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Protein

Heterogeneous nuclear ribonucleoprotein 27C

Gene

Hrb27C

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a component of ribonucleosomes. Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle.

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: FlyBase
  • mRNA 5'-UTR binding Source: FlyBase
  • mRNA binding Source: FlyBase
  • nucleotide binding Source: InterPro
  • single-stranded DNA binding Source: FlyBase

GO - Biological processi

  • axon guidance Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • lateral inhibition Source: FlyBase
  • negative regulation of oskar mRNA translation Source: FlyBase
  • pole plasm oskar mRNA localization Source: FlyBase
  • positive regulation of translation Source: FlyBase
  • regulation of mRNA splicing, via spliceosome Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein 27C
Short name:
Hrb27-C
Alternative name(s):
HRP48.1
hnRNP 48
Gene namesi
Name:Hrb27C
Synonyms:hrp48, Rbp7
ORF Names:CG10377
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0004838. Hrb27C.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • intracellular ribonucleoprotein complex Source: FlyBase
  • nucleoplasm Source: FlyBase
  • nucleus Source: FlyBase
  • P granule Source: FlyBase
  • protein complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817481 – 421Heterogeneous nuclear ribonucleoprotein 27CAdd BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei177Phosphoserine1 Publication1
Modified residuei366Phosphoserine1 Publication1
Modified residuei368Phosphoserine1 Publication1
Modified residuei370Phosphoserine1 Publication1
Modified residuei372Phosphotyrosine1 Publication1
Modified residuei379Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP48809.
PRIDEiP48809.

PTM databases

iPTMnetiP48809.

Expressioni

Gene expression databases

BgeeiFBgn0004838.
ExpressionAtlasiP48809. baseline.
GenevisibleiP48809. DM.

Interactioni

Protein-protein interaction databases

BioGridi60119. 19 interactors.
IntActiP48809. 8 interactors.
MINTiMINT-939547.
STRINGi7227.FBpp0297875.

Structurei

3D structure databases

ProteinModelPortaliP48809.
SMRiP48809.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 88RRM 1PROSITE-ProRule annotationAdd BLAST82
Domaini96 – 173RRM 2PROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4205. Eukaryota.
ENOG410YA8Z. LUCA.
GeneTreeiENSGT00760000118873.
InParanoidiP48809.
KOiK14411.
OMAiNTNSARN.
OrthoDBiEOG091G1CPI.
PhylomeDBiP48809.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEDERGKLF VGGLSWETTQ ENLSRYFCRF GDIIDCVVMK NNESGRSRGF
60 70 80 90 100
GFVTFADPTN VNHVLQNGPH TLDGRTIDPK PCNPRTLQKP KKGGGYKVFL
110 120 130 140 150
GGLPSNVTET DLRTFFNRYG KVTEVVIMYD QEKKKSRGFG FLSFEEESSV
160 170 180 190 200
EHVTNERYIN LNGKQVEIKK AEPRDGSGGQ NSNNSTVGGA YGKLGNECSH
210 220 230 240 250
WGPHHAPINM MQGQNGQMGG PPLNMPIGAP NMMPGYQGWG TSPQQQQYGY
260 270 280 290 300
GNSGPGSYQG WGAPPGPQGP PPQWSNYAGP QQTQGYGGYD MYNSTSTGAP
310 320 330 340 350
SGPSGGGSWN SWNMPPNSAG PTGAPGAGAG TATDMYSRAQ AWATGGPSTT
360 370 380 390 400
GPVGGMPRTG PGNSASKSGS EYDYGGYGSG YDYDYSNYVK QEGASNYGAG
410 420
PRSAYGNDSS TQPPYATSQA V
Length:421
Mass (Da):44,770
Last modified:September 27, 2005 - v2
Checksum:iD59DD2A647CE23F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti262 – 297Missing in CAA44505 (PubMed:1730754).CuratedAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62639 mRNA. Translation: CAA44505.1.
DQ062784 mRNA. Translation: AAY56657.1.
AE014134 Genomic DNA. Translation: AAF52456.1.
AE014134 Genomic DNA. Translation: AAF52457.1.
AE014134 Genomic DNA. Translation: AAN10605.1.
AY069699 mRNA. Translation: AAL39844.1.
AY128430 mRNA. Translation: AAM75023.1.
S51720 mRNA. Translation: AAB24628.1.
PIRiD41732.
RefSeqiNP_001162897.1. NM_001169426.2.
NP_001162898.1. NM_001169427.2.
NP_001245917.1. NM_001258988.2.
NP_001245918.1. NM_001258989.2.
NP_001245919.1. NM_001258990.2.
NP_476869.1. NM_057521.6.
NP_723228.1. NM_164720.4.
NP_723229.1. NM_164721.3.
UniGeneiDm.1997.

Genome annotation databases

EnsemblMetazoaiFBtr0079346; FBpp0078974; FBgn0004838.
FBtr0079347; FBpp0078975; FBgn0004838.
FBtr0079348; FBpp0078976; FBgn0004838.
FBtr0301403; FBpp0290617; FBgn0004838.
FBtr0301404; FBpp0290618; FBgn0004838.
FBtr0307030; FBpp0297873; FBgn0004838.
FBtr0307031; FBpp0297874; FBgn0004838.
FBtr0307032; FBpp0297875; FBgn0004838.
GeneIDi33968.
KEGGidme:Dmel_CG10377.
UCSCiCG10377-RB. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62639 mRNA. Translation: CAA44505.1.
DQ062784 mRNA. Translation: AAY56657.1.
AE014134 Genomic DNA. Translation: AAF52456.1.
AE014134 Genomic DNA. Translation: AAF52457.1.
AE014134 Genomic DNA. Translation: AAN10605.1.
AY069699 mRNA. Translation: AAL39844.1.
AY128430 mRNA. Translation: AAM75023.1.
S51720 mRNA. Translation: AAB24628.1.
PIRiD41732.
RefSeqiNP_001162897.1. NM_001169426.2.
NP_001162898.1. NM_001169427.2.
NP_001245917.1. NM_001258988.2.
NP_001245918.1. NM_001258989.2.
NP_001245919.1. NM_001258990.2.
NP_476869.1. NM_057521.6.
NP_723228.1. NM_164720.4.
NP_723229.1. NM_164721.3.
UniGeneiDm.1997.

3D structure databases

ProteinModelPortaliP48809.
SMRiP48809.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60119. 19 interactors.
IntActiP48809. 8 interactors.
MINTiMINT-939547.
STRINGi7227.FBpp0297875.

PTM databases

iPTMnetiP48809.

Proteomic databases

PaxDbiP48809.
PRIDEiP48809.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079346; FBpp0078974; FBgn0004838.
FBtr0079347; FBpp0078975; FBgn0004838.
FBtr0079348; FBpp0078976; FBgn0004838.
FBtr0301403; FBpp0290617; FBgn0004838.
FBtr0301404; FBpp0290618; FBgn0004838.
FBtr0307030; FBpp0297873; FBgn0004838.
FBtr0307031; FBpp0297874; FBgn0004838.
FBtr0307032; FBpp0297875; FBgn0004838.
GeneIDi33968.
KEGGidme:Dmel_CG10377.
UCSCiCG10377-RB. d. melanogaster.

Organism-specific databases

CTDi33968.
FlyBaseiFBgn0004838. Hrb27C.

Phylogenomic databases

eggNOGiKOG4205. Eukaryota.
ENOG410YA8Z. LUCA.
GeneTreeiENSGT00760000118873.
InParanoidiP48809.
KOiK14411.
OMAiNTNSARN.
OrthoDBiEOG091G1CPI.
PhylomeDBiP48809.

Miscellaneous databases

ChiTaRSiHrb27C. fly.
GenomeRNAii33968.
PROiP48809.

Gene expression databases

BgeeiFBgn0004838.
ExpressionAtlasiP48809. baseline.
GenevisibleiP48809. DM.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRB27C_DROME
AccessioniPrimary (citable) accession number: P48809
Secondary accession number(s): A4V0B8
, Q7JPT5, Q9TY67, Q9VM68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 27, 2005
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.