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P48774

- GSTM5_MOUSE

UniProt

P48774 - GSTM5_MOUSE

Protein

Glutathione S-transferase Mu 5

Gene

Gstm5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei119 – 1191SubstrateBy similarity

    GO - Molecular functioni

    1. glutathione binding Source: Ensembl
    2. glutathione transferase activity Source: MGI
    3. protein binding Source: MGI
    4. protein homodimerization activity Source: MGI

    GO - Biological processi

    1. cellular detoxification of nitrogen compound Source: Ensembl
    2. glutathione metabolic process Source: UniProtKB
    3. nitrobenzene metabolic process Source: Ensembl
    4. response to estrogen Source: Ensembl
    5. xenobiotic catabolic process Source: Ensembl

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    ReactomeiREACT_215316. Glutathione conjugation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase Mu 5 (EC:2.5.1.18)
    Alternative name(s):
    Fibrous sheath component 2
    Short name:
    Fsc2
    GST class-mu 5
    Gene namesi
    Name:Gstm5
    Synonyms:Fsc2, Gstm3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1309466. Gstm5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. sperm fibrous sheath Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 224224Glutathione S-transferase Mu 5PRO_0000185829Add
    BLAST

    Proteomic databases

    MaxQBiP48774.
    PaxDbiP48774.
    PRIDEiP48774.

    PTM databases

    PhosphoSiteiP48774.

    Expressioni

    Gene expression databases

    ArrayExpressiP48774.
    BgeeiP48774.
    CleanExiMM_GSTM3.
    MM_GSTM5.
    GenevestigatoriP48774.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiP48774. 2 interactions.
    MINTiMINT-4096984.
    STRINGi10090.ENSMUSP00000004134.

    Structurei

    3D structure databases

    ProteinModelPortaliP48774.
    SMRiP48774. Positions 5-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 9188GST N-terminalAdd
    BLAST
    Domaini93 – 211119GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni10 – 112Glutathione bindingBy similarity
    Regioni49 – 535Glutathione bindingBy similarity
    Regioni62 – 632Glutathione bindingBy similarity
    Regioni75 – 762Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Mu family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG300089.
    GeneTreeiENSGT00550000074559.
    HOGENOMiHOG000115735.
    HOVERGENiHBG106842.
    InParanoidiP48774.
    KOiK00799.
    OMAiCYNSDHE.
    OrthoDBiEOG7KH9M3.
    PhylomeDBiP48774.
    TreeFamiTF353040.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003081. GST_mu.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    PRINTSiPR01267. GSTRNSFRASEM.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48774-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSKSMVLGY WDIRGLAHAI RMLLEFTDTS YEEKRYICGE APDYDRSQWL    50
    DVKFKLDLDF PNLPYLMDGK NKITQSNAIL RYIARKHNMC GDTEEEKIRV 100
    DIMENQIMDF RMQLVRLCYN SNHENLKPQY LEQLPAQLKQ FSLFLGKFTW 150
    FAGEKLTFVD FLTYDVLDQN RIFEPKCLDE FPNLKAFMCR FEALEKIAAF 200
    LQSDRFFKMP INNKMAKWGN KCLC 224
    Length:224
    Mass (Da):26,635
    Last modified:February 1, 1996 - v1
    Checksum:i70122FD0682237E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24428 mRNA. Translation: AAB04096.1.
    AK002750 mRNA. Translation: BAB22327.1.
    AK019317 mRNA. Translation: BAB31661.1.
    AK028098 mRNA. Translation: BAC25746.1.
    BC008206 mRNA. Translation: AAH08206.1.
    CCDSiCCDS17741.1.
    RefSeqiNP_034490.1. NM_010360.2.
    UniGeneiMm.282351.

    Genome annotation databases

    EnsembliENSMUST00000004134; ENSMUSP00000004134; ENSMUSG00000004032.
    GeneIDi14866.
    KEGGimmu:14866.
    UCSCiuc008qxs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24428 mRNA. Translation: AAB04096.1 .
    AK002750 mRNA. Translation: BAB22327.1 .
    AK019317 mRNA. Translation: BAB31661.1 .
    AK028098 mRNA. Translation: BAC25746.1 .
    BC008206 mRNA. Translation: AAH08206.1 .
    CCDSi CCDS17741.1.
    RefSeqi NP_034490.1. NM_010360.2.
    UniGenei Mm.282351.

    3D structure databases

    ProteinModelPortali P48774.
    SMRi P48774. Positions 5-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P48774. 2 interactions.
    MINTi MINT-4096984.
    STRINGi 10090.ENSMUSP00000004134.

    PTM databases

    PhosphoSitei P48774.

    Proteomic databases

    MaxQBi P48774.
    PaxDbi P48774.
    PRIDEi P48774.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004134 ; ENSMUSP00000004134 ; ENSMUSG00000004032 .
    GeneIDi 14866.
    KEGGi mmu:14866.
    UCSCi uc008qxs.1. mouse.

    Organism-specific databases

    CTDi 2949.
    MGIi MGI:1309466. Gstm5.

    Phylogenomic databases

    eggNOGi NOG300089.
    GeneTreei ENSGT00550000074559.
    HOGENOMi HOG000115735.
    HOVERGENi HBG106842.
    InParanoidi P48774.
    KOi K00799.
    OMAi CYNSDHE.
    OrthoDBi EOG7KH9M3.
    PhylomeDBi P48774.
    TreeFami TF353040.

    Enzyme and pathway databases

    Reactomei REACT_215316. Glutathione conjugation.

    Miscellaneous databases

    ChiTaRSi GSTM5. mouse.
    NextBioi 287121.
    PROi P48774.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P48774.
    Bgeei P48774.
    CleanExi MM_GSTM3.
    MM_GSTM5.
    Genevestigatori P48774.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003081. GST_mu.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01267. GSTRNSFRASEM.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a unique mu-class glutathione S-transferase in mouse spermatogenic cells."
      Fulcher K.D., Welch J.E., Klapper D.G., O'Brien D.A., Eddy E.M.
      Mol. Reprod. Dev. 42:415-424(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
      Tissue: Testis.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hippocampus, Kidney and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    4. Lubec G., Kang S.U., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 22-34; 54-70; 71-81; 156-171 AND 197-205, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6 and OF1.
      Tissue: Brain and Hippocampus.

    Entry informationi

    Entry nameiGSTM5_MOUSE
    AccessioniPrimary (citable) accession number: P48774
    Secondary accession number(s): Q545W5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3