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Protein

Vasopressin V1b receptor

Gene

Avpr1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: RGD
  2. peptide hormone binding Source: RGD
  3. protein homodimerization activity Source: RGD
  4. vasopressin receptor activity Source: RGD

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
  2. cellular response to hormone stimulus Source: GO_Central
  3. G-protein coupled receptor signaling pathway Source: RGD
  4. hyperosmotic salinity response Source: RGD
  5. positive regulation of cellular pH reduction Source: RGD
  6. positive regulation of cytosolic calcium ion concentration Source: RGD
  7. positive regulation of glutamate secretion Source: RGD
  8. positive regulation of vasoconstriction Source: GO_Central
  9. regulation of systemic arterial blood pressure by vasopressin Source: GO_Central
  10. response to peptide Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1b receptor
Short name:
V1bR
Alternative name(s):
AVPR V1b
AVPR V3
Antidiuretic hormone receptor 1b
Vasopressin V3 receptor
Gene namesi
Name:Avpr1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61886. Avpr1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei36 – 5924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini60 – 7112CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei72 – 9322Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini94 – 10815ExtracellularSequence AnalysisAdd
BLAST
Transmembranei109 – 13022Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini131 – 15121CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei152 – 17322Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini174 – 20229ExtracellularSequence AnalysisAdd
BLAST
Transmembranei203 – 22321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini224 – 28461CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei285 – 30420Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini305 – 32218ExtracellularSequence AnalysisAdd
BLAST
Transmembranei323 – 34220Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini343 – 42583CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: RGD
  2. integral component of plasma membrane Source: GO_Central
  3. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Vasopressin V1b receptorPRO_0000070205Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi107 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP48974.

PTM databases

PhosphoSiteiP48974.

Expressioni

Gene expression databases

GenevestigatoriP48974.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009102.

Structurei

3D structure databases

ProteinModelPortaliP48974.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299951.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP48974.
PhylomeDBiP48974.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000628. Vprs_rcpt_V1B.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00897. VASOPRSNV1BR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48974-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSEPSWTAT PSPGGTLPVP NATTPWLGRD EELAKVEIGI LATVLVLATG
60 70 80 90 100
GNLAVLLTLG RHGHKRSRMH LFVLHLALTD LGVALFQVLP QLLWDITYRF
110 120 130 140 150
QGSDLLCRAV KYLQVLSMFA STYMLLAMTL DRYLAVCHPL RSLRQPSQST
160 170 180 190 200
YPLIAAPWLL AAILSLPQVF IFSLREVIQG SGVLDCWADF YFSWGPRAYI
210 220 230 240 250
TWTTMAIFVL PVAVLSACYG LICHEIYKNL KVKTQAGREE RRGWRTWDKS
260 270 280 290 300
SSSAVATAAT RGLPSRVSSI STISRAKIRT VKMTFVIVLA YIACWAPFFS
310 320 330 340 350
VQMWSVWDEN APNEDSTNVA FTISMLLGNL SSCCNPWIYM GFNSRLLPRS
360 370 380 390 400
LSHHACCTGS KPQVHRQLST SSLTSRRTTL LTHACGSPTL RLSLNLSLRA
410 420
KPRPAGSLKD LEQVDGEATM ETSIF
Length:425
Mass (Da):47,086
Last modified:February 1, 1996 - v1
Checksum:i87EE6B7A897305F8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661R → P in AAC52235 (PubMed:7624319).Curated
Sequence conflicti216 – 2161S → T in AAC52235 (PubMed:7624319).Curated
Sequence conflicti255 – 2584Missing (PubMed:7624319).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45400 mRNA. Translation: BAA08242.1.
U27322 mRNA. Translation: AAC52235.1.
PIRiJC4179.
UniGeneiRn.10096.

Genome annotation databases

UCSCiRGD:61886. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45400 mRNA. Translation: BAA08242.1.
U27322 mRNA. Translation: AAC52235.1.
PIRiJC4179.
UniGeneiRn.10096.

3D structure databases

ProteinModelPortaliP48974.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009102.

Chemistry

BindingDBiP48974.
ChEMBLiCHEMBL2096622.
GuidetoPHARMACOLOGYi367.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP48974.

Proteomic databases

PRIDEiP48974.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:61886. rat.

Organism-specific databases

RGDi61886. Avpr1b.

Phylogenomic databases

eggNOGiNOG299951.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP48974.
PhylomeDBiP48974.

Miscellaneous databases

NextBioi609260.
PROiP48974.

Gene expression databases

GenevestigatoriP48974.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000628. Vprs_rcpt_V1B.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00897. VASOPRSNV1BR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of rat V1b vasopressin receptor: evidence for its expression in extra-pituitary tissues."
    Saito M., Sugimoto T., Tahara A., Kawashima H.
    Biochem. Biophys. Res. Commun. 212:751-757(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Pituitary.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Pituitary.

Entry informationi

Entry nameiV1BR_RAT
AccessioniPrimary (citable) accession number: P48974
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 4, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.