P48861 (DDC_MANSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aromatic-L-amino-acid decarboxylase
Short name=AADC
EC=4.1.1.28

Alternative name(s):
DOPA decarboxylase
Short name=DDC

Gene names

Name:

Ddc

Organism

Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)

Taxonomic identifier

7130 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Amphiesmenoptera › Lepidoptera › Glossata › Neolepidoptera › Heteroneura › Ditrysia › Obtectomera › Bombycoidea › Sphingidae › Sphinginae › Sphingini › Manduca

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Catalytic activity	L-dopa = dopamine + CO2. 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.
Cofactor	Pyridoxal phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the group II decarboxylase family.

Ontologies

Keywords
Biological process	Catecholamine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological_process	catecholamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	aromatic-L-amino-acid decarboxylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	Aromatic-L-amino-acid decarboxylase		PRO_0000146948
Sites
	Binding site	82	1	Substrate By similarity
	Binding site	192	1	Substrate By similarity
Amino acid modifications
	Modified residue	303	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P48861 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 87538994956A7C77	FASTA	508	57,892
	10 20 30 40 50 60 MNPGDFKDFA KAMTDYITEY LENIRDRQVV PSVKPGYLRP LVPEQAPQQA EPWTAVMADI 70 80 90 100 110 120 ERVVMSGVTH WQSPRFHAYF PTANSYPSIV ADMLSGAIAC IGFTWIASPA CTELEVVMLD 130 140 150 160 170 180 WLGQMLGLPD QFLARSGGEG GGVIQGTASE ATFVALLGAK SRMMHRVKEQ HPEWTETDIL 190 200 210 220 230 240 GKLVGYCNQQ AHSSVERAGL LGGVKLRSLK PDSKRRLRGD TLREAIDEDI RNGLIPFYVV 250 260 270 280 290 300 ATLGTTSSCA FDALDEIGDV CNASDIWLHV DAAYAGSAFI CPEYRHFMKG VEKADSFNFN 310 320 330 340 350 360 PHKWMLVNFD CSAMWLKQPR WIVDAFNVDP LYLKHEQQGS APDYRHWQIP LGRRFRSLKL 370 380 390 400 410 420 WFVLRLYGVE NLQKYIRKQI GFAHLFERLL TSDERFELFE EVTMGLVCFR LKGSNEINEE 430 440 450 460 470 480 LLRRINGRGK IHLVPSKVDD VYFLRLAICS RFTEESDMHV SWEEIKDRLM MFLKSKGAVL 490 500 IKIICSTTRR TKNILTYIKQ NIFRDVGL

References

[1]	"Characterization of the dopa decarboxylase gene of Manduca sexta and its suppression by 20-hydroxyecdysone." Hiruma K., Carter M.S., Riddiford L.M. Dev. Biol. 169:195-209(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Epidermis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U03909 mRNA. Translation: AAC46604.1.
3D structure databases
ProteinModelPortal	P48861.
SMR	P48861. Positions 1-467.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	4.1.1.28. 3173.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterPro	IPR010977. Aromatic_deC. IPR002129. PyrdxlP-dep_de-COase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. IPR021115. Pyridoxal-P_BS. [Graphical view]
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
PRINTS	PR00800. YHDCRBOXLASE.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00392. DDC_GAD_HDC_YDC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DDC_MANSE

Accession

Primary (citable) accession number: P48861

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)