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P48848 (G6PD_NOSP7) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase

Short name=G6PD
EC=1.1.1.49
Gene names
Name:zwf
Ordered Locus Names:Npun_F4025
OrganismNostoc punctiforme (strain ATCC 29133 / PCC 73102) [Complete proteome] [HAMAP]
Taxonomic identifier63737 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity. HAMAP-Rule MF_00966

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. HAMAP-Rule MF_00966

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. HAMAP-Rule MF_00966

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNADP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Glucose-6-phosphate 1-dehydrogenase HAMAP-Rule MF_00966
PRO_0000068130

Regions

Nucleotide binding104 – 1052NADP By similarity

Sites

Active site2591Proton acceptor By similarity
Binding site621NADP By similarity
Binding site1671NADP By similarity
Binding site1971Substrate By similarity
Binding site2011Substrate By similarity
Binding site2351Substrate By similarity
Binding site2541Substrate By similarity
Binding site3591Substrate By similarity
Binding site3641Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P48848 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 7FA3196A3199A8AA

FASTA50958,268
        10         20         30         40         50         60 
MVSLLENPLR VGLQQQGMPE PQIIVIFGAS GDLTWRKLVP ALYKLRRERR IPPETTIVGV 

        70         80         90        100        110        120 
ARREWSHEYF REQMQKGMEE AHPDVDLGEL WQDFSQGLFY SPGDIDNPES YQKLKTLLSE 

       130        140        150        160        170        180 
LDEKRGTRGN RMFYLSVAPS FFPEAIKQLG SGGMLEDPYK HRLVIEKPFG RDLASAQSLN 

       190        200        210        220        230        240 
QVVQKYCKEH QVYRIDHYLG KETVQNLLVF RFANAIFEPL WNRQFVDHVQ ITVAETVGVE 

       250        260        270        280        290        300 
DRAGYYESAG ALRDMLQNHL MQLYCLTAME APNAMDADSI RTEKVKVLQA TRLADVHNLS 

       310        320        330        340        350        360 
RSAVRGQYSA GWMKGQAVPG YRTEPGVDPN STTPTYVAMK FLVDNWRWKG VPFYLRTGKR 

       370        380        390        400        410        420 
MPKKVSEIAI HFREVPSRMF QSAAQQTNAN ILTMRIQPNE GISLRFDVKM PGAEFRTRSV 

       430        440        450        460        470        480 
DMDFSYGSFG IQATSDAYDR LFLDCMMGDQ TLFTRADEVE AAWQVVTPAL SVWDAPADPT 

       490        500 
TIPQYEAGTW EPEQAELLIN QDGRRWRRL 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of an operon in Nostoc sp. strain ATCC 29133 encoding four genes of the oxidative pentose phosphate cycle."
Summers M.L., Meeks J.C., Chu S., Wolf R.E. Jr.
Plant Physiol. 107:267-268(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequence of chromosome of Nostoc punctiforme ATCC 29133."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C. expand/collapse author list , Elhai J., Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29133 / PCC 73102.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L32796 Genomic DNA. Translation: AAA50770.1.
CP001037 Genomic DNA. Translation: ACC82404.1.
RefSeqYP_001867347.1. NC_010628.1.

3D structure databases

ProteinModelPortalP48848.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING63737.Npun_F4025.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACC82404; ACC82404; Npun_F4025.
GeneID6253370.
KEGGnpu:Npun_F4025.
PATRIC22761132. VBINosPun48114_4725.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0364.
HOGENOMHOG000046191.
KOK00036.
OMAWRWVEPL.
OrthoDBEOG61308Z.
PhylomeDBP48848.

Enzyme and pathway databases

BioCycNPUN63737:GJNP-3894-MONOMER.
UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00966. G6PD.
InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_NOSP7
AccessionPrimary (citable) accession number: P48848
Secondary accession number(s): B2J6J9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways