P48828 (G6PD_KLULA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate 1-dehydrogenase
Short name=G6PD
EC=1.1.1.49

Gene names

Name:	ZWF
Ordered Locus Names:	KLLA0D19855g

Organism

Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

284590 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces › Kluyveromyces lactis

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	NADP binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068104
Sites
	Active site	245	1	Proton acceptor By similarity
	Binding site	17	1	NADP By similarity
	Binding site	49	1	NADP By similarity
	Binding site	183	1	Substrate By similarity
	Binding site	187	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P48828 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: C6EC57AD6B6E9F1F	FASTA	497	56,574
	10 20 30 40 50 60 MATQFDENTV ITIFGASGDL SKKKTFPALF GLYREGYLNP TTKIIGYARS KLSNEDLREK 70 80 90 100 110 120 VKPFLKKPNG AKDDAKVNEF LSMVSYHAGP YDSDEGYLEL KKIIEEFEAE KKVDEPHRLF 130 140 150 160 170 180 YLALPPSIFI DVCSKLKENL YTESGIQRVI VEKPFGHDLQ SATELQEKLA PLFSEDELFR 190 200 210 220 230 240 IDHYLGKEMV KNLLLMRFGN TFLNAAWNKE NIQSVQVVFK EPFGTEGRGG YFDSIGIIRD 250 260 270 280 290 300 VMQNHLLQVL TLLTMERPVS FDPESVRDEK VKVLKAFSPI DHDDILIGQY GRSVDGSKPS 310 320 330 340 350 360 YLDDETVKED SKCVTFAAIG FKIANERWDG VPIVMRAGKA LNEGKVEIRI QFRRVASGMF 370 380 390 400 410 420 TDIPNNELVI RIQPNEAIYL KCNAKTPGLA NENQTTELDL TYSERYKNYW IPEAYESLIR 430 440 450 460 470 480 DALLGDHSNF VRDDELDVSW KLFTPLLNYL EGPDGPQPKI YPYGCRSPDG LVEFLADHGY 490 TFSKPGSYQW PVTTPKM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Wesolowski-Louvel M., Tanguy-Rougeau C., Fukuhara H. Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 76492 / CBS 2359/152 / CLIB 210.
[2]	"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X70373 Genomic DNA. Translation: CAA49834.1. CR382124 Genomic DNA. Translation: CAH01040.1.
PIR	S31337.
RefSeq	XP_453944.1. XM_453944.1.
3D structure databases
ProteinModelPortal	P48828.
ModBase	Search...
Protein-protein interaction databases
STRING	28985.P48828.
Proteomic databases
PRIDE	P48828.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2893289.
KEGG	kla:KLLA0D19855g.
Phylogenomic databases
eggNOG	COG0364.
HOGENOM	HOG000046192.
KO	K00036.
OMA	KSPGITF.
OrthoDB	EOG4RBTSW.
Enzyme and pathway databases
UniPathway	UPA00115; UER00408.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR001282. G6P_DH. IPR019796. G6P_DH_AS. IPR022675. G6P_DH_C. IPR022674. G6P_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR23429. PTHR23429. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_KLULA

Accession

Primary (citable) accession number: P48828

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program