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Protein

CD97 antigen

Gene

CD97

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity).By similarity

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • G-protein coupled receptor activity Source: ProtInc
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • cell adhesion Source: ProtInc
  • cell-cell signaling Source: ProtInc
  • cell surface receptor signaling pathway Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • immune response Source: ProtInc
  • inflammatory response Source: ProtInc
  • movement of cell or subcellular component Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-HSA-373080. Class B/2 (Secretin family receptors).

Protein family/group databases

MEROPSiP02.002.
TCDBi9.A.14.6.2. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
CD97 antigen
Alternative name(s):
Leukocyte antigen CD97
CD_antigen: CD97
Cleaved into the following 2 chains:
Gene namesi
Name:CD97
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1711. CD97.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 552532ExtracellularSequence analysisAdd
BLAST
Transmembranei553 – 57220Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini573 – 5819CytoplasmicSequence analysis
Transmembranei582 – 60120Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini602 – 62019ExtracellularSequence analysisAdd
BLAST
Transmembranei621 – 64222Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini643 – 65311CytoplasmicSequence analysisAdd
BLAST
Transmembranei654 – 67421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini675 – 69117ExtracellularSequence analysisAdd
BLAST
Transmembranei692 – 71221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini713 – 73927CytoplasmicSequence analysisAdd
BLAST
Transmembranei740 – 76021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini761 – 7666ExtracellularSequence analysis
Transmembranei767 – 78923Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini790 – 83546CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB-SubCell
  • focal adhesion Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26248.

Polymorphism and mutation databases

BioMutaiCD97.
DMDMi90110013.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 835815CD97 antigenPRO_0000012868Add
BLAST
Chaini21 – 530510CD97 antigen subunit alphaBy similarityPRO_0000296235Add
BLAST
Chaini531 – 835305CD97 antigen subunit betaBy similarityPRO_0000296236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 36PROSITE-ProRule annotation
Disulfide bondi30 ↔ 42PROSITE-ProRule annotation
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence analysis
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi44 ↔ 62PROSITE-ProRule annotation
Disulfide bondi68 ↔ 82PROSITE-ProRule annotation
Disulfide bondi76 ↔ 91PROSITE-ProRule annotation
Disulfide bondi93 ↔ 114PROSITE-ProRule annotation
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence analysis
Disulfide bondi120 ↔ 133PROSITE-ProRule annotation
Disulfide bondi127 ↔ 142PROSITE-ProRule annotation
Disulfide bondi144 ↔ 158PROSITE-ProRule annotation
Disulfide bondi164 ↔ 177PROSITE-ProRule annotation
Disulfide bondi171 ↔ 186PROSITE-ProRule annotation
Disulfide bondi188 ↔ 207PROSITE-ProRule annotation
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi213 ↔ 226PROSITE-ProRule annotation
Disulfide bondi220 ↔ 235PROSITE-ProRule annotation
Disulfide bondi237 ↔ 256PROSITE-ProRule annotation
Glycosylationi371 – 3711N-linked (GlcNAc...)1 Publication
Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence analysis
Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence analysis
Glycosylationi453 – 4531N-linked (GlcNAc...)1 Publication
Glycosylationi520 – 5201N-linked (GlcNAc...)Sequence analysis
Modified residuei831 – 8311PhosphoserineCombined sources
Modified residuei833 – 8331PhosphoserineCombined sources

Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei530 – 5312CleavageBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP48960.
MaxQBiP48960.
PaxDbiP48960.
PRIDEiP48960.
TopDownProteomicsiP48960-2. [P48960-2]

PTM databases

iPTMnetiP48960.
PhosphoSiteiP48960.
SwissPalmiP48960.

Expressioni

Tissue specificityi

Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in the synovial fluid.

Inductioni

Rapid up-regulation during lymphocyte activation.

Gene expression databases

BgeeiP48960.
CleanExiHS_CD97.
ExpressionAtlasiP48960. baseline and differential.
GenevisibleiP48960. HS.

Organism-specific databases

HPAiHPA013707.

