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P48816

- LYS_BOMMO

UniProt

P48816 - LYS_BOMMO

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Protein
Lysozyme
Gene
N/A
Organism
Bombyx mori (Silk moth)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Active against E.coli and M.luteus.1 Publication

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei50 – 501 By similarity
Active sitei67 – 671 By similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase
OrganismiBombyx mori (Silk moth)
Taxonomic identifieri7091 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaBombycidaeBombycinaeBombyx
ProteomesiUP000005204: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 Publication
Add
BLAST
Chaini19 – 137119Lysozyme
PRO_0000018505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 137 By similarity
Disulfide bondi45 ↔ 127 By similarity
Disulfide bondi79 ↔ 93 By similarity
Disulfide bondi89 ↔ 107 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Developmental stagei

Expressed within 6 hours after induction, reaches maximum levels after 48 hours and declines after 72 hours after induction.

Inductioni

By bacterial infection.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi23 – 3210
Helixi37 – 393
Helixi40 – 5011
Turni51 – 533
Beta strandi58 – 603
Beta strandi66 – 683
Turni69 – 724
Turni75 – 784
Beta strandi80 – 845
Turni87 – 904
Helixi93 – 964
Beta strandi97 – 993
Helixi102 – 11514
Helixi116 – 1194
Helixi121 – 1244
Beta strandi127 – 1293

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GD6X-ray2.50A19-137[»]
2RSCNMR-A19-137[»]
ProteinModelPortaliP48816.
SMRiP48816. Positions 19-137.

Miscellaneous databases

EvolutionaryTraceiP48816.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

KOiK13915.
OMAiEDDIRCA.
OrthoDBiEOG7BW0M5.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48816-1 [UniParc]FASTAAdd to Basket

« Hide

MQKLIIFALV VLCVGSEAKT FTRCGLVHEL RKHGFEENLM RNWVCLVEHE    50
SSRDTSKTNT NRNGSKDYGL FQINDRYWCS KGASPGKDCN VKCSDLLTDD 100
ITKAAKCAKK IYKRHRFDAW YGWKNHCQGS LPDISSC 137
Length:137
Mass (Da):15,668
Last modified:February 1, 1996 - v1
Checksum:iFFE5710506C61A1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37416 mRNA. Translation: AAB40947.1.
PIRiJC4233.
RefSeqiNP_001037448.1. NM_001043983.1.
UniGeneiBmo.2011.
Bmo.2379.

Genome annotation databases

EnsemblMetazoaiBGIBMGA010439-RA; BGIBMGA010439-TA; BGIBMGA010439.
GeneIDi693015.
KEGGibmor:693015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37416 mRNA. Translation: AAB40947.1 .
PIRi JC4233.
RefSeqi NP_001037448.1. NM_001043983.1.
UniGenei Bmo.2011.
Bmo.2379.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1GD6 X-ray 2.50 A 19-137 [» ]
2RSC NMR - A 19-137 [» ]
ProteinModelPortali P48816.
SMRi P48816. Positions 19-137.
ModBasei Search...

Protein family/group databases

CAZyi GH22. Glycoside Hydrolase Family 22.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai BGIBMGA010439-RA ; BGIBMGA010439-TA ; BGIBMGA010439 .
GeneIDi 693015.
KEGGi bmor:693015.

Organism-specific databases

CTDi 693015.

Phylogenomic databases

KOi K13915.
OMAi EDDIRCA.
OrthoDBi EOG7BW0M5.

Miscellaneous databases

EvolutionaryTracei P48816.

Family and domain databases

InterProi IPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view ]
Pfami PF00062. Lys. 1 hit.
[Graphical view ]
PRINTSi PR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTi SM00263. LYZ1. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
PROSITEi PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of the lysozyme-encoding gene from the silkworm Bombyx mori."
    Lee W.J., Brey P.T.
    Gene 161:199-203(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fat body.
  2. "Purification and partial characterization of an induced antibacterial protein in the silkworm, Bombyx mori."
    Abraham E.G., Nagaraju J., Salunke D., Gupta H.M., Datta R.K.
    J. Invertebr. Pathol. 65:17-24(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-38, FUNCTION.
    Strain: NB18.
    Tissue: Larval hemolymph.

Entry informationi

Entry nameiLYS_BOMMO
AccessioniPrimary (citable) accession number: P48816
Secondary accession number(s): Q9TWL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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