Reviewed,
UniProtKB/Swiss-Prot P48775 (T23O_HUMAN)
Last modified
November 3, 2009.
Version 80.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tryptophan 2,3-dioxygenase Short name=TDO EC=1.13.11.11 Alternative name(s): Tryptophan pyrrolase Short name=Tryptophanase Tryptophan oxygenase Short name=TRPO Short name=TO Tryptamin 2,3-dioxygenase | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 406 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin By similarity. |
| Catalytic activity | L-tryptophan + O2 = N-formyl-L-kynurenine. |
| Cofactor | Binds 2 heme groups per tetramer By similarity. |
| Pathway | |
| Subunit structure | Homotetramer By similarity. |
| Sequence similarities | Belongs to the tryptophan 2,3-dioxygenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Tryptophan catabolism |
| Domain | Coiled coil |
| Ligand | Heme Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | NAD metabolic process Inferred from Experiment. Source: Reactome oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW tryptophan catabolic process to kynurenineInferred from electronic annotation. Source: InterPro |
| Cellular component | cytosol Ref.1 Inferred from Experiment. Source: Reactome |
| Molecular function | iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW tryptophan 2,3-dioxygenase activity Ref.1Inferred from Experiment. Source: Reactome |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 406 | 406 | Tryptophan 2,3-dioxygenase | PRO_0000072399 | |||||
Regions | |||||||||
| Region | 42 – 46 | 5 | Substrate binding By similarity | ||||||
| Region | 72 – 76 | 5 | Substrate binding By similarity | ||||||
| Coiled coil | 239 – 271 | 33 | Potential | ||||||
Sites | |||||||||
| Metal binding | 328 | 1 | Iron (heme axial ligand) By similarity | ||||||
| Binding site | 144 | 1 | Substrate By similarity | ||||||
| Binding site | 151 | 1 | Heme By similarity | ||||||
| Binding site | 342 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 155 | 1 | Phosphoserine Ref.5 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat." Comings D.E., Muhleman D., Dietz G., Sherman M., Forest G.L. Genomics 29:390-396(1995) [PubMed: 8666386] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland. |
| [3] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver. |
| [5] | "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry." Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J., Bodenmiller B., Watts J.D., Hood L., Aebersold R. Nat. Methods 2:591-598(2005) [PubMed: 16094384] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155, MASS SPECTROMETRY. Tissue: T-cell. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U32989 mRNA. Translation: AAB08514.1. AK289418 mRNA. Translation: BAF82107.1. CH471056 Genomic DNA. Translation: EAX04885.1. BC005355 mRNA. Translation: AAH05355.1. | |
| IPI | IPI00011206. |
| PIR | G02022. |
| RefSeq | NP_005642.1. |
| UniGene | Hs.183671 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P48775. 1 interaction. |
| STRING | P48775. |
PTM databases | |
| PhosphoSite | P48775. |
Proteomic databases | |
| PRIDE | P48775. |
Genome annotation databases | |
| Ensembl | ENST00000281525; ENSP00000281525; ENSG00000151790; Homo sapiens. [Genome view] |
| GeneID | 6999. |
| KEGG | hsa:6999. |
| UCSC | uc003ipf.1. human. |
Organism-specific databases | |
| CTD | 6999. |
| GeneCards | GC04P157044. |
| HGNC | HGNC:11708. TDO2. |
| MIM | 191070. gene. |
| PharmGKB | PA36427. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P48775. |
| HOVERGEN | P48775. |
| OMA | MKLILHE. |
Enzyme and pathway databases | |
| BRENDA | 1.13.11.11. 247. |
| Reactome | REACT_11193. Metabolism of vitamins and cofactors. REACT_13. Metabolism of amino acids. |
Gene expression databases | |
| ArrayExpress | P48775. |
| Bgee | P48775. |
| CleanEx | HS_TDO2. |
| Genevestigator | P48775. |
| GermOnline | ENSG00000151790. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR004981. Trp_2_3_dOase. [Graphical view] |
| PANTHER | PTHR10138. Trp_2_3_dOase. 1 hit. |
| Pfam | PF03301. Trp_dioxygenase. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| DrugBank | DB00150. L-Tryptophan. |
| NextBio | 27338. |
| SOURCE | Search... |
Entry information
| Entry name | T23O_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P48775 Secondary accession number(s): A8K053 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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