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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

ZWF

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (ZWF)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (KLLA0_A09339g)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei49NADPBy similarity1
Binding sitei153NADP; via carbonyl oxygenBy similarity1
Binding sitei153SubstrateBy similarity1
Binding sitei221SubstrateBy similarity1
Binding sitei240SubstrateBy similarity1
Active sitei245Proton acceptorBy similarity1
Binding sitei339SubstrateBy similarity1
Binding sitei373SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22NADPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:ZWF
Ordered Locus Names:KLLA0D19855g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome D

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681041 – 497Glucose-6-phosphate 1-dehydrogenaseAdd BLAST497

Proteomic databases

PRIDEiP48828.

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_453944.1.

Structurei

3D structure databases

ProteinModelPortaliP48828.
SMRiP48828.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni183 – 187Substrate bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0563. Eukaryota.
COG0364. LUCA.
HOGENOMiHOG000046192.
InParanoidiP48828.
KOiK00036.
OMAiVEICVYE.
OrthoDBiEOG092C2MOH.

Family and domain databases

HAMAPiMF_00966. G6PD. 1 hit.
InterProiView protein in InterPro
IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiView protein in Pfam
PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiView protein in PROSITE
PS00069. G6P_DEHYDROGENASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P48828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQFDENTV ITIFGASGDL SKKKTFPALF GLYREGYLNP TTKIIGYARS
60 70 80 90 100
KLSNEDLREK VKPFLKKPNG AKDDAKVNEF LSMVSYHAGP YDSDEGYLEL
110 120 130 140 150
KKIIEEFEAE KKVDEPHRLF YLALPPSIFI DVCSKLKENL YTESGIQRVI
160 170 180 190 200
VEKPFGHDLQ SATELQEKLA PLFSEDELFR IDHYLGKEMV KNLLLMRFGN
210 220 230 240 250
TFLNAAWNKE NIQSVQVVFK EPFGTEGRGG YFDSIGIIRD VMQNHLLQVL
260 270 280 290 300
TLLTMERPVS FDPESVRDEK VKVLKAFSPI DHDDILIGQY GRSVDGSKPS
310 320 330 340 350
YLDDETVKED SKCVTFAAIG FKIANERWDG VPIVMRAGKA LNEGKVEIRI
360 370 380 390 400
QFRRVASGMF TDIPNNELVI RIQPNEAIYL KCNAKTPGLA NENQTTELDL
410 420 430 440 450
TYSERYKNYW IPEAYESLIR DALLGDHSNF VRDDELDVSW KLFTPLLNYL
460 470 480 490
EGPDGPQPKI YPYGCRSPDG LVEFLADHGY TFSKPGSYQW PVTTPKM
Length:497
Mass (Da):56,574
Last modified:February 1, 1996 - v1
Checksum:iC6EC57AD6B6E9F1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70373 Genomic DNA. Translation: CAA49834.1.
CR382124 Genomic DNA. Translation: CAH01040.1.
PIRiS31337.
RefSeqiXP_453944.1. XM_453944.1.

Genome annotation databases

EnsemblFungiiCAH01040; CAH01040; KLLA0_D19855g.
GeneIDi2893289.
KEGGikla:KLLA0D19855g.

Similar proteinsi

Entry informationi

Entry nameiG6PD_KLULA
AccessioniPrimary (citable) accession number: P48828
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 25, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families