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P48836

- VATG_YEAST

UniProt

P48836 - VATG_YEAST

Protein

V-type proton ATPase subunit G

Gene

VMA10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

    GO - Molecular functioni

    1. proton-transporting ATPase activity, rotational mechanism Source: SGD

    GO - Biological processi

    1. hydrogen ion transmembrane transport Source: GOC
    2. vacuolar acidification Source: SGD

    Keywords - Biological processi

    Hydrogen ion transport, Ion transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31242-MONOMER.
    ReactomeiREACT_189031. Phagosomal maturation (early endosomal stage).
    REACT_189190. Transferrin endocytosis and recycling.

    Protein family/group databases

    TCDBi3.A.2.2.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase subunit G
    Short name:
    V-ATPase subunit G
    Alternative name(s):
    V-ATPase 13 kDa subunit
    Vacuolar proton pump subunit G
    Gene namesi
    Name:VMA10
    Ordered Locus Names:YHR039C-A
    ORF Names:YHR039BC, YHR039C-B
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR039c-a.
    SGDiS000002100. VMA10.

    Subcellular locationi

    GO - Cellular componenti

    1. vacuolar proton-transporting V-type ATPase, V1 domain Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 114113V-type proton ATPase subunit GPRO_0000192916Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP48836.
    PaxDbiP48836.
    PeptideAtlasiP48836.

    Expressioni

    Gene expression databases

    GenevestigatoriP48836.

    Interactioni

    Subunit structurei

    V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d and e).

    Protein-protein interaction databases

    BioGridi36471. 33 interactions.
    DIPiDIP-2720N.
    IntActiP48836. 3 interactions.
    MINTiMINT-492687.
    STRINGi4932.YHR039C-A.

    Structurei

    Secondary structure

    1
    114
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 6057
    Helixi70 – 734
    Beta strandi74 – 763
    Helixi77 – 8913
    Helixi91 – 10212

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2K88NMR-A2-58[»]
    2KWYNMR-A61-101[»]
    4DL0X-ray2.90G/K1-114[»]
    4EFAX-ray2.82G1-114[»]
    ProteinModelPortaliP48836.
    SMRiP48836. Positions 2-106.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP48836.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the V-ATPase G subunit family.Curated

    Phylogenomic databases

    eggNOGiNOG272364.
    GeneTreeiENSGT00390000011172.
    HOGENOMiHOG000186416.
    KOiK02152.
    OMAiHTRNAGR.
    OrthoDBiEOG7HHX5N.

    Family and domain databases

    InterProiIPR005124. V-ATPase_G.
    [Graphical view]
    PANTHERiPTHR12713. PTHR12713. 1 hit.
    TIGRFAMsiTIGR01147. V_ATP_synt_G. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48836-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQKNGIATL LQAEKEAHEI VSKARKYRQD KLKQAKTDAA KEIDSYKIQK    50
    DKELKEFEQK NAGGVGELEK KAEAGVQGEL AEIKKIAEKK KDDVVKILIE 100
    TVIKPSAEVH INAL 114
    Length:114
    Mass (Da):12,713
    Last modified:February 1, 1996 - v1
    Checksum:i259660D440A933D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U21240 mRNA. Translation: AAA74570.1.
    U00062 Genomic DNA. Translation: AAB68921.1.
    BK006934 Genomic DNA. Translation: DAA06731.1.
    PIRiS70777.
    RefSeqiNP_011905.1. NM_001180027.1.

    Genome annotation databases

    EnsemblFungiiYHR039C-A; YHR039C-A; YHR039C-A.
    GeneIDi856435.
    KEGGisce:YHR039C-A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U21240 mRNA. Translation: AAA74570.1 .
    U00062 Genomic DNA. Translation: AAB68921.1 .
    BK006934 Genomic DNA. Translation: DAA06731.1 .
    PIRi S70777.
    RefSeqi NP_011905.1. NM_001180027.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2K88 NMR - A 2-58 [» ]
    2KWY NMR - A 61-101 [» ]
    4DL0 X-ray 2.90 G/K 1-114 [» ]
    4EFA X-ray 2.82 G 1-114 [» ]
    ProteinModelPortali P48836.
    SMRi P48836. Positions 2-106.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36471. 33 interactions.
    DIPi DIP-2720N.
    IntActi P48836. 3 interactions.
    MINTi MINT-492687.
    STRINGi 4932.YHR039C-A.

    Protein family/group databases

    TCDBi 3.A.2.2.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Proteomic databases

    MaxQBi P48836.
    PaxDbi P48836.
    PeptideAtlasi P48836.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR039C-A ; YHR039C-A ; YHR039C-A .
    GeneIDi 856435.
    KEGGi sce:YHR039C-A.

    Organism-specific databases

    CYGDi YHR039c-a.
    SGDi S000002100. VMA10.

    Phylogenomic databases

    eggNOGi NOG272364.
    GeneTreei ENSGT00390000011172.
    HOGENOMi HOG000186416.
    KOi K02152.
    OMAi HTRNAGR.
    OrthoDBi EOG7HHX5N.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31242-MONOMER.
    Reactomei REACT_189031. Phagosomal maturation (early endosomal stage).
    REACT_189190. Transferrin endocytosis and recycling.

    Miscellaneous databases

    EvolutionaryTracei P48836.
    NextBioi 982033.

    Gene expression databases

    Genevestigatori P48836.

    Family and domain databases

    InterProi IPR005124. V-ATPase_G.
    [Graphical view ]
    PANTHERi PTHR12713. PTHR12713. 1 hit.
    TIGRFAMsi TIGR01147. V_ATP_synt_G. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The Saccharomyces cerevisiae VMA10 is an intron-containing gene encoding a novel 13-kDa subunit of vacuolar H(+)-ATPase."
      Supekova L., Supek F., Nelson N.
      J. Biol. Chem. 270:13726-13732(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 5-15; 57-65 AND 71-84.
      Strain: ATCC 200060 / W303.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiVATG_YEAST
    AccessioniPrimary (citable) accession number: P48836
    Secondary accession number(s): D3DKY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2280 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3