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Protein

Pathogenesis-related homeodomain protein

Gene

PRH

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Specifically binds to the fungal elicitor-responsive DNA element, 5'-CTAATTGTTTA-3', of the gene PR2 promoter.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri190 – 247PHD-typePROSITE-ProRule annotationAdd BLAST58
DNA bindingi452 – 511HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • sequence-specific DNA binding Source: TAIR
  • transcription factor activity, sequence-specific DNA binding Source: TAIR
  • zinc ion binding Source: InterPro

GO - Biological processi

  • defense response Source: UniProtKB-KW
  • positive regulation of transcription, DNA-templated Source: TAIR
  • response to auxin Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Plant defense, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Pathogenesis-related homeodomain protein
Short name:
PRHA
Gene namesi
Name:PRH
Synonyms:PRHA
Ordered Locus Names:At4g29940
ORF Names:F27B13.180
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G29940.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492641 – 796Pathogenesis-related homeodomain proteinAdd BLAST796

Proteomic databases

PaxDbiP48785.

PTM databases

iPTMnetiP48785.

Expressioni

Inductioni

By pathogen infection.

Gene expression databases

ExpressionAtlasiP48785. baseline and differential.
GenevisibleiP48785. AT.

Interactioni

Protein-protein interaction databases

IntActiP48785. 1 interactor.
MINTiMINT-145050.
STRINGi3702.AT4G29940.1.

Structurei

3D structure databases

ProteinModelPortaliP48785.
SMRiP48785.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati605 – 6311Add BLAST27
Repeati632 – 6582Add BLAST27
Repeati659 – 6853Add BLAST27
Repeati686 – 7124Add BLAST27
Repeati713 – 7355; truncatedAdd BLAST23

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni605 – 7355 X 27 AA tandem repeatsAdd BLAST131
Regioni738 – 759Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi294 – 303Asp-rich (acidic)10

Sequence similaritiesi

Belongs to the PHD-associated homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri190 – 247PHD-typePROSITE-ProRule annotationAdd BLAST58

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4299. Eukaryota.
ENOG410XQQA. LUCA.
HOGENOMiHOG000115692.
InParanoidiP48785.
OMAiEETVCGP.
OrthoDBiEOG09360725.
PhylomeDBiP48785.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: P48785-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEESETKGRI SQETDKACVS VERIGSTLLS SFVKKGKEVS NKRNSKQNKR
60 70 80 90 100
KAEEELCSKS RTKKYSRGWV RCEEMEEEKV KKTRKRKSKR QQKDNKVEVD
110 120 130 140 150
DSLRLQRRTR YLLIKMKMQQ NLIDAYATEG WKGQSREKIR PDKELERARK
160 170 180 190 200
EILNCKLGLR DAIRQLDLLS SVGSMEEKVI ASDGSIHHDH IFCAECNSRE
210 220 230 240 250
AFPDNDIILC DGTCNRAFHQ KCLDPPLETE SIPPGDQGWF CKFCDCKIEI
260 270 280 290 300
IDTMNAQIGT HFPVDSNWQD IFNEEASLPI GSEATVNNEA DWPSDDSKDD
310 320 330 340 350
DYDPEMRENG GGNSSNVSGD GGGDNDEESI STSLSLSSDG VALSTGSWEG
360 370 380 390 400
HRLSNMVEQC ETSNEETVCG PRQRRTVDYT QLYYEMFGKD AVLQEQGSED
410 420 430 440 450
EDWGPNDRRK RKRESDAGST LVTMCESSKK DQDVVETLEQ SERDSVSVEN
460 470 480 490 500
KGGRRRMFRL PRNAVEKLRQ VFAETELPSK AVRDRLAKEL SLDPEKVNKW
510 520 530 540 550
FKNTRYMALR NRKTESVKQP GDSKTVSGGD SGPEAVMENN TETNEVQDTL
560 570 580 590 600
DDTVPPGFDA TNQNILSPCN NNQEEFQQEN VSFPSPTDES QQYLEQNDSS
610 620 630 640 650
FVLVPHEKQS SEISLKTAVE ENETESKMMK EPHEELSSEM SLKTAAEEKE
660 670 680 690 700
TESKMIEEPH EELSREMSLK TAVEEKETES KMMEEPHDEL NSEMSLSTAV
710 720 730 740 750
EEKETGSKMT EESHEELSNE MSLEEKETGR KMTEEEELEA VMEMLCRTEN
760 770 780 790
KLLDVTQRLD RFKTPKGRKK LGNSSSPLLE EDSVVYVPIA EIKEKR
Length:796
Mass (Da):90,657
Last modified:February 1, 1996 - v1
Checksum:i5E61509A0CAD6175
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21991 mRNA. Translation: AAA32843.1.
U48864 Genomic DNA. Translation: AAC49836.1.
AL050352 Genomic DNA. Translation: CAB43669.1.
AL161575 Genomic DNA. Translation: CAB79752.1.
CP002687 Genomic DNA. Translation: AEE85698.1.
PIRiT08555.
RefSeqiNP_194723.1. NM_119140.2. [P48785-1]
UniGeneiAt.19983.

Genome annotation databases

EnsemblPlantsiAT4G29940.1; AT4G29940.1; AT4G29940. [P48785-1]
GeneIDi829117.
GrameneiAT4G29940.1; AT4G29940.1; AT4G29940.
KEGGiath:AT4G29940.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21991 mRNA. Translation: AAA32843.1.
U48864 Genomic DNA. Translation: AAC49836.1.
AL050352 Genomic DNA. Translation: CAB43669.1.
AL161575 Genomic DNA. Translation: CAB79752.1.
CP002687 Genomic DNA. Translation: AEE85698.1.
PIRiT08555.
RefSeqiNP_194723.1. NM_119140.2. [P48785-1]
UniGeneiAt.19983.

3D structure databases

ProteinModelPortaliP48785.
SMRiP48785.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP48785. 1 interactor.
MINTiMINT-145050.
STRINGi3702.AT4G29940.1.

PTM databases

iPTMnetiP48785.

Proteomic databases

PaxDbiP48785.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G29940.1; AT4G29940.1; AT4G29940. [P48785-1]
GeneIDi829117.
GrameneiAT4G29940.1; AT4G29940.1; AT4G29940.
KEGGiath:AT4G29940.

Organism-specific databases

TAIRiAT4G29940.

Phylogenomic databases

eggNOGiKOG4299. Eukaryota.
ENOG410XQQA. LUCA.
HOGENOMiHOG000115692.
InParanoidiP48785.
OMAiEETVCGP.
OrthoDBiEOG09360725.
PhylomeDBiP48785.

Miscellaneous databases

PROiP48785.

Gene expression databases

ExpressionAtlasiP48785. baseline and differential.
GenevisibleiP48785. AT.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRH_ARATH
AccessioniPrimary (citable) accession number: P48785
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.