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P48769

- DCK_RAT

UniProt

P48769 - DCK_RAT

Protein

Deoxycytidine kinase

Gene

Dck

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA).By similarity

    Catalytic activityi

    NTP + deoxycytidine = NDP + dCMP.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei53 – 531SubstrateBy similarity
    Binding sitei86 – 861SubstrateBy similarity
    Binding sitei97 – 971SubstrateBy similarity
    Active sitei127 – 1271Proton acceptorSequence Analysis
    Binding sitei128 – 1281SubstrateBy similarity
    Binding sitei133 – 1331SubstrateBy similarity
    Binding sitei197 – 1971SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi28 – 369ATPBy similarity
    Nucleotide bindingi188 – 1925ATPBy similarity
    Nucleotide bindingi240 – 2423ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: RGD
    2. deoxycytidine kinase activity Source: RGD
    3. drug binding Source: RGD
    4. magnesium ion binding Source: RGD
    5. phosphotransferase activity, alcohol group as acceptor Source: InterPro
    6. pyrimidine deoxyribonucleoside binding Source: RGD

    GO - Biological processi

    1. deoxycytidine metabolic process Source: RGD
    2. deoxyribonucleoside monophosphate biosynthetic process Source: GOC
    3. drug metabolic process Source: RGD
    4. pyrimidine nucleotide metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SABIO-RKP48769.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxycytidine kinase (EC:2.7.1.74)
    Short name:
    dCK
    Gene namesi
    Name:Dck
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620667. Dck.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytosol Source: RGD
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260Deoxycytidine kinasePRO_0000175092Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei11 – 111Phosphoserine; by CK1By similarity
    Modified residuei15 – 151Phosphoserine; by CK1By similarity
    Modified residuei72 – 721Phosphothreonine; by CK1By similarity
    Modified residuei74 – 741Phosphoserine; by CK1By similarity

    Post-translational modificationi

    Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.By similarity

    Keywords - PTMi

    Phosphoprotein

    PTM databases

    PhosphoSiteiP48769.

    Expressioni

    Gene expression databases

    GenevestigatoriP48769.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000004440.

    Structurei

    3D structure databases

    ProteinModelPortaliP48769.
    SMRiP48769. Positions 19-259.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DCK/DGK family.Curated

    Phylogenomic databases

    eggNOGiCOG1428.
    HOGENOMiHOG000290165.
    HOVERGENiHBG006216.
    InParanoidiP48769.
    KOiK00893.
    PhylomeDBiP48769.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR002624. DNK.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10513. PTHR10513. 1 hit.
    PfamiPF01712. dNK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000705. DNK. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P48769-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATPPKRFCS SPSTSSEGTR IKKISIEGNI AAGKSTFVNI LKQVCEDWEV    50
    VPEPVARWCN VQSTQDEFEE LTTSQKSGGN VLQMMYEKPE RWSFIFQSYA 100
    CLSRIRAQLA SLNGSLRDAE KPVLFFERSV YSDRYIFASN LYESDCMNET 150
    EWTIYQDWHD WMNSQFGQSL ELDGIIYLRA TPEKCLNRIY IRGRDEEQGI 200
    PLEYLEKLHY KHESWLLHRT LKTNFEYLQE VPILTLDVNL DFKDKEESLV 250
    EKVKEFLSTT 260
    Length:260
    Mass (Da):30,406
    Last modified:February 1, 1996 - v1
    Checksum:i4F6C9FAAC09EDBB7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33894 mRNA. Translation: AAA65098.1.
    RefSeqiNP_077072.1. NM_024158.1.
    UniGeneiRn.10058.

    Genome annotation databases

    GeneIDi79127.
    KEGGirno:79127.
    UCSCiRGD:620667. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33894 mRNA. Translation: AAA65098.1 .
    RefSeqi NP_077072.1. NM_024158.1.
    UniGenei Rn.10058.

    3D structure databases

    ProteinModelPortali P48769.
    SMRi P48769. Positions 19-259.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000004440.

    PTM databases

    PhosphoSitei P48769.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 79127.
    KEGGi rno:79127.
    UCSCi RGD:620667. rat.

    Organism-specific databases

    CTDi 1633.
    RGDi 620667. Dck.

    Phylogenomic databases

    eggNOGi COG1428.
    HOGENOMi HOG000290165.
    HOVERGENi HBG006216.
    InParanoidi P48769.
    KOi K00893.
    PhylomeDBi P48769.

    Enzyme and pathway databases

    SABIO-RK P48769.

    Miscellaneous databases

    NextBioi 614566.
    PROi P48769.

    Gene expression databases

    Genevestigatori P48769.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR002624. DNK.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10513. PTHR10513. 1 hit.
    Pfami PF01712. dNK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000705. DNK. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the Dck gene encoding rat deoxycytidine kinase."
      Stegmann A.P., Honders M.W., Willemze R., Landegent J.E.
      Gene 150:351-354(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiDCK_RAT
    AccessioniPrimary (citable) accession number: P48769
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3