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) interacts with chondroitin sulfate.2 Publications

Protein-protein interaction databases

BioGridi107414. 51 interactions.
DIPiDIP-52292N.
IntActiP48960. 11 interactions.
MINTiMINT-4531069.
STRINGi9606.ENSP00000242786.

Structurei

3D structure databases

ProteinModelPortaliP48960.
SMRiP48960. Positions 25-257, 549-796.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 6342EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini64 – 11552EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini116 – 15944EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini160 – 20849EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini209 – 25749EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini492 – 54251GPSPROSITE-ProRule annotationAdd
BLAST

Domaini

The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region.
Binding to chondroitin sulfate is mediated by the fourth EGF domain.

Sequence similaritiesi

Contains 5 EGF-like domains.PROSITE-ProRule annotation
Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOVERGENiHBG048917.
InParanoidiP48960.
KOiK08446.
OMAiILCNAVI.
OrthoDBiEOG75J0MK.
PhylomeDBiP48960.
TreeFamiTF316380.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR003056. GPCR_2_CD97.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF07645. EGF_CA. 4 hits.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR01278. CD97PROTEIN.
PR00249. GPCRSECRETIN.
SMARTiSM00181. EGF. 5 hits.
SM00179. EGF_CA. 4 hits.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 4 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P48960-1) [UniParc]FASTAAdd to basket

Also known as: EGF(1,2,3,4,5)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGRVFLAFC VWLTLPGAET QDSRGCARWC PQNSSCVNAT ACRCNPGFSS
60 70 80 90 100
FSEIITTPTE TCDDINECAT PSKVSCGKFS DCWNTEGSYD CVCSPGYEPV
110 120 130 140 150
SGAKTFKNES ENTCQDVDEC QQNPRLCKSY GTCVNTLGSY TCQCLPGFKF
160 170 180 190 200
IPEDPKVCTD VNECTSGQNP CHSSTHCLNN VGSYQCRCRP GWQPIPGSPN
210 220 230 240 250
GPNNTVCEDV DECSSGQHQC DSSTVCFNTV GSYSCRCRPG WKPRHGIPNN
260 270 280 290 300
QKDTVCEDMT FSTWTPPPGV HSQTLSRFFD KVQDLGRDSK TSSAEVTIQN
310 320 330 340 350
VIKLVDELME APGDVEALAP PVRHLIATQL LSNLEDIMRI LAKSLPKGPF
360 370 380 390 400
TYISPSNTEL TLMIQERGDK NVTMGQSSAR MKLNWAVAAG AEDPGPAVAG
410 420 430 440 450
ILSIQNMTTL LANASLNLHS KKQAELEEIY ESSIRGVQLR RLSAVNSIFL
460 470 480 490 500
SHNNTKELNS PILFAFSHLE SSDGEAGRDP PAKDVMPGPR QELLCAFWKS
510 520 530 540 550
DSDRGGHWAT EGCQVLGSKN GSTTCQCSHL SSFAILMAHY DVEDWKLTLI
560 570 580 590 600
TRVGLALSLF CLLLCILTFL LVRPIQGSRT TIHLHLCICL FVGSTIFLAG
610 620 630 640 650
IENEGGQVGL RCRLVAGLLH YCFLAAFCWM SLEGLELYFL VVRVFQGQGL
660 670 680 690 700
STRWLCLIGY GVPLLIVGVS AAIYSKGYGR PRYCWLDFEQ GFLWSFLGPV
710 720 730 740 750
TFIILCNAVI FVTTVWKLTQ KFSEINPDMK KLKKARALTI TAIAQLFLLG
760 770 780 790 800
CTWVFGLFIF DDRSLVLTYV FTILNCLQGA FLYLLHCLLN KKVREEYRKW
810 820 830
ACLVAGGSKY SEFTSTTSGT GHNQTRALRA SESGI
Length:835
Mass (Da):91,869
Last modified:March 21, 2006 - v4
Checksum:i06DDDE9178BC494B
GO
Isoform 2 (identifier: P48960-2) [UniParc]FASTAAdd to basket

Also known as: EGF(1,2,5)

The sequence of this isoform differs from the canonical sequence as follows:
     116-208: Missing.

