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P48845

- DEXT_PENMI

UniProt

P48845 - DEXT_PENMI

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Protein

Dextranase

Gene

DEX

Organism
Penicillium minioluteum (Filamentous fungus) (Talaromyces minioluteus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->6)-alpha-D-glucosidic linkages in dextran.

GO - Molecular functioni

  1. dextranase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH49. Glycoside Hydrolase Family 49.
mycoCLAPiDEX49A_PENMI.

Names & Taxonomyi

Protein namesi
Recommended name:
Dextranase (EC:3.2.1.11)
Alternative name(s):
Alpha-1,6-glucan-6-glucanohydrolase
Gene namesi
Name:DEX
OrganismiPenicillium minioluteum (Filamentous fungus) (Talaromyces minioluteus)
Taxonomic identifieri28574 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 34151 PublicationPRO_0000012213Add
BLAST
Chaini35 – 608574DextranasePRO_0000012214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi571 – 5711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi574 – 5741N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Glycoprotein

Structurei

Secondary structure

1
608
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi43 – 486Combined sources
Beta strandi59 – 613Combined sources
Beta strandi68 – 703Combined sources
Beta strandi72 – 809Combined sources
Beta strandi87 – 893Combined sources
Beta strandi92 – 943Combined sources
Helixi96 – 994Combined sources
Helixi126 – 1294Combined sources
Beta strandi132 – 14211Combined sources
Beta strandi144 – 1507Combined sources
Helixi159 – 1613Combined sources
Beta strandi162 – 1665Combined sources
Beta strandi172 – 1754Combined sources
Beta strandi181 – 1855Combined sources
Beta strandi192 – 1987Combined sources
Helixi199 – 2013Combined sources
Beta strandi202 – 2076Combined sources
Beta strandi209 – 23426Combined sources
Helixi238 – 2403Combined sources
Turni246 – 2483Combined sources
Beta strandi249 – 2513Combined sources
Beta strandi254 – 2574Combined sources
Turni259 – 2624Combined sources
Beta strandi264 – 2707Combined sources
Beta strandi272 – 2776Combined sources
Beta strandi288 – 2903Combined sources
Beta strandi301 – 3044Combined sources
Beta strandi308 – 3125Combined sources
Beta strandi314 – 3163Combined sources
Beta strandi322 – 3276Combined sources
Beta strandi329 – 3313Combined sources
Turni341 – 3455Combined sources
Turni351 – 3533Combined sources
Beta strandi357 – 3604Combined sources
Beta strandi365 – 3739Combined sources
Beta strandi375 – 3773Combined sources
Beta strandi383 – 3864Combined sources
Beta strandi388 – 3903Combined sources
Beta strandi392 – 40211Combined sources
Beta strandi419 – 42911Combined sources
Beta strandi431 – 4333Combined sources
Beta strandi440 – 4489Combined sources
Beta strandi450 – 4523Combined sources
Beta strandi454 – 4563Combined sources
Beta strandi464 – 47613Combined sources
Turni484 – 4874Combined sources
Beta strandi489 – 4935Combined sources
Beta strandi497 – 5004Combined sources
Beta strandi504 – 51815Combined sources
Beta strandi520 – 5223Combined sources
Beta strandi524 – 5285Combined sources
Beta strandi531 – 54414Combined sources
Beta strandi558 – 5603Combined sources
Beta strandi568 – 57710Combined sources
Turni584 – 5863Combined sources
Beta strandi591 – 5933Combined sources
Beta strandi595 – 5973Combined sources
Helixi599 – 6013Combined sources
Turni602 – 6043Combined sources
Beta strandi606 – 6083Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OGMX-ray1.80X35-608[»]
1OGOX-ray1.65X35-608[»]
ProteinModelPortaliP48845.
SMRiP48845. Positions 37-608.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48845.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 49 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
2.60.350.10. 1 hit.
InterProiIPR005192. Glyco_hydro_49.
IPR023226. Glyco_hydro_49_N_dom.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
PfamiPF03718. Glyco_hydro_49. 1 hit.
[Graphical view]
SUPFAMiSSF101596. SSF101596. 1 hit.
SSF51126. SSF51126. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48845-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATMLKLLAL TLAISESAIG AVMHPPGNSH PGTHMGTTNN THCGADFCTW
60 70 80 90 100
WHDSGEINTQ TPVQPGNVRQ SHKYSVQVSL AGTNNFHDSF VYESIPRNGN
110 120 130 140 150
GRIYAPTDPP NSNTLDSSVD DGISIEPSIG LNMAWSQFEY SHDVDVKILA
160 170 180 190 200
TDGSSLGSPS DVVIRPVSIS YAISQSDDGG IVIRVPADAN GRKFSVEFKT
210 220 230 240 250
DLYTFLSDGN EYVTSGGSVV GVEPTNALVI FASPFLPSGM IPHMTPDNTQ
260 270 280 290 300
TMTPGPINNG DWGAKSILYF PPGVYWMNQD QSGNSGKLGS NHIRLNSNTY
310 320 330 340 350
WVYLAPGAYV KGAIEYFTKQ NFYATGHGIL SGENYVYQAN AGDNYIAVKS
360 370 380 390 400
DSTSLRMWWH NNLGGGQTWY CVGPTINAPP FNTMDFNGNS GISSQISDYK
410 420 430 440 450
QVGAFFFQTD GPEIYPNSVV HDVFWHVNDD AIKIYYSGAS VSRATIWKCH
460 470 480 490 500
NDPIIQMGWT SRDISGVTID TLNVIHTRYI KSETVVPSAI IGASPFYASG
510 520 530 540 550
MSPDSRKSIS MTVSNVVCEG LCPSLFRITP LQNYKNFVVK NVAFPDGLQT
560 570 580 590 600
NSIGTGESII PAASGLTMGL NISNWTVGGQ KVTMENFQAN SLGQFNIDGS

YWGEWQIS
Length:608
Mass (Da):65,961
Last modified:February 1, 1996 - v1
Checksum:i6309B5FB372D381D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41562 Genomic DNA. Translation: AAB47720.1.
PIRiS72177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41562 Genomic DNA. Translation: AAB47720.1 .
PIRi S72177.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OGM X-ray 1.80 X 35-608 [» ]
1OGO X-ray 1.65 X 35-608 [» ]
ProteinModelPortali P48845.
SMRi P48845. Positions 37-608.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH49. Glycoside Hydrolase Family 49.
mycoCLAPi DEX49A_PENMI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P48845.

Family and domain databases

Gene3Di 2.160.20.10. 1 hit.
2.60.350.10. 1 hit.
InterProi IPR005192. Glyco_hydro_49.
IPR023226. Glyco_hydro_49_N_dom.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view ]
Pfami PF03718. Glyco_hydro_49. 1 hit.
[Graphical view ]
SUPFAMi SSF101596. SSF101596. 1 hit.
SSF51126. SSF51126. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning of the Penicillium minioluteum gene encoding dextranase and its expression in Pichia pastoris."
    Roca H., Garcia B.M., Rodriguez E., Mateu D., Coroas L., Cremata J.A., Garcia R., Pons T., Delgado J.
    Yeast 12:1187-1200(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 35-50.
    Strain: Sp. Dierckx / MUCL 38929.

Entry informationi

Entry nameiDEXT_PENMI
AccessioniPrimary (citable) accession number: P48845
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3