ID DEXT_TALMI Reviewed; 608 AA. AC P48845; DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 1. DT 22-FEB-2023, entry version 98. DE RecName: Full=Dextranase; DE EC=3.2.1.11; DE AltName: Full=Alpha-1,6-glucan-6-glucanohydrolase; DE Flags: Precursor; GN Name=DEX; OS Talaromyces minioluteus (Filamentous fungus) (Penicillium minioluteum). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces; OC Talaromyces sect. Trachyspermi. OX NCBI_TaxID=28574; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 35-50. RC STRAIN=Sp. Dierckx / MUCL 38929; RX PubMed=8905923; RX DOI=10.1002/(sici)1097-0061(19960930)12:12<1187::aid-yea986>3.0.co;2-u; RA Roca H., Garcia B.M., Rodriguez E., Mateu D., Coroas L., Cremata J.A., RA Garcia R., Pons T., Delgado J.; RT "Cloning of the Penicillium minioluteum gene encoding dextranase and its RT expression in Pichia pastoris."; RL Yeast 12:1187-1200(1996). CC -!- CATALYTIC ACTIVITY: CC Reaction=Endohydrolysis of (1->6)-alpha-D-glucosidic linkages in CC dextran.; EC=3.2.1.11; CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- PTM: N-glycosylated. CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 49 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L41562; AAB47720.1; -; Genomic_DNA. DR PIR; S72177; S72177. DR PDB; 1OGM; X-ray; 1.80 A; X=35-608. DR PDB; 1OGO; X-ray; 1.65 A; X=35-608. DR PDBsum; 1OGM; -. DR PDBsum; 1OGO; -. DR AlphaFoldDB; P48845; -. DR SMR; P48845; -. DR CAZy; GH49; Glycoside Hydrolase Family 49. DR CLAE; DEX49A_PENMI; -. DR GlyCosmos; P48845; 3 sites, No reported glycans. DR BRENDA; 3.2.1.11; 7460. DR EvolutionaryTrace; P48845; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0033904; F:dextranase activity; IEA:UniProtKB-EC. DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW. DR Gene3D; 2.60.350.10; Dextranase, N-terminal; 1. DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 1. DR InterPro; IPR041402; B_solenoid_dext. DR InterPro; IPR035953; Dextranase_N-ter. DR InterPro; IPR005192; Glyco_hydro_49_C. DR InterPro; IPR023226; Glyco_hydro_49_N_dom. DR InterPro; IPR041274; IPU_b_solenoid. DR InterPro; IPR012334; Pectin_lyas_fold. DR InterPro; IPR011050; Pectin_lyase_fold/virulence. DR Pfam; PF18841; B_solenoid_dext; 1. DR Pfam; PF03718; Glyco_hydro_49; 1. DR Pfam; PF17433; Glyco_hydro_49N; 1. DR Pfam; PF18783; IPU_b_solenoid; 1. DR SUPFAM; SSF101596; Dextranase, N-terminal domain; 1. DR SUPFAM; SSF51126; Pectin lyase-like; 1. PE 1: Evidence at protein level; KW 3D-structure; Direct protein sequencing; Glycoprotein; Glycosidase; KW Hydrolase; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000255" FT PROPEP 20..34 FT /evidence="ECO:0000269|PubMed:8905923" FT /id="PRO_0000012213" FT CHAIN 35..608 FT /note="Dextranase" FT /id="PRO_0000012214" FT CARBOHYD 39 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 571 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 574 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT STRAND 43..48 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 59..61 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 68..70 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 72..80 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 87..89 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 92..94 FT /evidence="ECO:0007829|PDB:1OGO" FT HELIX 96..99 FT /evidence="ECO:0007829|PDB:1OGO" FT HELIX 126..129 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 132..142 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 144..150 FT /evidence="ECO:0007829|PDB:1OGO" FT HELIX 159..161 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 162..166 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 172..175 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 181..185 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 192..198 FT /evidence="ECO:0007829|PDB:1OGO" FT HELIX 199..201 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 202..207 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 209..234 FT /evidence="ECO:0007829|PDB:1OGO" FT HELIX 238..240 FT /evidence="ECO:0007829|PDB:1OGO" FT TURN 246..248 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 249..251 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 254..257 FT /evidence="ECO:0007829|PDB:1OGO" FT TURN 259..262 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 264..270 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 272..277 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 288..290 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 301..304 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 308..312 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 314..316 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 322..327 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 329..331 FT /evidence="ECO:0007829|PDB:1OGO" FT TURN 341..345 FT /evidence="ECO:0007829|PDB:1OGO" FT TURN 351..353 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 357..360 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 365..373 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 375..377 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 383..386 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 388..390 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 392..402 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 419..429 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 431..433 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 440..448 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 450..452 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 454..456 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 464..476 FT /evidence="ECO:0007829|PDB:1OGO" FT TURN 484..487 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 489..493 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 497..500 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 504..518 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 520..522 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 524..528 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 531..544 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 558..560 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 568..577 FT /evidence="ECO:0007829|PDB:1OGO" FT TURN 584..586 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 591..593 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 595..597 FT /evidence="ECO:0007829|PDB:1OGO" FT HELIX 599..601 FT /evidence="ECO:0007829|PDB:1OGO" FT TURN 602..604 FT /evidence="ECO:0007829|PDB:1OGO" FT STRAND 606..608 FT /evidence="ECO:0007829|PDB:1OGO" SQ SEQUENCE 608 AA; 65961 MW; 6309B5FB372D381D CRC64; MATMLKLLAL TLAISESAIG AVMHPPGNSH PGTHMGTTNN THCGADFCTW WHDSGEINTQ TPVQPGNVRQ SHKYSVQVSL AGTNNFHDSF VYESIPRNGN GRIYAPTDPP NSNTLDSSVD DGISIEPSIG LNMAWSQFEY SHDVDVKILA TDGSSLGSPS DVVIRPVSIS YAISQSDDGG IVIRVPADAN GRKFSVEFKT DLYTFLSDGN EYVTSGGSVV GVEPTNALVI FASPFLPSGM IPHMTPDNTQ TMTPGPINNG DWGAKSILYF PPGVYWMNQD QSGNSGKLGS NHIRLNSNTY WVYLAPGAYV KGAIEYFTKQ NFYATGHGIL SGENYVYQAN AGDNYIAVKS DSTSLRMWWH NNLGGGQTWY CVGPTINAPP FNTMDFNGNS GISSQISDYK QVGAFFFQTD GPEIYPNSVV HDVFWHVNDD AIKIYYSGAS VSRATIWKCH NDPIIQMGWT SRDISGVTID TLNVIHTRYI KSETVVPSAI IGASPFYASG MSPDSRKSIS MTVSNVVCEG LCPSLFRITP LQNYKNFVVK NVAFPDGLQT NSIGTGESII PAASGLTMGL NISNWTVGGQ KVTMENFQAN SLGQFNIDGS YWGEWQIS //