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P48802

- FGF3_DANRE

UniProt

P48802 - FGF3_DANRE

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Protein

Fibroblast growth factor 3

Gene

fgf3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation.By similarity

GO - Molecular functioni

  1. fibroblast growth factor receptor binding Source: ZFIN

GO - Biological processi

  1. adenohypophysis development Source: ZFIN
  2. anterior/posterior pattern specification Source: ZFIN
  3. cartilage development Source: ZFIN
  4. cell fate specification Source: ZFIN
  5. dorsal/ventral pattern formation Source: ZFIN
  6. embryonic pattern specification Source: ZFIN
  7. embryonic retina morphogenesis in camera-type eye Source: ZFIN
  8. fibroblast growth factor receptor signaling pathway Source: InterPro
  9. hindbrain development Source: ZFIN
  10. inner ear morphogenesis Source: ZFIN
  11. locus ceruleus development Source: ZFIN
  12. midbrain development Source: ZFIN
  13. negative regulation of apoptotic process Source: ZFIN
  14. neuron fate specification Source: ZFIN
  15. oligodendrocyte differentiation Source: ZFIN
  16. otic placode formation Source: ZFIN
  17. otic vesicle formation Source: ZFIN
  18. otolith development Source: ZFIN
  19. peripheral nervous system development Source: ZFIN
  20. positive regulation of cell division Source: UniProtKB-KW
  21. positive regulation of cell migration Source: ZFIN
  22. positive regulation of neurogenesis Source: ZFIN
  23. positive regulation of neuron differentiation Source: ZFIN
  24. positive regulation of Wnt signaling pathway Source: ZFIN
  25. posterior lateral line neuromast primordium migration Source: ZFIN
  26. retina development in camera-type eye Source: ZFIN
  27. rhombomere 5 development Source: ZFIN
  28. rhombomere 6 development Source: ZFIN
  29. skeletal system development Source: ZFIN
  30. vestibular receptor cell development Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

ReactomeiREACT_204298. Constitutive PI3K/AKT Signaling in Cancer.
REACT_205098. Signaling by FGFR mutants.
REACT_211854. SHC-mediated cascade.
REACT_223377. Activated point mutants of FGFR2.
REACT_225510. Negative regulation of FGFR signaling.
REACT_234868. PI-3K cascade.
REACT_239502. PI3K Cascade.
REACT_240056. FGFR2b ligand binding and activation.
REACT_241053. FGFR1b ligand binding and activation.
REACT_248177. PIP3 activates AKT signaling.
REACT_262090. Phospholipase C-mediated cascade.
REACT_262311. FRS2-mediated cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 3
Short name:
FGF-3
Alternative name(s):
Heparin-binding growth factor 3
Short name:
HBGF-3
Gene namesi
Name:fgf3
Synonyms:fgf-3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-980526-178. fgf3.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular space Source: ZFIN
  2. proteinaceous extracellular matrix Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 256238Fibroblast growth factor 3PRO_0000008950Add
BLAST

Expressioni

Gene expression databases

BgeeiP48802.

Interactioni

Protein-protein interaction databases

BioGridi78723. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP48802.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG300661.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP48802.
KOiK04358.
OMAiYHLQIHP.
OrthoDBiEOG7992S1.
PhylomeDBiP48802.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028232. FGF3.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF26. PTHR11486:SF26. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48802-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVIILLLLLL SFLDPSLEES LAPRLTRTPR APCARGQACD PRQRRDAGGR
60 70 80 90 100
GGVYEHLGGA PRRRKLYCAT KYHLQIHPNG KIDGSLEENN PLSILEITAV
110 120 130 140 150
DVGVVAIKGL FSGRYLAMNE KGRLYASEVF NRECEFLERI HELGYNTYAS
160 170 180 190 200
RHHATTQPPP TGSGIGGSKR RASSKRQWYV SINGKGRPRR GFKTRSTDKA
210 220 230 240 250
SLFLPRVLAN KDHEMVRKLR ESQRHHTGSH RAPVGRAERR RRRHRGSKGH

NRRADI
Length:256
Mass (Da):28,923
Last modified:February 1, 1996 - v1
Checksum:iCEBA1C72A170BBDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48714 Genomic DNA. Translation: CAA88596.1.
PIRiJC4627.
RefSeqiNP_571366.1. NM_131291.1.
UniGeneiDr.83293.

Genome annotation databases

EnsembliENSDART00000110754; ENSDARP00000099184; ENSDARG00000068094.
GeneIDi30549.
KEGGidre:30549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48714 Genomic DNA. Translation: CAA88596.1 .
PIRi JC4627.
RefSeqi NP_571366.1. NM_131291.1.
UniGenei Dr.83293.

3D structure databases

ProteinModelPortali P48802.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 78723. 2 interactions.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000110754 ; ENSDARP00000099184 ; ENSDARG00000068094 .
GeneIDi 30549.
KEGGi dre:30549.

Organism-specific databases

CTDi 2248.
ZFINi ZDB-GENE-980526-178. fgf3.

Phylogenomic databases

eggNOGi NOG300661.
GeneTreei ENSGT00760000118859.
HOGENOMi HOG000236341.
HOVERGENi HBG007580.
InParanoidi P48802.
KOi K04358.
OMAi YHLQIHP.
OrthoDBi EOG7992S1.
PhylomeDBi P48802.
TreeFami TF317805.

Enzyme and pathway databases

Reactomei REACT_204298. Constitutive PI3K/AKT Signaling in Cancer.
REACT_205098. Signaling by FGFR mutants.
REACT_211854. SHC-mediated cascade.
REACT_223377. Activated point mutants of FGFR2.
REACT_225510. Negative regulation of FGFR signaling.
REACT_234868. PI-3K cascade.
REACT_239502. PI3K Cascade.
REACT_240056. FGFR2b ligand binding and activation.
REACT_241053. FGFR1b ligand binding and activation.
REACT_248177. PIP3 activates AKT signaling.
REACT_262090. Phospholipase C-mediated cascade.
REACT_262311. FRS2-mediated cascade.

Miscellaneous databases

NextBioi 20806928.
PROi P48802.

Gene expression databases

Bgeei P48802.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028232. FGF3.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF26. PTHR11486:SF26. 1 hit.
PRINTSi PR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The zebrafish Fgf-3 gene: cDNA sequence, transcript structure and genomic organization."
    Kiefer P., Strahle U., Dickson C.
    Gene 168:211-215(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Secretion and mitogenic activity of zebrafish FGF3 reveal intermediate properties relative to mouse and Xenopus homologues."
    Kiefer P., Strahle U., Mason I., Dickson C.
    Oncogene 12:1503-1511(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiFGF3_DANRE
AccessioniPrimary (citable) accession number: P48802
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3