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P48759 (PTX3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pentraxin-related protein PTX3
Alternative name(s):
Pentaxin-related protein PTX3
Tumor necrosis factor-inducible gene 14 protein
Short name=TSG-14
Gene names
Name:Ptx3
Synonyms:Tsg14
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Ref.4

Subunit structure

Homooctamer; disulfide-linked By similarity. Binds to C1q. Ref.4

Subcellular location

Secreted.

Sequence similarities

Contains 1 pentaxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 381364Pentraxin-related protein PTX3
PRO_0000023546

Regions

Domain183 – 381199Pentaxin

Amino acid modifications

Glycosylation2201N-linked (GlcNAc...) Potential
Disulfide bond47Interchain By similarity
Disulfide bond49Interchain By similarity
Disulfide bond103Interchain By similarity
Disulfide bond179 ↔ 357 By similarity
Disulfide bond210 ↔ 271 By similarity
Disulfide bond317Interchain By similarity
Disulfide bond318Interchain By similarity

Experimental info

Sequence conflict501R → A in AAC52273. Ref.3
Sequence conflict901A → S in AAC52273. Ref.3
Sequence conflict1291L → R in AAH22176. Ref.2
Sequence conflict1421P → S in AAH22176. Ref.2
Sequence conflict1471P → S in AAH22176. Ref.2
Sequence conflict1611A → S in AAC52273. Ref.3
Sequence conflict1721R → H in AAC52273. Ref.3
Sequence conflict1841F → L in AAH22176. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P48759 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: E3CA3B1D93CFE4EB

FASTA38141,812
        10         20         30         40         50         60 
MHLPAILLCA LWSAVVAETS DDYELMYVNL DNEIDNGLHP TEDPTPCDCR QEHSEWDKLF 

        70         80         90        100        110        120 
IMLENSQMRE GMLLQATDDV LRGELQRLRA ELGRLAGGMA RPCAAGGPAD ARLVRALEPL 

       130        140        150        160        170        180 
LQESRDASLR LARLEDAEAR RPEATVPGLG AVLEELRRTR ADLSAVQSWV ARHWLPAGCE 

       190        200        210        220        230        240 
TAIFFPMRSK KIFGSVHPVR PMKLESFSTC IWVKATDVLN KTILFSYGTK WNPYEIQLYL 

       250        260        270        280        290        300 
SSQSLVLVVG GKENKLAADT VVSLGRWSHL CGTWSSEQGS MSLWANGELV ATTVEMAKSH 

       310        320        330        340        350        360 
SVPEGGLLQI GQEKNGCCVG GGFDESLAFS GRITGFNIWD RVLSEEEIRA SGGVESCHIR 

       370        380 
GNVVGWGVTE IQAHGGAQYV S 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites."
Introna M., Vidal Alles V., Castellano M., Picardi G., de Gioia L., Bottazzai B., Peri G., Breviario F., Salmona M., de Gregorio I., Dragani T.A., Srinivasan N., Blundell T.L., Hamilton T.A., Mantovani A.
Blood 87:1862-1872(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Fibroblast.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary tumor.
[3]"Promoter structure and transcriptional activation of the murine TSG-14 gene encoding a tumor necrosis factor/interleukin-1-inducible pentraxin protein."
Altmeyer A., Klampfer L., Goodman A.R., Vilcek J.
J. Biol. Chem. 270:25584-25590(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-177.
Strain: 129/Sv.
[4]"Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component."
Bottazzi B., Vouret-Craviari V., Bastone A., De Gioia L., Matteucci C., Peri G., Spreafico F., Pausa M., D'Ettorre C., Gianazza E., Tagliabue A., Salmona M., Tedesco F., Introna M., Mantovani A.
J. Biol. Chem. 272:32817-32823(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT.
[5]"Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity."
Mantovani A., Garlanda C., Bottazzi B.
Vaccine 21:S43-S47(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X83601 mRNA. Translation: CAA58580.1.
BC022176 mRNA. Translation: AAH22176.1.
U33842 Genomic DNA. Translation: AAC52273.1.
CCDSCCDS17392.1.
RefSeqNP_033013.3. NM_008987.3.
UniGeneMm.276776.
Mm.442151.

3D structure databases

ProteinModelPortalP48759.
SMRP48759. Positions 182-375.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP48759. 1 interaction.
MINTMINT-8178435.
STRING10090.ENSMUSP00000029421.

PTM databases

PhosphoSiteP48759.

Proteomic databases

PRIDEP48759.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029421; ENSMUSP00000029421; ENSMUSG00000027832.
GeneID19288.
KEGGmmu:19288.
UCSCuc008pla.1. mouse.

Organism-specific databases

CTD5806.
MGIMGI:104641. Ptx3.

Phylogenomic databases

eggNOGNOG40461.
GeneTreeENSGT00650000093195.
HOGENOMHOG000247046.
HOVERGENHBG008331.
InParanoidP48759.
OMANIVGWGV.
OrthoDBEOG74XS6F.
PhylomeDBP48759.
TreeFamTF330208.

Gene expression databases

BgeeP48759.
CleanExMM_PTX3.
GenevestigatorP48759.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view]
PfamPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSPR00895. PENTAXIN.
SMARTSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio296214.
PROP48759.
SOURCESearch...

Entry information

Entry namePTX3_MOUSE
AccessionPrimary (citable) accession number: P48759
Secondary accession number(s): Q8VDF1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot