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P48866

- COX1_CHOCR

UniProt

P48866 - COX1_CHOCR

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Protein
Cytochrome c oxidase subunit 1
Gene
COX1
Organism
Chondrus crispus (Carragheen moss) (Irish moss)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Iron (heme A axial ligand) Inferred
Metal bindingi248 – 2481Copper B Inferred
Metal bindingi252 – 2521Copper B Inferred
Metal bindingi297 – 2971Copper B Inferred
Metal bindingi298 – 2981Copper B Inferred
Metal bindingi383 – 3831Iron (heme A3 axial ligand) Inferred
Metal bindingi385 – 3851Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Encoded oniMitochondrion
OrganismiChondrus crispus (Carragheen moss) (Irish moss)
Taxonomic identifieri2769 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaFlorideophyceaeGigartinalesGigartinaceaeChondrus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321Helical; Reviewed prediction
Add
BLAST
Transmembranei71 – 9121Helical; Reviewed prediction
Add
BLAST
Transmembranei110 – 13021Helical; Reviewed prediction
Add
BLAST
Transmembranei153 – 17321Helical; Reviewed prediction
Add
BLAST
Transmembranei191 – 21121Helical; Reviewed prediction
Add
BLAST
Transmembranei242 – 26221Helical; Reviewed prediction
Add
BLAST
Transmembranei274 – 29421Helical; Reviewed prediction
Add
BLAST
Transmembranei315 – 33521Helical; Reviewed prediction
Add
BLAST
Transmembranei345 – 36521Helical; Reviewed prediction
Add
BLAST
Transmembranei384 – 40421Helical; Reviewed prediction
Add
BLAST
Transmembranei421 – 44121Helical; Reviewed prediction
Add
BLAST
Transmembranei463 – 48321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. plasma membrane Source: InterPro
  4. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Cytochrome c oxidase subunit 1
PRO_0000183313Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki248 ↔ 2521'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliP48866.
SMRiP48866. Positions 8-522.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02256.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48866-1 [UniParc]FASTAAdd to Basket

« Hide

MQSFFTQWIS RWIFSTNHKD IGTLYLIFGA FSGVLGGCMS MLIRMELAQP    50
SNHLLLGNHQ IYNVLITAHA FLMIFFMVMP VMIGGFGNWL VPIMIGSPDM 100
AFPRLNNISF WLLPPSLCLL LMSALVEVGV GTGWTVYPPL SSIQSHSGGA 150
VDLAIFSLHI SGASSILGAV NFISTILNMR SPGQSMYRIP LFVWSILVTA 200
FLLLLAVPVL AGAITMLLTD RNFNTSFFDA SGGGDPILYQ HLFWFFGHPE 250
VYILILPGFG MISHIVSTFS RKPVFGYIGM VYAMVSIGVL GFIVWAHHMY 300
TVGLDVDTRA YFTAATMIIA VPTGIKIFSW IATIWEGSIH LKTPMLFAIG 350
FIFLFTIGGL TGIVLANSGL DISLHDTYYV VAHFHYVLSM GAVFAIFAGF 400
YYWFGKITGL QYPETLGQIH FWSTFIGVNL TFMPMHFLGL AGMPRRIPDY 450
PDAYAGWNLI ASYGSYIALF STLFFFYIVF VSLTSNNPCT NFPWEFNKSK 500
TYGVSTLEWI VTSPPAYHTF EEMPLIYETK SN 532
Length:532
Mass (Da):59,291
Last modified:February 1, 1996 - v1
Checksum:iA0F18B4B35BA636F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z47547 Genomic DNA. Translation: CAA87603.1.
PIRiS59087.
RefSeqiNP_062482.1. NC_001677.2.

Genome annotation databases

GeneIDi809360.
KEGGiccp:ChcroMp03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z47547 Genomic DNA. Translation: CAA87603.1 .
PIRi S59087.
RefSeqi NP_062482.1. NC_001677.2.

3D structure databases

ProteinModelPortali P48866.
SMRi P48866. Positions 8-522.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 809360.
KEGGi ccp:ChcroMp03.

Phylogenomic databases

KOi K02256.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of the mitochondrial DNA of the rhodophyte Chondrus crispus (Gigartinales). Gene content and genome organization."
    Leblanc C., Boyen C., Richard O., Bonnard G., Grienenberger J.-M., Kloareg B.
    J. Mol. Biol. 250:484-495(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Apices.

Entry informationi

Entry nameiCOX1_CHOCR
AccessioniPrimary (citable) accession number: P48866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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