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P48823

- HEXA_PSEO7

UniProt

P48823 - HEXA_PSEO7

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Protein

Beta-hexosaminidase A

Gene

cht60

Organism
Pseudoalteromonas piscicida
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Most active towards p-nitrophenyl-N-acetyl-beta-D-glucosaminide(PNP-beta-GlcNAc) and diacetylchitobiose.

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

pH dependencei

Optimum pH is 7.5.

Temperature dependencei

Optimum temperature is 37 degrees Celsius.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei305 – 3051By similarity

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase A (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase
Chitobiase
N-acetyl-beta-glucosaminidase
Gene namesi
Name:cht60
OrganismiPseudoalteromonas piscicida
Taxonomic identifieri43662 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 11111 PublicationAdd
BLAST
Chaini12 – 598587Beta-hexosaminidase APRO_0000011784Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP48823.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
InterProiIPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48823-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFITSAHAT AAQVPLTTSQ MLGQKLMLDF RYYCGESKKP SGDCRAAMTT
60 70 80 90 100
LPPELSELIS RYDIGGAILF AENVQNTAQI ISLTNALQSA AQQSKSQLPL
110 120 130 140 150
FIAIDQEGGR VARINREQAT SFTGNMSIGA TYPKQGDIYA TKVASAIGKE
160 170 180 190 200
LNSLGINVNF APTVDVNSNP NNPVINVRSF SENPTVVTKL GLAQVKAFEA
210 220 230 240 250
AGVLSALKHF PGHGDTHVDS HTGLPRVDHD RDKINQQDLL PFAEIIKASP
260 270 280 290 300
PGMIMTAHIQ YPALDNSKVV NSQGESMIRP ATMSYQIMTQ LLRHELGYQG
310 320 330 340 350
VTVTDALDMA GISDFFNPVD ATIETFNAGV DIALMPIAIR NRADIKRFEQ
360 370 380 390 400
YMAQLADALE TNKLNQEQLS SSMARIAKLK TKLPQSSASL AIANSTLGNP
410 420 430 440 450
SHRRLEAELA LAAITEVKND GVLPLRDNAQ VVHLIMPDRQ KCFALEQALQ
460 470 480 490 500
TYSKNSLTLS CTSLQAYDPD IAHDAIKQAD MIIAAHASPP QSAVEIGGMD
510 520 530 540 550
DVKKLREHGV ARNVQPAALK ALLQYGQQQG KKQLFISLRA PYEISTFGPL
560 570 580 590
SNAVLASYAY NVDVNHDKKV AGPAYTALAK VILGIAKAEG SLPVTVNH
Length:598
Mass (Da):64,539
Last modified:February 1, 1996 - v1
Checksum:i5131B17B84DA9688
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17399 Genomic DNA. Translation: BAA04223.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17399 Genomic DNA. Translation: BAA04223.1 .

3D structure databases

ProteinModelPortali P48823.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
InterProi IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00933. Glyco_hydro_3. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene sequence, purification and characterization of N-acetyl-beta-glucosaminidase from a marine bacterium, Alteromonas sp. strain O-7."
    Tsujibo H., Fujimoto K., Tanno H., Miyamoto K., Imada C., Okami Y., Inamori Y.
    Gene 146:111-115(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 12-22.
    Strain: O-7.

Entry informationi

Entry nameiHEXA_PSEO7
AccessioniPrimary (citable) accession number: P48823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3