Reviewed,
UniProtKB/Swiss-Prot P48776 (T23O_MOUSE)
Last modified
November 25, 2008.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tryptophan 2,3-dioxygenase Short name=TO EC=1.13.11.11 Alternative name(s): Tryptophan pyrrolase Short name=Tryptophanase Tryptophan oxygenase Tryptamin 2,3-dioxygenase Short name=TRPO | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 406 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin By similarity. |
| Catalytic activity | L-tryptophan + O(2) = N-formyl-L-kynurenine. |
| Cofactor | Binds 2 heme groups per tetramer. The hemes are protoheme IV By similarity. |
| Pathway | |
| Subunit structure | Homotetramer By similarity. |
| Sequence similarities | Belongs to the tryptophan 2,3-dioxygenase family. |
Ontologies
Keywords | |
|---|---|
| Ligand | Heme Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: InterPro tryptophan catabolic process to kynurenineInferred from electronic annotation. Source: InterPro |
| Molecular function | iron ion binding Inferred from electronic annotation. Source: InterPro tryptophan 2,3-dioxygenase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Novoradovsky A., Goldman D. Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: DBA/2J. |
| [2] | "Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R. J. Proteome Res. 6:250-262(2007) [PubMed: 17203969] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, MASS SPECTROMETRY. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U24493 mRNA. Translation: AAB60491.1. | |
| UniGene | Mm.258622 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P48776. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000028011. Mus musculus. [Contig view] |
Organism-specific databases | |
| MGI | MGI:1928486. Tdo2. |
Phylogenomic databases | |
| HOGENOM | P48776. |
| HOVERGEN | P48776. |
Gene expression databases | |
| ArrayExpress | P48776. |
| CleanEx | MM_TDO2. |
| GermOnline | ENSMUSG00000028011. Mus musculus. |
Family and domain databases | |
| InterPro | IPR004981. Trp_2_3_dOase. [Graphical view] |
| PANTHER | PTHR10138. Trp_2_3_dOase. 1 hit. |
| Pfam | PF03301. Trp_dioxygenase. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | T23O_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P48776 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


