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P48825 (BGL1_ASPAC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-glucosidase 1

EC=3.2.1.21
Alternative name(s):
Beta-D-glucoside glucohydrolase
Cellobiase
Gentiobiase
OrganismAspergillus aculeatus
Taxonomic identifier5053 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length860 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathway

Glycan metabolism; cellulose degradation.

Sequence similarities

Belongs to the glycosyl hydrolase 3 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Cellulose degradation
Polysaccharide degradation
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processcellulose catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionbeta-glucosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 860841Beta-glucosidase 1
PRO_0000011776

Sites

Active site2801 By similarity

Amino acid modifications

Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation2111N-linked (GlcNAc...) Potential
Glycosylation2521N-linked (GlcNAc...) Potential
Glycosylation3151N-linked (GlcNAc...) Potential
Glycosylation3221N-linked (GlcNAc...) Potential
Glycosylation3541N-linked (GlcNAc...) Potential
Glycosylation3871N-linked (GlcNAc...) Potential
Glycosylation4421N-linked (GlcNAc...) Potential
Glycosylation5231N-linked (GlcNAc...) Potential
Glycosylation5421N-linked (GlcNAc...) Potential
Glycosylation5641N-linked (GlcNAc...) Potential
Glycosylation6581N-linked (GlcNAc...) Potential
Glycosylation6681N-linked (GlcNAc...) Potential
Glycosylation6901N-linked (GlcNAc...) Potential
Glycosylation7121N-linked (GlcNAc...) Potential

Secondary structure

............................................................................................................................................ 860
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P48825 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 4B484778B00FC694

FASTA86093,053
        10         20         30         40         50         60 
MKLSWLEAAA LTAASVVSAD ELAFSPPFYP SPWANGQGEW AEAYQRAVAI VSQMTLDEKV 

        70         80         90        100        110        120 
NLTTGTGWEL EKCVGQTGGV PRLNIGGMCL QDSPLGIRDS DYNSAFPAGV NVAATWDKNL 

       130        140        150        160        170        180 
AYLRGQAMGQ EFSDKGIDVQ LGPAAGPLGR SPDGGRNWEG FSPDPALTGV LFAETIKGIQ 

       190        200        210        220        230        240 
DAGVVATAKH YILNEQEHFR QVAEAAGYGF NISDTISSNV DDKTIHEMYL WPFADAVRAG 

       250        260        270        280        290        300 
VGAIMCSYNQ INNSYGCQNS YTLNKLLKAE LGFQGFVMSD WGAHHSGVGS ALAGLDMSMP 

       310        320        330        340        350        360 
GDITFDSATS FWGTNLTIAV LNGTVPQWRV DDMAVRIMAA YYKVGRDRLY QPPNFSSWTR 

       370        380        390        400        410        420 
DEYGFKYFYP QEGPYEKVNH FVNVQRNHSE VIRKLGADST VLLKNNNALP LTGKERKVAI 

       430        440        450        460        470        480 
LGEDAGSNSY GANGCSDRGC DNGTLAMAWG SGTAEFPYLV TPEQAIQAEV LKHKGSVYAI 

       490        500        510        520        530        540 
TDNWALSQVE TLAKQASVSL VFVNSDAGEG YISVDGNEGD RNNLTLWKNG DNLIKAAANN 

       550        560        570        580        590        600 
CNNTIVVIHS VGPVLVDEWY DHPNVTAILW AGLPGQESGN SLADVLYGRV NPGAKSPFTW 

       610        620        630        640        650        660 
GKTREAYGDY LVRELNNGNG APQDDFSEGV FIDYRGFDKR NETPIYEFGH GLSYTTFNYS 

       670        680        690        700        710        720 
GLHIQVLNAS SNAQVATETG AAPTFGQVGN ASDYVYPEGL TRISKFIYPW LNSTDLKASS 

       730        740        750        760        770        780 
GDPYYGVDTA EHVPEGATDG SPQPVLPAGG GSGGNPRLYD ELIRVSVTVK NTGRVAGDAV 

       790        800        810        820        830        840 
PQLYVSLGGP NEPKVVLRKF DRLTLKPSEE TVWTTTLTRR DLSNWDVAAQ DWVITSYPKK 

       850        860 
VHVGSSSRQL PLHAALPKVQ 

« Hide

References

[1]"Cloning and sequencing of the cDNA encoding beta-glucosidase 1 from Aspergillus aculeatus."
Kawaguchi T., Enoki T., Tsurumaki S., Sumitani J., Ueda M., Ooi T., Arai M.
Gene 173:287-288(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: F-50.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D64088 mRNA. Translation: BAA10968.1.
PIRJC4939.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4IIBX-ray1.80A/B20-860[»]
4IICX-ray1.90A/B20-860[»]
4IIDX-ray2.30A/B20-860[»]
4IIEX-ray2.00A/B20-860[»]
4IIFX-ray2.45A/B20-860[»]
4IIGX-ray2.30A/B20-860[»]
4IIHX-ray2.00A/B20-860[»]
ProteinModelPortalP48825.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP48825.
ChEMBLCHEMBL3493.

Protein family/group databases

CAZyGH3. Glycoside Hydrolase Family 3.
mycoCLAPBGL3A_ASPAC.
BGL3A_ASPSA.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00696.

Family and domain databases

Gene3D3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR30620. PTHR30620. 1 hit.
PfamPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSPR00133. GLHYDRLASE3.
SUPFAMSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
PROSITEPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGL1_ASPAC
AccessionPrimary (citable) accession number: P48825
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 22, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries