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Protein

Cytochrome c oxidase subunit 3

Gene

COX3

Organism
Wickerhamomyces canadensis (Yeast) (Pichia canadensis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:COX3
Encoded oniMitochondrion
OrganismiWickerhamomyces canadensis (Yeast) (Pichia canadensis)
Taxonomic identifieri1156965 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeWickerhamomyces

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001838321 – 269Cytochrome c oxidase subunit 3Add BLAST269

Structurei

3D structure databases

ProteinModelPortaliP48874
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd01665 Cyt_c_Oxidase_III, 1 hit
Gene3Di1.20.120.80, 1 hit
InterProiView protein in InterPro
IPR024791 Cyt_c/ubiquinol_Oxase_su3
IPR033945 Cyt_c_oxase_su3_dom
IPR000298 Cyt_c_oxidase-like_su3
IPR035973 Cyt_c_oxidase_su3-like_sf
IPR013833 Cyt_c_oxidase_su3_a-hlx
PANTHERiPTHR11403 PTHR11403, 1 hit
PfamiView protein in Pfam
PF00510 COX3, 1 hit
SUPFAMiSSF81452 SSF81452, 1 hit
PROSITEiView protein in PROSITE
PS50253 COX3, 1 hit

Sequencei

Sequence statusi: Complete.

P48874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHLERSRHQ LFPFHLVSPS PWPITVSFAL MSFALSLGLT MHGYIVGNSV
60 70 80 90 100
LFTSIILVLY SMTMWFRDII AEGTYLGDHT LAVRKGLNYG FLLFVVSEIL
110 120 130 140 150
IFAGIFWAYF HSAMSPAIEI GGVWPPVGIT AIGATELPLL NTIILLASGA
160 170 180 190 200
TITYSHHATI EGNRNHALNG LFITLWLIVI FVVCQYIEYT NAPFTISDGV
210 220 230 240 250
YGSVFFAGTG LHFLHMGMLI IMLAVCYWRM RQYHFTTGHH VNYETTILYL
260
HVLDVIWLFL YIVMYWWGA
Length:269
Mass (Da):30,467
Last modified:August 30, 2002 - v2
Checksum:iEA9311386322BE51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31785 Genomic DNA Translation: BAA06569.2
PIRiS58746
RefSeqiNP_038214.1, NC_001762.1

Genome annotation databases

GeneIDi800535

Similar proteinsi

Entry informationi

Entry nameiCOX3_WICCA
AccessioniPrimary (citable) accession number: P48874
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 30, 2002
Last modified: May 23, 2018
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

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