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Protein

Deoxycytidine kinase

Gene

Dck

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA).By similarity

Catalytic activityi

NTP + deoxycytidine = NDP + dCMP.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53SubstrateBy similarity1
Binding sitei86SubstrateBy similarity1
Binding sitei97SubstrateBy similarity1
Active sitei127Proton acceptorSequence analysis1
Binding sitei128SubstrateBy similarity1
Binding sitei133SubstrateBy similarity1
Binding sitei197SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 36ATPBy similarity9
Nucleotide bindingi188 – 192ATPBy similarity5
Nucleotide bindingi240 – 242ATPBy similarity3

GO - Molecular functioni

  • ATP binding Source: RGD
  • deoxycytidine kinase activity Source: RGD
  • drug binding Source: RGD
  • magnesium ion binding Source: RGD
  • pyrimidine deoxyribonucleoside binding Source: RGD

GO - Biological processi

  • deoxycytidine metabolic process Source: RGD
  • drug metabolic process Source: RGD
  • pyrimidine nucleotide metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKP48769.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidine kinase (EC:2.7.1.74)
Short name:
dCK
Gene namesi
Name:Dck
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620667. Dck.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3271929.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001750921 – 260Deoxycytidine kinaseAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11Phosphoserine; by CK1By similarity1
Modified residuei15Phosphoserine; by CK1By similarity1
Modified residuei72Phosphothreonine; by CK1By similarity1
Modified residuei74Phosphoserine; by CK1By similarity1

Post-translational modificationi

Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP48769.
PRIDEiP48769.

PTM databases

iPTMnetiP48769.
PhosphoSitePlusiP48769.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004440.

Structurei

3D structure databases

ProteinModelPortaliP48769.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DCK/DGK family.Curated

Phylogenomic databases

eggNOGiKOG4235. Eukaryota.
COG1428. LUCA.
HOGENOMiHOG000290165.
HOVERGENiHBG006216.
InParanoidiP48769.
KOiK00893.
PhylomeDBiP48769.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DCK/DGK.
IPR031314. DNK_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000705. DNK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P48769-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPPKRFCS SPSTSSEGTR IKKISIEGNI AAGKSTFVNI LKQVCEDWEV
60 70 80 90 100
VPEPVARWCN VQSTQDEFEE LTTSQKSGGN VLQMMYEKPE RWSFIFQSYA
110 120 130 140 150
CLSRIRAQLA SLNGSLRDAE KPVLFFERSV YSDRYIFASN LYESDCMNET
160 170 180 190 200
EWTIYQDWHD WMNSQFGQSL ELDGIIYLRA TPEKCLNRIY IRGRDEEQGI
210 220 230 240 250
PLEYLEKLHY KHESWLLHRT LKTNFEYLQE VPILTLDVNL DFKDKEESLV
260
EKVKEFLSTT
Length:260
Mass (Da):30,406
Last modified:February 1, 1996 - v1
Checksum:i4F6C9FAAC09EDBB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33894 mRNA. Translation: AAA65098.1.
RefSeqiNP_077072.1. NM_024158.1.
UniGeneiRn.10058.

Genome annotation databases

GeneIDi79127.
KEGGirno:79127.
UCSCiRGD:620667. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33894 mRNA. Translation: AAA65098.1.
RefSeqiNP_077072.1. NM_024158.1.
UniGeneiRn.10058.

3D structure databases

ProteinModelPortaliP48769.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004440.

Chemistry databases

ChEMBLiCHEMBL3271929.

PTM databases

iPTMnetiP48769.
PhosphoSitePlusiP48769.

Proteomic databases

PaxDbiP48769.
PRIDEiP48769.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi79127.
KEGGirno:79127.
UCSCiRGD:620667. rat.

Organism-specific databases

CTDi1633.
RGDi620667. Dck.

Phylogenomic databases

eggNOGiKOG4235. Eukaryota.
COG1428. LUCA.
HOGENOMiHOG000290165.
HOVERGENiHBG006216.
InParanoidiP48769.
KOiK00893.
PhylomeDBiP48769.

Enzyme and pathway databases

SABIO-RKP48769.

Miscellaneous databases

PROiP48769.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DCK/DGK.
IPR031314. DNK_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000705. DNK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCK_RAT
AccessioniPrimary (citable) accession number: P48769
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.