Reviewed, UniProtKB/Swiss-Prot P48828 (G6PD_KLULA)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	ZWF
Ordered Locus Names:	KLLA0D19855g

Organism

Kluyveromyces lactis (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

28985 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068104
Sites
	Active site	245	1	Proton acceptor By similarity
	Binding site	17	1	NADP By similarity
	Binding site	49	1	NADP By similarity
	Binding site	183	1	Substrate By similarity
	Binding site	187	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P48828-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: C6EC57AD6B6E9F1F	FASTA	497	56,574
	10 20 30 40 50 60 MATQFDENTV ITIFGASGDL SKKKTFPALF GLYREGYLNP TTKIIGYARS KLSNEDLREK 70 80 90 100 110 120 VKPFLKKPNG AKDDAKVNEF LSMVSYHAGP YDSDEGYLEL KKIIEEFEAE KKVDEPHRLF 130 140 150 160 170 180 YLALPPSIFI DVCSKLKENL YTESGIQRVI VEKPFGHDLQ SATELQEKLA PLFSEDELFR 190 200 210 220 230 240 IDHYLGKEMV KNLLLMRFGN TFLNAAWNKE NIQSVQVVFK EPFGTEGRGG YFDSIGIIRD 250 260 270 280 290 300 VMQNHLLQVL TLLTMERPVS FDPESVRDEK VKVLKAFSPI DHDDILIGQY GRSVDGSKPS 310 320 330 340 350 360 YLDDETVKED SKCVTFAAIG FKIANERWDG VPIVMRAGKA LNEGKVEIRI QFRRVASGMF 370 380 390 400 410 420 TDIPNNELVI RIQPNEAIYL KCNAKTPGLA NENQTTELDL TYSERYKNYW IPEAYESLIR 430 440 450 460 470 480 DALLGDHSNF VRDDELDVSW KLFTPLLNYL EGPDGPQPKI YPYGCRSPDG LVEFLADHGY 490 TFSKPGSYQW PVTTPKM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Wesolowski-Louvel M., Tanguy-Rougeau C., Fukuhara H. Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 76492 / CBS 2359/152 / CLIB 210.
[2]	"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X70373 Genomic DNA. Translation: CAA49834.1. CR382124 Genomic DNA. Translation: CAH01040.1.
PIR	S31337.
RefSeq	XP_453944.1.
3D structure databases
SMR	P48828. Positions 7-491.
ModBase	Search...
Protein-protein interaction databases
STRING	P48828.
Genome annotation databases
GeneID	2893289.
GenomeReviews	Gene locus KLLA0D19855g in contig CR382124_GR.
KEGG	kla:KLLA0D19855g.
Phylogenomic databases
eggNOG	fuNOG04834.
HOGENOM	HBG322449.
OMA	VVRGNAT.
OrthoDB	EOG98KSTG.
PhylomeDB	P48828.
Enzyme and pathway databases
BRENDA	1.1.1.49. 74088.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DH. IPR019796. Glc-6-P_DH_AS. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_KLULA

Accession

Primary (citable) accession number: P48828

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	February 9, 2010
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)