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P48816 (LYS_BOMMO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme

EC=3.2.1.17
Alternative name(s):
1,4-beta-N-acetylmuramidase
OrganismBombyx mori (Silk moth) [Reference proteome]
Taxonomic identifier7091 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaBombycidaeBombycinaeBombyx

Protein attributes

Sequence length137 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Active against E.coli and M.luteus. Ref.2

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Developmental stage

Expressed within 6 hours after induction, reaches maximum levels after 48 hours and declines after 72 hours after induction.

Induction

By bacterial infection.

Sequence similarities

Belongs to the glycosyl hydrolase 22 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Ref.2
Chain19 – 137119Lysozyme
PRO_0000018505

Sites

Active site501 By similarity
Active site671 By similarity

Amino acid modifications

Disulfide bond24 ↔ 137 By similarity
Disulfide bond45 ↔ 127 By similarity
Disulfide bond79 ↔ 93 By similarity
Disulfide bond89 ↔ 107 By similarity

Secondary structure

............................ 137
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P48816 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: FFE5710506C61A1D

FASTA13715,668
        10         20         30         40         50         60 
MQKLIIFALV VLCVGSEAKT FTRCGLVHEL RKHGFEENLM RNWVCLVEHE SSRDTSKTNT 

        70         80         90        100        110        120 
NRNGSKDYGL FQINDRYWCS KGASPGKDCN VKCSDLLTDD ITKAAKCAKK IYKRHRFDAW 

       130 
YGWKNHCQGS LPDISSC 

« Hide

References

[1]"Isolation and characterization of the lysozyme-encoding gene from the silkworm Bombyx mori."
Lee W.J., Brey P.T.
Gene 161:199-203(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fat body.
[2]"Purification and partial characterization of an induced antibacterial protein in the silkworm, Bombyx mori."
Abraham E.G., Nagaraju J., Salunke D., Gupta H.M., Datta R.K.
J. Invertebr. Pathol. 65:17-24(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 19-38, FUNCTION.
Strain: NB18.
Tissue: Larval hemolymph.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L37416 mRNA. Translation: AAB40947.1.
PIRJC4233.
RefSeqNP_001037448.1. NM_001043983.1.
UniGeneBmo.2011.
Bmo.2379.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1GD6X-ray2.50A19-137[»]
2RSCNMR-A19-137[»]
ProteinModelPortalP48816.
SMRP48816. Positions 19-137.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH22. Glycoside Hydrolase Family 22.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaBGIBMGA010439-RA; BGIBMGA010439-TA; BGIBMGA010439.
GeneID693015.
KEGGbmor:693015.

Organism-specific databases

CTD693015.

Phylogenomic databases

KOK13915.
OMAEDDIRCA.
OrthoDBEOG7BW0M5.

Family and domain databases

InterProIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamPF00062. Lys. 1 hit.
[Graphical view]
PRINTSPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMSSF53955. SSF53955. 1 hit.
PROSITEPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP48816.

Entry information

Entry nameLYS_BOMMO
AccessionPrimary (citable) accession number: P48816
Secondary accession number(s): Q9TWL7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries