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P48887

- COX1_ALBCA

UniProt

P48887 - COX1_ALBCA

Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Albinaria caerulea (Land snail)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi57 – 571Iron (heme A axial ligand)Curated
    Metal bindingi236 – 2361Copper BCurated
    Metal bindingi240 – 2401Copper BCurated
    Metal bindingi285 – 2851Copper BCurated
    Metal bindingi286 – 2861Copper BCurated
    Metal bindingi371 – 3711Iron (heme A3 axial ligand)Curated
    Metal bindingi373 – 3731Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COI
    Encoded oniMitochondrion
    OrganismiAlbinaria caerulea (Land snail)
    Taxonomic identifieri42349 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraPanpulmonataEupulmonataStylommatophoraSigmurethraClausilioideaClausiliidaeAlopiinaeAlbinaria

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Cytochrome c oxidase subunit 1PRO_0000183277Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki236 ↔ 2401'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP48887.
    SMRiP48887. Positions 2-509.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei333 – 35321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei409 – 42921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei452 – 47221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48887-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRWFYSTNHK DIGTLYMLFG IWCGMVGTGL SLLIRLELGT SGTLTDDHFY    50
    NVIVTAHAFV MIFFMVMPIM IGGFGNWMVP LLIGAPDMSF PRMNNMSFWL 100
    LPPAFILLIC SSMVEGGAGT GWTVYPPLSS SLAHSGASVD LAIFSLHLAG 150
    MSSILGAINF ITTIFNMRSP GMTMERVSLF VWSILVTVFL LLLSLPVLAG 200
    AITMLLTDRN FNTSFFDPAG GGDPILYQHL FWFFGHPEVY ILILPGFGMI 250
    SHILGNSAMK QPFGTLGMIY AMISIGILGF IVWAHHMFTV GMDVDTRAYF 300
    TAATMIIAIP TGIKVFSWLM TIYGSKVQYT ASMYWVLGFI FLFTLGGLTG 350
    IVLSNSSLDI MLHDTYYVVA HFHYVLSMGA VFAIFAGFNF WFPVMTGLIL 400
    HERLAKAQFV VMFIAVNMTF FPQHFLGLAG MPRRYSDYPD SYFMWNQLSS 450
    YGSLMSVFAV LLFVLIVWEA FLSQRSLLFV DATLYSREWS DGYFPPDFHS 500
    NIYQSYITI 509
    Length:509
    Mass (Da):57,034
    Last modified:February 1, 1996 - v1
    Checksum:i07236D1343151A6B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83390 Genomic DNA. Translation: CAA58307.1.
    PIRiS59154.
    RefSeqiNP_007340.1. NC_001761.1.

    Genome annotation databases

    GeneIDi807999.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83390 Genomic DNA. Translation: CAA58307.1 .
    PIRi S59154.
    RefSeqi NP_007340.1. NC_001761.1.

    3D structure databases

    ProteinModelPortali P48887.
    SMRi P48887. Positions 2-509.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 807999.

    Organism-specific databases

    CTDi 4512.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence and gene organization of the mitochondrial genome of the land snail Albinaria coerulea."
      Hatzoglou E., Rodakis G.C., Lecanidou R.
      Genetics 140:1353-1366(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX1_ALBCA
    AccessioniPrimary (citable) accession number: P48887
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3