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P48816

- LYS_BOMMO

UniProt

P48816 - LYS_BOMMO

Protein

Lysozyme

Gene
N/A
Organism
Bombyx mori (Silk moth)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Active against E.coli and M.luteus.1 PublicationPROSITE-ProRule annotation

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei50 – 501PROSITE-ProRule annotation
    Active sitei67 – 671PROSITE-ProRule annotation

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH22. Glycoside Hydrolase Family 22.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme (EC:3.2.1.17)
    Alternative name(s):
    1,4-beta-N-acetylmuramidase
    OrganismiBombyx mori (Silk moth)
    Taxonomic identifieri7091 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaBombycidaeBombycinaeBombyx
    ProteomesiUP000005204: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 18181 PublicationAdd
    BLAST
    Chaini19 – 137119LysozymePRO_0000018505Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 137PROSITE-ProRule annotation
    Disulfide bondi45 ↔ 127PROSITE-ProRule annotation
    Disulfide bondi79 ↔ 93PROSITE-ProRule annotation
    Disulfide bondi89 ↔ 107PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Developmental stagei

    Expressed within 6 hours after induction, reaches maximum levels after 48 hours and declines after 72 hours after induction.

    Inductioni

    By bacterial infection.

    Structurei

    Secondary structure

    1
    137
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi23 – 3210
    Helixi37 – 393
    Helixi40 – 5011
    Turni51 – 533
    Beta strandi58 – 603
    Beta strandi66 – 683
    Turni69 – 724
    Turni75 – 784
    Beta strandi80 – 845
    Turni87 – 904
    Helixi93 – 964
    Beta strandi97 – 993
    Helixi102 – 11514
    Helixi116 – 1194
    Helixi121 – 1244
    Beta strandi127 – 1293

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1GD6X-ray2.50A19-137[»]
    2RSCNMR-A19-137[»]
    ProteinModelPortaliP48816.
    SMRiP48816. Positions 19-137.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP48816.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    KOiK13915.
    OMAiEDDIRCA.
    OrthoDBiEOG7BW0M5.

    Family and domain databases

    InterProiIPR001916. Glyco_hydro_22.
    IPR019799. Glyco_hydro_22_CS.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view]
    PfamiPF00062. Lys. 1 hit.
    [Graphical view]
    PRINTSiPR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTiSM00263. LYZ1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.
    PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
    PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48816-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKLIIFALV VLCVGSEAKT FTRCGLVHEL RKHGFEENLM RNWVCLVEHE    50
    SSRDTSKTNT NRNGSKDYGL FQINDRYWCS KGASPGKDCN VKCSDLLTDD 100
    ITKAAKCAKK IYKRHRFDAW YGWKNHCQGS LPDISSC 137
    Length:137
    Mass (Da):15,668
    Last modified:February 1, 1996 - v1
    Checksum:iFFE5710506C61A1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37416 mRNA. Translation: AAB40947.1.
    PIRiJC4233.
    RefSeqiNP_001037448.1. NM_001043983.1.
    UniGeneiBmo.2011.
    Bmo.2379.

    Genome annotation databases

    EnsemblMetazoaiBGIBMGA010439-RA; BGIBMGA010439-TA; BGIBMGA010439.
    GeneIDi693015.
    KEGGibmor:693015.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37416 mRNA. Translation: AAB40947.1 .
    PIRi JC4233.
    RefSeqi NP_001037448.1. NM_001043983.1.
    UniGenei Bmo.2011.
    Bmo.2379.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1GD6 X-ray 2.50 A 19-137 [» ]
    2RSC NMR - A 19-137 [» ]
    ProteinModelPortali P48816.
    SMRi P48816. Positions 19-137.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH22. Glycoside Hydrolase Family 22.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai BGIBMGA010439-RA ; BGIBMGA010439-TA ; BGIBMGA010439 .
    GeneIDi 693015.
    KEGGi bmor:693015.

    Organism-specific databases

    CTDi 693015.

    Phylogenomic databases

    KOi K13915.
    OMAi EDDIRCA.
    OrthoDBi EOG7BW0M5.

    Miscellaneous databases

    EvolutionaryTracei P48816.

    Family and domain databases

    InterProi IPR001916. Glyco_hydro_22.
    IPR019799. Glyco_hydro_22_CS.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view ]
    Pfami PF00062. Lys. 1 hit.
    [Graphical view ]
    PRINTSi PR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTi SM00263. LYZ1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    PROSITEi PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
    PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the lysozyme-encoding gene from the silkworm Bombyx mori."
      Lee W.J., Brey P.T.
      Gene 161:199-203(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fat body.
    2. "Purification and partial characterization of an induced antibacterial protein in the silkworm, Bombyx mori."
      Abraham E.G., Nagaraju J., Salunke D., Gupta H.M., Datta R.K.
      J. Invertebr. Pathol. 65:17-24(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 19-38, FUNCTION.
      Strain: NB18.
      Tissue: Larval hemolymph.

    Entry informationi

    Entry nameiLYS_BOMMO
    AccessioniPrimary (citable) accession number: P48816
    Secondary accession number(s): Q9TWL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3