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Protein

Cytochrome c oxidase subunit 7A2, mitochondrial

Gene

Cox7a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIa-liver/heart
Short name:
Cytochrome c oxidase subunit VIIa-L
Gene namesi
Name:Cox7a2
Synonyms:Cox7a3, Cox7al
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1316715. Cox7a2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • mitochondrial inner membrane Source: MGI
  • mitochondrial respiratory chain Source: InterPro
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2323MitochondrionBy similarityAdd
BLAST
Chaini24 – 8360Cytochrome c oxidase subunit 7A2, mitochondrialPRO_0000006146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP48771.
MaxQBiP48771.
PaxDbiP48771.
PRIDEiP48771.
TopDownProteomicsiP48771.

PTM databases

iPTMnetiP48771.
PhosphoSiteiP48771.

Expressioni

Gene expression databases

BgeeiP48771.
CleanExiMM_COX7A2.
GenevisibleiP48771. MM.

Interactioni

Subunit structurei

Interacts with PET100.By similarity

Protein-protein interaction databases

BioGridi198847. 2 interactions.
IntActiP48771. 3 interactions.
MINTiMINT-1842097.
STRINGi10090.ENSMUSP00000034881.

Structurei

3D structure databases

ProteinModelPortaliP48771.
SMRiP48771. Positions 24-79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IZJ9. Eukaryota.
ENOG41124EQ. LUCA.
GeneTreeiENSGT00400000022054.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP48771.
KOiK02270.
OMAiHFENKVP.
OrthoDBiEOG7BGHNV.
PhylomeDBiP48771.
TreeFamiTF105067.

Family and domain databases

Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48771-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNLLALRQ IAQRTISTTS RRHFENKVPE KQKLFQEDNG MPVHLKGGAS
60 70 80
DALLYRATMA LTLGGTAYAI YLLAMAAFPK KQN
Length:83
Mass (Da):9,291
Last modified:December 1, 2000 - v2
Checksum:i06A3766E23ED69ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101Q → K in CAA41396 (PubMed:1659684).Curated
Sequence conflicti51 – 511D → N in CAA41396 (PubMed:1659684).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58486 mRNA. Translation: CAA41396.1.
AF037371 mRNA. Translation: AAB92615.1.
AK007875 mRNA. Translation: BAB25324.1.
AK011269 mRNA. Translation: BAB27507.1.
AK019210 mRNA. Translation: BAB31602.1.
AK153173 mRNA. Translation: BAE31778.1.
BC010979 mRNA. Translation: AAH10979.1.
CCDSiCCDS23366.1.
PIRiI48286.
RefSeqiNP_034075.2. NM_009945.3.
UniGeneiMm.152627.

Genome annotation databases

EnsembliENSMUST00000034881; ENSMUSP00000034881; ENSMUSG00000032330.
GeneIDi12866.
KEGGimmu:12866.
UCSCiuc009quv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58486 mRNA. Translation: CAA41396.1.
AF037371 mRNA. Translation: AAB92615.1.
AK007875 mRNA. Translation: BAB25324.1.
AK011269 mRNA. Translation: BAB27507.1.
AK019210 mRNA. Translation: BAB31602.1.
AK153173 mRNA. Translation: BAE31778.1.
BC010979 mRNA. Translation: AAH10979.1.
CCDSiCCDS23366.1.
PIRiI48286.
RefSeqiNP_034075.2. NM_009945.3.
UniGeneiMm.152627.

3D structure databases

ProteinModelPortaliP48771.
SMRiP48771. Positions 24-79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198847. 2 interactions.
IntActiP48771. 3 interactions.
MINTiMINT-1842097.
STRINGi10090.ENSMUSP00000034881.

PTM databases

iPTMnetiP48771.
PhosphoSiteiP48771.

Proteomic databases

EPDiP48771.
MaxQBiP48771.
PaxDbiP48771.
PRIDEiP48771.
TopDownProteomicsiP48771.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034881; ENSMUSP00000034881; ENSMUSG00000032330.
GeneIDi12866.
KEGGimmu:12866.
UCSCiuc009quv.1. mouse.

Organism-specific databases

CTDi1347.
MGIiMGI:1316715. Cox7a2.

Phylogenomic databases

eggNOGiENOG410IZJ9. Eukaryota.
ENOG41124EQ. LUCA.
GeneTreeiENSGT00400000022054.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiP48771.
KOiK02270.
OMAiHFENKVP.
OrthoDBiEOG7BGHNV.
PhylomeDBiP48771.
TreeFamiTF105067.

Miscellaneous databases

PROiP48771.
SOURCEiSearch...

Gene expression databases

BgeeiP48771.
CleanExiMM_COX7A2.
GenevisibleiP48771. MM.

Family and domain databases

Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a large number of novel mammalian genes by a differential cDNA library screening strategy."
    Hoeoeg C.
    Nucleic Acids Res. 19:6123-6127(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Testis.
  2. "Mouse liver cytochrome c oxidase subunit VIIa cDNA."
    Jaradat S.A., Grossman L.I.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Pancreas.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  5. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 34-56, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  7. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-33, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCX7A2_MOUSE
AccessioniPrimary (citable) accession number: P48771
Secondary accession number(s): O54969, Q545J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: June 8, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.