Reviewed, UniProtKB/Swiss-Prot P48960 (CD97_HUMAN)

Names and origin

Protein names

Recommended name:
    CD97 antigen
Alternative name(s):
    Leukocyte antigen CD97
    CD_antigen=CD97
Cleaved into the following 2 chains:
    1- Recommended name:
            CD97 antigen subunit alpha
    2- Recommended name:
            CD97 antigen subunit beta

Gene names

Name:

CD97

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	835 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration By similarity.
Subunit structure	Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Interacts with complement decay-accelerating factor (DAF). The largest isoform 1) interacts with chondroitin sulfate. Ref.8 Ref.9
Subcellular location	Cell membrane; Multi-pass membrane protein. CD97 antigen subunit alpha: Secreted › extracellular space.
Tissue specificity	Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompagnied by detectable levels of soluble CD97 in the synovial fluid.
Induction	Rapid up-regulation during lymphocyte activation.
Domain	The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region. Binding to chondroitin sulfate is mediated by the fourth EGF domain.
Post-translational modification	Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 5 EGF-like domains. Contains 1 GPS domain.
Sequence caution	The sequence AAC27673.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAC06178.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Repeat Signal Transmembrane
Ligand	Calcium
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	cell adhesion Ref.1 Traceable author statement. Source: ProtInc cell motion Ref.1 Traceable author statement. Source: ProtInc cell-cell signaling Ref.1 Traceable author statement. Source: ProtInc immune response Ref.1 Traceable author statement. Source: ProtInc inflammatory response Ref.4 Traceable author statement. Source: ProtInc neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Ref.4 Traceable author statement. Source: ProtInc
Molecular function	G-protein coupled receptor activity Ref.4 Traceable author statement. Source: ProtInc calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Ref.8 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SRC	P12931	1	EBI-1756009,EBI-621482

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P48960-1)

Also known as: EGF(1,2,3,4,5);

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P48960-2)

Also known as: EGF(1,2,5);

The sequence of this isoform differs from the canonical sequence as follows:
     116-208: Missing.

Isoform 3 (identifier: P48960-3)

Also known as: EGF(1,2,3,5);

