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P48757

- GAST_MOUSE

UniProt

P48757 - GAST_MOUSE

Protein

Gastrin

Gene

Gast

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_188573. Gastrin-CREB signalling pathway via PKC and MAPK.
    REACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gastrin
    Cleaved into the following 3 chains:
    Gastrin-71
    Short name:
    G71
    Alternative name(s):
    Gastrin-34
    Short name:
    G34
    Gene namesi
    Name:Gast
    Synonyms:Gas
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:104768. Gast.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Peptidei22 – 9271Gastrin-71PRO_0000010640Add
    BLAST
    Peptidei59 – 9234Big gastrinPRO_0000010641Add
    BLAST
    Peptidei76 – 9217GastrinPRO_0000010642Add
    BLAST
    Propeptidei96 – 1016By similarityPRO_0000010643

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei59 – 591Pyrrolidone carboxylic acidBy similarity
    Modified residuei76 – 761Pyrrolidone carboxylic acidBy similarity
    Modified residuei87 – 871SulfotyrosineBy similarity
    Modified residuei92 – 921Phenylalanine amide
    Modified residuei96 – 961PhosphoserineBy similarity

    Post-translational modificationi

    Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins and between tissues By similarity.By similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Phosphoprotein, Pyrrolidone carboxylic acid, Sulfation

    PTM databases

    PhosphoSiteiP48757.

    Expressioni

    Tissue specificityi

    Abundantly expressed in the stomach and duodenum. Low levels in brain, ovary and pancreas.1 Publication

    Gene expression databases

    CleanExiMM_GAST.
    GenevestigatoriP48757.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the gastrin/cholecystokinin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39909.
    GeneTreeiENSGT00390000014792.
    HOGENOMiHOG000073533.
    HOVERGENiHBG097593.
    InParanoidiP48757.
    KOiK13768.
    OMAiKQRPRME.
    OrthoDBiEOG72ZCH9.
    TreeFamiTF336994.

    Family and domain databases

    InterProiIPR001651. Gastrin.
    IPR013152. Gastrin/cholecystokinin_CS.
    [Graphical view]
    PfamiPF00918. Gastrin. 1 hit.
    [Graphical view]
    SMARTiSM00029. GASTRIN. 1 hit.
    [Graphical view]
    PROSITEiPS00259. GASTRIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P48757-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRLCVYMLV LVLALATFSE ASWKPRSQLQ DASSGPGTNE DLEQRQFNKL    50
    GSASHHRRQL GPQGPQHFIA DLSKKQRPRM EEEEEAYGWM DFGRRSAEED 100
    Q 101
    Length:101
    Mass (Da):11,590
    Last modified:October 3, 2012 - v2
    Checksum:i41DE15814DBFB68E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti45 – 451R → G in AAB06947. (PubMed:7492958)Curated
    Sequence conflicti62 – 621P → L in AAB97872. (PubMed:7488110)Curated
    Sequence conflicti62 – 621P → L in AAB06947. (PubMed:7492958)Curated
    Sequence conflicti62 – 621P → L in CAA64385. (PubMed:8647266)Curated
    Sequence conflicti62 – 621P → L in CAA64386. (PubMed:8647266)Curated
    Sequence conflicti76 – 761Q → E in AAB97872. (PubMed:7488110)Curated
    Sequence conflicti76 – 761Q → E in AAB06947. (PubMed:7492958)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34293 Genomic DNA. Translation: AAB97872.1.
    U58136 Genomic DNA. Translation: AAB06947.1.
    X94760 Genomic DNA. Translation: CAA64386.1.
    X94758 mRNA. Translation: CAA64385.1.
    AK008062 mRNA. Translation: BAB25437.1.
    AK008159 mRNA. Translation: BAB25501.1.
    AK008313 mRNA. Translation: BAB25596.1.
    AK008420 mRNA. Translation: BAB25658.1.
    AK008494 mRNA. Translation: BAB25699.1.
    AK008649 mRNA. Translation: BAB25807.1.
    AL590968 Genomic DNA. Translation: CAM23027.1.
    CCDSiCCDS25418.1.
    PIRiS68861.
    RefSeqiNP_034387.3. NM_010257.3.
    UniGeneiMm.4767.

    Genome annotation databases

    EnsembliENSMUST00000017309; ENSMUSP00000017309; ENSMUSG00000017165.
    GeneIDi14459.
    KEGGimmu:14459.
    UCSCiuc007lkw.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34293 Genomic DNA. Translation: AAB97872.1 .
    U58136 Genomic DNA. Translation: AAB06947.1 .
    X94760 Genomic DNA. Translation: CAA64386.1 .
    X94758 mRNA. Translation: CAA64385.1 .
    AK008062 mRNA. Translation: BAB25437.1 .
    AK008159 mRNA. Translation: BAB25501.1 .
    AK008313 mRNA. Translation: BAB25596.1 .
    AK008420 mRNA. Translation: BAB25658.1 .
    AK008494 mRNA. Translation: BAB25699.1 .
    AK008649 mRNA. Translation: BAB25807.1 .
    AL590968 Genomic DNA. Translation: CAM23027.1 .
    CCDSi CCDS25418.1.
    PIRi S68861.
    RefSeqi NP_034387.3. NM_010257.3.
    UniGenei Mm.4767.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P48757.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000017309 ; ENSMUSP00000017309 ; ENSMUSG00000017165 .
    GeneIDi 14459.
    KEGGi mmu:14459.
    UCSCi uc007lkw.2. mouse.

    Organism-specific databases

    CTDi 2520.
    MGIi MGI:104768. Gast.

    Phylogenomic databases

    eggNOGi NOG39909.
    GeneTreei ENSGT00390000014792.
    HOGENOMi HOG000073533.
    HOVERGENi HBG097593.
    InParanoidi P48757.
    KOi K13768.
    OMAi KQRPRME.
    OrthoDBi EOG72ZCH9.
    TreeFami TF336994.

    Enzyme and pathway databases

    Reactomei REACT_188573. Gastrin-CREB signalling pathway via PKC and MAPK.
    REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 286088.
    PROi P48757.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_GAST.
    Genevestigatori P48757.

    Family and domain databases

    InterProi IPR001651. Gastrin.
    IPR013152. Gastrin/cholecystokinin_CS.
    [Graphical view ]
    Pfami PF00918. Gastrin. 1 hit.
    [Graphical view ]
    SMARTi SM00029. GASTRIN. 1 hit.
    [Graphical view ]
    PROSITEi PS00259. GASTRIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequencing of the murine gastrin gene."
      Koh T.J., Wang T.C.
      Biochem. Biophys. Res. Commun. 216:34-41(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "Sequences responsible for transcription termination of the mouse gastrin gene."
      Noh M.J., Kim S.J., Kang Y.K., Yoo O.J.
      Biochem. Mol. Biol. Int. 35:1205-1213(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    3. "Molecular structure and genetic mapping of the mouse gastrin gene."
      Friis-Hansen L., Rourke I.J., Bundgaard J.R., Rehfeld J.F., Samuelson L.C.
      FEBS Lett. 386:128-132(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
      Strain: 129/SvJ.
      Tissue: Stomach.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Small intestine and Stomach.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiGAST_MOUSE
    AccessioniPrimary (citable) accession number: P48757
    Secondary accession number(s): P70334, Q64295, Q9CPR2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3