P48802 (FGF3_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 3
Short name=FGF-3

Alternative name(s):
Heparin-binding growth factor 3
Short name=HBGF-3

Gene names

Name:	fgf3
Synonyms:	fgf-3

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation By similarity.
Subcellular location	Secreted Probable Ref.2.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Biological process	Differentiation
Cellular component	Secreted
Domain	Signal
Molecular function	Developmental protein Growth factor Mitogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adenohypophysis development Inferred from mutant phenotype PubMed 18514643. Source: ZFIN anterior/posterior pattern specification Inferred from genetic interaction PubMed 15342476. Source: ZFIN cartilage development Inferred from mutant phenotype PubMed 14651935PubMed 15327784PubMed 15509770. Source: ZFIN dorsal/ventral pattern formation Inferred from mutant phenotype PubMed 14757644PubMed 15151985PubMed 15228953. Source: ZFIN embryonic pattern specification Inferred from genetic interaction PubMed 16873584. Source: ZFIN embryonic retina morphogenesis in camera-type eye Inferred from genetic interaction PubMed 19823566. Source: ZFIN locus ceruleus development Inferred from genetic interaction PubMed 17215310. Source: ZFIN negative regulation of apoptotic process Inferred from mutant phenotype PubMed 15229178. Source: ZFIN neuron fate specification Inferred from genetic interaction PubMed 16256099. Source: ZFIN oligodendrocyte differentiation Inferred from genetic interaction PubMed 16256099. Source: ZFIN otic placode formation Inferred from mutant phenotype PubMed 14757644PubMed 15459102PubMed 17522161. Source: ZFIN otolith development Inferred from genetic interaction PubMed 17522161. Source: ZFIN peripheral nervous system development Inferred from genetic interaction PubMed 17215310. Source: ZFIN positive regulation of Wnt receptor signaling pathway Inferred from genetic interaction PubMed 14757644. Source: ZFIN positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cell migration Inferred from genetic interaction PubMed 15509770. Source: ZFIN positive regulation of neurogenesis Inferred from mutant phenotype PubMed 16077091. Source: ZFIN positive regulation of neuron differentiation Inferred from mutant phenotype PubMed 15262889. Source: ZFIN posterior lateral line neuromast primordium migration Inferred from genetic interaction PubMed 18599504. Source: ZFIN rhombomere 5 development Inferred from genetic interaction PubMed 12835397. Source: ZFIN rhombomere 6 development Inferred from genetic interaction PubMed 12835397. Source: ZFIN
Cellular_component	extracellular space Inferred from direct assay Ref.2. Source: ZFIN proteinaceous extracellular matrix Inferred from direct assay Ref.2. Source: ZFIN
Molecular_function	fibroblast growth factor receptor binding Inferred from direct assay Ref.2. Source: ZFIN
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 256	238	Fibroblast growth factor 3		PRO_0000008950

Sequences

	Sequence		Length	Mass (Da)
	P48802 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: CEBA1C72A170BBDC	FASTA	256	28,923
	10 20 30 40 50 60 MVIILLLLLL SFLDPSLEES LAPRLTRTPR APCARGQACD PRQRRDAGGR GGVYEHLGGA 70 80 90 100 110 120 PRRRKLYCAT KYHLQIHPNG KIDGSLEENN PLSILEITAV DVGVVAIKGL FSGRYLAMNE 130 140 150 160 170 180 KGRLYASEVF NRECEFLERI HELGYNTYAS RHHATTQPPP TGSGIGGSKR RASSKRQWYV 190 200 210 220 230 240 SINGKGRPRR GFKTRSTDKA SLFLPRVLAN KDHEMVRKLR ESQRHHTGSH RAPVGRAERR 250 RRRHRGSKGH NRRADI

References

[1]	"The zebrafish Fgf-3 gene: cDNA sequence, transcript structure and genomic organization." Kiefer P., Strahle U., Dickson C. Gene 168:211-215(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Secretion and mitogenic activity of zebrafish FGF3 reveal intermediate properties relative to mouse and Xenopus homologues." Kiefer P., Strahle U., Mason I., Dickson C. Oncogene 12:1503-1511(1996) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z48714 Genomic DNA. Translation: CAA88596.1.
IPI	IPI00482372.
PIR	JC4627.
RefSeq	NP_571366.1. NM_131291.1.
UniGene	Dr.83293.
3D structure databases
ProteinModelPortal	P48802.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000110754; ENSDARP00000099184; ENSDARG00000068094.
GeneID	30549.
KEGG	dre:30549.
Organism-specific databases
CTD	2248.
ZFIN	ZDB-GENE-980526-178. fgf3.
Phylogenomic databases
eggNOG	NOG300661.
GeneTree	ENSGT00700000104371.
HOGENOM	HOG000236341.
HOVERGEN	HBG007580.
InParanoid	P48802.
KO	K04358.
OMA	NKDHEMV.
OrthoDB	EOG4QJRP7.
Gene expression databases
ArrayExpress	P48802.
Bgee	P48802.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin-bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. PTHR11486. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
SMART	SM00442. FGF. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20806928.

Entry information

Entry name

FGF3_DANRE

Accession

Primary (citable) accession number: P48802

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program