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P48933 (SDHB_CYACA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit

EC=1.3.5.1
Alternative name(s):
Iron-sulfur subunit of complex II
Short name=Ip
Gene names
Name:SDH2
Synonyms:SDHB
Encoded onMitochondrion
OrganismCyanidium caldarium
Taxonomic identifier2771 [NCBI]
Taxonomic lineageEukaryotaRhodophytaBangiophyceaeCyanidialesCyanidiaceaeCyanidium

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 1 3Fe-4S cluster By similarity.

Binds 1 4Fe-4S cluster By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Subunit structure

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Succinate dehydrogenase [ubiquinone] iron-sulfur subunit
PRO_0000158695

Regions

Domain21 – 110902Fe-2S ferredoxin-type
Domain154 – 184314Fe-4S ferredoxin-type

Sites

Metal binding731Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding781Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding811Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding931Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1641Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1671Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1701Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1741Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2211Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2271Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2311Iron-sulfur 2 (4Fe-4S) By similarity
Binding site1791Ubiquinone; shared with DHSD By similarity

Sequences

Sequence LengthMass (Da)Tools
P48933 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: D068EBCDB33B5580

FASTA26230,268
        10         20         30         40         50         60 
MNLFSLKAEK FLNLKTLSDL KLIKIFRWDS SEKKDPWYST YVVSLKNCGP IVLDALIKIK 

        70         80         90        100        110        120 
NECDSTVSFR RSCREGICGS CAININGTNS LACLQKLNIK NNIIYVYPLP HIFVLKDLVV 

       130        140        150        160        170        180 
DLTNFYAQYR LIQPWLQSSL NIKSKKEIYQ SKQDRLYLDG LYECILCACC SASCPSYWWN 

       190        200        210        220        230        240 
HDKYLGPAVL LQAYRWIVDS RDDNTLSRLL SLKDSYKLYR CHTIMNCTKT CPKHLNPGKV 

       250        260 
IASIKKRLLN LEVLGEKRDL NS 

« Hide

References

[1]"Genes for two subunits of succinate dehydrogenase form a cluster on the mitochondrial genome of Rhodophyta."
Viehmann S., Richard O., Boyen C., Zetsche K.
Curr. Genet. 29:199-201(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: RK-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z48930 Genomic DNA. Translation: CAA88766.1.
PIRS62756.

3D structure databases

ProteinModelPortalP48933.
SMRP48933. Positions 20-248.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00223; UER01006.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHB_CYACA
AccessionPrimary (citable) accession number: P48933
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways