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P48974 (V1BR_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vasopressin V1b receptor

Short name=V1bR
Alternative name(s):
AVPR V1b
AVPR V3
Antidiuretic hormone receptor 1b
Vasopressin V3 receptor
Gene names
Name:Avpr1b
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 19047484. Source: RGD

adenylate cyclase-modulating G-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 19047484. Source: RGD

hyperosmotic salinity response

Inferred from expression pattern PubMed 11884209. Source: RGD

positive regulation of cellular pH reduction

Inferred from mutant phenotype PubMed 17762181. Source: RGD

positive regulation of cytosolic calcium ion concentration

Inferred from mutant phenotype PubMed 17877638. Source: RGD

positive regulation of glutamate secretion

Inferred from mutant phenotype PubMed 17877638. Source: RGD

   Cellular_componentintegral component of membrane

Inferred from direct assay PubMed 11250948. Source: RGD

plasma membrane

Inferred from direct assay PubMed 19047484. Source: RGD

   Molecular_functionG-protein coupled receptor activity

Traceable author statement PubMed 12023277. Source: RGD

peptide hormone binding

Inferred from direct assay PubMed 19047484. Source: RGD

protein homodimerization activity

Inferred from direct assay PubMed 19047484. Source: RGD

vasopressin receptor activity

Inferred from direct assay PubMed 19047484. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Vasopressin V1b receptor
PRO_0000070205

Regions

Topological domain1 – 3535Extracellular Potential
Transmembrane36 – 5924Helical; Name=1; Potential
Topological domain60 – 7112Cytoplasmic Potential
Transmembrane72 – 9322Helical; Name=2; Potential
Topological domain94 – 10815Extracellular Potential
Transmembrane109 – 13022Helical; Name=3; Potential
Topological domain131 – 15121Cytoplasmic Potential
Transmembrane152 – 17322Helical; Name=4; Potential
Topological domain174 – 20229Extracellular Potential
Transmembrane203 – 22321Helical; Name=5; Potential
Topological domain224 – 28461Cytoplasmic Potential
Transmembrane285 – 30420Helical; Name=6; Potential
Topological domain305 – 32218Extracellular Potential
Transmembrane323 – 34220Helical; Name=7; Potential
Topological domain343 – 42583Cytoplasmic Potential

Amino acid modifications

Glycosylation211N-linked (GlcNAc...) Potential
Disulfide bond107 ↔ 186 By similarity

Experimental info

Sequence conflict661R → P in AAC52235. Ref.2
Sequence conflict2161S → T in AAC52235. Ref.2
Sequence conflict255 – 2584Missing Ref.2

Sequences

Sequence LengthMass (Da)Tools
P48974 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 87EE6B7A897305F8

FASTA42547,086
        10         20         30         40         50         60 
MNSEPSWTAT PSPGGTLPVP NATTPWLGRD EELAKVEIGI LATVLVLATG GNLAVLLTLG 

        70         80         90        100        110        120 
RHGHKRSRMH LFVLHLALTD LGVALFQVLP QLLWDITYRF QGSDLLCRAV KYLQVLSMFA 

       130        140        150        160        170        180 
STYMLLAMTL DRYLAVCHPL RSLRQPSQST YPLIAAPWLL AAILSLPQVF IFSLREVIQG 

       190        200        210        220        230        240 
SGVLDCWADF YFSWGPRAYI TWTTMAIFVL PVAVLSACYG LICHEIYKNL KVKTQAGREE 

       250        260        270        280        290        300 
RRGWRTWDKS SSSAVATAAT RGLPSRVSSI STISRAKIRT VKMTFVIVLA YIACWAPFFS 

       310        320        330        340        350        360 
VQMWSVWDEN APNEDSTNVA FTISMLLGNL SSCCNPWIYM GFNSRLLPRS LSHHACCTGS 

       370        380        390        400        410        420 
KPQVHRQLST SSLTSRRTTL LTHACGSPTL RLSLNLSLRA KPRPAGSLKD LEQVDGEATM 


ETSIF 

« Hide

References

[1]"Molecular cloning and characterization of rat V1b vasopressin receptor: evidence for its expression in extra-pituitary tissues."
Saito M., Sugimoto T., Tahara A., Kawashima H.
Biochem. Biophys. Res. Commun. 212:751-757(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Pituitary.
[2]"Extrapituitary expression of the rat V1b vasopressin receptor gene."
Lolait S.J., O'Carroll A.-M., Mahan L.C., Felder C.C., Button D.C., Young W.S. III, Mezey E., Brownstein M.J.
Proc. Natl. Acad. Sci. U.S.A. 92:6783-6787(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Pituitary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D45400 mRNA. Translation: BAA08242.1.
U27322 mRNA. Translation: AAC52235.1.
PIRJC4179.
UniGeneRn.10096.

3D structure databases

ProteinModelPortalP48974.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000009102.

Chemistry

BindingDBP48974.
ChEMBLCHEMBL2096622.
GuidetoPHARMACOLOGY367.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP48974.

Proteomic databases

PRIDEP48974.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

KEGGrno:29462.
UCSCRGD:61886. rat.

Organism-specific databases

RGD61886. Avpr1b.

Phylogenomic databases

eggNOGNOG299951.
HOGENOMHOG000237331.
HOVERGENHBG105710.
InParanoidP48974.
PhylomeDBP48974.

Gene expression databases

GenevestigatorP48974.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000628. Vprs_rcpt_V1B.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00897. VASOPRSNV1BR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio609260.
PROP48974.

Entry information

Entry nameV1BR_RAT
AccessionPrimary (citable) accession number: P48974
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries