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P48871

- COX2_WICCA

UniProt

P48871 - COX2_WICCA

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Protein
Cytochrome c oxidase subunit 2
Gene
COX2
Organism
Wickerhamomyces canadensis (Yeast) (Pichia canadensis)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi182 – 1821Copper A Inferred
Metal bindingi217 – 2171Copper A Inferred
Metal bindingi221 – 2211Copper A Inferred
Metal bindingi225 – 2251Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Encoded oniMitochondrion
OrganismiWickerhamomyces canadensis (Yeast) (Pichia canadensis)
Taxonomic identifieri1156965 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeWickerhamomyces

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini12 – 3827Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei39 – 5921Helical; Reviewed prediction
Add
BLAST
Topological domaini60 – 7819Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei79 – 10123Helical; Reviewed prediction
Add
BLAST
Topological domaini102 – 247146Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1111 By similarity
Add
BLAST
Chaini12 – 247236Cytochrome c oxidase subunit 2
PRO_0000006038Add
BLAST

Post-translational modificationi

The signal sequence of COX2 is processed by IMP1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliP48871.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48871-1 [UniParc]FASTAAdd to Basket

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MLLIINNIIN NDVPTPWGVY FQDSATPNHE GIIELHDNIM FYLVLILCLV    50
SWLLFSIVKD GSKNPLPHKY LVHGQTIEII WTILPALVLL VIAFPSFILL 100
YLCDEVISPA MTIKAIGLQW YWKYEYSDFI NDSGETIEFE SYVIPEDLLE 150
DGQLPLLDTD TSIVCPVNTH IRFIVSAADV IHDFAVPSLG IKIDACPGRL 200
NQVSALIQRE GVYYGQCSEL CGVAHSAMPI KVEAVSLKEF LTWLNEQ 247
Length:247
Mass (Da):27,809
Last modified:August 30, 2002 - v2
Checksum:iC41D811809897DDD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31785 Genomic DNA. Translation: BAA06577.2.
PIRiS58754.
RefSeqiNP_038222.1. NC_001762.1.

Genome annotation databases

GeneIDi800566.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31785 Genomic DNA. Translation: BAA06577.2 .
PIRi S58754.
RefSeqi NP_038222.1. NC_001762.1.

3D structure databases

ProteinModelPortali P48871.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 800566.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete mitochondrial DNA sequence of Hansenula wingei reveals new characteristics of yeast mitochondria."
    Sekito T., Okamoto K., Kitano H., Yoshida K.
    Curr. Genet. 28:39-53(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 21.

Entry informationi

Entry nameiCOX2_WICCA
AccessioniPrimary (citable) accession number: P48871
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 30, 2002
Last modified: April 16, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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