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P48867

- COX1_CYACA

UniProt

P48867 - COX1_CYACA

Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Cyanidium caldarium
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi65 – 651Iron (heme A axial ligand)Curated
    Metal bindingi244 – 2441Copper BCurated
    Metal bindingi248 – 2481Copper BCurated
    Metal bindingi293 – 2931Copper BCurated
    Metal bindingi294 – 2941Copper BCurated
    Metal bindingi379 – 3791Iron (heme A3 axial ligand)Curated
    Metal bindingi381 – 3811Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. electron transport chain Source: InterPro
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COX1
    Synonyms:COXI
    Encoded oniMitochondrion
    OrganismiCyanidium caldarium
    Taxonomic identifieri2771 [NCBI]
    Taxonomic lineageiEukaryotaRhodophytaBangiophyceaeCyanidialesCyanidiaceaeCyanidium

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. plasma membrane Source: InterPro
    4. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 526526Cytochrome c oxidase subunit 1PRO_0000183319Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki244 ↔ 2481'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP48867.
    SMRiP48867. Positions 4-519.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei67 – 8721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei308 – 32821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei341 – 36121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei417 – 43721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei464 – 48421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48867-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRWIQRWFF STNHKDIGTL YLIFGAFSGL LGASISLLMR IELSHPGNQV    50
    LIGNHQLYNV LVTAHGLLIL FFMVIPTLMG GFGNWFVPLI IGAPDMAFPR 100
    LNNISFWLMP PSLILLLASA FVETGAGTGW TLYPPLSSVQ AHSGGAVDLA 150
    IFSLHISGIS SILGASNFIA TIFNIRNPGQ NLYRIPLFVW SVLVTAFIIL 200
    LTFPVLAGAI TILLTDRNFN TSFFDSSGGG DPVLFQHLFW FFGHPEVYIL 250
    VLPAFGIISQ VVSTFSRKPV FGYVGIIYAL ISIRILGSMV WAHHMFTIGM 300
    DVDTRAYFTA ASLLIAVPTG IKVFSWIATM WKGSISLKTP MLFAIGFIIL 350
    FTVGGLTGLV VANSGLDISL HDTYYVVAHF HYVLSIGALF GIFAGFYYWI 400
    GKICGKQYSE TLGQIHFWIT FIGVNLTFFP MHFLGLAGIP RRIPDYPDAY 450
    EGWNIVSTYG AKVSIIGTIL FFYVVYLAFT NGLISEPNPW SLRRERLDSS 500
    SRTTEWLIAS PPIYHTFNEI PVIKET 526
    Length:526
    Mass (Da):58,354
    Last modified:February 1, 1996 - v1
    Checksum:i5A6CA16E336901B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48930 Genomic DNA. Translation: CAA88773.1.
    PIRiS62763.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48930 Genomic DNA. Translation: CAA88773.1 .
    PIRi S62763.

    3D structure databases

    ProteinModelPortali P48867.
    SMRi P48867. Positions 4-519.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Viehmann S.
      Thesis (1995), Justus Liebig University / Frankfurt, Germany
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: RK-1.

    Entry informationi

    Entry nameiCOX1_CYACA
    AccessioniPrimary (citable) accession number: P48867
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3