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Protein

C-X-C motif chemokine 10

Gene

Cxcl10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.By similarity

GO - Molecular functioni

  • chemokine activity Source: RGD
  • CXCR3 chemokine receptor binding Source: UniProtKB
  • cytokine activity Source: RGD
  • heparin binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 10
Alternative name(s):
10 kDa interferon gamma-induced protein
Short name:
Gamma-IP10
Short name:
IP-10
Interferon-inducible protein 10
Protein Mob-1
Small-inducible cytokine B10
Gene namesi
Name:Cxcl10
Synonyms:Inp10, Mob1, Scyb10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi620209. Cxcl10.

Subcellular locationi

GO - Cellular componenti

  • external side of plasma membrane Source: Ensembl
  • extracellular region Source: RGD
  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 9877C-X-C motif chemokine 10PRO_0000005105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261CitrullineBy similarity
Disulfide bondi30 ↔ 57By similarity
Disulfide bondi32 ↔ 74By similarity

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

PaxDbiP48973.
PRIDEiP48973.

Expressioni

Tissue specificityi

Spleen.

Inductioni

By oncogenic Ras and serum growth factors. The oncogenic induction is constitutive whereas the serum induction is transient.

Gene expression databases

GenevisibleiP48973. RN.

Interactioni

GO - Molecular functioni

  • chemokine activity Source: RGD
  • CXCR3 chemokine receptor binding Source: UniProtKB
  • cytokine activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003649.

Structurei

3D structure databases

ProteinModelPortaliP48973.
SMRiP48973. Positions 22-88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1VC. Eukaryota.
ENOG410ZTJK. LUCA.
GeneTreeiENSGT00530000063958.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP48973.
KOiK12671.
OMAiRCTCIKI.
OrthoDBiEOG7HHWVH.
PhylomeDBiP48973.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR027220. Chemokine_CXCL10.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF47. PTHR10179:SF47. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48973-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPSAAVVLC LVLLSLSGTQ GIPLARTVRC TCIDFHEQPL RPRAIGKLEI
60 70 80 90
IPASLSCPHV EIIATMKKNN EKRCLNPESE AIKSLLKAVS QRRSKRAP
Length:98
Mass (Da):10,729
Last modified:May 1, 2007 - v2
Checksum:i5CAF8790695F72D5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391P → T in AAB60485 (PubMed:7809069).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17035 mRNA. Translation: AAB60485.1.
U22520 mRNA. Translation: AAC52811.1.
BC058444 mRNA. Translation: AAH58444.1.
RefSeqiNP_620789.1. NM_139089.1.
UniGeneiRn.10584.

Genome annotation databases

EnsembliENSRNOT00000003075; ENSRNOP00000003649; ENSRNOG00000022256.
GeneIDi245920.
KEGGirno:245920.
UCSCiRGD:620209. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17035 mRNA. Translation: AAB60485.1.
U22520 mRNA. Translation: AAC52811.1.
BC058444 mRNA. Translation: AAH58444.1.
RefSeqiNP_620789.1. NM_139089.1.
UniGeneiRn.10584.

3D structure databases

ProteinModelPortaliP48973.
SMRiP48973. Positions 22-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003649.

Proteomic databases

PaxDbiP48973.
PRIDEiP48973.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003075; ENSRNOP00000003649; ENSRNOG00000022256.
GeneIDi245920.
KEGGirno:245920.
UCSCiRGD:620209. rat.

Organism-specific databases

CTDi3627.
RGDi620209. Cxcl10.

Phylogenomic databases

eggNOGiENOG410J1VC. Eukaryota.
ENOG410ZTJK. LUCA.
GeneTreeiENSGT00530000063958.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP48973.
KOiK12671.
OMAiRCTCIKI.
OrthoDBiEOG7HHWVH.
PhylomeDBiP48973.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

NextBioi623166.
PROiP48973.

Gene expression databases

GenevisibleiP48973. RN.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR027220. Chemokine_CXCL10.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF47. PTHR10179:SF47. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Interferon-inducible protein-10 involves vascular smooth muscle cell migration, proliferation, and inflammatory response."
    Wang X., Yue T.L., Ohlstein E.H., Sung C., Feuerstein G.Z.
    J. Biol. Chem. 271:24286-24293(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiCXL10_RAT
AccessioniPrimary (citable) accession number: P48973
Secondary accession number(s): P70538, Q6GTC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 1, 2007
Last modified: May 11, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.