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P48802

- FGF3_DANRE

UniProt

P48802 - FGF3_DANRE

Protein

Fibroblast growth factor 3

Gene

fgf3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation.By similarity

    GO - Molecular functioni

    1. fibroblast growth factor receptor binding Source: ZFIN

    GO - Biological processi

    1. adenohypophysis development Source: ZFIN
    2. anterior/posterior pattern specification Source: ZFIN
    3. cartilage development Source: ZFIN
    4. cell fate specification Source: ZFIN
    5. dorsal/ventral pattern formation Source: ZFIN
    6. embryonic pattern specification Source: ZFIN
    7. embryonic retina morphogenesis in camera-type eye Source: ZFIN
    8. fibroblast growth factor receptor signaling pathway Source: InterPro
    9. hindbrain development Source: ZFIN
    10. inner ear morphogenesis Source: ZFIN
    11. locus ceruleus development Source: ZFIN
    12. midbrain development Source: ZFIN
    13. negative regulation of apoptotic process Source: ZFIN
    14. neuron fate specification Source: ZFIN
    15. oligodendrocyte differentiation Source: ZFIN
    16. otic placode formation Source: ZFIN
    17. otic vesicle formation Source: ZFIN
    18. otolith development Source: ZFIN
    19. peripheral nervous system development Source: ZFIN
    20. positive regulation of cell division Source: UniProtKB-KW
    21. positive regulation of cell migration Source: ZFIN
    22. positive regulation of neurogenesis Source: ZFIN
    23. positive regulation of neuron differentiation Source: ZFIN
    24. positive regulation of Wnt signaling pathway Source: ZFIN
    25. posterior lateral line neuromast primordium migration Source: ZFIN
    26. retina development in camera-type eye Source: ZFIN
    27. rhombomere 5 development Source: ZFIN
    28. rhombomere 6 development Source: ZFIN
    29. skeletal system development Source: ZFIN
    30. vestibular receptor cell development Source: ZFIN

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Keywords - Biological processi

    Differentiation

    Enzyme and pathway databases

    ReactomeiREACT_204298. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_205098. Signaling by FGFR mutants.
    REACT_211854. SHC-mediated cascade.
    REACT_223377. Activated point mutants of FGFR2.
    REACT_225510. Negative regulation of FGFR signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 3
    Short name:
    FGF-3
    Alternative name(s):
    Heparin-binding growth factor 3
    Short name:
    HBGF-3
    Gene namesi
    Name:fgf3
    Synonyms:fgf-3
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 7

    Organism-specific databases

    ZFINiZDB-GENE-980526-178. fgf3.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: ZFIN
    2. proteinaceous extracellular matrix Source: ZFIN

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 256238Fibroblast growth factor 3PRO_0000008950Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiP48802.

    Interactioni

    Protein-protein interaction databases

    BioGridi78723. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP48802.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG300661.
    GeneTreeiENSGT00730000110261.
    HOGENOMiHOG000236341.
    HOVERGENiHBG007580.
    InParanoidiP48802.
    KOiK04358.
    OMAiYHLQIHP.
    OrthoDBiEOG7992S1.
    PhylomeDBiP48802.
    TreeFamiTF317805.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028232. FGF3.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF26. PTHR11486:SF26. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48802-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVIILLLLLL SFLDPSLEES LAPRLTRTPR APCARGQACD PRQRRDAGGR    50
    GGVYEHLGGA PRRRKLYCAT KYHLQIHPNG KIDGSLEENN PLSILEITAV 100
    DVGVVAIKGL FSGRYLAMNE KGRLYASEVF NRECEFLERI HELGYNTYAS 150
    RHHATTQPPP TGSGIGGSKR RASSKRQWYV SINGKGRPRR GFKTRSTDKA 200
    SLFLPRVLAN KDHEMVRKLR ESQRHHTGSH RAPVGRAERR RRRHRGSKGH 250
    NRRADI 256
    Length:256
    Mass (Da):28,923
    Last modified:February 1, 1996 - v1
    Checksum:iCEBA1C72A170BBDC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48714 Genomic DNA. Translation: CAA88596.1.
    PIRiJC4627.
    RefSeqiNP_571366.1. NM_131291.1.
    UniGeneiDr.83293.

    Genome annotation databases

    EnsembliENSDART00000110754; ENSDARP00000099184; ENSDARG00000068094.
    GeneIDi30549.
    KEGGidre:30549.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48714 Genomic DNA. Translation: CAA88596.1 .
    PIRi JC4627.
    RefSeqi NP_571366.1. NM_131291.1.
    UniGenei Dr.83293.

    3D structure databases

    ProteinModelPortali P48802.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 78723. 2 interactions.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000110754 ; ENSDARP00000099184 ; ENSDARG00000068094 .
    GeneIDi 30549.
    KEGGi dre:30549.

    Organism-specific databases

    CTDi 2248.
    ZFINi ZDB-GENE-980526-178. fgf3.

    Phylogenomic databases

    eggNOGi NOG300661.
    GeneTreei ENSGT00730000110261.
    HOGENOMi HOG000236341.
    HOVERGENi HBG007580.
    InParanoidi P48802.
    KOi K04358.
    OMAi YHLQIHP.
    OrthoDBi EOG7992S1.
    PhylomeDBi P48802.
    TreeFami TF317805.

    Enzyme and pathway databases

    Reactomei REACT_204298. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_205098. Signaling by FGFR mutants.
    REACT_211854. SHC-mediated cascade.
    REACT_223377. Activated point mutants of FGFR2.
    REACT_225510. Negative regulation of FGFR signaling.

    Miscellaneous databases

    NextBioi 20806928.
    PROi P48802.

    Gene expression databases

    Bgeei P48802.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028232. FGF3.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF26. PTHR11486:SF26. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish Fgf-3 gene: cDNA sequence, transcript structure and genomic organization."
      Kiefer P., Strahle U., Dickson C.
      Gene 168:211-215(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Secretion and mitogenic activity of zebrafish FGF3 reveal intermediate properties relative to mouse and Xenopus homologues."
      Kiefer P., Strahle U., Mason I., Dickson C.
      Oncogene 12:1503-1511(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiFGF3_DANRE
    AccessioniPrimary (citable) accession number: P48802
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3