The sequence of this isoform differs from the canonical sequence as follows:
     160-208: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 835	815	CD97 antigen		PRO_0000012868
	Chain	21 – 530	510	CD97 antigen subunit alpha By similarity		PRO_0000296235
	Chain	531 – 835	305	CD97 antigen subunit beta By similarity		PRO_0000296236
Regions
	Topological domain	21 – 552	532	Extracellular Potential
	Transmembrane	553 – 572	20	1 Potential
	Topological domain	573 – 581	9	Cytoplasmic Potential
	Transmembrane	582 – 601	20	2 Potential
	Topological domain	602 – 620	19	Extracellular Potential
	Transmembrane	621 – 642	22	3 Potential
	Topological domain	643 – 653	11	Cytoplasmic Potential
	Transmembrane	654 – 674	21	4 Potential
	Topological domain	675 – 691	17	Extracellular Potential
	Transmembrane	692 – 712	21	5 Potential
	Topological domain	713 – 739	27	Cytoplasmic Potential
	Transmembrane	740 – 760	21	6 Potential
	Topological domain	761 – 766	6	Extracellular Potential
	Transmembrane	767 – 789	23	7 Potential
	Topological domain	790 – 835	46	Cytoplasmic Potential
	Domain	22 – 63	42	EGF-like 1
	Domain	64 – 115	52	EGF-like 2; calcium-binding Potential
	Domain	116 – 159	44	EGF-like 3; calcium-binding Potential
	Domain	160 – 208	49	EGF-like 4; calcium-binding Potential
	Domain	209 – 257	49	EGF-like 5; calcium-binding Potential
	Domain	492 – 542	51	GPS
Sites
	Site	530 – 531	2	Cleavage By similarity
Amino acid modifications
	Modified residue	818	1	Phosphoserine Ref.11
	Modified residue	831	1	Phosphoserine Ref.11 Ref.12
	Modified residue	833	1	Phosphoserine Ref.12
	Glycosylation	33	1	N-linked (GlcNAc...) Potential
	Glycosylation	38	1	N-linked (GlcNAc...) Potential
	Glycosylation	108	1	N-linked (GlcNAc...) Potential
	Glycosylation	203	1	N-linked (GlcNAc...) Potential
	Glycosylation	371	1	N-linked (GlcNAc...) Potential
	Glycosylation	406	1	N-linked (GlcNAc...) Potential
	Glycosylation	413	1	N-linked (GlcNAc...) Potential
	Glycosylation	453	1	N-linked (GlcNAc...)
	Glycosylation	520	1	N-linked (GlcNAc...) Potential
	Disulfide bond	26 ↔ 36		By similarity
	Disulfide bond	30 ↔ 42		By similarity
	Disulfide bond	44 ↔ 62		By similarity
	Disulfide bond	68 ↔ 82		By similarity
	Disulfide bond	76 ↔ 91		By similarity
	Disulfide bond	93 ↔ 114		By similarity
	Disulfide bond	120 ↔ 133		By similarity
	Disulfide bond	127 ↔ 142		By similarity
	Disulfide bond	144 ↔ 158		By similarity
	Disulfide bond	164 ↔ 177		By similarity
	Disulfide bond	171 ↔ 186		By similarity
	Disulfide bond	188 ↔ 207		By similarity
	Disulfide bond	213 ↔ 226		By similarity
	Disulfide bond	220 ↔ 235		By similarity
	Disulfide bond	237 ↔ 256		By similarity
Natural variations
	Alternative sequence	116 – 208	93	Missing in isoform 2.		VSP_009411
	Alternative sequence	160 – 208	49	Missing in isoform 3.		VSP_009412
	Natural variant	367	1	R → Q: dbSNP rs2230748.		VAR_017760
Experimental info
	Sequence conflict	103	1	A → T in AAB36682. Ref.4
	Sequence conflict	512	1	G → V Ref.1
	Sequence conflict	512	1	G → V Ref.2
	Sequence conflict	534	1	A → T Ref.1
	Sequence conflict	534	1	A → T Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (EGF(1,2,3,4,5)) [UniParc]. Last modified March 21, 2006. Version 4. Checksum: 06DDDE9178BC494B	FASTA	835	91,869
