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P48816

- LYS_BOMMO

UniProt

P48816 - LYS_BOMMO

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Protein

Lysozyme

Gene
N/A
Organism
Bombyx mori (Silk moth)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Active against E.coli and M.luteus.1 PublicationPROSITE-ProRule annotation

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei50 – 501PROSITE-ProRule annotation
Active sitei67 – 671PROSITE-ProRule annotation

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase
OrganismiBombyx mori (Silk moth)
Taxonomic identifieri7091 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaBombycidaeBombycinaeBombyx
ProteomesiUP000005204: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 137119LysozymePRO_0000018505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 137PROSITE-ProRule annotation
Disulfide bondi45 ↔ 127PROSITE-ProRule annotation
Disulfide bondi79 ↔ 93PROSITE-ProRule annotation
Disulfide bondi89 ↔ 107PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Developmental stagei

Expressed within 6 hours after induction, reaches maximum levels after 48 hours and declines after 72 hours after induction.

Inductioni

By bacterial infection.

Structurei

Secondary structure

1
137
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi23 – 3210Combined sources
Helixi37 – 393Combined sources
Helixi40 – 5011Combined sources
Turni51 – 533Combined sources
Beta strandi58 – 603Combined sources
Beta strandi66 – 683Combined sources
Turni69 – 724Combined sources
Turni75 – 784Combined sources
Beta strandi80 – 845Combined sources
Turni87 – 904Combined sources
Helixi93 – 964Combined sources
Beta strandi97 – 993Combined sources
Helixi102 – 11514Combined sources
Helixi116 – 1194Combined sources
Helixi121 – 1244Combined sources
Beta strandi127 – 1293Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GD6X-ray2.50A19-137[»]
2RSCNMR-A19-137[»]
ProteinModelPortaliP48816.
SMRiP48816. Positions 19-137.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48816.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiP48816.
KOiK13915.
OMAiEDDIRCA.
OrthoDBiEOG7BW0M5.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48816-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQKLIIFALV VLCVGSEAKT FTRCGLVHEL RKHGFEENLM RNWVCLVEHE
60 70 80 90 100
SSRDTSKTNT NRNGSKDYGL FQINDRYWCS KGASPGKDCN VKCSDLLTDD
110 120 130
ITKAAKCAKK IYKRHRFDAW YGWKNHCQGS LPDISSC
Length:137
Mass (Da):15,668
Last modified:February 1, 1996 - v1
Checksum:iFFE5710506C61A1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37416 mRNA. Translation: AAB40947.1.
PIRiJC4233.
RefSeqiNP_001037448.1. NM_001043983.1.
UniGeneiBmo.2011.
Bmo.2379.

Genome annotation databases

EnsemblMetazoaiBGIBMGA010439-RA; BGIBMGA010439-TA; BGIBMGA010439.
GeneIDi693015.
KEGGibmor:693015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37416 mRNA. Translation: AAB40947.1 .
PIRi JC4233.
RefSeqi NP_001037448.1. NM_001043983.1.
UniGenei Bmo.2011.
Bmo.2379.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1GD6 X-ray 2.50 A 19-137 [» ]
2RSC NMR - A 19-137 [» ]
ProteinModelPortali P48816.
SMRi P48816. Positions 19-137.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH22. Glycoside Hydrolase Family 22.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai BGIBMGA010439-RA ; BGIBMGA010439-TA ; BGIBMGA010439 .
GeneIDi 693015.
KEGGi bmor:693015.

Organism-specific databases

CTDi 693015.

Phylogenomic databases

InParanoidi P48816.
KOi K13915.
OMAi EDDIRCA.
OrthoDBi EOG7BW0M5.

Miscellaneous databases

EvolutionaryTracei P48816.

Family and domain databases

InterProi IPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view ]
Pfami PF00062. Lys. 1 hit.
[Graphical view ]
PRINTSi PR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTi SM00263. LYZ1. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
PROSITEi PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of the lysozyme-encoding gene from the silkworm Bombyx mori."
    Lee W.J., Brey P.T.
    Gene 161:199-203(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fat body.
  2. "Purification and partial characterization of an induced antibacterial protein in the silkworm, Bombyx mori."
    Abraham E.G., Nagaraju J., Salunke D., Gupta H.M., Datta R.K.
    J. Invertebr. Pathol. 65:17-24(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-38, FUNCTION.
    Strain: NB18.
    Tissue: Larval hemolymph.

Entry informationi

Entry nameiLYS_BOMMO
AccessioniPrimary (citable) accession number: P48816
Secondary accession number(s): Q9TWL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3