Cytochrome c oxidase subunit 1

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Reviewed, UniProtKB/Swiss-Prot P48888 (COX1_FELCA)

Last modified October 13, 2009. Version 63. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Cytochrome c oxidase subunit 1
    EC=1.9.3.1
Alternative name(s):
    Cytochrome c oxidase polypeptide I

Gene names

Name:	MT-CO1
Synonyms:	COI, COXI, MTCO1

Encoded on

Mitochondrion

Organism

Felis catus (Cat) (Felis silvestris catus)

Taxonomic identifier

9685 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

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Protein attributes

Sequence length	514 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity	4 ferrocytochrome c + O₂ + 4 H⁺ = 4 ferricytochrome c + 2 H₂O.
Pathway	Energy metabolism; oxidative phosphorylation.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the heme-copper respiratory oxidase family.

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Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	aerobic respiration Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-KW respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 514

514

Cytochrome c oxidase subunit 1

PRO_0000183334

Regions

Transmembrane

17 – 37

Potential

Transmembrane

56 – 76

Potential

Transmembrane

102 – 122

Potential

Transmembrane

145 – 165

Potential

Transmembrane

183 – 203

Potential

Transmembrane

234 – 254

Potential

Transmembrane

268 – 288

Potential

Transmembrane

310 – 330

Potential

Transmembrane

338 – 358

Potential

Transmembrane

380 – 400

Potential

Transmembrane

412 – 432

Potential

Transmembrane

456 – 476

Potential

Sites

Metal binding

Iron (heme A axial ligand) Probable

Metal binding

240

Copper B Probable

Metal binding

244

Copper B Probable

Metal binding

290

Copper B Probable

Metal binding

291

Copper B Probable

Metal binding

376

Iron (heme A3 axial ligand) Probable

Metal binding

378

Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link

240 ↔ 244

1'-histidyl-3'-tyrosine (His-Tyr) By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

P48888-1 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: D9CF17030A733BF0
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FASTA

514

57,056

        10         20         30         40         50         60 
MFMNRWLFST NHKDIGTLYL LFGAWAGMVG TALSLLIRAE LGQPGTLLGD DQIYNVIVTA 

        70         80         90        100        110        120 
HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM SFWLLPPSFL LLLASSMVEA 

       130        140        150        160        170        180 
GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL HLAGVSSILG AINFITTIIN MKPPAMSQYQ 

       190        200        210        220        230        240 
TPLFVWSVLI TAVLLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH 

       250        260        270        280        290        300 
PEVYILILPG FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD 

       310        320        330        340        350        360 
TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPAMLW ALGFIFLFTV GGLTGIVLAN 

       370        380        390        400        410        420 
SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFVHWFPLF SGYTLDNTWA KIHFTIMFVG 

       430        440        450        460        470        480 
VNMTFFPQHF LGLSGMPRRY SDYPDAYTTW NTISSMGSFI SLTAVMLMVF MVWEAFASKR 

       490        500        510 
EVAMVELTTT NLEWLHGCPP PYHTFEEPTY VLLK

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References

[1]	"Complete nucleotide sequences of the domestic cat (Felis catus) mitochondrial genome and a transposed mtDNA tandem repeat (Numt) in the nuclear genome." Lopez J.V., Cevario S., O'Brien S.J. Genomics 33:229-246(1996) [PubMed: 8660972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Blood.
[2]	"Numt, a recent transfer and tandem amplification of mitochondrial DNA to the nuclear genome of the domestic cat." Lopez J.V., Yuhki N., Masuda R., Modi W., O'Brien S.J. J. Mol. Evol. 39:174-190(1994) [PubMed: 7932781] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 106-184.

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Cross-references

Sequence databases
	U20753 Genomic DNA. Translation: AAC48571.1. S75099 Genomic DNA. Translation: AAB32047.1.
PIR	T11404.
RefSeq	NP_008253.1.
3D structure databases
HSSP	HSSP built from PDB template 2OCC based on UniProtKB P00396.
SMR	P48888. Positions 1-514.
ModBase	Search...
Genome annotation databases
GeneID	807934.
Organism-specific databases
CTD	807934.
Phylogenomic databases
HOVERGEN	P48888.
Enzyme and pathway databases
BRENDA	1.9.3.1. 273949.
Family and domain databases
InterPro	IPR000883. Cyt_c_oxidase_su1. [Graphical view]
Gene3D	G3DSA:1.20.210.10. COX1. 1 hit.
PANTHER	PTHR10422. COX1. 1 hit.
Pfam	PF00115. COX1. 1 hit. [Graphical view]
PRINTS	PR01165. CYCOXIDASEI.
PROSITE	PS50855. COX1. 1 hit. PS00077. COX1_CUB. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

COX1_FELCA

Accession

Primary (citable) accession number: P48888

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	October 13, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents