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P48759

- PTX3_MOUSE

UniProt

P48759 - PTX3_MOUSE

Protein

Pentraxin-related protein PTX3

Gene

Ptx3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.1 Publication

    GO - Molecular functioni

    1. (1->3)-beta-D-glucan binding Source: MGI

    GO - Biological processi

    1. opsonization Source: MGI
    2. positive regulation of nitric oxide biosynthetic process Source: MGI
    3. positive regulation of phagocytosis Source: MGI
    4. response to yeast Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pentraxin-related protein PTX3
    Alternative name(s):
    Pentaxin-related protein PTX3
    Tumor necrosis factor-inducible gene 14 protein
    Short name:
    TSG-14
    Gene namesi
    Name:Ptx3
    Synonyms:Tsg14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:104641. Ptx3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 381364Pentraxin-related protein PTX3PRO_0000023546Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 – 47InterchainBy similarity
    Disulfide bondi49 – 49InterchainBy similarity
    Disulfide bondi103 – 103InterchainBy similarity
    Disulfide bondi179 ↔ 357By similarity
    Disulfide bondi210 ↔ 271By similarity
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi317 – 317InterchainBy similarity
    Disulfide bondi318 – 318InterchainBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP48759.

    PTM databases

    PhosphoSiteiP48759.

    Expressioni

    Gene expression databases

    BgeeiP48759.
    CleanExiMM_PTX3.
    GenevestigatoriP48759.

    Interactioni

    Subunit structurei

    Homooctamer; disulfide-linked By similarity. Binds to C1q.By similarity1 Publication

    Protein-protein interaction databases

    IntActiP48759. 1 interaction.
    MINTiMINT-8178435.
    STRINGi10090.ENSMUSP00000029421.

    Structurei

    3D structure databases

    ProteinModelPortaliP48759.
    SMRiP48759. Positions 182-375.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini183 – 381199PentaxinAdd
    BLAST

    Sequence similaritiesi

    Contains 1 pentaxin domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40461.
    GeneTreeiENSGT00650000093195.
    HOGENOMiHOG000247046.
    HOVERGENiHBG008331.
    InParanoidiP48759.
    OMAiNIVGWGV.
    OrthoDBiEOG74XS6F.
    PhylomeDBiP48759.
    TreeFamiTF330208.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view]
    PfamiPF00354. Pentaxin. 1 hit.
    [Graphical view]
    PRINTSiPR00895. PENTAXIN.
    SMARTiSM00159. PTX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS00289. PENTAXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48759-1 [UniParc]FASTAAdd to Basket

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    MHLPAILLCA LWSAVVAETS DDYELMYVNL DNEIDNGLHP TEDPTPCDCR    50
    QEHSEWDKLF IMLENSQMRE GMLLQATDDV LRGELQRLRA ELGRLAGGMA 100
    RPCAAGGPAD ARLVRALEPL LQESRDASLR LARLEDAEAR RPEATVPGLG 150
    AVLEELRRTR ADLSAVQSWV ARHWLPAGCE TAIFFPMRSK KIFGSVHPVR 200
    PMKLESFSTC IWVKATDVLN KTILFSYGTK WNPYEIQLYL SSQSLVLVVG 250
    GKENKLAADT VVSLGRWSHL CGTWSSEQGS MSLWANGELV ATTVEMAKSH 300
    SVPEGGLLQI GQEKNGCCVG GGFDESLAFS GRITGFNIWD RVLSEEEIRA 350
    SGGVESCHIR GNVVGWGVTE IQAHGGAQYV S 381
    Length:381
    Mass (Da):41,812
    Last modified:October 1, 1996 - v2
    Checksum:iE3CA3B1D93CFE4EB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti50 – 501R → A in AAC52273. (PubMed:7592730)Curated
    Sequence conflicti90 – 901A → S in AAC52273. (PubMed:7592730)Curated
    Sequence conflicti129 – 1291L → R in AAH22176. (PubMed:15489334)Curated
    Sequence conflicti142 – 1421P → S in AAH22176. (PubMed:15489334)Curated
    Sequence conflicti147 – 1471P → S in AAH22176. (PubMed:15489334)Curated
    Sequence conflicti161 – 1611A → S in AAC52273. (PubMed:7592730)Curated
    Sequence conflicti172 – 1721R → H in AAC52273. (PubMed:7592730)Curated
    Sequence conflicti184 – 1841F → L in AAH22176. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83601 mRNA. Translation: CAA58580.1.
    BC022176 mRNA. Translation: AAH22176.1.
    U33842 Genomic DNA. Translation: AAC52273.1.
    CCDSiCCDS17392.1.
    RefSeqiNP_033013.3. NM_008987.3.
    UniGeneiMm.276776.
    Mm.442151.

