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P48870

- COX2_CYACA

UniProt

P48870 - COX2_CYACA

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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Cyanidium caldarium
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi187 – 1871Copper ACurated
Metal bindingi222 – 2221Copper ACurated
Metal bindingi226 – 2261Copper ACurated
Metal bindingi230 – 2301Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:COXII
Encoded oniMitochondrion
OrganismiCyanidium caldarium
Taxonomic identifieri2771 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaBangiophyceaeCyanidialesCyanidiaceaeCyanidium

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Cytochrome c oxidase subunit 2PRO_0000183562Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP48870.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini64 – 8320Mitochondrial matrixSequence AnalysisAdd
BLAST
Topological domaini105 – 255151Mitochondrial intermembraneSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48870-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFFFFSFIN YKVLNDAARP WQIGFQDPAT PIMEGIVNLH HDIIFFLIII
60 70 80 90 100
IIFVSWILFR TLFLFNSKTN PVAYNFSHGT FIELLWTLTP SLVLIGIAVP
110 120 130 140 150
SFALLYSIDE IIDPAITIKA VGRQWYWSYE YSDYVNEENE FLAFHSYILP
160 170 180 190 200
EEDLELGQFR LLEVDNRIII PVNTHIRIIV TGADVIHSWA VPSLGVKCDA
210 220 230 240 250
IPGRLNQISF FIKREGIYYG QCSEICGVNH GFMPIVIEAV SFDDYIRWVQ

NKILD
Length:255
Mass (Da):29,512
Last modified:February 1, 1996 - v1
Checksum:i5026107CB4B69015
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48930 Genomic DNA. Translation: CAA88769.1.
PIRiS62759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48930 Genomic DNA. Translation: CAA88769.1 .
PIRi S62759.

3D structure databases

ProteinModelPortali P48870.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Viehmann S.
    Thesis (1995), Justus Liebig University / Frankfurt, Germany
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RK-1.

Entry informationi

Entry nameiCOX2_CYACA
AccessioniPrimary (citable) accession number: P48870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3