Show »
Length:742
Mass (Da):81,743
Checksum:iC98F20493CA3E482
GO
Isoform 3 (identifier: P48960-3) [UniParc]FASTAAdd to basket

Also known as: EGF(1,2,3,5)

The sequence of this isoform differs from the canonical sequence as follows:
     160-208: Missing.

Show »
Length:786
Mass (Da):86,628
Checksum:i03982263B73EFA2A
GO

Sequence cautioni

The sequence AAC27673.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAC06178.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031A → T in AAB36682 (PubMed:8955192).Curated
Sequence conflicti512 – 5121G → V (PubMed:7636245).Curated
Sequence conflicti512 – 5121G → V (PubMed:8786105).Curated
Sequence conflicti534 – 5341A → T (PubMed:7636245).Curated
Sequence conflicti534 – 5341A → T (PubMed:8786105).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti367 – 3671R → Q.
Corresponds to variant rs2230748 [ dbSNP | Ensembl ].
VAR_017760

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei116 – 20893Missing in isoform 2. 4 PublicationsVSP_009411Add
BLAST
Alternative sequencei160 – 20849Missing in isoform 3. 1 PublicationVSP_009412Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84700 mRNA. Translation: CAA59173.1.
X94630
, X94631, X94632, X94633, Z99830, Z99831, X94634, X94635, X94636, X94637, X94638, X94639, X94640, X94641, X94642, X94643, X94644, X94645, X94646, X94647 Genomic DNA. Translation: CAA64333.1.
U76764 mRNA. Translation: AAB36682.1.
AB065966 Genomic DNA. Translation: BAC06178.1. Sequence problems.
AC005327 Genomic DNA. Translation: AAC27673.1. Sequence problems.
AK292159 mRNA. Translation: BAF84848.1.
AK314697 mRNA. Translation: BAG37246.1.
CH471106 Genomic DNA. Translation: EAW84412.1.
CH471106 Genomic DNA. Translation: EAW84413.1.
BC026690 mRNA. Translation: AAH26690.1.
CCDSiCCDS32929.1. [P48960-1]
CCDS32930.1. [P48960-3]
CCDS32931.1. [P48960-2]
PIRiI37225.
RefSeqiNP_001020331.1. NM_001025160.2. [P48960-3]
NP_001775.2. NM_001784.4. [P48960-2]
NP_510966.1. NM_078481.3. [P48960-1]
UniGeneiHs.466039.
Hs.531619.

Genome annotation databases

EnsembliENST00000242786; ENSP00000242786; ENSG00000123146. [P48960-1]
ENST00000357355; ENSP00000349918; ENSG00000123146. [P48960-3]
ENST00000358600; ENSP00000351413; ENSG00000123146. [P48960-2]
GeneIDi976.
KEGGihsa:976.
UCSCiuc002myl.4. human. [P48960-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84700 mRNA. Translation: CAA59173.1.
X94630
, X94631, X94632, X94633, Z99830, Z99831, X94634, X94635, X94636, X94637, X94638, X94639, X94640, X94641, X94642, X94643, X94644, X94645, X94646, X94647 Genomic DNA. Translation: CAA64333.1.
U76764 mRNA. Translation: AAB36682.1.
AB065966 Genomic DNA. Translation: BAC06178.1. Sequence problems.
AC005327 Genomic DNA. Translation: AAC27673.1. Sequence problems.
AK292159 mRNA. Translation: BAF84848.1.
AK314697 mRNA. Translation: BAG37246.1.
CH471106 Genomic DNA. Translation: EAW84412.1.
CH471106 Genomic DNA. Translation: EAW84413.1.
BC026690 mRNA. Translation: AAH26690.1.
CCDSiCCDS32929.1. [P48960-1]
CCDS32930.1. [P48960-3]
CCDS32931.1. [P48960-2]
PIRiI37225.
RefSeqiNP_001020331.1. NM_001025160.2. [P48960-3]
NP_001775.2. NM_001784.4. [P48960-2]
NP_510966.1. NM_078481.3. [P48960-1]
UniGeneiHs.466039.
Hs.531619.

