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P48828

- G6PD_KLULA

UniProt

P48828 - G6PD_KLULA

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

ZWF

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei49 – 491NADPBy similarity
    Binding sitei153 – 1531NADP; via carbonyl oxygenBy similarity
    Binding sitei153 – 1531SubstrateBy similarity
    Binding sitei221 – 2211SubstrateBy similarity
    Binding sitei240 – 2401SubstrateBy similarity
    Active sitei245 – 2451Proton acceptorBy similarity
    Binding sitei339 – 3391SubstrateBy similarity
    Binding sitei373 – 3731SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 228NADPBy similarity

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
    Short name:
    G6PD
    Gene namesi
    Name:ZWF
    Ordered Locus Names:KLLA0D19855g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome D

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Glucose-6-phosphate 1-dehydrogenasePRO_0000068104Add
    BLAST

    Proteomic databases

    PRIDEiP48828.

    Interactioni

    Protein-protein interaction databases

    STRINGi28985.P48828.

    Structurei

    3D structure databases

    ProteinModelPortaliP48828.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni183 – 1875Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0364.
    HOGENOMiHOG000046192.
    KOiK00036.
    OMAiYCVTAVS.
    OrthoDBiEOG7TXKRP.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48828-1 [UniParc]FASTAAdd to Basket

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    MATQFDENTV ITIFGASGDL SKKKTFPALF GLYREGYLNP TTKIIGYARS    50
    KLSNEDLREK VKPFLKKPNG AKDDAKVNEF LSMVSYHAGP YDSDEGYLEL 100
    KKIIEEFEAE KKVDEPHRLF YLALPPSIFI DVCSKLKENL YTESGIQRVI 150
    VEKPFGHDLQ SATELQEKLA PLFSEDELFR IDHYLGKEMV KNLLLMRFGN 200
    TFLNAAWNKE NIQSVQVVFK EPFGTEGRGG YFDSIGIIRD VMQNHLLQVL 250
    TLLTMERPVS FDPESVRDEK VKVLKAFSPI DHDDILIGQY GRSVDGSKPS 300
    YLDDETVKED SKCVTFAAIG FKIANERWDG VPIVMRAGKA LNEGKVEIRI 350
    QFRRVASGMF TDIPNNELVI RIQPNEAIYL KCNAKTPGLA NENQTTELDL 400
    TYSERYKNYW IPEAYESLIR DALLGDHSNF VRDDELDVSW KLFTPLLNYL 450
    EGPDGPQPKI YPYGCRSPDG LVEFLADHGY TFSKPGSYQW PVTTPKM 497
    Length:497
    Mass (Da):56,574
    Last modified:February 1, 1996 - v1
    Checksum:iC6EC57AD6B6E9F1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70373 Genomic DNA. Translation: CAA49834.1.
    CR382124 Genomic DNA. Translation: CAH01040.1.
    PIRiS31337.
    RefSeqiXP_453944.1. XM_453944.1.

    Genome annotation databases

    GeneIDi2893289.
    KEGGikla:KLLA0D19855g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70373 Genomic DNA. Translation: CAA49834.1 .
    CR382124 Genomic DNA. Translation: CAH01040.1 .
    PIRi S31337.
    RefSeqi XP_453944.1. XM_453944.1.

    3D structure databases

    ProteinModelPortali P48828.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.P48828.

    Proteomic databases

    PRIDEi P48828.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2893289.
    KEGGi kla:KLLA0D19855g.

    Phylogenomic databases

    eggNOGi COG0364.
    HOGENOMi HOG000046192.
    KOi K00036.
    OMAi YCVTAVS.
    OrthoDBi EOG7TXKRP.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Wesolowski-Louvel M., Tanguy-Rougeau C., Fukuhara H.
      Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 76492 / CBS 2359/152 / CLIB 210.
    2. "Genome evolution in yeasts."
      Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
      , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
      Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

    Entry informationi

    Entry nameiG6PD_KLULA
    AccessioniPrimary (citable) accession number: P48828
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3