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Protein

Cytochrome c oxidase subunit 7A2, mitochondrial

Gene

Cox7a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIa-liver/heart
Short name:
Cytochrome c oxidase subunit VIIa-L
Gene namesi
Name:Cox7a2
Synonyms:Cox7a3, Cox7al
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1316715. Cox7a2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • mitochondrial inner membrane Source: MGI
  • mitochondrial respiratory chain Source: InterPro
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 23MitochondrionBy similarityAdd BLAST23
ChainiPRO_000000614624 – 83Cytochrome c oxidase subunit 7A2, mitochondrialAdd BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP48771.
MaxQBiP48771.
PaxDbiP48771.
PeptideAtlasiP48771.
PRIDEiP48771.
TopDownProteomicsiP48771.

PTM databases

iPTMnetiP48771.
PhosphoSitePlusiP48771.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032330.
CleanExiMM_COX7A2.
GenevisibleiP48771. MM.

Interactioni

Subunit structurei

Interacts with PET100.By similarity

Protein-protein interaction databases

BioGridi198847. 2 interactors.
IntActiP48771. 3 interactors.
MINTiMINT-1842097.
STRINGi10090.ENSMUSP00000034881.

Structurei

3D structure databases

ProteinModelPortaliP48771.
SMRiP48771.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IZJ9. Eukaryota.
ENOG41124EQ. LUCA.
GeneTreeiENSGT00400000022054.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP48771.
KOiK02270.
OMAiHFENKVP.
OrthoDBiEOG091G12UD.
PhylomeDBiP48771.
TreeFamiTF105067.

Family and domain databases

CDDicd00928. Cyt_c_Oxidase_VIIa. 1 hit.
Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48771-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNLLALRQ IAQRTISTTS RRHFENKVPE KQKLFQEDNG MPVHLKGGAS
60 70 80
DALLYRATMA LTLGGTAYAI YLLAMAAFPK KQN
Length:83
Mass (Da):9,291
Last modified:December 1, 2000 - v2
Checksum:i06A3766E23ED69ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10Q → K in CAA41396 (PubMed:1659684).Curated1
Sequence conflicti51D → N in CAA41396 (PubMed:1659684).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58486 mRNA. Translation: CAA41396.1.
AF037371 mRNA. Translation: AAB92615.1.
AK007875 mRNA. Translation: BAB25324.1.
AK011269 mRNA. Translation: BAB27507.1.
AK019210 mRNA. Translation: BAB31602.1.
AK153173 mRNA. Translation: BAE31778.1.
BC010979 mRNA. Translation: AAH10979.1.
CCDSiCCDS23366.1.
PIRiI48286.
RefSeqiNP_034075.2. NM_009945.3.
UniGeneiMm.152627.

Genome annotation databases

EnsembliENSMUST00000034881; ENSMUSP00000034881; ENSMUSG00000032330.
GeneIDi12866.
KEGGimmu:12866.
UCSCiuc009quv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58486 mRNA. Translation: CAA41396.1.
AF037371 mRNA. Translation: AAB92615.1.
AK007875 mRNA. Translation: BAB25324.1.
AK011269 mRNA. Translation: BAB27507.1.
AK019210 mRNA. Translation: BAB31602.1.
AK153173 mRNA. Translation: BAE31778.1.
BC010979 mRNA. Translation: AAH10979.1.
CCDSiCCDS23366.1.
PIRiI48286.
RefSeqiNP_034075.2. NM_009945.3.
UniGeneiMm.152627.

3D structure databases

ProteinModelPortaliP48771.
SMRiP48771.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198847. 2 interactors.
IntActiP48771. 3 interactors.
MINTiMINT-1842097.
STRINGi10090.ENSMUSP00000034881.

PTM databases

iPTMnetiP48771.
PhosphoSitePlusiP48771.

Proteomic databases

EPDiP48771.
MaxQBiP48771.
PaxDbiP48771.
PeptideAtlasiP48771.
PRIDEiP48771.
TopDownProteomicsiP48771.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034881; ENSMUSP00000034881; ENSMUSG00000032330.
GeneIDi12866.
KEGGimmu:12866.
UCSCiuc009quv.1. mouse.

Organism-specific databases

CTDi1347.
MGIiMGI:1316715. Cox7a2.

Phylogenomic databases

eggNOGiENOG410IZJ9. Eukaryota.
ENOG41124EQ. LUCA.
GeneTreeiENSGT00400000022054.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP48771.
KOiK02270.
OMAiHFENKVP.
OrthoDBiEOG091G12UD.
PhylomeDBiP48771.
TreeFamiTF105067.

Miscellaneous databases

PROiP48771.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032330.
CleanExiMM_COX7A2.
GenevisibleiP48771. MM.

Family and domain databases

CDDicd00928. Cyt_c_Oxidase_VIIa. 1 hit.
Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCX7A2_MOUSE
AccessioniPrimary (citable) accession number: P48771
Secondary accession number(s): O54969, Q545J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.