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Protein

G1/S-specific cyclin-D3

Gene

Ccnd3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • G1/S transition of mitotic cell cycle Source: RGD
  • hyaluronan biosynthetic process Source: RGD
  • negative regulation of transcription by RNA polymerase II Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • regulation of cell cycle Source: RGD
  • regulation of cell proliferation Source: RGD
  • regulation of insulin receptor signaling pathway Source: RGD
  • response to glucose Source: RGD
  • response to organic substance Source: RGD
  • response to peptide hormone Source: RGD
  • signal transduction Source: RGD
  • T cell proliferation Source: RGD

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-D3
Gene namesi
Name:Ccnd3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2293 Ccnd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804441 – 293G1/S-specific cyclin-D3Add BLAST293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei265PhosphoserineCombined sources1
Modified residuei280PhosphoserineBy similarity1

Post-translational modificationi

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP48961
PRIDEiP48961

PTM databases

iPTMnetiP48961
PhosphoSitePlusiP48961

Interactioni

Subunit structurei

Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with ATF5 and EIF3K (By similarity).By similarity

GO - Molecular functioni

  • protein kinase binding Source: RGD

Protein-protein interaction databases

BioGridi247241, 1 interactor
STRINGi10116.ENSRNOP00000064704

Structurei

3D structure databases

ProteinModelPortaliP48961
SMRiP48961
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 152Cyclin N-terminalAdd BLAST126

Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated

Phylogenomic databases

eggNOGiKOG0656 Eukaryota
ENOG410XRKC LUCA
HOVERGENiHBG050837
InParanoidiP48961
KOiK10152
PhylomeDBiP48961

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR015451 Cyclin_D
IPR006671 Cyclin_N
PANTHERiPTHR10177:SF65 PTHR10177:SF65, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

P48961-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLCCEGTR LAPRAGPDPR LLGDQRVLQS LLRLEERYVP RGSYFQCVQK
60 70 80 90 100
EIKPHMRKML AYWMLEVCEE QRCEEDVFPL AMNYLDRYLS CVPTRKAQLQ
110 120 130 140 150
LLGTVCLLLA SKLRETTPLT IEKLCIYTDQ AMAPWQLREW EVLVLGKLKW
160 170 180 190 200
DLAAVIAHDF LALILHRLSL PSDRQALVKK HAQTFLALCA TDYTFAMYPP
210 220 230 240 250
SMIATGSIGA AVLGLGACSM SADELTELLA GITGTEVDCL RACQEQQIEA
260 270 280 290
ALRESLREAA QTAPSPVPKA PGGSSSQGPS QTSTPTDVTA IHL
Length:293
Mass (Da):32,434
Last modified:February 1, 1996 - v1
Checksum:i35A84447C30A82B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11L → H in AAB40713 (PubMed:8973324).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16309 mRNA Translation: BAA03816.1
U49935 Genomic DNA Translation: AAB40713.1
PIRiJC4012
RefSeqiNP_036898.1, NM_012766.1
UniGeneiRn.3483
Rn.54319

Genome annotation databases

GeneIDi25193
KEGGirno:25193

Similar proteinsi

Entry informationi

Entry nameiCCND3_RAT
AccessioniPrimary (citable) accession number: P48961
Secondary accession number(s): Q63628
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health