Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dextranase

Gene

DEX

Organism
Talaromyces minioluteus (Filamentous fungus) (Penicillium minioluteum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->6)-alpha-D-glucosidic linkages in dextran.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.11. 7460.

Protein family/group databases

CAZyiGH49. Glycoside Hydrolase Family 49.
mycoCLAPiDEX49A_PENMI.

Names & Taxonomyi

Protein namesi
Recommended name:
Dextranase (EC:3.2.1.11)
Alternative name(s):
Alpha-1,6-glucan-6-glucanohydrolase
Gene namesi
Name:DEX
OrganismiTalaromyces minioluteus (Filamentous fungus) (Penicillium minioluteum)
Taxonomic identifieri28574 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000001221320 – 341 PublicationAdd BLAST15
ChainiPRO_000001221435 – 608DextranaseAdd BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi571N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi574N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Glycoprotein

Structurei

Secondary structure

1608
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi43 – 48Combined sources6
Beta strandi59 – 61Combined sources3
Beta strandi68 – 70Combined sources3
Beta strandi72 – 80Combined sources9
Beta strandi87 – 89Combined sources3
Beta strandi92 – 94Combined sources3
Helixi96 – 99Combined sources4
Helixi126 – 129Combined sources4
Beta strandi132 – 142Combined sources11
Beta strandi144 – 150Combined sources7
Helixi159 – 161Combined sources3
Beta strandi162 – 166Combined sources5
Beta strandi172 – 175Combined sources4
Beta strandi181 – 185Combined sources5
Beta strandi192 – 198Combined sources7
Helixi199 – 201Combined sources3
Beta strandi202 – 207Combined sources6
Beta strandi209 – 234Combined sources26
Helixi238 – 240Combined sources3
Turni246 – 248Combined sources3
Beta strandi249 – 251Combined sources3
Beta strandi254 – 257Combined sources4
Turni259 – 262Combined sources4
Beta strandi264 – 270Combined sources7
Beta strandi272 – 277Combined sources6
Beta strandi288 – 290Combined sources3
Beta strandi301 – 304Combined sources4
Beta strandi308 – 312Combined sources5
Beta strandi314 – 316Combined sources3
Beta strandi322 – 327Combined sources6
Beta strandi329 – 331Combined sources3
Turni341 – 345Combined sources5
Turni351 – 353Combined sources3
Beta strandi357 – 360Combined sources4
Beta strandi365 – 373Combined sources9
Beta strandi375 – 377Combined sources3
Beta strandi383 – 386Combined sources4
Beta strandi388 – 390Combined sources3
Beta strandi392 – 402Combined sources11
Beta strandi419 – 429Combined sources11
Beta strandi431 – 433Combined sources3
Beta strandi440 – 448Combined sources9
Beta strandi450 – 452Combined sources3
Beta strandi454 – 456Combined sources3
Beta strandi464 – 476Combined sources13
Turni484 – 487Combined sources4
Beta strandi489 – 493Combined sources5
Beta strandi497 – 500Combined sources4
Beta strandi504 – 518Combined sources15
Beta strandi520 – 522Combined sources3
Beta strandi524 – 528Combined sources5
Beta strandi531 – 544Combined sources14
Beta strandi558 – 560Combined sources3
Beta strandi568 – 577Combined sources10
Turni584 – 586Combined sources3
Beta strandi591 – 593Combined sources3
Beta strandi595 – 597Combined sources3
Helixi599 – 601Combined sources3
Turni602 – 604Combined sources3
Beta strandi606 – 608Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OGMX-ray1.80X35-608[»]
1OGOX-ray1.65X35-608[»]
ProteinModelPortaliP48845.
SMRiP48845.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48845.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 49 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
InterProiView protein in InterPro
IPR005192. Glyco_hydro_49_C.
IPR023226. Glyco_hydro_49_N_dom.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
PfamiView protein in Pfam
PF03718. Glyco_hydro_49. 1 hit.
PF17433. Glyco_hydro_49N. 1 hit.
SUPFAMiSSF101596. SSF101596. 1 hit.
SSF51126. SSF51126. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48845-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATMLKLLAL TLAISESAIG AVMHPPGNSH PGTHMGTTNN THCGADFCTW
60 70 80 90 100
WHDSGEINTQ TPVQPGNVRQ SHKYSVQVSL AGTNNFHDSF VYESIPRNGN
110 120 130 140 150
GRIYAPTDPP NSNTLDSSVD DGISIEPSIG LNMAWSQFEY SHDVDVKILA
160 170 180 190 200
TDGSSLGSPS DVVIRPVSIS YAISQSDDGG IVIRVPADAN GRKFSVEFKT
210 220 230 240 250
DLYTFLSDGN EYVTSGGSVV GVEPTNALVI FASPFLPSGM IPHMTPDNTQ
260 270 280 290 300
TMTPGPINNG DWGAKSILYF PPGVYWMNQD QSGNSGKLGS NHIRLNSNTY
310 320 330 340 350
WVYLAPGAYV KGAIEYFTKQ NFYATGHGIL SGENYVYQAN AGDNYIAVKS
360 370 380 390 400
DSTSLRMWWH NNLGGGQTWY CVGPTINAPP FNTMDFNGNS GISSQISDYK
410 420 430 440 450
QVGAFFFQTD GPEIYPNSVV HDVFWHVNDD AIKIYYSGAS VSRATIWKCH
460 470 480 490 500
NDPIIQMGWT SRDISGVTID TLNVIHTRYI KSETVVPSAI IGASPFYASG
510 520 530 540 550
MSPDSRKSIS MTVSNVVCEG LCPSLFRITP LQNYKNFVVK NVAFPDGLQT
560 570 580 590 600
NSIGTGESII PAASGLTMGL NISNWTVGGQ KVTMENFQAN SLGQFNIDGS

YWGEWQIS
Length:608
Mass (Da):65,961
Last modified:February 1, 1996 - v1
Checksum:i6309B5FB372D381D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41562 Genomic DNA. Translation: AAB47720.1.
PIRiS72177.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDEXT_TALMI
AccessioniPrimary (citable) accession number: P48845
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 5, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families