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Protein

Univin

Gene
N/A
Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Could have a critical role in early developmental decisions in the sea urchin embryo.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Univin
OrganismiStrongylocentrotus purpuratus (Purple sea urchin)
Taxonomic identifieri7668 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus
Proteomesi
  • UP000007110 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003400220 – 272Sequence analysisAdd BLAST253
ChainiPRO_0000034003273 – 395UnivinAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi294 ↔ 360By similarity
Disulfide bondi323 ↔ 392By similarity
Disulfide bondi327 ↔ 394By similarity
Glycosylationi336N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi359InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Expressioni

Developmental stagei

Highest levels of expression in the egg and prehatching blastula. During late cleavage stages, it accumulates progressively to a circumequatorial band. During gastrulation it is detected primarily in the presumptive foregut and ciliated band. By pluteus stage, it is detected only in these cell types.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.Curated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7668.SPU_000668tr.

Structurei

3D structure databases

ProteinModelPortaliP48970.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_propeptide.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiView protein in Pfam
PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
SMARTiView protein in SMART
SM00204. TGFB. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVSKVLILT LIWLLTADSA PPDYVTLTRK MESKILRVMG LSERPRPKPN
60 70 80 90 100
ATAPQYMWDL YRQQMAATEG AAASRGGETE IGKEEEEDGR PCSETKLSSN
110 120 130 140 150
IIRSVSHTGG DLRASNSTSL QQILLFDVAS IPHAETIEAA DLRLEIPALP
160 170 180 190 200
SATDVPSLAV RIYQLESRTR LNSIVSLKDK RLRLLDVVLA DLSQGYAGTI
210 220 230 240 250
DILSTVNSWR SKKTSNHGLL LHVELMSTSG NNRRGSQVIK ELGAISKKCT
260 270 280 290 300
ANLIVTSSEY RQCSKRNRRN KRQAESEAPA DISSFPTASL TNLCQRHRLF
310 320 330 340 350
VSFRDVGWEN WIIAPMGYQA YYCDGECPFP LGERLNGTNH AIIQTLVNSI
360 370 380 390
DNRAVPKVCC APTKLSGISM LYFDNNENVV LRQYEDMVVE ACGCR
Length:395
Mass (Da):43,837
Last modified:August 14, 2001 - v2
Checksum:i0FA3340DF5A6360E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10533 mRNA. Translation: AAA57553.2.
RefSeqiNP_999793.1. NM_214628.1.
UniGeneiSpu.3753.

Genome annotation databases

GeneIDi373488.
KEGGispu:373488.

Similar proteinsi

Entry informationi

Entry nameiUNIV_STRPU
AccessioniPrimary (citable) accession number: P48970
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 14, 2001
Last modified: May 10, 2017
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families