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P48769 (DCK_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Deoxycytidine kinase
Short name=dCK
EC=2.7.1.74
Gene names
Name:Dck
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA) By similarity.

Catalytic activity

NTP + deoxycytidine = NDP + dCMP.

Subunit structure

Homodimer.

Subcellular location

Nucleus By similarity.

Post-translational modification

Phosphorylated upon DNA damage, probably by ATM or ATR By similarity. Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1 By similarity.

Sequence similarities

Belongs to the DCK/DGK family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Deoxycytidine kinase
PRO_0000175092

Regions

Nucleotide binding28 – 369ATP By similarity
Nucleotide binding188 – 1925ATP By similarity
Nucleotide binding240 – 2423ATP By similarity

Sites

Active site1271Proton acceptor Potential
Binding site531Substrate By similarity
Binding site861Substrate By similarity
Binding site971Substrate By similarity
Binding site1281Substrate By similarity
Binding site1331Substrate By similarity
Binding site1971Substrate By similarity

Amino acid modifications

Modified residue31Phosphothreonine By similarity
Modified residue111Phosphoserine; by CK1 By similarity
Modified residue131Phosphoserine By similarity
Modified residue151Phosphoserine; by CK1 By similarity
Modified residue161Phosphoserine By similarity
Modified residue351Phosphoserine By similarity
Modified residue631Phosphoserine By similarity
Modified residue721Phosphothreonine; by CK1 By similarity
Modified residue741Phosphoserine; by CK1 By similarity

Sequences

Sequence LengthMass (Da)Tools
P48769 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 4F6C9FAAC09EDBB7

FASTA26030,406
        10         20         30         40         50         60 
MATPPKRFCS SPSTSSEGTR IKKISIEGNI AAGKSTFVNI LKQVCEDWEV VPEPVARWCN 

        70         80         90        100        110        120 
VQSTQDEFEE LTTSQKSGGN VLQMMYEKPE RWSFIFQSYA CLSRIRAQLA SLNGSLRDAE 

       130        140        150        160        170        180 
KPVLFFERSV YSDRYIFASN LYESDCMNET EWTIYQDWHD WMNSQFGQSL ELDGIIYLRA 

       190        200        210        220        230        240 
TPEKCLNRIY IRGRDEEQGI PLEYLEKLHY KHESWLLHRT LKTNFEYLQE VPILTLDVNL 

       250        260 
DFKDKEESLV EKVKEFLSTT

« Hide

References

[1]"Cloning of the Dck gene encoding rat deoxycytidine kinase."
Stegmann A.P., Honders M.W., Willemze R., Landegent J.E.
Gene 150:351-354(1994) [PubMed: 7821805] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L33894 mRNA. Translation: AAA65098.1.
IPIIPI00193680.
RefSeqNP_077072.1. NM_024158.1.
UniGeneRn.10058.

3D structure databases

ProteinModelPortalP48769.
SMRP48769. Positions 19-259.
ModBaseSearch...

Protein-protein interaction databases

STRINGP48769.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID79127.
KEGGrno:79127.
UCSCNM_024158. rat.

Organism-specific databases

CTD1633.
RGD620667. Dck.

Phylogenomic databases

eggNOGroNOG14466.
GeneTreeENSGT00510000046588.
HOVERGENHBG006216.
InParanoidP48769.
OrthoDBEOG48WC2T.

Gene expression databases

ArrayExpressP48769.
GenevestigatorP48769.
GermOnlineENSRNOG00000003296. Rattus norvegicus.

Family and domain databases

InterProIPR002624. Deoxynucleoside_kinase.
[Graphical view]
KOK00893.
PANTHERPTHR10513. dNK. 1 hit.
PfamPF01712. dNK. 1 hit.
[Graphical view]
PIRSFPIRSF000705. DNK. 1 hit.
ProtoNetSearch...

Other

NextBio614566.

Entry information

Entry nameDCK_RAT
AccessionPrimary (citable) accession number: P48769
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: December 14, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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