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P48826

- G6PD_ASPNG

UniProt

P48826 - G6PD_ASPNG

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

gsdA

Organism
Aspergillus niger
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei63 – 631NADPBy similarity
    Binding sitei164 – 1641NADP; via carbonyl oxygenBy similarity
    Binding sitei164 – 1641SubstrateBy similarity
    Binding sitei232 – 2321SubstrateBy similarity
    Binding sitei251 – 2511SubstrateBy similarity
    Active sitei256 – 2561Proton acceptorBy similarity
    Binding sitei350 – 3501SubstrateBy similarity
    Binding sitei384 – 3841SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi29 – 368NADPBy similarity

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
    Short name:
    G6PD
    Gene namesi
    Name:gsdA
    Synonyms:g6pdh
    OrganismiAspergillus niger
    Taxonomic identifieri5061 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 510510Glucose-6-phosphate 1-dehydrogenasePRO_0000068102Add
    BLAST

    Proteomic databases

    PRIDEiP48826.

    Structurei

    3D structure databases

    ProteinModelPortaliP48826.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni194 – 1985Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0364.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48826-1 [UniParc]FASTAAdd to Basket

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    MASTIARTEE RQNAGTMELK DDTVIIVLGA SGDLAKKKTF PALFGLYRNK    50
    FLPKGIKIVG YARTNMDHEE YLRRVRSYIK TPTKEIEEQL DSFCQFCTYI 100
    SGQYDKDDSF INLNKHLEEI EKGQKEQNRI YYMALPPSVF TTVSDQLKRN 150
    CYPKNGVARI IVEKPFGKDL QSSRDLQKAL EPNWKEEEIF RIDHYLGKEM 200
    VKNILIMRFG NEFFNATWNR HHIDNVQITF KEPFGTEGRG GYFDEFGIIR 250
    DVMQNHLLQV LTLLAMERPI SFSAEDIRDE KVRVLRAMDA IEPKNVIIGQ 300
    YGKSLDGSKP AYKEDETVPQ DSRCPTFCAM VAYIKNERWD GVPFIMKAGK 350
    ALNEQKTEIR IQFRDVTSGI FKDIPRNELV IRVQPNESVY IKMNSKLPGL 400
    SMQTVVTELD LTYRRRFSDL KIPEAYESLI LDALKGDHSN FVRDDELDAS 450
    WRIFTPLLHY LDDNKEIIPM EYPYGSRGPA VLDDFTASFG YKFSDAAGYQ 500
    WPLTSTPNRL 510
    Length:510
    Mass (Da):58,950
    Last modified:February 1, 1996 - v1
    Checksum:iFDDF3F5025483AF6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti135 – 1351L → F in CAA54840. (PubMed:7753033)Curated
    Sequence conflicti508 – 5103NRL → TVCK in CAA54840. (PubMed:7753033)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87942 mRNA. Translation: CAA61194.1.
    X77829 Genomic DNA. Translation: CAA54840.1.
    PIRiS54720.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87942 mRNA. Translation: CAA61194.1 .
    X77829 Genomic DNA. Translation: CAA54840.1 .
    PIRi S54720.

    3D structure databases

    ProteinModelPortali P48826.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P48826.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0364.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "G6PD-promoter activity in A. niger."
      Thamm A.
      Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.
    2. "Isolation and characterization of the glucose-6-phosphate dehydrogenase encoding gene (gsdA) from Aspergillus niger."
      van den Broek P., Goosen T., Wennekes B., van den Broek H.
      Mol. Gen. Genet. 247:229-239(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.

    Entry informationi

    Entry nameiG6PD_ASPNG
    AccessioniPrimary (citable) accession number: P48826
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3