Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P48828

- G6PD_KLULA

UniProt

P48828 - G6PD_KLULA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

ZWF

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491NADPBy similarity
Binding sitei153 – 1531NADP; via carbonyl oxygenBy similarity
Binding sitei153 – 1531SubstrateBy similarity
Binding sitei221 – 2211SubstrateBy similarity
Binding sitei240 – 2401SubstrateBy similarity
Active sitei245 – 2451Proton acceptorBy similarity
Binding sitei339 – 3391SubstrateBy similarity
Binding sitei373 – 3731SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228NADPBy similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:ZWF
Ordered Locus Names:KLLA0D19855g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome D

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Glucose-6-phosphate 1-dehydrogenasePRO_0000068104Add
BLAST

Proteomic databases

PRIDEiP48828.

Interactioni

Protein-protein interaction databases

STRINGi28985.P48828.

Structurei

3D structure databases

ProteinModelPortaliP48828.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni183 – 1875Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046192.
InParanoidiP48828.
KOiK00036.
OMAiYCVTAVS.
OrthoDBiEOG7TXKRP.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48828-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATQFDENTV ITIFGASGDL SKKKTFPALF GLYREGYLNP TTKIIGYARS
60 70 80 90 100
KLSNEDLREK VKPFLKKPNG AKDDAKVNEF LSMVSYHAGP YDSDEGYLEL
110 120 130 140 150
KKIIEEFEAE KKVDEPHRLF YLALPPSIFI DVCSKLKENL YTESGIQRVI
160 170 180 190 200
VEKPFGHDLQ SATELQEKLA PLFSEDELFR IDHYLGKEMV KNLLLMRFGN
210 220 230 240 250
TFLNAAWNKE NIQSVQVVFK EPFGTEGRGG YFDSIGIIRD VMQNHLLQVL
260 270 280 290 300
TLLTMERPVS FDPESVRDEK VKVLKAFSPI DHDDILIGQY GRSVDGSKPS
310 320 330 340 350
YLDDETVKED SKCVTFAAIG FKIANERWDG VPIVMRAGKA LNEGKVEIRI
360 370 380 390 400
QFRRVASGMF TDIPNNELVI RIQPNEAIYL KCNAKTPGLA NENQTTELDL
410 420 430 440 450
TYSERYKNYW IPEAYESLIR DALLGDHSNF VRDDELDVSW KLFTPLLNYL
460 470 480 490
EGPDGPQPKI YPYGCRSPDG LVEFLADHGY TFSKPGSYQW PVTTPKM
Length:497
Mass (Da):56,574
Last modified:February 1, 1996 - v1
Checksum:iC6EC57AD6B6E9F1F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70373 Genomic DNA. Translation: CAA49834.1.
CR382124 Genomic DNA. Translation: CAH01040.1.
PIRiS31337.
RefSeqiXP_453944.1. XM_453944.1.

Genome annotation databases

GeneIDi2893289.
KEGGikla:KLLA0D19855g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70373 Genomic DNA. Translation: CAA49834.1 .
CR382124 Genomic DNA. Translation: CAH01040.1 .
PIRi S31337.
RefSeqi XP_453944.1. XM_453944.1.

3D structure databases

ProteinModelPortali P48828.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.P48828.

Proteomic databases

PRIDEi P48828.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2893289.
KEGGi kla:KLLA0D19855g.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046192.
InParanoidi P48828.
KOi K00036.
OMAi YCVTAVS.
OrthoDBi EOG7TXKRP.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Wesolowski-Louvel M., Tanguy-Rougeau C., Fukuhara H.
    Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 76492 / CBS 2359/152 / CLIB 210.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Entry informationi

Entry nameiG6PD_KLULA
AccessioniPrimary (citable) accession number: P48828
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3