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P48823

- HEXA_PSEO7

UniProt

P48823 - HEXA_PSEO7

Protein

Beta-hexosaminidase A

Gene

cht60

Organism
Pseudoalteromonas piscicida
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Most active towards p-nitrophenyl-N-acetyl-beta-D-glucosaminide(PNP-beta-GlcNAc) and diacetylchitobiose.

    Catalytic activityi

    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

    pH dependencei

    Optimum pH is 7.5.

    Temperature dependencei

    Optimum temperature is 37 degrees Celsius.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei305 – 3051By similarity

    GO - Molecular functioni

    1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH3. Glycoside Hydrolase Family 3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-hexosaminidase A (EC:3.2.1.52)
    Alternative name(s):
    Beta-N-acetylhexosaminidase
    Chitobiase
    N-acetyl-beta-glucosaminidase
    Gene namesi
    Name:cht60
    OrganismiPseudoalteromonas piscicida
    Taxonomic identifieri43662 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 11111 PublicationAdd
    BLAST
    Chaini12 – 598587Beta-hexosaminidase APRO_0000011784Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP48823.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    InterProiIPR019800. Glyco_hydro_3_AS.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00933. Glyco_hydro_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48823-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFITSAHAT AAQVPLTTSQ MLGQKLMLDF RYYCGESKKP SGDCRAAMTT    50
    LPPELSELIS RYDIGGAILF AENVQNTAQI ISLTNALQSA AQQSKSQLPL 100
    FIAIDQEGGR VARINREQAT SFTGNMSIGA TYPKQGDIYA TKVASAIGKE 150
    LNSLGINVNF APTVDVNSNP NNPVINVRSF SENPTVVTKL GLAQVKAFEA 200
    AGVLSALKHF PGHGDTHVDS HTGLPRVDHD RDKINQQDLL PFAEIIKASP 250
    PGMIMTAHIQ YPALDNSKVV NSQGESMIRP ATMSYQIMTQ LLRHELGYQG 300
    VTVTDALDMA GISDFFNPVD ATIETFNAGV DIALMPIAIR NRADIKRFEQ 350
    YMAQLADALE TNKLNQEQLS SSMARIAKLK TKLPQSSASL AIANSTLGNP 400
    SHRRLEAELA LAAITEVKND GVLPLRDNAQ VVHLIMPDRQ KCFALEQALQ 450
    TYSKNSLTLS CTSLQAYDPD IAHDAIKQAD MIIAAHASPP QSAVEIGGMD 500
    DVKKLREHGV ARNVQPAALK ALLQYGQQQG KKQLFISLRA PYEISTFGPL 550
    SNAVLASYAY NVDVNHDKKV AGPAYTALAK VILGIAKAEG SLPVTVNH 598
    Length:598
    Mass (Da):64,539
    Last modified:February 1, 1996 - v1
    Checksum:i5131B17B84DA9688
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17399 Genomic DNA. Translation: BAA04223.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17399 Genomic DNA. Translation: BAA04223.1 .

    3D structure databases

    ProteinModelPortali P48823.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH3. Glycoside Hydrolase Family 3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    InterProi IPR019800. Glyco_hydro_3_AS.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00933. Glyco_hydro_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene sequence, purification and characterization of N-acetyl-beta-glucosaminidase from a marine bacterium, Alteromonas sp. strain O-7."
      Tsujibo H., Fujimoto K., Tanno H., Miyamoto K., Imada C., Okami Y., Inamori Y.
      Gene 146:111-115(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 12-22.
      Strain: O-7.

    Entry informationi

    Entry nameiHEXA_PSEO7
    AccessioniPrimary (citable) accession number: P48823
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3