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Protein

Beta-agarase A

Gene

agaA

Organism
Vibrio sp. (strain JT0107)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes agarose and also neoagarotetraose to yield neoagarobiose.

Catalytic activityi

Hydrolysis of (1->4)-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product.

GO - Molecular functioni

  1. beta-agarase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16649.
BRENDAi3.2.1.81. 6640.

Protein family/group databases

CAZyiGH50. Glycoside Hydrolase Family 50.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-agarase A (EC:3.2.1.81)
Alternative name(s):
Agarase 0107
Gene namesi
Name:agaA
OrganismiVibrio sp. (strain JT0107)
Taxonomic identifieri47913 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 995975Beta-agarase APRO_0000012215Add
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi781 – 7844Poly-Ala
Compositional biasi971 – 9744Poly-Gly

Sequence similaritiesi

Belongs to the glycosyl hydrolase 50 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIKFLSAAI AASLALPLSA ATLVTSFEEA DYSSSENNAE FLEVSGDATS
60 70 80 90 100
EVSTEQATDG NQSIKASFDA AFKPMVVWNW ASWNWGAEDV MSVDVVNPND
110 120 130 140 150
TDVTFAIKLI DSDILPDWVD ESQTSLDYFT VSANTTQTFS FNLNGGNEFQ
160 170 180 190 200
THGENFSKDK VIGVQFMLSE NDPQVLYFDN IMVDGETVTP PPSDGAVNTQ
210 220 230 240 250
TAPVATLAQI EDFETIPDYL RPDGGVNVST TTEIVTKGAA AMAAEFTAGW
260 270 280 290 300
NGLVFAGTWN WAELGEHTAV AVDVSNNSDS NIWLYSRIED VNSQGETATR
310 320 330 340 350
GVLVKAGESK TIYTSLNDNP SLLTQDERVS ALGLRDIPAD PMSAQNGWGD
360 370 380 390 400
FVALDKSQIT AIRYFIGELA SGETSQTLVF DNMRVIKDLN HESAYAEMTD
410 420 430 440 450
AMGQNNLVTY AGKVASKEEL AKLSDPEMAA LGELTNRNMY GGNPDSSPAT
460 470 480 490 500
DCVLATPASF NACKDADGNW QLVDPAGNAF FSTGVDNIRL QDTYTMTGVS
510 520 530 540 550
SDAESESALR QSMFTEIPSD YVNENYGPVH SGPVSQGQAV SFYANNLITR
560 570 580 590 600
HASEDVWRDI TVKRMKDWGF NTLGNWTDPA LYANGDVPYV ANGWSTSGAD
610 620 630 640 650
RLPVKQIGSG YWGPLPDPWD ANFATNAATM AAEIKAQVEG NEEYLVGIFV
660 670 680 690 700
DNEMSWGNVT DVEGSRYAQT LAVFNTDGTD ATTSPAKNSF IWFLENQRYT
710 720 730 740 750
GGIADLNAAW GTDYASWDAT SPAQELAYVA GMEADMQFLA WQFAFQYFNT
760 770 780 790 800
VNTALKAELP NHLYLGSRFA DWGRTPDVVS AAAAVVDVMS YNIYKDSIAA
810 820 830 840 850
ADWDADALSQ IEAIDKPVII GEFHFGALDS GSFAEGVVNA TSQQDRADKM
860 870 880 890 900
VSFYESVNAH KNFVGAHWFQ YIDSPLTGRA WDGENYNVGF VSNTDTPYTL
910 920 930 940 950
MTDAAREFNC GMYGTDCSSL SNATEAASRA GELYTGTNIG VSHSGPEAPD
960 970 980 990
PGEPVDPPID PPTPPTGGVT GGGGSAGWLS LLGLAGVFLL RRRKV
Length:995
Mass (Da):107,276
Last modified:February 1, 1996 - v1
Checksum:i437142F6C254124B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14721 Genomic DNA. Translation: BAA03541.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14721 Genomic DNA. Translation: BAA03541.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH50. Glycoside Hydrolase Family 50.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16649.
BRENDAi3.2.1.81. 6640.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequencing of agaA, a unique agarase 0107 gene from a marine bacterium, Vibrio sp. strain JT0107."
    Sugano Y., Matsumoto T., Kodama H., Noma M.
    Appl. Environ. Microbiol. 59:3750-3756(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiAGAA_VIBS7
AccessioniPrimary (citable) accession number: P48839
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 1, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.