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Protein

Pentraxin-related protein PTX3

Gene

Ptx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.1 Publication

GO - Molecular functioni

  1. (1->3)-beta-D-glucan binding Source: MGI
  2. complement component C1q binding Source: MGI
  3. virion binding Source: MGI

GO - Biological processi

  1. innate immune response Source: MGI
  2. negative regulation by host of viral exo-alpha-sialidase activity Source: MGI
  3. negative regulation by host of viral glycoprotein metabolic process Source: MGI
  4. negative regulation of exo-alpha-sialidase activity Source: MGI
  5. negative regulation of glycoprotein metabolic process Source: MGI
  6. negative regulation of viral entry into host cell Source: MGI
  7. opsonization Source: MGI
  8. positive regulation of nitric oxide biosynthetic process Source: MGI
  9. positive regulation of phagocytosis Source: MGI
  10. response to yeast Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pentraxin-related protein PTX3
Alternative name(s):
Pentaxin-related protein PTX3
Tumor necrosis factor-inducible gene 14 protein
Short name:
TSG-14
Gene namesi
Name:Ptx3
Synonyms:Tsg14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:104641. Ptx3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 381364Pentraxin-related protein PTX3PRO_0000023546Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 – 47InterchainBy similarity
Disulfide bondi49 – 49InterchainBy similarity
Disulfide bondi103 – 103InterchainBy similarity
Disulfide bondi179 ↔ 357By similarity
Disulfide bondi210 ↔ 271By similarity
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi317 – 317InterchainBy similarity
Disulfide bondi318 – 318InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP48759.

PTM databases

PhosphoSiteiP48759.

Expressioni

Gene expression databases

BgeeiP48759.
CleanExiMM_PTX3.
GenevestigatoriP48759.

Interactioni

Subunit structurei

Homooctamer; disulfide-linked (By similarity). Binds to C1q.By similarity1 Publication

Protein-protein interaction databases

IntActiP48759. 1 interaction.
MINTiMINT-8178435.
STRINGi10090.ENSMUSP00000029421.

Structurei

3D structure databases

ProteinModelPortaliP48759.
SMRiP48759. Positions 182-375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini183 – 381199PentaxinAdd
BLAST

Sequence similaritiesi

Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40461.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000247046.
HOVERGENiHBG008331.
InParanoidiP48759.
OMAiCHIRGNI.
OrthoDBiEOG74XS6F.
PhylomeDBiP48759.
TreeFamiTF330208.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLPAILLCA LWSAVVAETS DDYELMYVNL DNEIDNGLHP TEDPTPCDCR
60 70 80 90 100
QEHSEWDKLF IMLENSQMRE GMLLQATDDV LRGELQRLRA ELGRLAGGMA
110 120 130 140 150
RPCAAGGPAD ARLVRALEPL LQESRDASLR LARLEDAEAR RPEATVPGLG
160 170 180 190 200
AVLEELRRTR ADLSAVQSWV ARHWLPAGCE TAIFFPMRSK KIFGSVHPVR
210 220 230 240 250
PMKLESFSTC IWVKATDVLN KTILFSYGTK WNPYEIQLYL SSQSLVLVVG
260 270 280 290 300
GKENKLAADT VVSLGRWSHL CGTWSSEQGS MSLWANGELV ATTVEMAKSH
310 320 330 340 350
SVPEGGLLQI GQEKNGCCVG GGFDESLAFS GRITGFNIWD RVLSEEEIRA
360 370 380
SGGVESCHIR GNVVGWGVTE IQAHGGAQYV S
Length:381
Mass (Da):41,812
Last modified:October 1, 1996 - v2
Checksum:iE3CA3B1D93CFE4EB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501R → A in AAC52273 (PubMed:7592730).Curated
Sequence conflicti90 – 901A → S in AAC52273 (PubMed:7592730).Curated
Sequence conflicti129 – 1291L → R in AAH22176 (PubMed:15489334).Curated
Sequence conflicti142 – 1421P → S in AAH22176 (PubMed:15489334).Curated
Sequence conflicti147 – 1471P → S in AAH22176 (PubMed:15489334).Curated
Sequence conflicti161 – 1611A → S in AAC52273 (PubMed:7592730).Curated
Sequence conflicti172 – 1721R → H in AAC52273 (PubMed:7592730).Curated
Sequence conflicti184 – 1841F → L in AAH22176 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83601 mRNA. Translation: CAA58580.1.
BC022176 mRNA. Translation: AAH22176.1.
U33842 Genomic DNA. Translation: AAC52273.1.
CCDSiCCDS17392.1.
RefSeqiNP_033013.3. NM_008987.3.
UniGeneiMm.276776.
Mm.442151.

Genome annotation databases

EnsembliENSMUST00000029421; ENSMUSP00000029421; ENSMUSG00000027832.
GeneIDi19288.
KEGGimmu:19288.
UCSCiuc008pla.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83601 mRNA. Translation: CAA58580.1.
BC022176 mRNA. Translation: AAH22176.1.
U33842 Genomic DNA. Translation: AAC52273.1.
CCDSiCCDS17392.1.
RefSeqiNP_033013.3. NM_008987.3.
UniGeneiMm.276776.
Mm.442151.

3D structure databases

ProteinModelPortaliP48759.
SMRiP48759. Positions 182-375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP48759. 1 interaction.
MINTiMINT-8178435.
STRINGi10090.ENSMUSP00000029421.

PTM databases

PhosphoSiteiP48759.

Proteomic databases

PRIDEiP48759.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029421; ENSMUSP00000029421; ENSMUSG00000027832.
GeneIDi19288.
KEGGimmu:19288.
UCSCiuc008pla.1. mouse.

Organism-specific databases

CTDi5806.
MGIiMGI:104641. Ptx3.

Phylogenomic databases

eggNOGiNOG40461.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000247046.
HOVERGENiHBG008331.
InParanoidiP48759.
OMAiCHIRGNI.
OrthoDBiEOG74XS6F.
PhylomeDBiP48759.
TreeFamiTF330208.

Miscellaneous databases

NextBioi296214.
PROiP48759.
SOURCEiSearch...

Gene expression databases

BgeeiP48759.
CleanExiMM_PTX3.
GenevestigatoriP48759.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites."
    Introna M., Vidal Alles V., Castellano M., Picardi G., de Gioia L., Bottazzai B., Peri G., Breviario F., Salmona M., de Gregorio I., Dragani T.A., Srinivasan N., Blundell T.L., Hamilton T.A., Mantovani A.
    Blood 87:1862-1872(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Fibroblast.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  3. "Promoter structure and transcriptional activation of the murine TSG-14 gene encoding a tumor necrosis factor/interleukin-1-inducible pentraxin protein."
    Altmeyer A., Klampfer L., Goodman A.R., Vilcek J.
    J. Biol. Chem. 270:25584-25590(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-177.
    Strain: 129/Sv.
  4. "Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component."
    Bottazzi B., Vouret-Craviari V., Bastone A., De Gioia L., Matteucci C., Peri G., Spreafico F., Pausa M., D'Ettorre C., Gianazza E., Tagliabue A., Salmona M., Tedesco F., Introna M., Mantovani A.
    J. Biol. Chem. 272:32817-32823(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  5. "Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity."
    Mantovani A., Garlanda C., Bottazzi B.
    Vaccine 21:S43-S47(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiPTX3_MOUSE
AccessioniPrimary (citable) accession number: P48759
Secondary accession number(s): Q8VDF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 1, 1996
Last modified: April 1, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.