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Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Chondrus crispus (Carrageen Irish moss) (Polymorpha crispa)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi69Iron (heme A axial ligand)Curated1
Metal bindingi248Copper BCurated1
Metal bindingi252Copper BCurated1
Metal bindingi297Copper BCurated1
Metal bindingi298Copper BCurated1
Metal bindingi383Iron (heme A3 axial ligand)Curated1
Metal bindingi385Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Encoded oniMitochondrion
OrganismiChondrus crispus (Carrageen Irish moss) (Polymorpha crispa)
Taxonomic identifieri2769 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaFlorideophyceaeGigartinalesGigartinaceaeChondrus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21
Transmembranei463 – 483HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001833131 – 532Cytochrome c oxidase subunit 1Add BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki248 ↔ 2521'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliP48866.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02256.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48866-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSFFTQWIS RWIFSTNHKD IGTLYLIFGA FSGVLGGCMS MLIRMELAQP
60 70 80 90 100
SNHLLLGNHQ IYNVLITAHA FLMIFFMVMP VMIGGFGNWL VPIMIGSPDM
110 120 130 140 150
AFPRLNNISF WLLPPSLCLL LMSALVEVGV GTGWTVYPPL SSIQSHSGGA
160 170 180 190 200
VDLAIFSLHI SGASSILGAV NFISTILNMR SPGQSMYRIP LFVWSILVTA
210 220 230 240 250
FLLLLAVPVL AGAITMLLTD RNFNTSFFDA SGGGDPILYQ HLFWFFGHPE
260 270 280 290 300
VYILILPGFG MISHIVSTFS RKPVFGYIGM VYAMVSIGVL GFIVWAHHMY
310 320 330 340 350
TVGLDVDTRA YFTAATMIIA VPTGIKIFSW IATIWEGSIH LKTPMLFAIG
360 370 380 390 400
FIFLFTIGGL TGIVLANSGL DISLHDTYYV VAHFHYVLSM GAVFAIFAGF
410 420 430 440 450
YYWFGKITGL QYPETLGQIH FWSTFIGVNL TFMPMHFLGL AGMPRRIPDY
460 470 480 490 500
PDAYAGWNLI ASYGSYIALF STLFFFYIVF VSLTSNNPCT NFPWEFNKSK
510 520 530
TYGVSTLEWI VTSPPAYHTF EEMPLIYETK SN
Length:532
Mass (Da):59,291
Last modified:February 1, 1996 - v1
Checksum:iA0F18B4B35BA636F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47547 Genomic DNA. Translation: CAA87603.1.
PIRiS59087.
RefSeqiNP_062482.1. NC_001677.2.

Genome annotation databases

GeneIDi809360.
KEGGiccp:ChcroMp03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47547 Genomic DNA. Translation: CAA87603.1.
PIRiS59087.
RefSeqiNP_062482.1. NC_001677.2.

3D structure databases

ProteinModelPortaliP48866.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi809360.
KEGGiccp:ChcroMp03.

Phylogenomic databases

KOiK02256.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_CHOCR
AccessioniPrimary (citable) accession number: P48866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.