Reviewed, UniProtKB/Swiss-Prot P48826 (G6PD_ASPNG)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	gsdA
Synonyms:	g6pdh

Organism

Aspergillus niger

Taxonomic identifier

5061 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 510	510	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068102
Sites
	Active site	256	1	Proton acceptor By similarity
	Binding site	31	1	NADP By similarity
	Binding site	63	1	NADP By similarity
	Binding site	194	1	Substrate By similarity
	Binding site	198	1	Substrate By similarity
Experimental info
	Sequence conflict	135	1	L → F in CAA54840. Ref.2
	Sequence conflict	508 – 510	3	NRL → TVCK in CAA54840. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P48826-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: FDDF3F5025483AF6	FASTA	510	58,950
	10 20 30 40 50 60 MASTIARTEE RQNAGTMELK DDTVIIVLGA SGDLAKKKTF PALFGLYRNK FLPKGIKIVG 70 80 90 100 110 120 YARTNMDHEE YLRRVRSYIK TPTKEIEEQL DSFCQFCTYI SGQYDKDDSF INLNKHLEEI 130 140 150 160 170 180 EKGQKEQNRI YYMALPPSVF TTVSDQLKRN CYPKNGVARI IVEKPFGKDL QSSRDLQKAL 190 200 210 220 230 240 EPNWKEEEIF RIDHYLGKEM VKNILIMRFG NEFFNATWNR HHIDNVQITF KEPFGTEGRG 250 260 270 280 290 300 GYFDEFGIIR DVMQNHLLQV LTLLAMERPI SFSAEDIRDE KVRVLRAMDA IEPKNVIIGQ 310 320 330 340 350 360 YGKSLDGSKP AYKEDETVPQ DSRCPTFCAM VAYIKNERWD GVPFIMKAGK ALNEQKTEIR 370 380 390 400 410 420 IQFRDVTSGI FKDIPRNELV IRVQPNESVY IKMNSKLPGL SMQTVVTELD LTYRRRFSDL 430 440 450 460 470 480 KIPEAYESLI LDALKGDHSN FVRDDELDAS WRIFTPLLHY LDDNKEIIPM EYPYGSRGPA 490 500 510 VLDDFTASFG YKFSDAAGYQ WPLTSTPNRL

References

[1]	"G6PD-promoter activity in A. niger." Thamm A. Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.
[2]	"Isolation and characterization of the glucose-6-phosphate dehydrogenase encoding gene (gsdA) from Aspergillus niger." van den Broek P., Goosen T., Wennekes B., van den Broek H. Mol. Gen. Genet. 247:229-239(1995) [PubMed: 7753033] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X87942 mRNA. Translation: CAA61194.1. X77829 Genomic DNA. Translation: CAA54840.1.
PIR	S54720.
3D structure databases
HSSP	HSSP built from PDB template 1QKI based on UniProtKB P11413.
ModBase	Search...
Family and domain databases
InterPro	IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
ProDom	PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_ASPNG

Accession

Primary (citable) accession number: P48826

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 25, 2008
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)