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P48845

- DEXT_PENMI

UniProt

P48845 - DEXT_PENMI

Protein

Dextranase

Gene

DEX

Organism
Penicillium minioluteum (Filamentous fungus) (Talaromyces minioluteus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Endohydrolysis of (1->6)-alpha-D-glucosidic linkages in dextran.

    GO - Molecular functioni

    1. dextranase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH49. Glycoside Hydrolase Family 49.
    mycoCLAPiDEX49A_PENMI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dextranase (EC:3.2.1.11)
    Alternative name(s):
    Alpha-1,6-glucan-6-glucanohydrolase
    Gene namesi
    Name:DEX
    OrganismiPenicillium minioluteum (Filamentous fungus) (Talaromyces minioluteus)
    Taxonomic identifieri28574 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 34151 PublicationPRO_0000012213Add
    BLAST
    Chaini35 – 608574DextranasePRO_0000012214Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi571 – 5711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi574 – 5741N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.

    Keywords - PTMi

    Glycoprotein

    Structurei

    Secondary structure

    1
    608
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi43 – 486
    Beta strandi59 – 613
    Beta strandi68 – 703
    Beta strandi72 – 809
    Beta strandi87 – 893
    Beta strandi92 – 943
    Helixi96 – 994
    Helixi126 – 1294
    Beta strandi132 – 14211
    Beta strandi144 – 1507
    Helixi159 – 1613
    Beta strandi162 – 1665
    Beta strandi172 – 1754
    Beta strandi181 – 1855
    Beta strandi192 – 1987
    Helixi199 – 2013
    Beta strandi202 – 2076
    Beta strandi209 – 23426
    Helixi238 – 2403
    Turni246 – 2483
    Beta strandi249 – 2513
    Beta strandi254 – 2574
    Turni259 – 2624
    Beta strandi264 – 2707
    Beta strandi272 – 2776
    Beta strandi288 – 2903
    Beta strandi301 – 3044
    Beta strandi308 – 3125
    Beta strandi314 – 3163
    Beta strandi322 – 3276
    Beta strandi329 – 3313
    Turni341 – 3455
    Turni351 – 3533
    Beta strandi357 – 3604
    Beta strandi365 – 3739
    Beta strandi375 – 3773
    Beta strandi383 – 3864
    Beta strandi388 – 3903
    Beta strandi392 – 40211
    Beta strandi419 – 42911
    Beta strandi431 – 4333
    Beta strandi440 – 4489
    Beta strandi450 – 4523
    Beta strandi454 – 4563
    Beta strandi464 – 47613
    Turni484 – 4874
    Beta strandi489 – 4935
    Beta strandi497 – 5004
    Beta strandi504 – 51815
    Beta strandi520 – 5223
    Beta strandi524 – 5285
    Beta strandi531 – 54414
    Beta strandi558 – 5603
    Beta strandi568 – 57710
    Turni584 – 5863
    Beta strandi591 – 5933
    Beta strandi595 – 5973
    Helixi599 – 6013
    Turni602 – 6043
    Beta strandi606 – 6083

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OGMX-ray1.80X35-608[»]
    1OGOX-ray1.65X35-608[»]
    ProteinModelPortaliP48845.
    SMRiP48845. Positions 37-608.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP48845.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 49 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di2.160.20.10. 1 hit.
    2.60.350.10. 1 hit.
    InterProiIPR005192. Glyco_hydro_49.
    IPR023226. Glyco_hydro_49_N_dom.
    IPR012334. Pectin_lyas_fold.
    IPR011050. Pectin_lyase_fold/virulence.
    [Graphical view]
    PfamiPF03718. Glyco_hydro_49. 1 hit.
    [Graphical view]
    SUPFAMiSSF101596. SSF101596. 1 hit.
    SSF51126. SSF51126. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48845-1 [UniParc]FASTAAdd to Basket

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    MATMLKLLAL TLAISESAIG AVMHPPGNSH PGTHMGTTNN THCGADFCTW    50
    WHDSGEINTQ TPVQPGNVRQ SHKYSVQVSL AGTNNFHDSF VYESIPRNGN 100
    GRIYAPTDPP NSNTLDSSVD DGISIEPSIG LNMAWSQFEY SHDVDVKILA 150
    TDGSSLGSPS DVVIRPVSIS YAISQSDDGG IVIRVPADAN GRKFSVEFKT 200
    DLYTFLSDGN EYVTSGGSVV GVEPTNALVI FASPFLPSGM IPHMTPDNTQ 250
    TMTPGPINNG DWGAKSILYF PPGVYWMNQD QSGNSGKLGS NHIRLNSNTY 300
    WVYLAPGAYV KGAIEYFTKQ NFYATGHGIL SGENYVYQAN AGDNYIAVKS 350
    DSTSLRMWWH NNLGGGQTWY CVGPTINAPP FNTMDFNGNS GISSQISDYK 400
    QVGAFFFQTD GPEIYPNSVV HDVFWHVNDD AIKIYYSGAS VSRATIWKCH 450
    NDPIIQMGWT SRDISGVTID TLNVIHTRYI KSETVVPSAI IGASPFYASG 500
    MSPDSRKSIS MTVSNVVCEG LCPSLFRITP LQNYKNFVVK NVAFPDGLQT 550
    NSIGTGESII PAASGLTMGL NISNWTVGGQ KVTMENFQAN SLGQFNIDGS 600
    YWGEWQIS 608
    Length:608
    Mass (Da):65,961
    Last modified:February 1, 1996 - v1
    Checksum:i6309B5FB372D381D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41562 Genomic DNA. Translation: AAB47720.1.
    PIRiS72177.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41562 Genomic DNA. Translation: AAB47720.1 .
    PIRi S72177.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OGM X-ray 1.80 X 35-608 [» ]
    1OGO X-ray 1.65 X 35-608 [» ]
    ProteinModelPortali P48845.
    SMRi P48845. Positions 37-608.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH49. Glycoside Hydrolase Family 49.
    mycoCLAPi DEX49A_PENMI.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P48845.

    Family and domain databases

    Gene3Di 2.160.20.10. 1 hit.
    2.60.350.10. 1 hit.
    InterProi IPR005192. Glyco_hydro_49.
    IPR023226. Glyco_hydro_49_N_dom.
    IPR012334. Pectin_lyas_fold.
    IPR011050. Pectin_lyase_fold/virulence.
    [Graphical view ]
    Pfami PF03718. Glyco_hydro_49. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101596. SSF101596. 1 hit.
    SSF51126. SSF51126. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the Penicillium minioluteum gene encoding dextranase and its expression in Pichia pastoris."
      Roca H., Garcia B.M., Rodriguez E., Mateu D., Coroas L., Cremata J.A., Garcia R., Pons T., Delgado J.
      Yeast 12:1187-1200(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 35-50.
      Strain: Sp. Dierckx / MUCL 38929.

    Entry informationi

    Entry nameiDEXT_PENMI
    AccessioniPrimary (citable) accession number: P48845
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3