P48793 (XYN_TRIHA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Endo-1,4-beta-xylanase Short name=Xylanase EC=3.2.1.8 Alternative name(s): 1,4-beta-D-xylan xylanohydrolase
Organism	Trichoderma harzianum (Hypocrea lixii)
Taxonomic identifier	5544 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Hypocreomycetidae › Hypocreales › Hypocreaceae › Hypocrea › mitosporic Hypocrea › Trichoderma

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.
Pathway	Glycan degradation; xylan degradation.
Sequence similarities	Belongs to the glycosyl hydrolase 11 (cellulase G) family.

Ontologies

Keywords
Biological process	Xylan degradation
Molecular function	Glycosidase Hydrolase
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological_process	xylan catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	endo-1,4-beta-xylanase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 190

190

Endo-1,4-beta-xylanase

PRO_0000184072

Sites

Active site

86

1

Nucleophile

Active site

177

1

Proton donor

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

190

Helix Strand Turn

Details...

Beta strand

5 – 12

8

Beta strand

14 – 19

6

Beta strand

25 – 29

5

Beta strand

34 – 41

8

Beta strand

44 – 53

10

Beta strand

59 – 81

23

Turn

82 – 84

3

Beta strand

85 – 93

9

Turn

98 – 101

4

Beta strand

103 – 110

8

Beta strand

113 – 125

13

Beta strand

130 – 143

14

Beta strand

146 – 151

6

Helix

152 – 161

10

Beta strand

168 – 180

13

Beta strand

182 – 189

8

Sequences

	Sequence		Length	Mass (Da)
	P48793 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 6A0F4D1C3599C698	FASTA	190	20,703
	10 20 30 40 50 60 QTIGPGTGYS NGYYYSYWND GHAGVTYTNG GGGSFTVNWS NSGNFVAGKG WQPGTKNKVI 70 80 90 100 110 120 NFSGSYNPNG NSYLSIYGWS RNPLIEYYIV ENFGTYNPST GATKLGEVTS DGSVYDIYRT 130 140 150 160 170 180 QRVNQPSIIG TATFYQYWSV RRNHRSSGSV NTANHFNAWA SHGLTLGTMD YQIVAVEGYF 190 SSGSASITVS

References

[1]

"The amino acid sequence of the 20 Kd xylanase from Trichoderma harzianum E58." Yaguchi M., Roy C., Watson D.C., Rollin F., Tan L.U.L., Senior D.J., Saddler J.N. (In) Visser J., Beldman G., Kusters-van Someren M.A., Voragen A.G.J. (eds.); Xylans and xylanases, pp.435-438, Elsevier, Amsterdam (1992) Cited for: PROTEIN SEQUENCE. Strain: E58.

[2]

"High-resolution structures of xylanases from B.circulans and T.harzianum identify a new folding pattern and implications for the atomic basis of the catalysis." Campbell R.L., Rose D.R., Wakarchuk W.W., To R.J., Sung W., Yaguchi M. (In) Suominen P., Reinikainen T. (eds.); Trichoderma reesei cellulases and other hydrolases, pp.63-72, Foundation for Biotechnical and Industrial Fermentation Research, Helsinki (1993) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).

Cross-references

Sequence databases

PIR

A44593.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XND	X-ray	2.00	A	1-190	[»]

ProteinModelPortal

P48793.

SMR

P48793. Positions 1-190.

ModBase

Search...

Protein family/group databases

CAZy

GH11. Glycoside Hydrolase Family 11.

mycoCLAP

XYN11A_TRIHA.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Enzyme and pathway databases

UniPathway

UPA00114.

Family and domain databases

Gene3D

2.60.120.180. 1 hit.

InterPro

IPR008985. ConA-like_lec_gl_sf.
IPR001137. Glyco_hydro_11.
IPR013319. Glyco_hydro_11/12.
IPR018208. Glyco_hydro_11_AS.
[Graphical view]

Pfam

PF00457. Glyco_hydro_11. 1 hit.
[Graphical view]

PRINTS

PR00911. GLHYDRLASE11.

SUPFAM

SSF49899. ConA_like_lec_gl. 1 hit.

PROSITE

PS00776. GLYCOSYL_HYDROL_F11_1. 1 hit.
PS00777. GLYCOSYL_HYDROL_F11_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P48793.

Entry information

Entry name

XYN_TRIHA

Accession

Primary (citable) accession number: P48793

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	March 6, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program