Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P48871 (COX2_WICCA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Encoded onMitochondrion
OrganismWickerhamomyces canadensis (Yeast) (Pichia canadensis)
Taxonomic identifier1156965 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeWickerhamomyces

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Post-translational modification

The signal sequence of COX2 is processed by IMP1 By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1111 By similarity
Chain12 – 247236Cytochrome c oxidase subunit 2
PRO_0000006038

Regions

Topological domain12 – 3827Mitochondrial intermembrane Potential
Transmembrane39 – 5921Helical; Potential
Topological domain60 – 7819Mitochondrial matrix Potential
Transmembrane79 – 10123Helical; Potential
Topological domain102 – 247146Mitochondrial intermembrane Potential

Sites

Metal binding1821Copper A Probable
Metal binding2171Copper A Probable
Metal binding2211Copper A Probable
Metal binding2251Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P48871 [UniParc].

Last modified August 30, 2002. Version 2.
Checksum: C41D811809897DDD

FASTA24727,809
        10         20         30         40         50         60 
MLLIINNIIN NDVPTPWGVY FQDSATPNHE GIIELHDNIM FYLVLILCLV SWLLFSIVKD 

        70         80         90        100        110        120 
GSKNPLPHKY LVHGQTIEII WTILPALVLL VIAFPSFILL YLCDEVISPA MTIKAIGLQW 

       130        140        150        160        170        180 
YWKYEYSDFI NDSGETIEFE SYVIPEDLLE DGQLPLLDTD TSIVCPVNTH IRFIVSAADV 

       190        200        210        220        230        240 
IHDFAVPSLG IKIDACPGRL NQVSALIQRE GVYYGQCSEL CGVAHSAMPI KVEAVSLKEF 


LTWLNEQ 

« Hide

References

[1]"The complete mitochondrial DNA sequence of Hansenula wingei reveals new characteristics of yeast mitochondria."
Sekito T., Okamoto K., Kitano H., Yoshida K.
Curr. Genet. 28:39-53(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 21.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D31785 Genomic DNA. Translation: BAA06577.2.
PIRS58754.
RefSeqNP_038222.1. NC_001762.1.

3D structure databases

ProteinModelPortalP48871.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID800566.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_WICCA
AccessionPrimary (citable) accession number: P48871
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 30, 2002
Last modified: April 16, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families