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P48823

- HEXA_PSEO7

UniProt

P48823 - HEXA_PSEO7

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Protein

Beta-hexosaminidase A

Gene
cht60
Organism
Pseudoalteromonas piscicida
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Most active towards p-nitrophenyl-N-acetyl-beta-D-glucosaminide(PNP-beta-GlcNAc) and diacetylchitobiose.

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

pH dependencei

Optimum pH is 7.5.

Temperature dependencei

Optimum temperature is 37 degrees Celsius.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei305 – 3051 By similarity

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase A (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase
Chitobiase
N-acetyl-beta-glucosaminidase
Gene namesi
Name:cht60
OrganismiPseudoalteromonas piscicida
Taxonomic identifieri43662 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 11111 PublicationAdd
BLAST
Chaini12 – 598587Beta-hexosaminidase APRO_0000011784Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP48823.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
InterProiIPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48823-1 [UniParc]FASTAAdd to Basket

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MSFITSAHAT AAQVPLTTSQ MLGQKLMLDF RYYCGESKKP SGDCRAAMTT    50
LPPELSELIS RYDIGGAILF AENVQNTAQI ISLTNALQSA AQQSKSQLPL 100
FIAIDQEGGR VARINREQAT SFTGNMSIGA TYPKQGDIYA TKVASAIGKE 150
LNSLGINVNF APTVDVNSNP NNPVINVRSF SENPTVVTKL GLAQVKAFEA 200
AGVLSALKHF PGHGDTHVDS HTGLPRVDHD RDKINQQDLL PFAEIIKASP 250
PGMIMTAHIQ YPALDNSKVV NSQGESMIRP ATMSYQIMTQ LLRHELGYQG 300
VTVTDALDMA GISDFFNPVD ATIETFNAGV DIALMPIAIR NRADIKRFEQ 350
YMAQLADALE TNKLNQEQLS SSMARIAKLK TKLPQSSASL AIANSTLGNP 400
SHRRLEAELA LAAITEVKND GVLPLRDNAQ VVHLIMPDRQ KCFALEQALQ 450
TYSKNSLTLS CTSLQAYDPD IAHDAIKQAD MIIAAHASPP QSAVEIGGMD 500
DVKKLREHGV ARNVQPAALK ALLQYGQQQG KKQLFISLRA PYEISTFGPL 550
SNAVLASYAY NVDVNHDKKV AGPAYTALAK VILGIAKAEG SLPVTVNH 598
Length:598
Mass (Da):64,539
Last modified:February 1, 1996 - v1
Checksum:i5131B17B84DA9688
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D17399 Genomic DNA. Translation: BAA04223.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D17399 Genomic DNA. Translation: BAA04223.1 .

3D structure databases

ProteinModelPortali P48823.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
InterProi IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00933. Glyco_hydro_3. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene sequence, purification and characterization of N-acetyl-beta-glucosaminidase from a marine bacterium, Alteromonas sp. strain O-7."
    Tsujibo H., Fujimoto K., Tanno H., Miyamoto K., Imada C., Okami Y., Inamori Y.
    Gene 146:111-115(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 12-22.
    Strain: O-7.

Entry informationi

Entry nameiHEXA_PSEO7
AccessioniPrimary (citable) accession number: P48823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 16, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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