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P48972

- MYBB_MOUSE

UniProt

P48972 - MYBB_MOUSE

Protein

Myb-related protein B

Gene

Mybl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi54 – 7724H-T-H motifPROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi106 – 12924H-T-H motifPROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi157 – 18024H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. DNA binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. spindle assembly involved in mitosis Source: MGI
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_199110. G0 and Early G1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myb-related protein B
    Short name:
    B-Myb
    Alternative name(s):
    Myb-like protein 2
    Gene namesi
    Name:Mybl2
    Synonyms:Bmyb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:101785. Mybl2.

    Subcellular locationi

    GO - Cellular componenti

    1. Myb complex Source: MGI
    2. nucleoplasm Source: Reactome
    3. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 704704Myb-related protein BPRO_0000197059Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei267 – 2671PhosphothreonineBy similarity
    Modified residuei443 – 4431Phosphothreonine; by CDK2By similarity
    Modified residuei447 – 4471Phosphothreonine; by CDK2By similarity
    Modified residuei490 – 4901Phosphothreonine; by CDK2By similarity
    Modified residuei497 – 4971Phosphothreonine; by CDK2By similarity
    Modified residuei524 – 5241Phosphothreonine; by CDK2By similarity
    Modified residuei581 – 5811Phosphoserine; by CDK2By similarity

    Post-translational modificationi

    Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-524 is probably involved in transcriptional activity By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP48972.

    PTM databases

    PhosphoSiteiP48972.

    Expressioni

    Gene expression databases

    ArrayExpressiP48972.
    BgeeiP48972.
    CleanExiMM_MYBL2.
    GenevestigatoriP48972.

    Interactioni

    Subunit structurei

    Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi201633. 7 interactions.
    IntActiP48972. 1 interaction.

    Structurei

    Secondary structure

    1
    704
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi36 – 4813
    Helixi54 – 607
    Beta strandi62 – 643
    Helixi66 – 7510

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2D9ANMR-A31-77[»]
    ProteinModelPortaliP48972.
    SMRiP48972. Positions 31-186.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP48972.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 7752HTH myb-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini78 – 13356HTH myb-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini134 – 18451HTH myb-type 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 HTH myb-type DNA-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5147.
    GeneTreeiENSGT00390000001038.
    HOGENOMiHOG000231021.
    HOVERGENiHBG007964.
    InParanoidiP48972.
    KOiK09421.
    OMAiMTPKSTP.
    OrthoDBiEOG7G7KNQ.
    PhylomeDBiP48972.
    TreeFamiTF326257.

    Family and domain databases

    Gene3Di1.10.10.60. 3 hits.
    InterProiIPR015395. C-myb_C.
    IPR009057. Homeodomain-like.
    IPR017930. Myb_dom.
    IPR028311. MYBL2.
    IPR001005. SANT/Myb.
    [Graphical view]
    PANTHERiPTHR10641:SF37. PTHR10641:SF37. 1 hit.
    PfamiPF09316. Cmyb_C. 1 hit.
    PF00249. Myb_DNA-binding. 1 hit.
    [Graphical view]
    SMARTiSM00717. SANT. 3 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 2 hits.
    PROSITEiPS51294. HTH_MYB. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48972-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRRTRCEDL DELHYQDVDS DLLEQRDNRC KVKWTHEEDE QLRALVRQFG    50
    QQDWKFLASH FPNRTDQQCQ YRWLRVLNPD LVKGPWTKEE DQKVIELVKK 100
    YGTKQWTLIA KHLKGRLGKQ CRERWHNHLN PEVKKSCWTE EEDRIICEAH 150
    KVLGNRWAEI AKMLPGRTDN AVKNHWNSTI KRKVDTGGFP AESRDCKPVY 200
    LLLELEDKEQ HQGVQPVDGQ GSLVSSWPLV PSIVKEESSE EEIAIAATSA 250
    KELGHEPVPA DLGEVRTPEP PESLKREYQE FSSPETSLPY KWVVEAANLL 300
    IPAVGSSLSE ALDLIESDPD AWCDLSKFDL PEEPSTEGSV VSSPVQPQTS 350
    QQQQEEALQS SQQAATPGPS VTEYRLDGHT ISDLSRSSRG ELIPISPSTE 400
    FGGSGIGTPP SVLKRQKKRR VALSPVTENS ASLSFLDSCN SLTPKSTPVK 450
    TLPFSPSQFL NFWNKQDTLE LESPSLTSTP VCSQKVVVTT PLHRDKTPLH 500
    QKYPSSEVLP DQKYSMDNTP HTPTPFKNAL EKYGPLKPLP QTPHLEEDLK 550
    EVLRSEAGME LIIEDDMRPE KQKRKPGLRR SPIKKVRKSL ALDIMDEDGK 600
    LMSSTMPKPL SLPTSVTPSS CGFTSPGSKE GNSLLNQGFL QAKPEKVVAA 650
    QKTRSHIPTP APMTHAWKTV ACGGTKDQLF MQEKARQLLS RLKSSHTSRT 700
    LILS 704
    Length:704
    Mass (Da):79,103
    Last modified:February 1, 1996 - v1
    Checksum:i0EF09C1EE2184E47
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70472 mRNA. Translation: CAA49898.1.
    AK028497 mRNA. Translation: BAC25979.1.
    BC050842 mRNA. Translation: AAH50842.1.
    X73028 Genomic DNA. Translation: CAA51511.1.
    CCDSiCCDS17006.1.
    PIRiS33704.
    RefSeqiNP_032678.1. NM_008652.2.
    UniGeneiMm.4594.

