Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor 4

Gene

FGF4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb development during embryogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen
Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 4
Short name:
FGF-4
Alternative name(s):
Heparin-binding growth factor 4
Short name:
HBGF-4
Gene namesi
Name:FGF4
Synonyms:FGF-4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000895524 – 194Fibroblast growth factor 4Add BLAST171

Proteomic databases

PRIDEiP48804.

Expressioni

Tissue specificityi

Posterior ridge.

Inductioni

By retinoic acid.

Interactioni

Subunit structurei

Reciprocal interactions may create a positive feedback loop between sonic hedgehog (SHH) and FGF4.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP48804.
SMRiP48804.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG007580.
InParanoidiP48804.
PhylomeDBiP48804.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiView protein in InterPro
IPR028239. FGF4.
IPR002209. Fibroblast_GF_fam.
IPR008996. IL1/FGF.
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF31. PTHR11486:SF31. 1 hit.
PfamiView protein in Pfam
PF00167. FGF. 1 hit.
PRINTSiPR00263. HBGFFGF.
SMARTiView protein in SMART
SM00442. FGF. 1 hit.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00247. HBGF_FGF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48804-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSAAALLPA LLLGLLWPGA VRGRPPPGRL PPGPRQRRWD AALFARSVAR
60 70 80 90 100
LPAERRDAAR DGDYLLGYKR LRRLYCNVGI GFHIQVLPDG RIDGIHSENR
110 120 130 140 150
YSLLEISPVE RGVVSIFGVR SGLFVAMNSK GKLYGSTHVN DECKFKEILL
160 170 180 190
PNNYNAYESR IYPGMYIALS KNGRTKKGNK VSPTMTVTHF LPRI
Length:194
Mass (Da):21,642
Last modified:February 1, 1996 - v1
Checksum:i5D44245BE97E664A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14654 Genomic DNA. Translation: AAA58706.1.
PIRiS78506. I50710.

Similar proteinsi

Entry informationi

Entry nameiFGF4_CHICK
AccessioniPrimary (citable) accession number: P48804
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 25, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families