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P48848

- G6PD_NOSP7

UniProt

P48848 - G6PD_NOSP7

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621NADPUniRule annotation
Binding sitei167 – 1671NADPUniRule annotation
Binding sitei197 – 1971SubstrateUniRule annotation
Binding sitei201 – 2011SubstrateUniRule annotation
Binding sitei235 – 2351SubstrateUniRule annotation
Binding sitei254 – 2541SubstrateUniRule annotation
Active sitei259 – 2591Proton acceptorUniRule annotation
Binding sitei359 – 3591SubstrateUniRule annotation
Binding sitei364 – 3641SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi104 – 1052NADPUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciNPUN63737:GJNP-3894-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:Npun_F4025
OrganismiNostoc punctiforme (strain ATCC 29133 / PCC 73102)
Taxonomic identifieri63737 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000001191: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Glucose-6-phosphate 1-dehydrogenasePRO_0000068130Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi63737.Npun_F4025.

Structurei

3D structure databases

ProteinModelPortaliP48848.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiWRWVEPL.
OrthoDBiEOG61308Z.
PhylomeDBiP48848.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48848-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSLLENPLR VGLQQQGMPE PQIIVIFGAS GDLTWRKLVP ALYKLRRERR
60 70 80 90 100
IPPETTIVGV ARREWSHEYF REQMQKGMEE AHPDVDLGEL WQDFSQGLFY
110 120 130 140 150
SPGDIDNPES YQKLKTLLSE LDEKRGTRGN RMFYLSVAPS FFPEAIKQLG
160 170 180 190 200
SGGMLEDPYK HRLVIEKPFG RDLASAQSLN QVVQKYCKEH QVYRIDHYLG
210 220 230 240 250
KETVQNLLVF RFANAIFEPL WNRQFVDHVQ ITVAETVGVE DRAGYYESAG
260 270 280 290 300
ALRDMLQNHL MQLYCLTAME APNAMDADSI RTEKVKVLQA TRLADVHNLS
310 320 330 340 350
RSAVRGQYSA GWMKGQAVPG YRTEPGVDPN STTPTYVAMK FLVDNWRWKG
360 370 380 390 400
VPFYLRTGKR MPKKVSEIAI HFREVPSRMF QSAAQQTNAN ILTMRIQPNE
410 420 430 440 450
GISLRFDVKM PGAEFRTRSV DMDFSYGSFG IQATSDAYDR LFLDCMMGDQ
460 470 480 490 500
TLFTRADEVE AAWQVVTPAL SVWDAPADPT TIPQYEAGTW EPEQAELLIN

QDGRRWRRL
Length:509
Mass (Da):58,268
Last modified:February 1, 1996 - v1
Checksum:i7FA3196A3199A8AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32796 Genomic DNA. Translation: AAA50770.1.
CP001037 Genomic DNA. Translation: ACC82404.1.
RefSeqiYP_001867347.1. NC_010628.1.

Genome annotation databases

EnsemblBacteriaiACC82404; ACC82404; Npun_F4025.
GeneIDi6253370.
KEGGinpu:Npun_F4025.
PATRICi22761132. VBINosPun48114_4725.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32796 Genomic DNA. Translation: AAA50770.1 .
CP001037 Genomic DNA. Translation: ACC82404.1 .
RefSeqi YP_001867347.1. NC_010628.1.

3D structure databases

ProteinModelPortali P48848.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 63737.Npun_F4025.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACC82404 ; ACC82404 ; Npun_F4025 .
GeneIDi 6253370.
KEGGi npu:Npun_F4025.
PATRICi 22761132. VBINosPun48114_4725.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046191.
KOi K00036.
OMAi WRWVEPL.
OrthoDBi EOG61308Z.
PhylomeDBi P48848.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci NPUN63737:GJNP-3894-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of an operon in Nostoc sp. strain ATCC 29133 encoding four genes of the oxidative pentose phosphate cycle."
    Summers M.L., Meeks J.C., Chu S., Wolf R.E. Jr.
    Plant Physiol. 107:267-268(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29133 / PCC 73102.

Entry informationi

Entry nameiG6PD_NOSP7
AccessioniPrimary (citable) accession number: P48848
Secondary accession number(s): B2J6J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3