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P48868

- COX1_WICCA

UniProt

P48868 - COX1_WICCA

Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Wickerhamomyces canadensis (Yeast) (Pichia canadensis)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (30 Aug 2002)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi63 – 631Iron (heme A axial ligand)Curated
    Metal bindingi242 – 2421Copper BCurated
    Metal bindingi246 – 2461Copper BCurated
    Metal bindingi291 – 2911Copper BCurated
    Metal bindingi292 – 2921Copper BCurated
    Metal bindingi377 – 3771Iron (heme A3 axial ligand)Curated
    Metal bindingi379 – 3791Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COX1
    Encoded oniMitochondrion
    OrganismiWickerhamomyces canadensis (Yeast) (Pichia canadensis)
    Taxonomic identifieri1156965 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeWickerhamomyces

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 535535Cytochrome c oxidase subunit 1PRO_0000183341Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki242 ↔ 2461'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP48868.
    SMRiP48868. Positions 1-533.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei58 – 7821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei184 – 20421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei339 – 35921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei373 – 39321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei413 – 43321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei453 – 47321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48868-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYIQRWLYST NAKDIAILYF IFAIFSGVIG STMSLIIRLE LAAPGNQILH    50
    GNHQLFNVLV VGHALLMIFF LVMPGLVGGF GNYMLPLLIG ASDMSFARLN 100
    NISFWLLPPA LVCLVASTLI ESWAGTGWTI YPPLSGIQAH SSPSVDLGIF 150
    AIHLTSISSL LGAINFIATS YNMRTNGMSY SKMPLFVWAI IITAVMLLLS 200
    LPVLTAGVTM LLMDRNFNTS FFEVAGGGDP VLYQHLFWFF GHPEVYILIV 250
    PGFGIISHIV STYSKKPVFG EISMVYAMAS IAFLGFLVWS HHMYIVGLDA 300
    DTRAYFTSST MVIAVPTGIK IFSWLATLYG GSIRLAVPML YAIAFLFLFT 350
    IGGLTGVALA NASLDVAFHD TYYVVGHFHY VLSMGAIFSL FAGYYYWSPQ 400
    ILGLYFNERL AQIQFWLIFV GANVIFMPMH FLGLQGMPRR IPDYPDAYAG 450
    WNYVSSIGSV IAIISLALFI YIIYDQLING LTNKIDNKSV VYSKAPDFVE 500
    SNTIFANNSI KSASIEFLLN SPPAIHSFNT PAVQS 535
    Length:535
    Mass (Da):59,025
    Last modified:August 30, 2002 - v2
    Checksum:i97F7C4EFAD1AD50A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31785 Genomic DNA. Translation: BAA06563.2.
    PIRiS58740.
    RefSeqiNP_038208.1. NC_001762.1.

    Genome annotation databases

    GeneIDi800565.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31785 Genomic DNA. Translation: BAA06563.2 .
    PIRi S58740.
    RefSeqi NP_038208.1. NC_001762.1.

    3D structure databases

    ProteinModelPortali P48868.
    SMRi P48868. Positions 1-533.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 800565.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete mitochondrial DNA sequence of Hansenula wingei reveals new characteristics of yeast mitochondria."
      Sekito T., Okamoto K., Kitano H., Yoshida K.
      Curr. Genet. 28:39-53(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 21.

    Entry informationi

    Entry nameiCOX1_WICCA
    AccessioniPrimary (citable) accession number: P48868
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: August 30, 2002
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3