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P48844 (PYRF_KODOH) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
OrganismKodamaea ohmeri (Yeast) (Yamadazyma ohmeri)
Taxonomic identifier34356 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeKodamaea

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Orotidine 5'-phosphate decarboxylase
PRO_0000134690

Regions

Region56 – 583Substrate binding By similarity
Region88 – 9710Substrate binding By similarity

Sites

Active site901Proton donor By similarity
Binding site341Substrate By similarity
Binding site2141Substrate By similarity
Binding site2321Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P48844 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: F9F237049A7A3A49

FASTA26128,793
        10         20         30         40         50         60 
MSYTARAAKH PSPVAQRLLR LMDTKKTNLC ASVDVKTTAE FLSLIDKLGP YICLVKTHID 

        70         80         90        100        110        120 
IIDDFSFDGT IKPLLELAKK HNFMIFEDRK FADIGNTVKS QYSGGVYKIA QWSDITNAHG 

       130        140        150        160        170        180 
ITGAGIVNGL KEAAQETTSE PRGLLMLAEL SSKGSLAYGE YTEKTVEIAK SDKEFVVGFI 

       190        200        210        220        230        240 
AQRDMGGRDE GFDWLIMTPG VGLDDKGDAL GQQYRTVNEV ISTGTDIIIV GRGLFGKGRD 

       250        260 
PEVEGKRYRD AGWKAYQKRL Q 

« Hide

References

[1]"Development of a transformation system for the yeast Yamadazyma (Pichia) ohmeri."
Piredda S., Gaillardin C.
Yeast 10:1601-1612(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z35100 Genomic DNA. Translation: CAA84483.1.
PIRS50699.

3D structure databases

ProteinModelPortalP48844.
SMRP48844. Positions 2-259.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_KODOH
AccessionPrimary (citable) accession number: P48844
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 16, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways