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P48869 (COX2_CHOCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Encoded onMitochondrion
OrganismChondrus crispus (Carragheen moss) (Irish moss)
Taxonomic identifier2769 [NCBI]
Taxonomic lineageEukaryotaRhodophytaFlorideophyceaeGigartinalesGigartinaceaeChondrus

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Cytochrome c oxidase subunit 2
PRO_0000183549

Regions

Topological domain1 – 3737Mitochondrial intermembrane Potential
Transmembrane38 – 5821Helical; Potential
Topological domain59 – 8325Mitochondrial matrix Potential
Transmembrane84 – 10421Helical; Potential
Topological domain105 – 254150Mitochondrial intermembrane Potential

Sites

Metal binding1861Copper A Probable
Metal binding2211Copper A Probable
Metal binding2251Copper A Probable
Metal binding2291Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P48869 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 81C809627C01B970

FASTA25429,186
        10         20         30         40         50         60 
MNNILNFYPA VITTDVAENW QIGFQDPATP IMEGIINLHY DLMFFICVIS VFVSWMLGRT 

        70         80         90        100        110        120 
LWHFEQNQNK IPSSLTHGTL IEMIWTVTPA FILLIIAVPS FSLLYAMDEI ISPAITIKTL 

       130        140        150        160        170        180 
GHQWYWSYEY SDYLNEDDDS INYDSYMIPE EDLEIGQFRL LEVDNRMVIP INTHIRVIVT 

       190        200        210        220        230        240 
AADVLHSWAV PSFRSKCDAI PGRLNQTSLF IKREGVYYGQ CSEICGINHG FMPIVVEATS 

       250 
LPNYVSWISN KLNE 

« Hide

References

[1]"Complete sequence of the mitochondrial DNA of the rhodophyte Chondrus crispus (Gigartinales). Gene content and genome organization."
Leblanc C., Boyen C., Richard O., Bonnard G., Grienenberger J.-M., Kloareg B.
J. Mol. Biol. 250:484-495(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Apices.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z47547 Genomic DNA. Translation: CAA87604.1.
PIRS59088.
RefSeqNP_062483.1. NC_001677.2.

3D structure databases

ProteinModelPortalP48869.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID809362.
KEGGccp:ChcroMp04.

Phylogenomic databases

KOK02261.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_CHOCR
AccessionPrimary (citable) accession number: P48869
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families