3D structure databases

ProteinModelPortaliP48960.
SMRiP48960. Positions 25-257, 549-796.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107414. 51 interactions.
DIPiDIP-52292N.
IntActiP48960. 11 interactions.
MINTiMINT-4531069.
STRINGi9606.ENSP00000242786.

Protein family/group databases

MEROPSiP02.002.
TCDBi9.A.14.6.2. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiP48960.
PhosphoSiteiP48960.
SwissPalmiP48960.

Polymorphism and mutation databases

BioMutaiCD97.
DMDMi90110013.

Proteomic databases

EPDiP48960.
MaxQBiP48960.
PaxDbiP48960.
PRIDEiP48960.
TopDownProteomicsiP48960-2. [P48960-2]

Protocols and materials databases

DNASUi976.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242786; ENSP00000242786; ENSG00000123146. [P48960-1]
ENST00000357355; ENSP00000349918; ENSG00000123146. [P48960-3]
ENST00000358600; ENSP00000351413; ENSG00000123146. [P48960-2]
GeneIDi976.
KEGGihsa:976.
UCSCiuc002myl.4. human. [P48960-1]

Organism-specific databases

CTDi976.
GeneCardsiADGRE5.
HGNCiHGNC:1711. CD97.
HPAiHPA013707.
MIMi601211. gene.
neXtProtiNX_P48960.
PharmGKBiPA26248.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOVERGENiHBG048917.
InParanoidiP48960.
KOiK08446.
OMAiILCNAVI.
OrthoDBiEOG75J0MK.
PhylomeDBiP48960.
TreeFamiTF316380.

Enzyme and pathway databases

ReactomeiR-HSA-373080. Class B/2 (Secretin family receptors).

Miscellaneous databases

ChiTaRSiCD97. human.
GeneWikiiCD97.
GenomeRNAii976.
NextBioi4094.
PROiP48960.
SOURCEiSearch...

Gene expression databases

BgeeiP48960.
CleanExiHS_CD97.
ExpressionAtlasiP48960. baseline and differential.
GenevisibleiP48960. HS.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR003056. GPCR_2_CD97.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF07645. EGF_CA. 4 hits.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR01278. CD97PROTEIN.
PR00249. GPCRSECRETIN.
SMARTiSM00181. EGF. 5 hits.
SM00179. EGF_CA. 4 hits.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 4 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain."
    Hamann J., Eichler W., Hamann D., Kerstens H.M.J., Poddighe P.J., Hoovers J.M.N., Hartmann J.M., Strauss M., van Lier R.A.W.
    J. Immunol. 155:1942-1950(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily."
    Hamann J., Hartmann E., van Lier R.A.W.
    Genomics 32:144-147(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    Tissue: Foreskin.
  3. Hamann J.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation."
    Gray J.X., Haino M., Roth M.J., Maguire J.E., Jensen P.N., Yarme A., Stetler-Stevenson M.-A., Siebenlist U., Kelly K.
    J. Immunol. 157:5438-5447(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
  5. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Synovium.
  7. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon adenocarcinoma.
  10. "Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex."
    Lin H.-H., Stacey M., Saxby C., Knott V., Chaudhry Y., Evans D., Gordon S., McKnight A.J., Handford P., Lea S.
    J. Biol. Chem. 276:24160-24169(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DAF.
  11. "The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans."
    Stacey M., Chang G.-W., Davies J.Q., Kwakkenbos M.J., Sanderson R.D., Hamann J., Gordon S., Lin H.-H.
    Blood 102:2916-2924(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CHONDROITIN SULFATE.
  12. Cited for: REVIEW.
  13. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-453.
    Tissue: Liver.
  16. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-371.
    Tissue: Leukemic T-cell.
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-831 AND SER-833, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCD97_HUMAN
AccessioniPrimary (citable) accession number: P48960
Secondary accession number(s): A8K7Z4
, B2RBJ9, O00718, O76101, Q8NG72, Q8TBQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: March 21, 2006
Last modified: May 11, 2016
This is version 169 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.