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P48848

- G6PD_NOSP7

UniProt

P48848 - G6PD_NOSP7

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei62 – 621NADPUniRule annotation
    Binding sitei167 – 1671NADPUniRule annotation
    Binding sitei197 – 1971SubstrateUniRule annotation
    Binding sitei201 – 2011SubstrateUniRule annotation
    Binding sitei235 – 2351SubstrateUniRule annotation
    Binding sitei254 – 2541SubstrateUniRule annotation
    Active sitei259 – 2591Proton acceptorUniRule annotation
    Binding sitei359 – 3591SubstrateUniRule annotation
    Binding sitei364 – 3641SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi104 – 1052NADPUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciNPUN63737:GJNP-3894-MONOMER.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:Npun_F4025
    OrganismiNostoc punctiforme (strain ATCC 29133 / PCC 73102)
    Taxonomic identifieri63737 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
    ProteomesiUP000001191: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Glucose-6-phosphate 1-dehydrogenasePRO_0000068130Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi63737.Npun_F4025.

    Structurei

    3D structure databases

    ProteinModelPortaliP48848.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    HOGENOMiHOG000046191.
    KOiK00036.
    OMAiWRWVEPL.
    OrthoDBiEOG61308Z.
    PhylomeDBiP48848.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48848-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSLLENPLR VGLQQQGMPE PQIIVIFGAS GDLTWRKLVP ALYKLRRERR    50
    IPPETTIVGV ARREWSHEYF REQMQKGMEE AHPDVDLGEL WQDFSQGLFY 100
    SPGDIDNPES YQKLKTLLSE LDEKRGTRGN RMFYLSVAPS FFPEAIKQLG 150
    SGGMLEDPYK HRLVIEKPFG RDLASAQSLN QVVQKYCKEH QVYRIDHYLG 200
    KETVQNLLVF RFANAIFEPL WNRQFVDHVQ ITVAETVGVE DRAGYYESAG 250
    ALRDMLQNHL MQLYCLTAME APNAMDADSI RTEKVKVLQA TRLADVHNLS 300
    RSAVRGQYSA GWMKGQAVPG YRTEPGVDPN STTPTYVAMK FLVDNWRWKG 350
    VPFYLRTGKR MPKKVSEIAI HFREVPSRMF QSAAQQTNAN ILTMRIQPNE 400
    GISLRFDVKM PGAEFRTRSV DMDFSYGSFG IQATSDAYDR LFLDCMMGDQ 450
    TLFTRADEVE AAWQVVTPAL SVWDAPADPT TIPQYEAGTW EPEQAELLIN 500
    QDGRRWRRL 509
    Length:509
    Mass (Da):58,268
    Last modified:February 1, 1996 - v1
    Checksum:i7FA3196A3199A8AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L32796 Genomic DNA. Translation: AAA50770.1.
    CP001037 Genomic DNA. Translation: ACC82404.1.
    RefSeqiYP_001867347.1. NC_010628.1.

    Genome annotation databases

    EnsemblBacteriaiACC82404; ACC82404; Npun_F4025.
    GeneIDi6253370.
    KEGGinpu:Npun_F4025.
    PATRICi22761132. VBINosPun48114_4725.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L32796 Genomic DNA. Translation: AAA50770.1 .
    CP001037 Genomic DNA. Translation: ACC82404.1 .
    RefSeqi YP_001867347.1. NC_010628.1.

    3D structure databases

    ProteinModelPortali P48848.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 63737.Npun_F4025.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACC82404 ; ACC82404 ; Npun_F4025 .
    GeneIDi 6253370.
    KEGGi npu:Npun_F4025.
    PATRICi 22761132. VBINosPun48114_4725.

    Phylogenomic databases

    eggNOGi COG0364.
    HOGENOMi HOG000046191.
    KOi K00036.
    OMAi WRWVEPL.
    OrthoDBi EOG61308Z.
    PhylomeDBi P48848.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    BioCyci NPUN63737:GJNP-3894-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of an operon in Nostoc sp. strain ATCC 29133 encoding four genes of the oxidative pentose phosphate cycle."
      Summers M.L., Meeks J.C., Chu S., Wolf R.E. Jr.
      Plant Physiol. 107:267-268(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29133 / PCC 73102.

    Entry informationi

    Entry nameiG6PD_NOSP7
    AccessioniPrimary (citable) accession number: P48848
    Secondary accession number(s): B2J6J9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3