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P48802 (FGF3_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 3

Short name=FGF-3
Alternative name(s):
Heparin-binding growth factor 3
Short name=HBGF-3
Gene names
Name:fgf3
Synonyms:fgf-3
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length256 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation By similarity.

Subcellular location

Secreted Probable Ref.2.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
   Biological processDifferentiation
   Cellular componentSecreted
   DomainSignal
   Molecular functionDevelopmental protein
Growth factor
Mitogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadenohypophysis development

Inferred from mutant phenotype PubMed 18514643. Source: ZFIN

anterior/posterior pattern specification

Inferred from genetic interaction PubMed 15342476. Source: ZFIN

cartilage development

Inferred from mutant phenotype PubMed 14651935PubMed 15327784PubMed 15509770. Source: ZFIN

cell fate specification

Inferred from mutant phenotype PubMed 15228953PubMed 15262889. Source: ZFIN

dorsal/ventral pattern formation

Inferred from mutant phenotype PubMed 14757644PubMed 15151985PubMed 15228953. Source: ZFIN

embryonic pattern specification

Inferred from genetic interaction PubMed 16873584. Source: ZFIN

embryonic retina morphogenesis in camera-type eye

Inferred from genetic interaction PubMed 19823566. Source: ZFIN

fibroblast growth factor receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

hindbrain development

Inferred from mutant phenotype PubMed 14745965. Source: ZFIN

inner ear morphogenesis

Inferred from mutant phenotype PubMed 15228953. Source: ZFIN

locus ceruleus development

Inferred from genetic interaction PubMed 17215310. Source: ZFIN

midbrain development

Inferred from genetic interaction PubMed 23789101. Source: ZFIN

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 15229178. Source: ZFIN

neuron fate specification

Inferred from genetic interaction PubMed 16256099. Source: ZFIN

oligodendrocyte differentiation

Inferred from genetic interaction PubMed 16256099. Source: ZFIN

otic placode formation

Inferred from mutant phenotype PubMed 14757644PubMed 15459102PubMed 17522161. Source: ZFIN

otic vesicle formation

Inferred from mutant phenotype PubMed 14757644. Source: ZFIN

otolith development

Inferred from genetic interaction PubMed 17522161. Source: ZFIN

peripheral nervous system development

Inferred from genetic interaction PubMed 17215310. Source: ZFIN

positive regulation of Wnt signaling pathway

Inferred from genetic interaction PubMed 14757644. Source: ZFIN

positive regulation of cell division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of cell migration

Inferred from genetic interaction PubMed 15509770. Source: ZFIN

positive regulation of neurogenesis

Inferred from mutant phenotype PubMed 16077091. Source: ZFIN

positive regulation of neuron differentiation

Inferred from mutant phenotype PubMed 15262889. Source: ZFIN

posterior lateral line neuromast primordium migration

Inferred from genetic interaction PubMed 18599504. Source: ZFIN

retina development in camera-type eye

Inferred from genetic interaction PubMed 15809038. Source: ZFIN

rhombomere 5 development

Inferred from genetic interaction PubMed 12835397. Source: ZFIN

rhombomere 6 development

Inferred from genetic interaction PubMed 12835397. Source: ZFIN

skeletal system development

Inferred from mutant phenotype PubMed 15228953. Source: ZFIN

   Cellular_componentextracellular space

Inferred from direct assay Ref.2. Source: ZFIN

proteinaceous extracellular matrix

Inferred from direct assay Ref.2. Source: ZFIN

   Molecular_functionfibroblast growth factor receptor binding

Inferred from direct assay Ref.2. Source: ZFIN

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 256238Fibroblast growth factor 3
PRO_0000008950

Sequences

Sequence LengthMass (Da)Tools
P48802 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: CEBA1C72A170BBDC

FASTA25628,923
        10         20         30         40         50         60 
MVIILLLLLL SFLDPSLEES LAPRLTRTPR APCARGQACD PRQRRDAGGR GGVYEHLGGA 

        70         80         90        100        110        120 
PRRRKLYCAT KYHLQIHPNG KIDGSLEENN PLSILEITAV DVGVVAIKGL FSGRYLAMNE 

       130        140        150        160        170        180 
KGRLYASEVF NRECEFLERI HELGYNTYAS RHHATTQPPP TGSGIGGSKR RASSKRQWYV 

       190        200        210        220        230        240 
SINGKGRPRR GFKTRSTDKA SLFLPRVLAN KDHEMVRKLR ESQRHHTGSH RAPVGRAERR 

       250 
RRRHRGSKGH NRRADI 

« Hide

References

[1]"The zebrafish Fgf-3 gene: cDNA sequence, transcript structure and genomic organization."
Kiefer P., Strahle U., Dickson C.
Gene 168:211-215(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Secretion and mitogenic activity of zebrafish FGF3 reveal intermediate properties relative to mouse and Xenopus homologues."
Kiefer P., Strahle U., Mason I., Dickson C.
Oncogene 12:1503-1511(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z48714 Genomic DNA. Translation: CAA88596.1.
PIRJC4627.
RefSeqNP_571366.1. NM_131291.1.
UniGeneDr.83293.

3D structure databases

ProteinModelPortalP48802.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid78723. 2 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000110754; ENSDARP00000099184; ENSDARG00000068094.
GeneID30549.
KEGGdre:30549.

Organism-specific databases

CTD2248.
ZFINZDB-GENE-980526-178. fgf3.

Phylogenomic databases

eggNOGNOG300661.
GeneTreeENSGT00730000110261.
HOGENOMHOG000236341.
HOVERGENHBG007580.
InParanoidP48802.
KOK04358.
OMAYHLQIHP.
OrthoDBEOG7992S1.
PhylomeDBP48802.
TreeFamTF317805.

Gene expression databases

BgeeP48802.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028232. FGF3.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF26. PTHR11486:SF26. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806928.
PROP48802.

Entry information

Entry nameFGF3_DANRE
AccessionPrimary (citable) accession number: P48802
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families