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P48974

- V1BR_RAT

UniProt

P48974 - V1BR_RAT

Protein

Vasopressin V1b receptor

Gene

Avpr1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: RGD
    2. peptide hormone binding Source: RGD
    3. protein homodimerization activity Source: RGD
    4. vasopressin receptor activity Source: RGD

    GO - Biological processi

    1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
    2. G-protein coupled receptor signaling pathway Source: RGD
    3. hyperosmotic salinity response Source: RGD
    4. positive regulation of cellular pH reduction Source: RGD
    5. positive regulation of cytosolic calcium ion concentration Source: RGD
    6. positive regulation of glutamate secretion Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vasopressin V1b receptor
    Short name:
    V1bR
    Alternative name(s):
    AVPR V1b
    AVPR V3
    Antidiuretic hormone receptor 1b
    Vasopressin V3 receptor
    Gene namesi
    Name:Avpr1b
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi61886. Avpr1b.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: RGD
    2. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Vasopressin V1b receptorPRO_0000070205Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi107 ↔ 186PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP48974.

    PTM databases

    PhosphoSiteiP48974.

    Expressioni

    Gene expression databases

    GenevestigatoriP48974.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000009102.

    Structurei

    3D structure databases

    ProteinModelPortaliP48974.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini60 – 7112CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini94 – 10815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini131 – 15121CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini174 – 20229ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini224 – 28461CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini305 – 32218ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini343 – 42583CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei72 – 9322Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei109 – 13022Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei152 – 17322Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei285 – 30420Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei323 – 34220Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299951.
    HOGENOMiHOG000237331.
    HOVERGENiHBG105710.
    InParanoidiP48974.
    PhylomeDBiP48974.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR015076. DUF1856.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR000628. Vprs_rcpt_V1B.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    PF08983. DUF1856. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00897. VASOPRSNV1BR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48974-1 [UniParc]FASTAAdd to Basket

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    MNSEPSWTAT PSPGGTLPVP NATTPWLGRD EELAKVEIGI LATVLVLATG    50
    GNLAVLLTLG RHGHKRSRMH LFVLHLALTD LGVALFQVLP QLLWDITYRF 100
    QGSDLLCRAV KYLQVLSMFA STYMLLAMTL DRYLAVCHPL RSLRQPSQST 150
    YPLIAAPWLL AAILSLPQVF IFSLREVIQG SGVLDCWADF YFSWGPRAYI 200
    TWTTMAIFVL PVAVLSACYG LICHEIYKNL KVKTQAGREE RRGWRTWDKS 250
    SSSAVATAAT RGLPSRVSSI STISRAKIRT VKMTFVIVLA YIACWAPFFS 300
    VQMWSVWDEN APNEDSTNVA FTISMLLGNL SSCCNPWIYM GFNSRLLPRS 350
    LSHHACCTGS KPQVHRQLST SSLTSRRTTL LTHACGSPTL RLSLNLSLRA 400
    KPRPAGSLKD LEQVDGEATM ETSIF 425
    Length:425
    Mass (Da):47,086
    Last modified:February 1, 1996 - v1
    Checksum:i87EE6B7A897305F8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661R → P in AAC52235. (PubMed:7624319)Curated
    Sequence conflicti216 – 2161S → T in AAC52235. (PubMed:7624319)Curated
    Sequence conflicti255 – 2584Missing(PubMed:7624319)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D45400 mRNA. Translation: BAA08242.1.
    U27322 mRNA. Translation: AAC52235.1.
    PIRiJC4179.
    UniGeneiRn.10096.

    Genome annotation databases

    UCSCiRGD:61886. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D45400 mRNA. Translation: BAA08242.1 .
    U27322 mRNA. Translation: AAC52235.1 .
    PIRi JC4179.
    UniGenei Rn.10096.

    3D structure databases

    ProteinModelPortali P48974.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000009102.

    Chemistry

    BindingDBi P48974.
    ChEMBLi CHEMBL2096622.
    GuidetoPHARMACOLOGYi 367.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P48974.

    Proteomic databases

    PRIDEi P48974.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:61886. rat.

    Organism-specific databases

    RGDi 61886. Avpr1b.

    Phylogenomic databases

    eggNOGi NOG299951.
    HOGENOMi HOG000237331.
    HOVERGENi HBG105710.
    InParanoidi P48974.
    PhylomeDBi P48974.

    Miscellaneous databases

    NextBioi 609260.
    PROi P48974.

    Gene expression databases

    Genevestigatori P48974.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR015076. DUF1856.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR000628. Vprs_rcpt_V1B.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    PF08983. DUF1856. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00897. VASOPRSNV1BR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of rat V1b vasopressin receptor: evidence for its expression in extra-pituitary tissues."
      Saito M., Sugimoto T., Tahara A., Kawashima H.
      Biochem. Biophys. Res. Commun. 212:751-757(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Pituitary.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Pituitary.

    Entry informationi

    Entry nameiV1BR_RAT
    AccessioniPrimary (citable) accession number: P48974
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3