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P48826

- G6PD_ASPNG

UniProt

P48826 - G6PD_ASPNG

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene
gsdA, g6pdh
Organism
Aspergillus niger
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei63 – 631NADP By similarity
Binding sitei164 – 1641NADP; via carbonyl oxygen By similarity
Binding sitei164 – 1641Substrate By similarity
Binding sitei232 – 2321Substrate By similarity
Binding sitei251 – 2511Substrate By similarity
Active sitei256 – 2561Proton acceptor By similarity
Binding sitei350 – 3501Substrate By similarity
Binding sitei384 – 3841Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 368NADP By similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:gsdA
Synonyms:g6pdh
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Glucose-6-phosphate 1-dehydrogenaseUniRule annotationPRO_0000068102Add
BLAST

Proteomic databases

PRIDEiP48826.

Structurei

3D structure databases

ProteinModelPortaliP48826.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni194 – 1985Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48826-1 [UniParc]FASTAAdd to Basket

« Hide

MASTIARTEE RQNAGTMELK DDTVIIVLGA SGDLAKKKTF PALFGLYRNK    50
FLPKGIKIVG YARTNMDHEE YLRRVRSYIK TPTKEIEEQL DSFCQFCTYI 100
SGQYDKDDSF INLNKHLEEI EKGQKEQNRI YYMALPPSVF TTVSDQLKRN 150
CYPKNGVARI IVEKPFGKDL QSSRDLQKAL EPNWKEEEIF RIDHYLGKEM 200
VKNILIMRFG NEFFNATWNR HHIDNVQITF KEPFGTEGRG GYFDEFGIIR 250
DVMQNHLLQV LTLLAMERPI SFSAEDIRDE KVRVLRAMDA IEPKNVIIGQ 300
YGKSLDGSKP AYKEDETVPQ DSRCPTFCAM VAYIKNERWD GVPFIMKAGK 350
ALNEQKTEIR IQFRDVTSGI FKDIPRNELV IRVQPNESVY IKMNSKLPGL 400
SMQTVVTELD LTYRRRFSDL KIPEAYESLI LDALKGDHSN FVRDDELDAS 450
WRIFTPLLHY LDDNKEIIPM EYPYGSRGPA VLDDFTASFG YKFSDAAGYQ 500
WPLTSTPNRL 510
Length:510
Mass (Da):58,950
Last modified:February 1, 1996 - v1
Checksum:iFDDF3F5025483AF6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351L → F in CAA54840. 1 Publication
Sequence conflicti508 – 5103NRL → TVCK in CAA54840. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87942 mRNA. Translation: CAA61194.1.
X77829 Genomic DNA. Translation: CAA54840.1.
PIRiS54720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87942 mRNA. Translation: CAA61194.1 .
X77829 Genomic DNA. Translation: CAA54840.1 .
PIRi S54720.

3D structure databases

ProteinModelPortali P48826.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P48826.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0364.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "G6PD-promoter activity in A. niger."
    Thamm A.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.
  2. "Isolation and characterization of the glucose-6-phosphate dehydrogenase encoding gene (gsdA) from Aspergillus niger."
    van den Broek P., Goosen T., Wennekes B., van den Broek H.
    Mol. Gen. Genet. 247:229-239(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.

Entry informationi

Entry nameiG6PD_ASPNG
AccessioniPrimary (citable) accession number: P48826
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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