	10 20 30 40 50 60 MGGRVFLAFC VWLTLPGAET QDSRGCARWC PQNSSCVNAT ACRCNPGFSS FSEIITTPTE 70 80 90 100 110 120 TCDDINECAT PSKVSCGKFS DCWNTEGSYD CVCSPGYEPV SGAKTFKNES ENTCQDVDEC 130 140 150 160 170 180 QQNPRLCKSY GTCVNTLGSY TCQCLPGFKF IPEDPKVCTD VNECTSGQNP CHSSTHCLNN 190 200 210 220 230 240 VGSYQCRCRP GWQPIPGSPN GPNNTVCEDV DECSSGQHQC DSSTVCFNTV GSYSCRCRPG 250 260 270 280 290 300 WKPRHGIPNN QKDTVCEDMT FSTWTPPPGV HSQTLSRFFD KVQDLGRDSK TSSAEVTIQN 310 320 330 340 350 360 VIKLVDELME APGDVEALAP PVRHLIATQL LSNLEDIMRI LAKSLPKGPF TYISPSNTEL 370 380 390 400 410 420 TLMIQERGDK NVTMGQSSAR MKLNWAVAAG AEDPGPAVAG ILSIQNMTTL LANASLNLHS 430 440 450 460 470 480 KKQAELEEIY ESSIRGVQLR RLSAVNSIFL SHNNTKELNS PILFAFSHLE SSDGEAGRDP 490 500 510 520 530 540 PAKDVMPGPR QELLCAFWKS DSDRGGHWAT EGCQVLGSKN GSTTCQCSHL SSFAILMAHY 550 560 570 580 590 600 DVEDWKLTLI TRVGLALSLF CLLLCILTFL LVRPIQGSRT TIHLHLCICL FVGSTIFLAG 610 620 630 640 650 660 IENEGGQVGL RCRLVAGLLH YCFLAAFCWM SLEGLELYFL VVRVFQGQGL STRWLCLIGY 670 680 690 700 710 720 GVPLLIVGVS AAIYSKGYGR PRYCWLDFEQ GFLWSFLGPV TFIILCNAVI FVTTVWKLTQ 730 740 750 760 770 780 KFSEINPDMK KLKKARALTI TAIAQLFLLG CTWVFGLFIF DDRSLVLTYV FTILNCLQGA 790 800 810 820 830 FLYLLHCLLN KKVREEYRKW ACLVAGGSKY SEFTSTTSGT GHNQTRALRA SESGI
	Isoform 2 (EGF(1,2,5)). Checksum: C98F20493CA3E482	FASTA	742	81,743
	10 20 30 40 50 60 MGGRVFLAFC VWLTLPGAET QDSRGCARWC PQNSSCVNAT ACRCNPGFSS FSEIITTPTE 70 80 90 100 110 120 TCDDINECAT PSKVSCGKFS DCWNTEGSYD CVCSPGYEPV SGAKTFKNES ENTCQDVDEC 130 140 150 160 170 180 SSGQHQCDSS TVCFNTVGSY SCRCRPGWKP RHGIPNNQKD TVCEDMTFST WTPPPGVHSQ 190 200 210 220 230 240 TLSRFFDKVQ DLGRDSKTSS AEVTIQNVIK LVDELMEAPG DVEALAPPVR HLIATQLLSN 250 260 270 280 290 300 LEDIMRILAK SLPKGPFTYI SPSNTELTLM IQERGDKNVT MGQSSARMKL NWAVAAGAED 310 320 330 340 350 360 PGPAVAGILS IQNMTTLLAN ASLNLHSKKQ AELEEIYESS IRGVQLRRLS AVNSIFLSHN 370 380 390 400 410 420 NTKELNSPIL FAFSHLESSD GEAGRDPPAK DVMPGPRQEL LCAFWKSDSD RGGHWATEGC 430 440 450 460 470 480 QVLGSKNGST TCQCSHLSSF AILMAHYDVE DWKLTLITRV GLALSLFCLL LCILTFLLVR 490 500 510 520 530 540 PIQGSRTTIH LHLCICLFVG STIFLAGIEN EGGQVGLRCR LVAGLLHYCF LAAFCWMSLE 550 560 570 580 590 600 GLELYFLVVR VFQGQGLSTR WLCLIGYGVP LLIVGVSAAI YSKGYGRPRY CWLDFEQGFL 610 620 630 640 650 660 WSFLGPVTFI ILCNAVIFVT TVWKLTQKFS EINPDMKKLK KARALTITAI AQLFLLGCTW 670 680 690 700 710 720 VFGLFIFDDR SLVLTYVFTI LNCLQGAFLY LLHCLLNKKV REEYRKWACL VAGGSKYSEF 730 740 TSTTSGTGHN QTRALRASES GI
	Isoform 3 (EGF(1,2,3,5)). Checksum: 03982263B73EFA2A	FASTA	786	86,628
	10 20 30 40 50 60 MGGRVFLAFC VWLTLPGAET QDSRGCARWC PQNSSCVNAT ACRCNPGFSS FSEIITTPTE 70 80 90 100 110 120 TCDDINECAT PSKVSCGKFS DCWNTEGSYD CVCSPGYEPV SGAKTFKNES ENTCQDVDEC 130 140 150 160 170 180 QQNPRLCKSY GTCVNTLGSY TCQCLPGFKF IPEDPKVCTD VDECSSGQHQ CDSSTVCFNT 190 200 210 220 230 240 VGSYSCRCRP GWKPRHGIPN NQKDTVCEDM TFSTWTPPPG VHSQTLSRFF DKVQDLGRDS 250 260 270 280 290 300 KTSSAEVTIQ NVIKLVDELM EAPGDVEALA PPVRHLIATQ LLSNLEDIMR ILAKSLPKGP 310 320 330 340 350 360 FTYISPSNTE LTLMIQERGD KNVTMGQSSA RMKLNWAVAA GAEDPGPAVA GILSIQNMTT 370 380 390 400 410 420 LLANASLNLH SKKQAELEEI YESSIRGVQL RRLSAVNSIF LSHNNTKELN SPILFAFSHL 430 440 450 460 470 480 ESSDGEAGRD PPAKDVMPGP RQELLCAFWK SDSDRGGHWA TEGCQVLGSK NGSTTCQCSH 490 500 510 520 530 540 LSSFAILMAH YDVEDWKLTL ITRVGLALSL FCLLLCILTF LLVRPIQGSR TTIHLHLCIC 550 560 570 580 590 600 LFVGSTIFLA GIENEGGQVG LRCRLVAGLL HYCFLAAFCW MSLEGLELYF LVVRVFQGQG 610 620 630 640 650 660 LSTRWLCLIG YGVPLLIVGV SAAIYSKGYG RPRYCWLDFE QGFLWSFLGP VTFIILCNAV 670 680 690 700 710 720 IFVTTVWKLT QKFSEINPDM KKLKKARALT ITAIAQLFLL GCTWVFGLFI FDDRSLVLTY 730 740 750 760 770 780 VFTILNCLQG AFLYLLHCLL NKKVREEYRK WACLVAGGSK YSEFTSTTSG TGHNQTRALR ASESGI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain." Hamann J., Eichler W., Hamann D., Kerstens H.M.J., Poddighe P.J., Hoovers J.M.N., Hartmann J.M., Strauss M., van Lier R.A.W. J. Immunol. 155:1942-1950(1995) [PubMed: 7636245] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily." Hamann J., Hartmann E., van Lier R.A.W. Genomics 32:144-147(1996) [PubMed: 8786105] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). Tissue: Foreskin.
