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Protein

Pentraxin-related protein PTX3

Gene

Ptx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.1 Publication

GO - Molecular functioni

  • (1->3)-beta-D-glucan binding Source: MGI
  • complement component C1q binding Source: MGI
  • identical protein binding Source: MGI
  • virion binding Source: MGI

GO - Biological processi

  • innate immune response Source: MGI
  • negative regulation by host of viral exo-alpha-sialidase activity Source: MGI
  • negative regulation by host of viral glycoprotein metabolic process Source: MGI
  • negative regulation of exo-alpha-sialidase activity Source: MGI
  • negative regulation of glycoprotein metabolic process Source: MGI
  • negative regulation of viral entry into host cell Source: MGI
  • opsonization Source: MGI
  • positive regulation of nitric oxide biosynthetic process Source: MGI
  • positive regulation of phagocytosis Source: MGI
  • response to yeast Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Pentraxin-related protein PTX3
Alternative name(s):
Pentaxin-related protein PTX3
Tumor necrosis factor-inducible gene 14 protein
Short name:
TSG-14
Gene namesi
Name:Ptx3
Synonyms:Tsg14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:104641 Ptx3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002354618 – 381Pentraxin-related protein PTX3Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47InterchainBy similarity
Disulfide bondi49InterchainBy similarity
Disulfide bondi103InterchainBy similarity
Disulfide bondi179 ↔ 357By similarity
Disulfide bondi210 ↔ 271PROSITE-ProRule annotation
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi317InterchainBy similarity
Disulfide bondi318InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP48759
PaxDbiP48759
PRIDEiP48759

PTM databases

PhosphoSitePlusiP48759

Expressioni

Gene expression databases

BgeeiENSMUSG00000027832
CleanExiMM_PTX3
GenevisibleiP48759 MM

Interactioni

Subunit structurei

Homooctamer; disulfide-linked (By similarity). Binds to C1q.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiP48759, 1 interactor
MINTiP48759
STRINGi10090.ENSMUSP00000029421

Structurei

3D structure databases

ProteinModelPortaliP48759
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 381Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST203

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHCT Eukaryota
ENOG410XRG6 LUCA
GeneTreeiENSGT00760000119128
HOGENOMiHOG000247046
HOVERGENiHBG008331
InParanoidiP48759
OMAiCHIRGNI
OrthoDBiEOG091G0AHP
PhylomeDBiP48759
TreeFamiTF330208

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLPAILLCA LWSAVVAETS DDYELMYVNL DNEIDNGLHP TEDPTPCDCR
60 70 80 90 100
QEHSEWDKLF IMLENSQMRE GMLLQATDDV LRGELQRLRA ELGRLAGGMA
110 120 130 140 150
RPCAAGGPAD ARLVRALEPL LQESRDASLR LARLEDAEAR RPEATVPGLG
160 170 180 190 200
AVLEELRRTR ADLSAVQSWV ARHWLPAGCE TAIFFPMRSK KIFGSVHPVR
210 220 230 240 250
PMKLESFSTC IWVKATDVLN KTILFSYGTK WNPYEIQLYL SSQSLVLVVG
260 270 280 290 300
GKENKLAADT VVSLGRWSHL CGTWSSEQGS MSLWANGELV ATTVEMAKSH
310 320 330 340 350
SVPEGGLLQI GQEKNGCCVG GGFDESLAFS GRITGFNIWD RVLSEEEIRA
360 370 380
SGGVESCHIR GNVVGWGVTE IQAHGGAQYV S
Length:381
Mass (Da):41,812
Last modified:October 1, 1996 - v2
Checksum:iE3CA3B1D93CFE4EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50R → A in AAC52273 (PubMed:7592730).Curated1
Sequence conflicti90A → S in AAC52273 (PubMed:7592730).Curated1
Sequence conflicti129L → R in AAH22176 (PubMed:15489334).Curated1
Sequence conflicti142P → S in AAH22176 (PubMed:15489334).Curated1
Sequence conflicti147P → S in AAH22176 (PubMed:15489334).Curated1
Sequence conflicti161A → S in AAC52273 (PubMed:7592730).Curated1
Sequence conflicti172R → H in AAC52273 (PubMed:7592730).Curated1
Sequence conflicti184F → L in AAH22176 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83601 mRNA Translation: CAA58580.1
BC022176 mRNA Translation: AAH22176.1
U33842 Genomic DNA Translation: AAC52273.1
CCDSiCCDS17392.1
RefSeqiNP_033013.3, NM_008987.3
UniGeneiMm.276776
Mm.442151

Genome annotation databases

EnsembliENSMUST00000029421; ENSMUSP00000029421; ENSMUSG00000027832
GeneIDi19288
KEGGimmu:19288
UCSCiuc008pla.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPTX3_MOUSE
AccessioniPrimary (citable) accession number: P48759
Secondary accession number(s): Q8VDF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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