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Protein

Vasopressin V1b receptor

Gene

Avpr1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: RGD
  • peptide hormone binding Source: RGD
  • protein homodimerization activity Source: RGD
  • vasopressin receptor activity Source: RGD

GO - Biological processi

  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
  • cellular response to hormone stimulus Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: RGD
  • hyperosmotic salinity response Source: RGD
  • positive regulation of cellular pH reduction Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of glutamate secretion Source: RGD
  • positive regulation of vasoconstriction Source: GO_Central
  • regulation of systemic arterial blood pressure by vasopressin Source: GO_Central
  • response to peptide Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1b receptor
Short name:
V1bR
Alternative name(s):
AVPR V1b
AVPR V3
Antidiuretic hormone receptor 1b
Vasopressin V3 receptor
Gene namesi
Name:Avpr1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61886. Avpr1b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 59Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini60 – 71CytoplasmicSequence analysisAdd BLAST12
Transmembranei72 – 93Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini94 – 108ExtracellularSequence analysisAdd BLAST15
Transmembranei109 – 130Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini131 – 151CytoplasmicSequence analysisAdd BLAST21
Transmembranei152 – 173Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini174 – 202ExtracellularSequence analysisAdd BLAST29
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 284CytoplasmicSequence analysisAdd BLAST61
Transmembranei285 – 304Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini305 – 322ExtracellularSequence analysisAdd BLAST18
Transmembranei323 – 342Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini343 – 425CytoplasmicSequence analysisAdd BLAST83

GO - Cellular componenti

  • integral component of membrane Source: RGD
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2659.
GuidetoPHARMACOLOGYi367.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702051 – 425Vasopressin V1b receptorAdd BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi107 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP48974.
PRIDEiP48974.

PTM databases

PhosphoSitePlusiP48974.

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067252.

Chemistry databases

BindingDBiP48974.

Structurei

3D structure databases

ProteinModelPortaliP48974.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP48974.
PhylomeDBiP48974.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000628. Vprs_rcpt_V1B.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00897. VASOPRSNV1BR.
SMARTiSM01164. DUF1856. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48974-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSEPSWTAT PSPGGTLPVP NATTPWLGRD EELAKVEIGI LATVLVLATG
60 70 80 90 100
GNLAVLLTLG RHGHKRSRMH LFVLHLALTD LGVALFQVLP QLLWDITYRF
110 120 130 140 150
QGSDLLCRAV KYLQVLSMFA STYMLLAMTL DRYLAVCHPL RSLRQPSQST
160 170 180 190 200
YPLIAAPWLL AAILSLPQVF IFSLREVIQG SGVLDCWADF YFSWGPRAYI
210 220 230 240 250
TWTTMAIFVL PVAVLSACYG LICHEIYKNL KVKTQAGREE RRGWRTWDKS
260 270 280 290 300
SSSAVATAAT RGLPSRVSSI STISRAKIRT VKMTFVIVLA YIACWAPFFS
310 320 330 340 350
VQMWSVWDEN APNEDSTNVA FTISMLLGNL SSCCNPWIYM GFNSRLLPRS
360 370 380 390 400
LSHHACCTGS KPQVHRQLST SSLTSRRTTL LTHACGSPTL RLSLNLSLRA
410 420
KPRPAGSLKD LEQVDGEATM ETSIF
Length:425
Mass (Da):47,086
Last modified:February 1, 1996 - v1
Checksum:i87EE6B7A897305F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66R → P in AAC52235 (PubMed:7624319).Curated1
Sequence conflicti216S → T in AAC52235 (PubMed:7624319).Curated1
Sequence conflicti255 – 258Missing (PubMed:7624319).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45400 mRNA. Translation: BAA08242.1.
U27322 mRNA. Translation: AAC52235.1.
PIRiJC4179.
UniGeneiRn.10096.

Genome annotation databases

UCSCiRGD:61886. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45400 mRNA. Translation: BAA08242.1.
U27322 mRNA. Translation: AAC52235.1.
PIRiJC4179.
UniGeneiRn.10096.

3D structure databases

ProteinModelPortaliP48974.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067252.

Chemistry databases

BindingDBiP48974.
ChEMBLiCHEMBL2659.
GuidetoPHARMACOLOGYi367.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP48974.

Proteomic databases

PaxDbiP48974.
PRIDEiP48974.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:61886. rat.

Organism-specific databases

RGDi61886. Avpr1b.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP48974.
PhylomeDBiP48974.

Miscellaneous databases

PROiP48974.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000628. Vprs_rcpt_V1B.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00897. VASOPRSNV1BR.
SMARTiSM01164. DUF1856. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV1BR_RAT
AccessioniPrimary (citable) accession number: P48974
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.