Reviewed, UniProtKB/Swiss-Prot P48848 (G6PD_NOSP7)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	zwf
Ordered Locus Names:	Npun_F4025

Organism

Nostoc punctiforme (strain ATCC 29133 / PCC 73102) [Complete proteome] [HAMAP]

Taxonomic identifier

63737 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	509 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 509	509	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068130
Sites
	Active site	259	1	Proton acceptor By similarity
	Binding site	30	1	NADP By similarity
	Binding site	62	1	NADP By similarity
	Binding site	197	1	Substrate By similarity
	Binding site	201	1	Substrate By similarity
	Binding site	364	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P48848-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 7FA3196A3199A8AA	FASTA	509	58,268
	10 20 30 40 50 60 MVSLLENPLR VGLQQQGMPE PQIIVIFGAS GDLTWRKLVP ALYKLRRERR IPPETTIVGV 70 80 90 100 110 120 ARREWSHEYF REQMQKGMEE AHPDVDLGEL WQDFSQGLFY SPGDIDNPES YQKLKTLLSE 130 140 150 160 170 180 LDEKRGTRGN RMFYLSVAPS FFPEAIKQLG SGGMLEDPYK HRLVIEKPFG RDLASAQSLN 190 200 210 220 230 240 QVVQKYCKEH QVYRIDHYLG KETVQNLLVF RFANAIFEPL WNRQFVDHVQ ITVAETVGVE 250 260 270 280 290 300 DRAGYYESAG ALRDMLQNHL MQLYCLTAME APNAMDADSI RTEKVKVLQA TRLADVHNLS 310 320 330 340 350 360 RSAVRGQYSA GWMKGQAVPG YRTEPGVDPN STTPTYVAMK FLVDNWRWKG VPFYLRTGKR 370 380 390 400 410 420 MPKKVSEIAI HFREVPSRMF QSAAQQTNAN ILTMRIQPNE GISLRFDVKM PGAEFRTRSV 430 440 450 460 470 480 DMDFSYGSFG IQATSDAYDR LFLDCMMGDQ TLFTRADEVE AAWQVVTPAL SVWDAPADPT 490 500 TIPQYEAGTW EPEQAELLIN QDGRRWRRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of an operon in Nostoc sp. strain ATCC 29133 encoding four genes of the oxidative pentose phosphate cycle." Summers M.L., Meeks J.C., Chu S., Wolf R.E. Jr. Plant Physiol. 107:267-268(1995) [PubMed: 7870816] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of chromosome of Nostoc punctiforme ATCC 29133." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C. , Elhai J., Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R. Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	L32796 Genomic DNA. Translation: AAA50770.1. CP001037 Genomic DNA. Translation: ACC82404.1.
RefSeq	YP_001867347.1.
3D structure databases
HSSP	HSSP built from PDB template 1QKI based on UniProtKB P11413.
ModBase	Search...
Genome annotation databases
GeneID	6253370.
GenomeReviews	Gene locus Npun_F4025 in contig CP001037_GR.
KEGG	npu:Npun_F4025.
Organism-specific databases
CMR	Search...
Family and domain databases
InterPro	IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
ProDom	PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_NOSP7

Accession

Primary (citable) accession number: P48848
Secondary accession number(s): B2J6J9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 25, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)