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P48845

- DEXT_PENMI

UniProt

P48845 - DEXT_PENMI

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Protein

Dextranase

Gene
DEX
Organism
Penicillium minioluteum (Filamentous fungus) (Talaromyces minioluteus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->6)-alpha-D-glucosidic linkages in dextran.

GO - Molecular functioni

  1. dextranase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH49. Glycoside Hydrolase Family 49.
mycoCLAPiDEX49A_PENMI.

Names & Taxonomyi

Protein namesi
Recommended name:
Dextranase (EC:3.2.1.11)
Alternative name(s):
Alpha-1,6-glucan-6-glucanohydrolase
Gene namesi
Name:DEX
OrganismiPenicillium minioluteum (Filamentous fungus) (Talaromyces minioluteus)
Taxonomic identifieri28574 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Propeptidei20 – 3415PRO_0000012213Add
BLAST
Chaini35 – 608574DextranasePRO_0000012214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi571 – 5711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi574 – 5741N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Glycoprotein

Structurei

Secondary structure

1
608
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi43 – 486
Beta strandi59 – 613
Beta strandi68 – 703
Beta strandi72 – 809
Beta strandi87 – 893
Beta strandi92 – 943
Helixi96 – 994
Helixi126 – 1294
Beta strandi132 – 14211
Beta strandi144 – 1507
Helixi159 – 1613
Beta strandi162 – 1665
Beta strandi172 – 1754
Beta strandi181 – 1855
Beta strandi192 – 1987
Helixi199 – 2013
Beta strandi202 – 2076
Beta strandi209 – 23426
Helixi238 – 2403
Turni246 – 2483
Beta strandi249 – 2513
Beta strandi254 – 2574
Turni259 – 2624
Beta strandi264 – 2707
Beta strandi272 – 2776
Beta strandi288 – 2903
Beta strandi301 – 3044
Beta strandi308 – 3125
Beta strandi314 – 3163
Beta strandi322 – 3276
Beta strandi329 – 3313
Turni341 – 3455
Turni351 – 3533
Beta strandi357 – 3604
Beta strandi365 – 3739
Beta strandi375 – 3773
Beta strandi383 – 3864
Beta strandi388 – 3903
Beta strandi392 – 40211
Beta strandi419 – 42911
Beta strandi431 – 4333
Beta strandi440 – 4489
Beta strandi450 – 4523
Beta strandi454 – 4563
Beta strandi464 – 47613
Turni484 – 4874
Beta strandi489 – 4935
Beta strandi497 – 5004
Beta strandi504 – 51815
Beta strandi520 – 5223
Beta strandi524 – 5285
Beta strandi531 – 54414
Beta strandi558 – 5603
Beta strandi568 – 57710
Turni584 – 5863
Beta strandi591 – 5933
Beta strandi595 – 5973
Helixi599 – 6013
Turni602 – 6043
Beta strandi606 – 6083

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OGMX-ray1.80X35-608[»]
1OGOX-ray1.65X35-608[»]
ProteinModelPortaliP48845.
SMRiP48845. Positions 37-608.

Miscellaneous databases

EvolutionaryTraceiP48845.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
2.60.350.10. 1 hit.
InterProiIPR005192. Glyco_hydro_49.
IPR023226. Glyco_hydro_49_N_dom.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
PfamiPF03718. Glyco_hydro_49. 1 hit.
[Graphical view]
SUPFAMiSSF101596. SSF101596. 1 hit.
SSF51126. SSF51126. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48845-1 [UniParc]FASTAAdd to Basket

« Hide

MATMLKLLAL TLAISESAIG AVMHPPGNSH PGTHMGTTNN THCGADFCTW    50
WHDSGEINTQ TPVQPGNVRQ SHKYSVQVSL AGTNNFHDSF VYESIPRNGN 100
GRIYAPTDPP NSNTLDSSVD DGISIEPSIG LNMAWSQFEY SHDVDVKILA 150
TDGSSLGSPS DVVIRPVSIS YAISQSDDGG IVIRVPADAN GRKFSVEFKT 200
DLYTFLSDGN EYVTSGGSVV GVEPTNALVI FASPFLPSGM IPHMTPDNTQ 250
TMTPGPINNG DWGAKSILYF PPGVYWMNQD QSGNSGKLGS NHIRLNSNTY 300
WVYLAPGAYV KGAIEYFTKQ NFYATGHGIL SGENYVYQAN AGDNYIAVKS 350
DSTSLRMWWH NNLGGGQTWY CVGPTINAPP FNTMDFNGNS GISSQISDYK 400
QVGAFFFQTD GPEIYPNSVV HDVFWHVNDD AIKIYYSGAS VSRATIWKCH 450
NDPIIQMGWT SRDISGVTID TLNVIHTRYI KSETVVPSAI IGASPFYASG 500
MSPDSRKSIS MTVSNVVCEG LCPSLFRITP LQNYKNFVVK NVAFPDGLQT 550
NSIGTGESII PAASGLTMGL NISNWTVGGQ KVTMENFQAN SLGQFNIDGS 600
YWGEWQIS 608
Length:608
Mass (Da):65,961
Last modified:February 1, 1996 - v1
Checksum:i6309B5FB372D381D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41562 Genomic DNA. Translation: AAB47720.1.
PIRiS72177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41562 Genomic DNA. Translation: AAB47720.1 .
PIRi S72177.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OGM X-ray 1.80 X 35-608 [» ]
1OGO X-ray 1.65 X 35-608 [» ]
ProteinModelPortali P48845.
SMRi P48845. Positions 37-608.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH49. Glycoside Hydrolase Family 49.
mycoCLAPi DEX49A_PENMI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P48845.

Family and domain databases

Gene3Di 2.160.20.10. 1 hit.
2.60.350.10. 1 hit.
InterProi IPR005192. Glyco_hydro_49.
IPR023226. Glyco_hydro_49_N_dom.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view ]
Pfami PF03718. Glyco_hydro_49. 1 hit.
[Graphical view ]
SUPFAMi SSF101596. SSF101596. 1 hit.
SSF51126. SSF51126. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning of the Penicillium minioluteum gene encoding dextranase and its expression in Pichia pastoris."
    Roca H., Garcia B.M., Rodriguez E., Mateu D., Coroas L., Cremata J.A., Garcia R., Pons T., Delgado J.
    Yeast 12:1187-1200(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 35-50.
    Strain: Sp. Dierckx / MUCL 38929.

Entry informationi

Entry nameiDEXT_PENMI
AccessioniPrimary (citable) accession number: P48845
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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