P48814 (ADH1_CERCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase 1
EC=1.1.1.1

Gene names

Name:

ADH1

Organism

Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata)

Taxonomic identifier

7213 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Tephritoidea › Tephritidae › Ceratitis › Ceratitis

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Molecular function	alcohol dehydrogenase (NAD) activity Inferred from direct assay. Source: UniProtKB nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Alcohol dehydrogenase 1		PRO_0000054448
Regions
	Nucleotide binding	9 – 33	25	NAD By similarity
Sites
	Active site	150	1	Proton acceptor By similarity
	Binding site	137	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P48814 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 043F39AC1E09CACE	FASTA	257	27,922
	10 20 30 40 50 60 MSLAGKNVVF VGGLGFIAYE ACKYLMNNDL ASLFVFDVLD KPEAIKALQE INPKTKVYYT 70 80 90 100 110 120 KFDITNKESI KQSLADVISK VQHIDALING AGILTDPNVE LTMNINLIGL INTTLEALPL 130 140 150 160 170 180 MDKNKHGRGG VIVNIASVLG LEPCPPAAVY CASKFGVVGF SRSLGDPFYY EHTGVAVVTF 190 200 210 220 230 240 CPGLTDTPLK NNIGSKYTFD YSKEIGEKLN SSKTQKPEVC GAHLAQAIEL MDNGAIYISN 250 QGTLTKVKPS VYWEPTY

References

[1]	"Acquisition of a potential marker for insect transformation: isolation of a novel alcohol dehydrogenase gene from Bactrocera oleae by functional complementation in yeast." Benos P., Tavernarakis N., Brogna S., Thireos G., Savakis C. Mol. Gen. Genet. 263:90-95(2000) [PubMed: 10732677] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Benakeion.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z30194 Genomic DNA. Translation: CAA82926.1.
3D structure databases
ProteinModelPortal	P48814.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002426. ADH_Ceratitis-type. IPR002424. ADH_insect. IPR002198. DH_sc/Rdtase_SDR. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01169. CERATITISADH. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH1_CERCA

Accession

Primary (citable) accession number: P48814

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	December 14, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)