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P48757 (GAST_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gastrin

Cleaved into the following 3 chains:

  1. Gastrin-71
    Short name=G71
  2. Big gastrin
    Alternative name(s):
    Gastrin-34
    Short name=G34
  3. Gastrin
Gene names
Name:Gast
Synonyms:Gas
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length101 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.

Subcellular location

Secreted.

Tissue specificity

Abundantly expressed in the stomach and duodenum. Low levels in brain, ovary and pancreas. Ref.3

Post-translational modification

Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins and between tissues By similarity.

Sequence similarities

Belongs to the gastrin/cholecystokinin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
Phosphoprotein
Pyrrolidone carboxylic acid
Sulfation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Peptide22 – 9271Gastrin-71
PRO_0000010640
Peptide59 – 9234Big gastrin
PRO_0000010641
Peptide76 – 9217Gastrin
PRO_0000010642
Propeptide96 – 1016 By similarity
PRO_0000010643

Amino acid modifications

Modified residue591Pyrrolidone carboxylic acid By similarity
Modified residue761Pyrrolidone carboxylic acid By similarity
Modified residue871Sulfotyrosine By similarity
Modified residue921Phenylalanine amide
Modified residue961Phosphoserine By similarity

Experimental info

Sequence conflict451R → G in AAB06947. Ref.2
Sequence conflict621P → L in AAB97872. Ref.1
Sequence conflict621P → L in AAB06947. Ref.2
Sequence conflict621P → L in CAA64385. Ref.3
Sequence conflict621P → L in CAA64386. Ref.3
Sequence conflict761Q → E in AAB97872. Ref.1
Sequence conflict761Q → E in AAB06947. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P48757 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 41DE15814DBFB68E

FASTA10111,590
        10         20         30         40         50         60 
MPRLCVYMLV LVLALATFSE ASWKPRSQLQ DASSGPGTNE DLEQRQFNKL GSASHHRRQL 

        70         80         90        100 
GPQGPQHFIA DLSKKQRPRM EEEEEAYGWM DFGRRSAEED Q 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and sequencing of the murine gastrin gene."
Koh T.J., Wang T.C.
Biochem. Biophys. Res. Commun. 216:34-41(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[2]"Sequences responsible for transcription termination of the mouse gastrin gene."
Noh M.J., Kim S.J., Kang Y.K., Yoo O.J.
Biochem. Mol. Biol. Int. 35:1205-1213(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
[3]"Molecular structure and genetic mapping of the mouse gastrin gene."
Friis-Hansen L., Rourke I.J., Bundgaard J.R., Rehfeld J.F., Samuelson L.C.
FEBS Lett. 386:128-132(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
Strain: 129/SvJ.
Tissue: Stomach.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Small intestine and Stomach.
[5]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U34293 Genomic DNA. Translation: AAB97872.1.
U58136 Genomic DNA. Translation: AAB06947.1.
X94760 Genomic DNA. Translation: CAA64386.1.
X94758 mRNA. Translation: CAA64385.1.
AK008062 mRNA. Translation: BAB25437.1.
AK008159 mRNA. Translation: BAB25501.1.
AK008313 mRNA. Translation: BAB25596.1.
AK008420 mRNA. Translation: BAB25658.1.
AK008494 mRNA. Translation: BAB25699.1.
AK008649 mRNA. Translation: BAB25807.1.
AL590968 Genomic DNA. Translation: CAM23027.1.
PIRS68861.
RefSeqNP_034387.3. NM_010257.3.
UniGeneMm.4767.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP48757.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000017309; ENSMUSP00000017309; ENSMUSG00000017165.
GeneID14459.
KEGGmmu:14459.
UCSCuc007lkw.2. mouse.

Organism-specific databases

CTD2520.
MGIMGI:104768. Gast.

Phylogenomic databases

eggNOGNOG39909.
GeneTreeENSGT00390000014792.
HOGENOMHOG000073533.
HOVERGENHBG097593.
InParanoidP48757.
KOK13768.
OMAKPRSQLQ.
OrthoDBEOG72ZCH9.
TreeFamTF336994.

Gene expression databases

CleanExMM_GAST.
GenevestigatorP48757.

Family and domain databases

InterProIPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PfamPF00918. Gastrin. 1 hit.
[Graphical view]
SMARTSM00029. GASTRIN. 1 hit.
[Graphical view]
PROSITEPS00259. GASTRIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286088.
PROP48757.
SOURCESearch...

Entry information

Entry nameGAST_MOUSE
AccessionPrimary (citable) accession number: P48757
Secondary accession number(s): P70334, Q64295, Q9CPR2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: April 16, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot