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P48870

- COX2_CYACA

UniProt

P48870 - COX2_CYACA

Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Cyanidium caldarium
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi187 – 1871Copper ACurated
    Metal bindingi222 – 2221Copper ACurated
    Metal bindingi226 – 2261Copper ACurated
    Metal bindingi230 – 2301Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:COX2
    Synonyms:COXII
    Encoded oniMitochondrion
    OrganismiCyanidium caldarium
    Taxonomic identifieri2771 [NCBI]
    Taxonomic lineageiEukaryotaRhodophytaBangiophyceaeCyanidialesCyanidiaceaeCyanidium

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 255255Cytochrome c oxidase subunit 2PRO_0000183562Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP48870.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4242Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini64 – 8320Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini105 – 255151Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48870-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFFFFSFIN YKVLNDAARP WQIGFQDPAT PIMEGIVNLH HDIIFFLIII    50
    IIFVSWILFR TLFLFNSKTN PVAYNFSHGT FIELLWTLTP SLVLIGIAVP 100
    SFALLYSIDE IIDPAITIKA VGRQWYWSYE YSDYVNEENE FLAFHSYILP 150
    EEDLELGQFR LLEVDNRIII PVNTHIRIIV TGADVIHSWA VPSLGVKCDA 200
    IPGRLNQISF FIKREGIYYG QCSEICGVNH GFMPIVIEAV SFDDYIRWVQ 250
    NKILD 255
    Length:255
    Mass (Da):29,512
    Last modified:February 1, 1996 - v1
    Checksum:i5026107CB4B69015
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48930 Genomic DNA. Translation: CAA88769.1.
    PIRiS62759.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48930 Genomic DNA. Translation: CAA88769.1 .
    PIRi S62759.

    3D structure databases

    ProteinModelPortali P48870.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Viehmann S.
      Thesis (1995), Justus Liebig University / Frankfurt, Germany
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: RK-1.

    Entry informationi

    Entry nameiCOX2_CYACA
    AccessioniPrimary (citable) accession number: P48870
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3