P48798 (FGF2_MONDO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heparin-binding growth factor 2
Short name=HBGF-2

Alternative name(s):
Basic fibroblast growth factor
Short name=bFGF

Gene names

Name:

FGF2

Organism

Monodelphis domestica (Gray short-tailed opossum)

Taxonomic identifier

13616 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Metatheria › Didelphimorphia › Didelphidae › Monodelphis

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro By similarity.
Subunit structure	Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2 By similarity.
Subcellular location	Secreted By similarity. Note: Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane By similarity.
Post-translational modification	Phosphorylation at Tyr-83 regulates FGF2 unconventional secretion By similarity.
Sequence similarities	Belongs to the heparin-binding growth factors family.
Sequence caution	The sequence CAA78854.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Angiogenesis Differentiation
Cellular component	Secreted
Ligand	Heparin-binding
Molecular function	Developmental protein Growth factor Mitogen
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	branching involved in ureteric bud morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell death Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW heparin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 9	9	By similarity		PRO_0000008934
	Chain	10 – 156	147	Heparin-binding growth factor 2		PRO_0000008935
Regions
	Region	129 – 145	17	Heparin-binding By similarity
Sites
	Binding site	37	1	Heparin By similarity
Amino acid modifications
	Modified residue	83	1	Phosphotyrosine; by TEC By similarity

Sequences

	Sequence		Length	Mass (Da)
	P48798 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 7E655FCC49BF1209	FASTA	156	17,303
	10 20 30 40 50 60 MAAGSITTLP ALSGDGGGGG AFPPGHFKDP KRLYCKNGGF FLRIHPDGRV DGIREKSDPN 70 80 90 100 110 120 IKLQLQAEER GVVSIKGVCA NRYLAMKEDG RLLALKYVTE ECFFFERLES NNYNTYRSRK 130 140 150 YSNWYVALKR TGQYKLGSKT GPGQKAILFL PMSAKS

References

[1]	"Characterization of cDNA encoding basic fibroblast growth factor of the marsupial Monodelphis domestica." Kusewitt D.F., Sabourin C.L.K., Sherburn T.E., Ley R.D. DNA Cell Biol. 13:549-554(1994) [PubMed: 8024698] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z15154 mRNA. Translation: CAA78854.1. Different initiation.
RefSeq	NP_001029148.1. NM_001033976.2.
UniGene	Mdm.220.
3D structure databases
ProteinModelPortal	P48798.
SMR	P48798. Positions 1-156.
ModBase	Search...
Protein-protein interaction databases
STRING	P48798.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMODT00000023996; ENSMODP00000023577; ENSMODG00000018899.
GeneID	619384.
KEGG	mdo:619384.
Organism-specific databases
CTD	2247.
Phylogenomic databases
eggNOG	maNOG17955.
GeneTree	ENSGT00600000084030.
HOVERGEN	HBG007580.
InParanoid	P48798.
OrthoDB	EOG4K0QPR.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin-bd. IPR002348. IL1_HBGF. [Graphical view]
KO	K04358.
PANTHER	PTHR11486. IL1_HBGF. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
SMART	SM00442. FGF. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FGF2_MONDO

Accession

Primary (citable) accession number: P48798

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	December 14, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program