028488; ENSRNOG00055020578.
DR   Ensembl; ENSRNOT00060025469; ENSRNOP00060020303; ENSRNOG00060014890.
DR   Ensembl; ENSRNOT00065032514; ENSRNOP00065025947; ENSRNOG00065019314.
DR   UCSC; RGD:61886; rat.
DR   AGR; RGD:6502812; -.
DR   RGD; 6502812; Avpr1b.
DR   eggNOG; KOG3656; Eukaryota.
DR   InParanoid; P48974; -.
DR   PhylomeDB; P48974; -.
DR   PRO; PR:P48974; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0030425; C:dendrite; IDA:RGD.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; IPI:RGD.
DR   GO; GO:0017046; F:peptide hormone binding; IDA:RGD.
DR   GO; GO:0005000; F:vasopressin receptor activity; IDA:RGD.
DR   GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IDA:RGD.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:RGD.
DR   GO; GO:0090238; P:positive regulation of arachidonic acid secretion; ISO:RGD.
DR   GO; GO:0032849; P:positive regulation of cellular pH reduction; IMP:RGD.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IMP:RGD.
DR   GO; GO:0014049; P:positive regulation of glutamate secretion; IMP:RGD.
DR   GO; GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; ISO:RGD.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:RGD.
DR   GO; GO:0008217; P:regulation of blood pressure; ISO:RGD.
DR   GO; GO:0042127; P:regulation of cell population proliferation; ISO:RGD.
DR   GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; ISO:RGD.
DR   CDD; cd15386; 7tmA_V1bR; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR015076; V1R_C.
DR   InterPro; IPR001817; Vasoprsn_rcpt.
DR   InterPro; IPR000628; Vprs_rcpt_V1B.
DR   PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24241:SF18; VASOPRESSIN V1B RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   Pfam; PF08983; V1R_C; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00896; VASOPRESSINR.
DR   PRINTS; PR00897; VASOPRSNV1BR.
DR   SMART; SM01164; DUF1856; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..425
FT                   /note="Vasopressin V1b receptor"
FT                   /id="PRO_0000070205"
FT   TOPO_DOM        1..35
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..59
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        60..71
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..93
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..108
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..130
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        131..151
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..173
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        174..202
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        224..284
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..304
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        305..322
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..342
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        343..425
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        21
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        107..186
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   CONFLICT        66
FT                   /note="R -> P (in Ref. 2; AAC52235)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        216
FT                   /note="S -> T (in Ref. 2; AAC52235)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        255..258
FT                   /note="Missing (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   425 AA;  47086 MW;  87EE6B7A897305F8 CRC64;
     MNSEPSWTAT PSPGGTLPVP NATTPWLGRD EELAKVEIGI LATVLVLATG GNLAVLLTLG
     RHGHKRSRMH LFVLHLALTD LGVALFQVLP QLLWDITYRF QGSDLLCRAV KYLQVLSMFA
     STYMLLAMTL DRYLAVCHPL RSLRQPSQST YPLIAAPWLL AAILSLPQVF IFSLREVIQG
     SGVLDCWADF YFSWGPRAYI TWTTMAIFVL PVAVLSACYG LICHEIYKNL KVKTQAGREE
     RRGWRTWDKS SSSAVATAAT RGLPSRVSSI STISRAKIRT VKMTFVIVLA YIACWAPFFS
     VQMWSVWDEN APNEDSTNVA FTISMLLGNL SSCCNPWIYM GFNSRLLPRS LSHHACCTGS
     KPQVHRQLST SSLTSRRTTL LTHACGSPTL RLSLNLSLRA KPRPAGSLKD LEQVDGEATM
     ETSIF
//