Reviewed, UniProtKB/Swiss-Prot P48815 (ADH2_CERCA)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase 2
    EC=1.1.1.1

Gene names

Name:

ADH2

Organism

Ceratitis capitata (Mediterranean fruit fly)

Taxonomic identifier

7213 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Tephritoidea › Tephritidae › Ceratitis › Ceratitis

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: InterPro binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Alcohol dehydrogenase 2		PRO_0000054449
Regions
	Nucleotide binding	9 – 33	25	NAD By similarity
Sites
	Active site	150	1	Proton acceptor By similarity
	Binding site	137	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P48815-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: C9C758B128775FCE	FASTA	258	27,936
	10 20 30 40 50 60 MGLSGKNVIF VGGLGFIGYE ACKQLMAKNM ASFFVFDVLD KPENIKALQA LNPKTKVYYT 70 80 90 100 110 120 KFDITSKQSI KSALADVVAK VKYIDALING AGILTDPNVE LTMNINLIGL INTTLEGLPL 130 140 150 160 170 180 MDKNKQGRGG VIVNIASVLG LEPCPPAAVY CASKFGVMGF SRSIGDPYYY NITGVAVVTF 190 200 210 220 230 240 CPGLTETPLK NNIGSKYTFE YSKKISEELN STKTQKPEVC GAHLAQVVES HENGGIYISN 250 QGTLAKVTPT VYWQPTYH

References

[1]

"Acquisition of a potential marker for insect transformation: isolation of a novel alcohol dehydrogenase gene from Bactrocera oleae by functional complementation in yeast." Benos P., Tavernarakis N., Brogna S., Thireos G., Savakis C. Mol. Gen. Genet. 263:90-95(2000) [PubMed: 10732677] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Benakeion.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z30195 Genomic DNA. Translation: CAA82927.1.
PIR	S46935.
3D structure databases
HSSP	HSSP built from PDB template 1B16 based on UniProtKB P10807.
ModBase	Search...
Family and domain databases
InterPro	IPR002426. Ceratitis_AlcDHase. IPR002198. DHase_sc/Rdtase_SDR. IPR002424. Insect_AlcDHase_fam. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01169. CERATITISADH. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH2_CERCA

Accession

Primary (citable) accession number: P48815

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 25, 2008
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)