Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor 3

Gene

fgf3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation.By similarity

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: ZFIN

GO - Biological processi

  • adenohypophysis development Source: ZFIN
  • anterior/posterior pattern specification Source: ZFIN
  • cartilage development Source: ZFIN
  • cell fate specification Source: ZFIN
  • dorsal/ventral pattern formation Source: ZFIN
  • ectodermal placode development Source: ZFIN
  • embryonic pattern specification Source: ZFIN
  • embryonic retina morphogenesis in camera-type eye Source: ZFIN
  • fibroblast growth factor receptor signaling pathway Source: InterPro
  • hindbrain development Source: ZFIN
  • inner ear morphogenesis Source: ZFIN
  • locus ceruleus development Source: ZFIN
  • midbrain development Source: ZFIN
  • negative regulation of apoptotic process Source: ZFIN
  • neurohypophysis development Source: ZFIN
  • neuron development Source: ZFIN
  • neuron fate specification Source: ZFIN
  • oligodendrocyte differentiation Source: ZFIN
  • otic placode formation Source: ZFIN
  • otic vesicle development Source: ZFIN
  • otic vesicle formation Source: ZFIN
  • otolith development Source: ZFIN
  • peripheral nervous system development Source: ZFIN
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell migration Source: ZFIN
  • positive regulation of neurogenesis Source: ZFIN
  • positive regulation of neuron differentiation Source: ZFIN
  • positive regulation of Wnt signaling pathway Source: ZFIN
  • posterior lateral line neuromast primordium migration Source: ZFIN
  • retina development in camera-type eye Source: ZFIN
  • rhombomere 5 development Source: ZFIN
  • rhombomere 6 development Source: ZFIN
  • skeletal system development Source: ZFIN
  • vestibular receptor cell development Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

ReactomeiREACT_303239. FGFR1b ligand binding and activation.
REACT_316109. PIP3 activates AKT signaling.
REACT_331488. PI3K Cascade.
REACT_349269. FGFR2b ligand binding and activation.
REACT_357374. Phospholipase C-mediated cascade, FGFR2.
REACT_359976. PI-3K cascade:FGFR2.
REACT_359977. FRS-mediated FGFR1 signaling.
REACT_360683. PI-3K cascade:FGFR1.
REACT_360759. FRS-mediated FGFR2 signaling.
REACT_361071. Negative regulation of FGFR2 signaling.
REACT_361620. SHC-mediated cascade:FGFR2.
REACT_361758. SHC-mediated cascade:FGFR1.
REACT_361857. Phospholipase C-mediated cascade: FGFR1.
REACT_362259. Negative regulation of FGFR1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 3
Short name:
FGF-3
Alternative name(s):
Heparin-binding growth factor 3
Short name:
HBGF-3
Gene namesi
Name:fgf3
Synonyms:fgf-3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-980526-178. fgf3.

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

  • extracellular space Source: ZFIN
  • proteinaceous extracellular matrix Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 256238Fibroblast growth factor 3PRO_0000008950Add
BLAST

Expressioni

Gene expression databases

BgeeiP48802.

Interactioni

Protein-protein interaction databases

BioGridi78723. 2 interactions.
STRINGi7955.ENSDARP00000099184.

Structurei

3D structure databases

ProteinModelPortaliP48802.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG300661.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP48802.
KOiK04358.
OMAiHYNAECE.
OrthoDBiEOG7992S1.
PhylomeDBiP48802.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028232. FGF3.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF26. PTHR11486:SF26. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48802-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIILLLLLL SFLDPSLEES LAPRLTRTPR APCARGQACD PRQRRDAGGR
60 70 80 90 100
GGVYEHLGGA PRRRKLYCAT KYHLQIHPNG KIDGSLEENN PLSILEITAV
110 120 130 140 150
DVGVVAIKGL FSGRYLAMNE KGRLYASEVF NRECEFLERI HELGYNTYAS
160 170 180 190 200
RHHATTQPPP TGSGIGGSKR RASSKRQWYV SINGKGRPRR GFKTRSTDKA
210 220 230 240 250
SLFLPRVLAN KDHEMVRKLR ESQRHHTGSH RAPVGRAERR RRRHRGSKGH

NRRADI
Length:256
Mass (Da):28,923
Last modified:February 1, 1996 - v1
Checksum:iCEBA1C72A170BBDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48714 Genomic DNA. Translation: CAA88596.1.
PIRiJC4627.
RefSeqiNP_571366.1. NM_131291.1.
UniGeneiDr.83293.

Genome annotation databases

EnsembliENSDART00000110754; ENSDARP00000099184; ENSDARG00000068094.
GeneIDi30549.
KEGGidre:30549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48714 Genomic DNA. Translation: CAA88596.1.
PIRiJC4627.
RefSeqiNP_571366.1. NM_131291.1.
UniGeneiDr.83293.

3D structure databases

ProteinModelPortaliP48802.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi78723. 2 interactions.
STRINGi7955.ENSDARP00000099184.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000110754; ENSDARP00000099184; ENSDARG00000068094.
GeneIDi30549.
KEGGidre:30549.

Organism-specific databases

CTDi2248.
ZFINiZDB-GENE-980526-178. fgf3.

Phylogenomic databases

eggNOGiNOG300661.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP48802.
KOiK04358.
OMAiHYNAECE.
OrthoDBiEOG7992S1.
PhylomeDBiP48802.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiREACT_303239. FGFR1b ligand binding and activation.
REACT_316109. PIP3 activates AKT signaling.
REACT_331488. PI3K Cascade.
REACT_349269. FGFR2b ligand binding and activation.
REACT_357374. Phospholipase C-mediated cascade, FGFR2.
REACT_359976. PI-3K cascade:FGFR2.
REACT_359977. FRS-mediated FGFR1 signaling.
REACT_360683. PI-3K cascade:FGFR1.
REACT_360759. FRS-mediated FGFR2 signaling.
REACT_361071. Negative regulation of FGFR2 signaling.
REACT_361620. SHC-mediated cascade:FGFR2.
REACT_361758. SHC-mediated cascade:FGFR1.
REACT_361857. Phospholipase C-mediated cascade: FGFR1.
REACT_362259. Negative regulation of FGFR1 signaling.

Miscellaneous databases

NextBioi20806928.
PROiP48802.

Gene expression databases

BgeeiP48802.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028232. FGF3.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF26. PTHR11486:SF26. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The zebrafish Fgf-3 gene: cDNA sequence, transcript structure and genomic organization."
    Kiefer P., Strahle U., Dickson C.
    Gene 168:211-215(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Secretion and mitogenic activity of zebrafish FGF3 reveal intermediate properties relative to mouse and Xenopus homologues."
    Kiefer P., Strahle U., Mason I., Dickson C.
    Oncogene 12:1503-1511(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiFGF3_DANRE
AccessioniPrimary (citable) accession number: P48802
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 24, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.