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P48866

- COX1_CHOCR

UniProt

P48866 - COX1_CHOCR

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Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Chondrus crispus (Carragheen moss) (Irish moss)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Iron (heme A axial ligand)Curated
Metal bindingi248 – 2481Copper BCurated
Metal bindingi252 – 2521Copper BCurated
Metal bindingi297 – 2971Copper BCurated
Metal bindingi298 – 2981Copper BCurated
Metal bindingi383 – 3831Iron (heme A3 axial ligand)Curated
Metal bindingi385 – 3851Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Encoded oniMitochondrion
OrganismiChondrus crispus (Carragheen moss) (Irish moss)
Taxonomic identifieri2769 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaFlorideophyceaeGigartinalesGigartinaceaeChondrus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321HelicalSequence AnalysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence AnalysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence AnalysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence AnalysisAdd
BLAST
Transmembranei242 – 26221HelicalSequence AnalysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence AnalysisAdd
BLAST
Transmembranei315 – 33521HelicalSequence AnalysisAdd
BLAST
Transmembranei345 – 36521HelicalSequence AnalysisAdd
BLAST
Transmembranei384 – 40421HelicalSequence AnalysisAdd
BLAST
Transmembranei421 – 44121HelicalSequence AnalysisAdd
BLAST
Transmembranei463 – 48321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. plasma membrane Source: InterPro
  4. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Cytochrome c oxidase subunit 1PRO_0000183313Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki248 ↔ 2521'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliP48866.
SMRiP48866. Positions 8-522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02256.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48866-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQSFFTQWIS RWIFSTNHKD IGTLYLIFGA FSGVLGGCMS MLIRMELAQP
60 70 80 90 100
SNHLLLGNHQ IYNVLITAHA FLMIFFMVMP VMIGGFGNWL VPIMIGSPDM
110 120 130 140 150
AFPRLNNISF WLLPPSLCLL LMSALVEVGV GTGWTVYPPL SSIQSHSGGA
160 170 180 190 200
VDLAIFSLHI SGASSILGAV NFISTILNMR SPGQSMYRIP LFVWSILVTA
210 220 230 240 250
FLLLLAVPVL AGAITMLLTD RNFNTSFFDA SGGGDPILYQ HLFWFFGHPE
260 270 280 290 300
VYILILPGFG MISHIVSTFS RKPVFGYIGM VYAMVSIGVL GFIVWAHHMY
310 320 330 340 350
TVGLDVDTRA YFTAATMIIA VPTGIKIFSW IATIWEGSIH LKTPMLFAIG
360 370 380 390 400
FIFLFTIGGL TGIVLANSGL DISLHDTYYV VAHFHYVLSM GAVFAIFAGF
410 420 430 440 450
YYWFGKITGL QYPETLGQIH FWSTFIGVNL TFMPMHFLGL AGMPRRIPDY
460 470 480 490 500
PDAYAGWNLI ASYGSYIALF STLFFFYIVF VSLTSNNPCT NFPWEFNKSK
510 520 530
TYGVSTLEWI VTSPPAYHTF EEMPLIYETK SN
Length:532
Mass (Da):59,291
Last modified:February 1, 1996 - v1
Checksum:iA0F18B4B35BA636F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47547 Genomic DNA. Translation: CAA87603.1.
PIRiS59087.
RefSeqiNP_062482.1. NC_001677.2.

Genome annotation databases

GeneIDi809360.
KEGGiccp:ChcroMp03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47547 Genomic DNA. Translation: CAA87603.1 .
PIRi S59087.
RefSeqi NP_062482.1. NC_001677.2.

3D structure databases

ProteinModelPortali P48866.
SMRi P48866. Positions 8-522.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 809360.
KEGGi ccp:ChcroMp03.

Phylogenomic databases

KOi K02256.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of the mitochondrial DNA of the rhodophyte Chondrus crispus (Gigartinales). Gene content and genome organization."
    Leblanc C., Boyen C., Richard O., Bonnard G., Grienenberger J.-M., Kloareg B.
    J. Mol. Biol. 250:484-495(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Apices.

Entry informationi

Entry nameiCOX1_CHOCR
AccessioniPrimary (citable) accession number: P48866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3