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Protein

Deoxycytidine kinase

Gene

Dck

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA).By similarity

Catalytic activityi

NTP + deoxycytidine = NDP + dCMP.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531SubstrateBy similarity
Binding sitei86 – 861SubstrateBy similarity
Binding sitei97 – 971SubstrateBy similarity
Active sitei127 – 1271Proton acceptorSequence Analysis
Binding sitei128 – 1281SubstrateBy similarity
Binding sitei133 – 1331SubstrateBy similarity
Binding sitei197 – 1971SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi28 – 369ATPBy similarity
Nucleotide bindingi188 – 1925ATPBy similarity
Nucleotide bindingi240 – 2423ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: RGD
  2. deoxycytidine kinase activity Source: RGD
  3. drug binding Source: RGD
  4. magnesium ion binding Source: RGD
  5. pyrimidine deoxyribonucleoside binding Source: RGD

GO - Biological processi

  1. deoxycytidine metabolic process Source: RGD
  2. deoxyribonucleoside monophosphate biosynthetic process Source: GOC
  3. drug metabolic process Source: RGD
  4. pyrimidine nucleotide metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKP48769.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidine kinase (EC:2.7.1.74)
Short name:
dCK
Gene namesi
Name:Dck
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620667. Dck.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytosol Source: RGD
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Deoxycytidine kinasePRO_0000175092Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111Phosphoserine; by CK1By similarity
Modified residuei15 – 151Phosphoserine; by CK1By similarity
Modified residuei72 – 721Phosphothreonine; by CK1By similarity
Modified residuei74 – 741Phosphoserine; by CK1By similarity

Post-translational modificationi

Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.By similarity

Keywords - PTMi

Phosphoprotein

PTM databases

PhosphoSiteiP48769.

Expressioni

Gene expression databases

GenevestigatoriP48769.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004440.

Structurei

3D structure databases

ProteinModelPortaliP48769.
SMRiP48769. Positions 19-259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DCK/DGK family.Curated

Phylogenomic databases

eggNOGiCOG1428.
HOGENOMiHOG000290165.
HOVERGENiHBG006216.
InParanoidiP48769.
KOiK00893.
PhylomeDBiP48769.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10513. PTHR10513. 1 hit.
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000705. DNK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P48769-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPPKRFCS SPSTSSEGTR IKKISIEGNI AAGKSTFVNI LKQVCEDWEV
60 70 80 90 100
VPEPVARWCN VQSTQDEFEE LTTSQKSGGN VLQMMYEKPE RWSFIFQSYA
110 120 130 140 150
CLSRIRAQLA SLNGSLRDAE KPVLFFERSV YSDRYIFASN LYESDCMNET
160 170 180 190 200
EWTIYQDWHD WMNSQFGQSL ELDGIIYLRA TPEKCLNRIY IRGRDEEQGI
210 220 230 240 250
PLEYLEKLHY KHESWLLHRT LKTNFEYLQE VPILTLDVNL DFKDKEESLV
260
EKVKEFLSTT
Length:260
Mass (Da):30,406
Last modified:February 1, 1996 - v1
Checksum:i4F6C9FAAC09EDBB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33894 mRNA. Translation: AAA65098.1.
RefSeqiNP_077072.1. NM_024158.1.
UniGeneiRn.10058.

Genome annotation databases

GeneIDi79127.
KEGGirno:79127.
UCSCiRGD:620667. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33894 mRNA. Translation: AAA65098.1.
RefSeqiNP_077072.1. NM_024158.1.
UniGeneiRn.10058.

3D structure databases

ProteinModelPortaliP48769.
SMRiP48769. Positions 19-259.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004440.

PTM databases

PhosphoSiteiP48769.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi79127.
KEGGirno:79127.
UCSCiRGD:620667. rat.

Organism-specific databases

CTDi1633.
RGDi620667. Dck.

Phylogenomic databases

eggNOGiCOG1428.
HOGENOMiHOG000290165.
HOVERGENiHBG006216.
InParanoidiP48769.
KOiK00893.
PhylomeDBiP48769.

Enzyme and pathway databases

SABIO-RKP48769.

Miscellaneous databases

NextBioi614566.
PROiP48769.

Gene expression databases

GenevestigatoriP48769.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10513. PTHR10513. 1 hit.
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000705. DNK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning of the Dck gene encoding rat deoxycytidine kinase."
    Stegmann A.P., Honders M.W., Willemze R., Landegent J.E.
    Gene 150:351-354(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiDCK_RAT
AccessioniPrimary (citable) accession number: P48769
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.