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P48932

- SDHB_CHOCR

UniProt

P48932 - SDHB_CHOCR

Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit

Gene

SDH2

Organism
Chondrus crispus (Carragheen moss) (Irish moss)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity
    Binds 1 3Fe-4S cluster.By similarity
    Binds 1 4Fe-4S cluster.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi73 – 731Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi78 – 781Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi81 – 811Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi93 – 931Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi163 – 1631Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi166 – 1661Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi169 – 1691Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi173 – 1731Iron-sulfur 3 (3Fe-4S)By similarity
    Binding sitei178 – 1781Ubiquinone; shared with DHSDBy similarity
    Metal bindingi220 – 2201Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi226 – 2261Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi230 – 2301Iron-sulfur 2 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    4. electron carrier activity Source: InterPro
    5. metal ion binding Source: UniProtKB-KW
    6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit (EC:1.3.5.1)
    Alternative name(s):
    Iron-sulfur subunit of complex II
    Short name:
    Ip
    Gene namesi
    Name:SDH2
    Synonyms:SDHB
    Encoded oniMitochondrion
    OrganismiChondrus crispus (Carragheen moss) (Irish moss)
    Taxonomic identifieri2769 [NCBI]
    Taxonomic lineageiEukaryotaRhodophytaFlorideophyceaeGigartinalesGigartinaceaeChondrus

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 250250Succinate dehydrogenase [ubiquinone] iron-sulfur subunitPRO_0000158694Add
    BLAST

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP48932.
    SMRiP48932. Positions 18-244.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 110812Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini153 – 183314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view]
    PfamiPF13085. Fer2_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR00384. dhsB. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48932-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIIKNLNQKI ITIDNSSPYQ KFIRIYRWNP NLNLNPWFSI FPISTNNCGP    50
    MILDALIQIK NIQDSSLTFR RSCREGICGS CSMNIDGTNS LACLRSLNTK 100
    SNFITIYPLP HTYIIKDLVP DLSNFYAQYK LIKPWLINKI GFSLKENLQS 150
    KIDRLELDGL YECILCACCS ASCPSYWWNQ DKYLGPAILL QAYRWIVDSR 200
    DNSTENRLNF LNNKMRLFRC HTIMNCSKTC PKSLNPGKAI ASIKYRIINN 250
    Length:250
    Mass (Da):28,887
    Last modified:February 1, 1996 - v1
    Checksum:i09511AE52A4CA149
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z47547 Genomic DNA. Translation: CAA87611.1.
    PIRiS59114.
    RefSeqiNP_062488.1. NC_001677.2.

    Genome annotation databases

    GeneIDi809396.
    KEGGiccp:ChcroMp09.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z47547 Genomic DNA. Translation: CAA87611.1 .
    PIRi S59114.
    RefSeqi NP_062488.1. NC_001677.2.

    3D structure databases

    ProteinModelPortali P48932.
    SMRi P48932. Positions 18-244.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 809396.
    KEGGi ccp:ChcroMp09.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view ]
    Pfami PF13085. Fer2_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR00384. dhsB. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genes for two subunits of succinate dehydrogenase form a cluster on the mitochondrial genome of Rhodophyta."
      Viehmann S., Richard O., Boyen C., Zetsche K.
      Curr. Genet. 29:199-201(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequence of the mitochondrial DNA of the rhodophyte Chondrus crispus (Gigartinales). Gene content and genome organization."
      Leblanc C., Boyen C., Richard O., Bonnard G., Grienenberger J.-M., Kloareg B.
      J. Mol. Biol. 250:484-495(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Apices.

    Entry informationi

    Entry nameiSDHB_CHOCR
    AccessioniPrimary (citable) accession number: P48932
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3