    Genome annotation databases

    EnsembliENSMUST00000018005; ENSMUSP00000018005; ENSMUSG00000017861.
    GeneIDi17865.
    KEGGimmu:17865.
    UCSCiuc008nsl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70472 mRNA. Translation: CAA49898.1 .
    AK028497 mRNA. Translation: BAC25979.1 .
    BC050842 mRNA. Translation: AAH50842.1 .
    X73028 Genomic DNA. Translation: CAA51511.1 .
    CCDSi CCDS17006.1.
    PIRi S33704.
    RefSeqi NP_032678.1. NM_008652.2.
    UniGenei Mm.4594.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2D9A NMR - A 31-77 [» ]
    ProteinModelPortali P48972.
    SMRi P48972. Positions 31-186.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201633. 7 interactions.
    IntActi P48972. 1 interaction.

    PTM databases

    PhosphoSitei P48972.

    Proteomic databases

    PRIDEi P48972.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018005 ; ENSMUSP00000018005 ; ENSMUSG00000017861 .
    GeneIDi 17865.
    KEGGi mmu:17865.
    UCSCi uc008nsl.1. mouse.

    Organism-specific databases

    CTDi 4605.
    MGIi MGI:101785. Mybl2.

    Phylogenomic databases

    eggNOGi COG5147.
    GeneTreei ENSGT00390000001038.
    HOGENOMi HOG000231021.
    HOVERGENi HBG007964.
    InParanoidi P48972.
    KOi K09421.
    OMAi MTPKSTP.
    OrthoDBi EOG7G7KNQ.
    PhylomeDBi P48972.
    TreeFami TF326257.

    Enzyme and pathway databases

    Reactomei REACT_199110. G0 and Early G1.

    Miscellaneous databases

    EvolutionaryTracei P48972.
    NextBioi 292633.
    PROi P48972.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48972.
    Bgeei P48972.
    CleanExi MM_MYBL2.
    Genevestigatori P48972.

    Family and domain databases

    Gene3Di 1.10.10.60. 3 hits.
    InterProi IPR015395. C-myb_C.
    IPR009057. Homeodomain-like.
    IPR017930. Myb_dom.
    IPR028311. MYBL2.
    IPR001005. SANT/Myb.
    [Graphical view ]
    PANTHERi PTHR10641:SF37. PTHR10641:SF37. 1 hit.
    Pfami PF09316. Cmyb_C. 1 hit.
    PF00249. Myb_DNA-binding. 1 hit.
    [Graphical view ]
    SMARTi SM00717. SANT. 3 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 2 hits.
    PROSITEi PS51294. HTH_MYB. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and cell cycle-regulated expression of mouse B-myb."
      Lam E.W., Robinson C., Watson R.J.
      Oncogene 7:1885-1890(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Skin.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Limb.
    4. "An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription."
      Lam E.W., Watson R.J.
      EMBO J. 12:2705-2713(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-6.
    5. "Solution structure of RSGI RUH-050, a myb DNA-binding domain in mouse."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUN-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 31-78.

    Entry informationi

    Entry nameiMYBB_MOUSE
    AccessioniPrimary (citable) accession number: P48972
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3