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P48867

- COX1_CYACA

UniProt

P48867 - COX1_CYACA

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Protein
Cytochrome c oxidase subunit 1
Gene
COX1, COXI
Organism
Cyanidium caldarium
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi65 – 651Iron (heme A axial ligand) Inferred
Metal bindingi244 – 2441Copper B Inferred
Metal bindingi248 – 2481Copper B Inferred
Metal bindingi293 – 2931Copper B Inferred
Metal bindingi294 – 2941Copper B Inferred
Metal bindingi379 – 3791Iron (heme A3 axial ligand) Inferred
Metal bindingi381 – 3811Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Synonyms:COXI
Encoded oniMitochondrion
OrganismiCyanidium caldarium
Taxonomic identifieri2771 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaBangiophyceaeCyanidialesCyanidiaceaeCyanidium

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Reviewed prediction
Add
BLAST
Transmembranei67 – 8721Helical; Reviewed prediction
Add
BLAST
Transmembranei104 – 12421Helical; Reviewed prediction
Add
BLAST
Transmembranei149 – 16921Helical; Reviewed prediction
Add
BLAST
Transmembranei187 – 20721Helical; Reviewed prediction
Add
BLAST
Transmembranei238 – 25821Helical; Reviewed prediction
Add
BLAST
Transmembranei270 – 29021Helical; Reviewed prediction
Add
BLAST
Transmembranei308 – 32821Helical; Reviewed prediction
Add
BLAST
Transmembranei341 – 36121Helical; Reviewed prediction
Add
BLAST
Transmembranei380 – 40021Helical; Reviewed prediction
Add
BLAST
Transmembranei417 – 43721Helical; Reviewed prediction
Add
BLAST
Transmembranei464 – 48421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. plasma membrane Source: InterPro
  4. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Cytochrome c oxidase subunit 1
PRO_0000183319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki244 ↔ 2481'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliP48867.
SMRiP48867. Positions 4-519.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48867-1 [UniParc]FASTAAdd to Basket

« Hide

MSRWIQRWFF STNHKDIGTL YLIFGAFSGL LGASISLLMR IELSHPGNQV    50
LIGNHQLYNV LVTAHGLLIL FFMVIPTLMG GFGNWFVPLI IGAPDMAFPR 100
LNNISFWLMP PSLILLLASA FVETGAGTGW TLYPPLSSVQ AHSGGAVDLA 150
IFSLHISGIS SILGASNFIA TIFNIRNPGQ NLYRIPLFVW SVLVTAFIIL 200
LTFPVLAGAI TILLTDRNFN TSFFDSSGGG DPVLFQHLFW FFGHPEVYIL 250
VLPAFGIISQ VVSTFSRKPV FGYVGIIYAL ISIRILGSMV WAHHMFTIGM 300
DVDTRAYFTA ASLLIAVPTG IKVFSWIATM WKGSISLKTP MLFAIGFIIL 350
FTVGGLTGLV VANSGLDISL HDTYYVVAHF HYVLSIGALF GIFAGFYYWI 400
GKICGKQYSE TLGQIHFWIT FIGVNLTFFP MHFLGLAGIP RRIPDYPDAY 450
EGWNIVSTYG AKVSIIGTIL FFYVVYLAFT NGLISEPNPW SLRRERLDSS 500
SRTTEWLIAS PPIYHTFNEI PVIKET 526
Length:526
Mass (Da):58,354
Last modified:February 1, 1996 - v1
Checksum:i5A6CA16E336901B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48930 Genomic DNA. Translation: CAA88773.1.
PIRiS62763.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48930 Genomic DNA. Translation: CAA88773.1 .
PIRi S62763.

3D structure databases

ProteinModelPortali P48867.
SMRi P48867. Positions 4-519.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Viehmann S.
    Thesis (1995), Justus Liebig University / Frankfurt, Germany
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RK-1.

Entry informationi

Entry nameiCOX1_CYACA
AccessioniPrimary (citable) accession number: P48867
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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