    Genome annotation databases

    EnsembliENSMUST00000029421; ENSMUSP00000029421; ENSMUSG00000027832.
    GeneIDi19288.
    KEGGimmu:19288.
    UCSCiuc008pla.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83601 mRNA. Translation: CAA58580.1 .
    BC022176 mRNA. Translation: AAH22176.1 .
    U33842 Genomic DNA. Translation: AAC52273.1 .
    CCDSi CCDS17392.1.
    RefSeqi NP_033013.3. NM_008987.3.
    UniGenei Mm.276776.
    Mm.442151.

    3D structure databases

    ProteinModelPortali P48759.
    SMRi P48759. Positions 182-375.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P48759. 1 interaction.
    MINTi MINT-8178435.
    STRINGi 10090.ENSMUSP00000029421.

    PTM databases

    PhosphoSitei P48759.

    Proteomic databases

    PRIDEi P48759.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029421 ; ENSMUSP00000029421 ; ENSMUSG00000027832 .
    GeneIDi 19288.
    KEGGi mmu:19288.
    UCSCi uc008pla.1. mouse.

    Organism-specific databases

    CTDi 5806.
    MGIi MGI:104641. Ptx3.

    Phylogenomic databases

    eggNOGi NOG40461.
    GeneTreei ENSGT00650000093195.
    HOGENOMi HOG000247046.
    HOVERGENi HBG008331.
    InParanoidi P48759.
    OMAi NIVGWGV.
    OrthoDBi EOG74XS6F.
    PhylomeDBi P48759.
    TreeFami TF330208.

    Miscellaneous databases

    NextBioi 296214.
    PROi P48759.
    SOURCEi Search...

    Gene expression databases

    Bgeei P48759.
    CleanExi MM_PTX3.
    Genevestigatori P48759.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view ]
    Pfami PF00354. Pentaxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00895. PENTAXIN.
    SMARTi SM00159. PTX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS00289. PENTAXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites."
      Introna M., Vidal Alles V., Castellano M., Picardi G., de Gioia L., Bottazzai B., Peri G., Breviario F., Salmona M., de Gregorio I., Dragani T.A., Srinivasan N., Blundell T.L., Hamilton T.A., Mantovani A.
      Blood 87:1862-1872(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Fibroblast.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.
    3. "Promoter structure and transcriptional activation of the murine TSG-14 gene encoding a tumor necrosis factor/interleukin-1-inducible pentraxin protein."
      Altmeyer A., Klampfer L., Goodman A.R., Vilcek J.
      J. Biol. Chem. 270:25584-25590(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-177.
      Strain: 129/Sv.
    4. "Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component."
      Bottazzi B., Vouret-Craviari V., Bastone A., De Gioia L., Matteucci C., Peri G., Spreafico F., Pausa M., D'Ettorre C., Gianazza E., Tagliabue A., Salmona M., Tedesco F., Introna M., Mantovani A.
      J. Biol. Chem. 272:32817-32823(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT.
    5. "Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity."
      Mantovani A., Garlanda C., Bottazzi B.
      Vaccine 21:S43-S47(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiPTX3_MOUSE
    AccessioniPrimary (citable) accession number: P48759
    Secondary accession number(s): Q8VDF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3