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Protein

Fibroblast growth factor 5

Gene

Fgf5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).By similarity

GO - Molecular functioni

  • growth factor activity Source: RGD
  • nerve growth factor receptor binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Enzyme and pathway databases

ReactomeiR-RNO-109704. PI3K Cascade.
R-RNO-1257604. PIP3 activates AKT signaling.
R-RNO-190372. FGFR3c ligand binding and activation.
R-RNO-190373. FGFR1c ligand binding and activation.
R-RNO-190375. FGFR2c ligand binding and activation.
R-RNO-5654219. Phospholipase C-mediated cascade: FGFR1.
R-RNO-5654221. Phospholipase C-mediated cascade, FGFR2.
R-RNO-5654227. Phospholipase C-mediated cascade, FGFR3.
R-RNO-5654687. Downstream signaling of activated FGFR1.
R-RNO-5654688. SHC-mediated cascade:FGFR1.
R-RNO-5654689. PI-3K cascade:FGFR1.
R-RNO-5654693. FRS-mediated FGFR1 signaling.
R-RNO-5654695. PI-3K cascade:FGFR2.
R-RNO-5654699. SHC-mediated cascade:FGFR2.
R-RNO-5654700. FRS-mediated FGFR2 signaling.
R-RNO-5654704. SHC-mediated cascade:FGFR3.
R-RNO-5654706. FRS-mediated FGFR3 signaling.
R-RNO-5654710. PI-3K cascade:FGFR3.
R-RNO-5654726. Negative regulation of FGFR1 signaling.
R-RNO-5654727. Negative regulation of FGFR2 signaling.
R-RNO-5654732. Negative regulation of FGFR3 signaling.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 5
Short name:
FGF-5
Alternative name(s):
Heparin-binding growth factor 5
Short name:
HBGF-5
Gene namesi
Name:Fgf5
Synonyms:Fgf-5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi620129. Fgf5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 266249Fibroblast growth factor 5PRO_0000008960Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP48807.

Expressioni

Gene expression databases

ExpressionAtlasiP48807. baseline and differential.

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

GO - Molecular functioni

  • growth factor activity Source: RGD
  • nerve growth factor receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029046.

Structurei

3D structure databases

ProteinModelPortaliP48807.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi54 – 596Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP48807.
KOiK04358.
PhylomeDBiP48807.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028240. FGF5.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF23. PTHR11486:SF23. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P48807-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLSLLFLIF CSHLILSAPA QGEKRLTPEG QPAPPRNPGD SSGSRGRSSA
60 70 80 90 100
TFASSSASSP VAASPGSQGS GSEHSSFQWS PSGRRTGSLY CRVGIGFHLQ
110 120 130 140 150
IYPDGKVNGS HEASVLSILE IFAVSQGIVG IRGVFSNKFL AMSKKGKLHA
160 170 180 190 200
SAKFTDDCKF RERFQENSYN TYASAIHRTE KTGREWYVAL NKRGKAKRGC
210 220 230 240 250
SPRVKPQHVS THFLPRFKQS EQPELSFTVT VPEKKKPPRP WKPKVPLSPS
260
RRSPSPVKYR LKFRFG
Length:266
Mass (Da):29,264
Last modified:February 1, 1996 - v1
Checksum:i95B0A0CA7C0A200C
GO
Isoform Short (identifier: P48807-2) [UniParc]FASTAAdd to basket
Also known as: FGF-5S

The sequence of this isoform differs from the canonical sequence as follows:
     118-121: ILEI → QIYR
     122-266: Missing.

Note: Seems to have an antagonistic effect compared to that of the isoform Long.
Show »
Length:121
Mass (Da):12,636
Checksum:i9B3FFD9BEC363EC4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei118 – 1214ILEI → QIYR in isoform Short. 1 PublicationVSP_001522
Alternative sequencei122 – 266145Missing in isoform Short. 1 PublicationVSP_001523Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D64085 mRNA. Translation: BAA10966.1.
D64086 mRNA. Translation: BAA10967.1.
PIRiS68144.
S68145.
RefSeqiNP_071547.1. NM_022211.1. [P48807-1]
XP_006250763.1. XM_006250701.2. [P48807-2]
UniGeneiRn.44445.

Genome annotation databases

EnsembliENSRNOT00000077861; ENSRNOP00000074979; ENSRNOG00000022631. [P48807-2]
GeneIDi60662.
KEGGirno:60662.
UCSCiRGD:620129. rat. [P48807-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D64085 mRNA. Translation: BAA10966.1.
D64086 mRNA. Translation: BAA10967.1.
PIRiS68144.
S68145.
RefSeqiNP_071547.1. NM_022211.1. [P48807-1]
XP_006250763.1. XM_006250701.2. [P48807-2]
UniGeneiRn.44445.

3D structure databases

ProteinModelPortaliP48807.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029046.

Proteomic databases

PaxDbiP48807.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000077861; ENSRNOP00000074979; ENSRNOG00000022631. [P48807-2]
GeneIDi60662.
KEGGirno:60662.
UCSCiRGD:620129. rat. [P48807-1]

Organism-specific databases

CTDi2250.
RGDi620129. Fgf5.

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP48807.
KOiK04358.
PhylomeDBiP48807.

Enzyme and pathway databases

ReactomeiR-RNO-109704. PI3K Cascade.
R-RNO-1257604. PIP3 activates AKT signaling.
R-RNO-190372. FGFR3c ligand binding and activation.
R-RNO-190373. FGFR1c ligand binding and activation.
R-RNO-190375. FGFR2c ligand binding and activation.
R-RNO-5654219. Phospholipase C-mediated cascade: FGFR1.
R-RNO-5654221. Phospholipase C-mediated cascade, FGFR2.
R-RNO-5654227. Phospholipase C-mediated cascade, FGFR3.
R-RNO-5654687. Downstream signaling of activated FGFR1.
R-RNO-5654688. SHC-mediated cascade:FGFR1.
R-RNO-5654689. PI-3K cascade:FGFR1.
R-RNO-5654693. FRS-mediated FGFR1 signaling.
R-RNO-5654695. PI-3K cascade:FGFR2.
R-RNO-5654699. SHC-mediated cascade:FGFR2.
R-RNO-5654700. FRS-mediated FGFR2 signaling.
R-RNO-5654704. SHC-mediated cascade:FGFR3.
R-RNO-5654706. FRS-mediated FGFR3 signaling.
R-RNO-5654710. PI-3K cascade:FGFR3.
R-RNO-5654726. Negative regulation of FGFR1 signaling.
R-RNO-5654727. Negative regulation of FGFR2 signaling.
R-RNO-5654732. Negative regulation of FGFR3 signaling.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Miscellaneous databases

PROiP48807.

Gene expression databases

ExpressionAtlasiP48807. baseline and differential.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028240. FGF5.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF23. PTHR11486:SF23. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGF5_RAT
AccessioniPrimary (citable) accession number: P48807
Secondary accession number(s): Q63402
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.