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Protein

G1/S-specific cyclin-D3

Gene

Ccnd3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

GO - Molecular functioni

  • protein kinase binding Source: RGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • G1/S transition of mitotic cell cycle Source: RGD
  • hyaluronan biosynthetic process Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • regulation of cell cycle Source: RGD
  • response to glucose Source: RGD
  • response to organic substance Source: RGD
  • response to peptide hormone Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-D3
Gene namesi
Name:Ccnd3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2293. Ccnd3.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Membrane By similarity

  • Note: Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804441 – 293G1/S-specific cyclin-D3Add BLAST293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei265PhosphoserineCombined sources1
Modified residuei280PhosphoserineBy similarity1

Post-translational modificationi

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP48961.
PRIDEiP48961.

PTM databases

iPTMnetiP48961.
PhosphoSitePlusiP48961.

Interactioni

Subunit structurei

Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with ATF5 and EIF3K (By similarity).By similarity

GO - Molecular functioni

  • protein kinase binding Source: RGD

Protein-protein interaction databases

BioGridi247241. 1 interactor.
STRINGi10116.ENSRNOP00000064704.

Structurei

3D structure databases

ProteinModelPortaliP48961.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 152Cyclin N-terminalAdd BLAST126

Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated
Contains 1 cyclin N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0656. Eukaryota.
ENOG410XRKC. LUCA.
HOVERGENiHBG050837.
InParanoidiP48961.
KOiK10152.
PhylomeDBiP48961.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF65. PTHR10177:SF65. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48961-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLCCEGTR LAPRAGPDPR LLGDQRVLQS LLRLEERYVP RGSYFQCVQK
60 70 80 90 100
EIKPHMRKML AYWMLEVCEE QRCEEDVFPL AMNYLDRYLS CVPTRKAQLQ
110 120 130 140 150
LLGTVCLLLA SKLRETTPLT IEKLCIYTDQ AMAPWQLREW EVLVLGKLKW
160 170 180 190 200
DLAAVIAHDF LALILHRLSL PSDRQALVKK HAQTFLALCA TDYTFAMYPP
210 220 230 240 250
SMIATGSIGA AVLGLGACSM SADELTELLA GITGTEVDCL RACQEQQIEA
260 270 280 290
ALRESLREAA QTAPSPVPKA PGGSSSQGPS QTSTPTDVTA IHL
Length:293
Mass (Da):32,434
Last modified:February 1, 1996 - v1
Checksum:i35A84447C30A82B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11L → H in AAB40713 (PubMed:8973324).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16309 mRNA. Translation: BAA03816.1.
U49935 Genomic DNA. Translation: AAB40713.1.
PIRiJC4012.
RefSeqiNP_036898.1. NM_012766.1.
UniGeneiRn.3483.
Rn.54319.

Genome annotation databases

GeneIDi25193.
KEGGirno:25193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16309 mRNA. Translation: BAA03816.1.
U49935 Genomic DNA. Translation: AAB40713.1.
PIRiJC4012.
RefSeqiNP_036898.1. NM_012766.1.
UniGeneiRn.3483.
Rn.54319.

3D structure databases

ProteinModelPortaliP48961.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247241. 1 interactor.
STRINGi10116.ENSRNOP00000064704.

PTM databases

iPTMnetiP48961.
PhosphoSitePlusiP48961.

Proteomic databases

PaxDbiP48961.
PRIDEiP48961.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25193.
KEGGirno:25193.

Organism-specific databases

CTDi896.
RGDi2293. Ccnd3.

Phylogenomic databases

eggNOGiKOG0656. Eukaryota.
ENOG410XRKC. LUCA.
HOVERGENiHBG050837.
InParanoidiP48961.
KOiK10152.
PhylomeDBiP48961.

Miscellaneous databases

PROiP48961.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR015451. Cyclin_D.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF65. PTHR10177:SF65. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCND3_RAT
AccessioniPrimary (citable) accession number: P48961
Secondary accession number(s): Q63628
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.