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P48836

- VATG_YEAST

UniProt

P48836 - VATG_YEAST

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Protein

V-type proton ATPase subunit G

Gene

VMA10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

  1. proton-transporting ATPase activity, rotational mechanism Source: SGD

GO - Biological processi

  1. hydrogen ion transmembrane transport Source: GOC
  2. vacuolar acidification Source: SGD
Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31242-MONOMER.
ReactomeiREACT_189031. Phagosomal maturation (early endosomal stage).
REACT_189190. Transferrin endocytosis and recycling.
REACT_255567. Insulin receptor recycling.

Protein family/group databases

TCDBi3.A.2.2.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit G
Short name:
V-ATPase subunit G
Alternative name(s):
V-ATPase 13 kDa subunit
Vacuolar proton pump subunit G
Gene namesi
Name:VMA10
Ordered Locus Names:YHR039C-A
ORF Names:YHR039BC, YHR039C-B
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR039c-a.
SGDiS000002100. VMA10.

Subcellular locationi

GO - Cellular componenti

  1. vacuolar proton-transporting V-type ATPase, V1 domain Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 114113V-type proton ATPase subunit GPRO_0000192916Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP48836.
PaxDbiP48836.
PeptideAtlasiP48836.

Expressioni

Gene expression databases

GenevestigatoriP48836.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d and e).

Protein-protein interaction databases

BioGridi36471. 33 interactions.
DIPiDIP-2720N.
IntActiP48836. 3 interactions.
MINTiMINT-492687.
STRINGi4932.YHR039C-A.

Structurei

Secondary structure

1
114
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 6057Combined sources
Helixi70 – 734Combined sources
Beta strandi74 – 763Combined sources
Helixi77 – 8913Combined sources
Helixi91 – 10212Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2K88NMR-A2-58[»]
2KWYNMR-A61-101[»]
4DL0X-ray2.90G/K1-114[»]
4EFAX-ray2.82G1-114[»]
ProteinModelPortaliP48836.
SMRiP48836. Positions 2-106.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48836.

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase G subunit family.Curated

Phylogenomic databases

eggNOGiNOG272364.
GeneTreeiENSGT00390000011172.
HOGENOMiHOG000186416.
InParanoidiP48836.
KOiK02152.
OMAiHTRNAGR.
OrthoDBiEOG7HHX5N.

Family and domain databases

InterProiIPR005124. V-ATPase_G.
[Graphical view]
PANTHERiPTHR12713. PTHR12713. 1 hit.
TIGRFAMsiTIGR01147. V_ATP_synt_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48836-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQKNGIATL LQAEKEAHEI VSKARKYRQD KLKQAKTDAA KEIDSYKIQK
60 70 80 90 100
DKELKEFEQK NAGGVGELEK KAEAGVQGEL AEIKKIAEKK KDDVVKILIE
110
TVIKPSAEVH INAL
Length:114
Mass (Da):12,713
Last modified:February 1, 1996 - v1
Checksum:i259660D440A933D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21240 mRNA. Translation: AAA74570.1.
U00062 Genomic DNA. Translation: AAB68921.1.
BK006934 Genomic DNA. Translation: DAA06731.1.
PIRiS70777.
RefSeqiNP_011905.1. NM_001180027.1.

Genome annotation databases

EnsemblFungiiYHR039C-A; YHR039C-A; YHR039C-A.
GeneIDi856435.
KEGGisce:YHR039C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21240 mRNA. Translation: AAA74570.1 .
U00062 Genomic DNA. Translation: AAB68921.1 .
BK006934 Genomic DNA. Translation: DAA06731.1 .
PIRi S70777.
RefSeqi NP_011905.1. NM_001180027.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2K88 NMR - A 2-58 [» ]
2KWY NMR - A 61-101 [» ]
4DL0 X-ray 2.90 G/K 1-114 [» ]
4EFA X-ray 2.82 G 1-114 [» ]
ProteinModelPortali P48836.
SMRi P48836. Positions 2-106.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36471. 33 interactions.
DIPi DIP-2720N.
IntActi P48836. 3 interactions.
MINTi MINT-492687.
STRINGi 4932.YHR039C-A.

Protein family/group databases

TCDBi 3.A.2.2.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Proteomic databases

MaxQBi P48836.
PaxDbi P48836.
PeptideAtlasi P48836.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR039C-A ; YHR039C-A ; YHR039C-A .
GeneIDi 856435.
KEGGi sce:YHR039C-A.

Organism-specific databases

CYGDi YHR039c-a.
SGDi S000002100. VMA10.

Phylogenomic databases

eggNOGi NOG272364.
GeneTreei ENSGT00390000011172.
HOGENOMi HOG000186416.
InParanoidi P48836.
KOi K02152.
OMAi HTRNAGR.
OrthoDBi EOG7HHX5N.

Enzyme and pathway databases

BioCyci YEAST:G3O-31242-MONOMER.
Reactomei REACT_189031. Phagosomal maturation (early endosomal stage).
REACT_189190. Transferrin endocytosis and recycling.
REACT_255567. Insulin receptor recycling.

Miscellaneous databases

EvolutionaryTracei P48836.
NextBioi 982033.

Gene expression databases

Genevestigatori P48836.

Family and domain databases

InterProi IPR005124. V-ATPase_G.
[Graphical view ]
PANTHERi PTHR12713. PTHR12713. 1 hit.
TIGRFAMsi TIGR01147. V_ATP_synt_G. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Saccharomyces cerevisiae VMA10 is an intron-containing gene encoding a novel 13-kDa subunit of vacuolar H(+)-ATPase."
    Supekova L., Supek F., Nelson N.
    J. Biol. Chem. 270:13726-13732(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 5-15; 57-65 AND 71-84.
    Strain: ATCC 200060 / W303.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVATG_YEAST
AccessioniPrimary (citable) accession number: P48836
Secondary accession number(s): D3DKY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2280 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3