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P48844

- PYRF_KODOH

UniProt

P48844 - PYRF_KODOH

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Kodamaea ohmeri (Yeast) (Yamadazyma ohmeri)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341SubstrateBy similarity
Active sitei90 – 901Proton donorPROSITE-ProRule annotation
Binding sitei214 – 2141SubstrateBy similarity
Binding sitei232 – 2321SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
OrganismiKodamaea ohmeri (Yeast) (Yamadazyma ohmeri)
Taxonomic identifieri34356 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeKodamaea

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Orotidine 5'-phosphate decarboxylasePRO_0000134690Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP48844.
SMRiP48844. Positions 2-259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni56 – 583Substrate bindingBy similarity
Regioni88 – 9710Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48844-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYTARAAKH PSPVAQRLLR LMDTKKTNLC ASVDVKTTAE FLSLIDKLGP
60 70 80 90 100
YICLVKTHID IIDDFSFDGT IKPLLELAKK HNFMIFEDRK FADIGNTVKS
110 120 130 140 150
QYSGGVYKIA QWSDITNAHG ITGAGIVNGL KEAAQETTSE PRGLLMLAEL
160 170 180 190 200
SSKGSLAYGE YTEKTVEIAK SDKEFVVGFI AQRDMGGRDE GFDWLIMTPG
210 220 230 240 250
VGLDDKGDAL GQQYRTVNEV ISTGTDIIIV GRGLFGKGRD PEVEGKRYRD
260
AGWKAYQKRL Q
Length:261
Mass (Da):28,793
Last modified:February 1, 1996 - v1
Checksum:iF9F237049A7A3A49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35100 Genomic DNA. Translation: CAA84483.1.
PIRiS50699.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35100 Genomic DNA. Translation: CAA84483.1 .
PIRi S50699.

3D structure databases

ProteinModelPortali P48844.
SMRi P48844. Positions 2-259.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Development of a transformation system for the yeast Yamadazyma (Pichia) ohmeri."
    Piredda S., Gaillardin C.
    Yeast 10:1601-1612(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPYRF_KODOH
AccessioniPrimary (citable) accession number: P48844
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3