[3]	Hamann J. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[4]	"CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation." Gray J.X., Haino M., Roth M.J., Maguire J.E., Jensen P.N., Yarme A., Stetler-Stevenson M.-A., Siebenlist U., Kelly K. J. Immunol. 157:5438-5447(1996) [PubMed: 8955192] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
[5]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Colon adenocarcinoma.
[8]	"Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex." Lin H.-H., Stacey M., Saxby C., Knott V., Chaudhry Y., Evans D., Gordon S., McKnight A.J., Handford P., Lea S. J. Biol. Chem. 276:24160-24169(2001) [PubMed: 11297558] [Abstract] Cited for: INTERACTION WITH DAF.
[9]	"The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans." Stacey M., Chang G.-W., Davies J.Q., Kwakkenbos M.J., Sanderson R.D., Hamann J., Gordon S., Lin H.-H. Blood 102:2916-2924(2003) [PubMed: 12829604] [Abstract] Cited for: INTERACTION WITH CHONDROITIN SULFATE.
[10]	"The EGF-TM7 family: a postgenomic view." Kwakkenbos M.J., Kop E.N., Stacey M., Matmati M., Gordon S., Lin H.H., Hamann J. Immunogenetics 55:655-666(2004) [PubMed: 14647991] [Abstract] Cited for: REVIEW.
[11]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-818 AND SER-831, MASS SPECTROMETRY.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-831 AND SER-833, MASS SPECTROMETRY.
[13]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-453, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	X84700 mRNA. Translation: CAA59173.1. X94630 , X94631, X94632, X94633, Z99830, Z99831, X94634, X94635, X94636, X94637, X94638, X94639, X94640, X94641, X94642, X94643, X94644, X94645, X94646, X94647 Genomic DNA. Translation: CAA64333.1. U76764 mRNA. Translation: AAB36682.1. AB065966 Genomic DNA. Translation: BAC06178.1. Sequence problems. AC005327 Genomic DNA. Translation: AAC27673.1. Sequence problems. BC026690 mRNA. Translation: AAH26690.1.
IPI	IPI00299412. IPI00397229. IPI00397230.
PIR	I37225.
RefSeq	NP_001020331.1. NP_001775.2. NP_510966.1.
UniGene	Hs.466039
3D structure databases
HSSP	HSSP built from PDB template 1FSB based on UniProtKB P16109.
ModBase	Search...
Protein-protein interaction databases
IntAct	P48960. 1 interaction.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P48960.
Proteomic databases
PRIDE	P48960.
Genome annotation databases
Ensembl	ENSG00000123146. Homo sapiens. [Contig view]
GeneID	976.
KEGG	hsa:976.
NMPDR	fig|9606.3.peg.15845.
Organism-specific databases
GeneCards	GC19P014353.
H-InvDB	HIX0014835.
HGNC	HGNC:1711. CD97.
HPA	HPA013707.
MIM	601211. gene.
PharmGKB	PA26248.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P48960.
HOVERGEN	P48960.
OMA	P48960. QVGLRCR.
Gene expression databases
Bgee	P48960.
CleanEx	HS_CD97.
GermOnline	ENSG00000123146. Homo sapiens.
Family and domain databases
InterPro	IPR000152. EGF-type_Asp/Asn_hydroxyl_CS. IPR000742. EGF_3. IPR001881. EGF_Ca_bd. IPR013091. EGF_Ca_bd_2. IPR018097. EGF_Ca_bd_CS. IPR017981. GPCR_2-like. IPR003056. GPCR_2_CD97. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. IPR000203. PKD_cys_rich. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF07645. EGF_CA. 4 hits. PF01825. GPS. 1 hit. [Graphical view]
PRINTS	PR01278. CD97PROTEIN. PR00249. GPCRSECRETIN.
SMART	SM00179. EGF_CA. 4 hits. SM00303. GPS. 1 hit. [Graphical view]
PROSITE	PS00010. ASX_HYDROXYL. 4 hits. PS50026. EGF_3. 4 hits. PS01187. EGF_CA. 4 hits. PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	4094.
SOURCE	Search...

Entry information

Entry name

CD97_HUMAN

Accession

Primary (citable) accession number: P48960
Secondary accession number(s): O00718 , O76101, Q8NG72, Q8TBQ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	March 21, 2006
Last modified:	June 16, 2009
This is version 101 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)